FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CLASRP-MAP4K1 (FusionGDB2 ID:16957)

Fusion Gene Summary for CLASRP-MAP4K1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLASRP-MAP4K1
Fusion gene ID: 16957
HgeneTgene
Gene symbol

CLASRP

MAP4K1

Gene ID

11129

11184

Gene nameCLK4 associating serine/arginine rich proteinmitogen-activated protein kinase kinase kinase kinase 1
SynonymsCLASP|SFRS16|SWAP2HPK1
Cytomap

19q13.32

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionCLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1
Modification date2020031320200327
UniProtAcc

Q8N2M8

Q92918

Ensembl transtripts involved in fusion geneENST00000221455, ENST00000391953, 
ENST00000544944, 		ENST00000423454, 
ENST00000589002, ENST00000396857, 
ENST00000586296, ENST00000589130, 
ENST00000591517, 
Fusion gene scores* DoF score16 X 12 X 9=17286 X 6 X 5=180
# samples 176
** MAII scorelog2(17/1728*10)=-3.34549656602577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLASRP [Title/Abstract] AND MAP4K1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLASRP(45543569)-MAP4K1(39083977), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP4K1

GO:0006468

protein phosphorylation

8824585

TgeneMAP4K1

GO:0007257

activation of JUN kinase activity

8824585

TgeneMAP4K1

GO:0018105

peptidyl-serine phosphorylation

11053428|24362026

TgeneMAP4K1

GO:0046777

protein autophosphorylation

8824585|24362026

TgeneMAP4K1

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

8824585


check buttonFusion gene breakpoints across CLASRP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP4K1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A25D-01ACLASRPchr19

45543569

+MAP4K1chr19

39083977

-


Top

Fusion Gene ORF analysis for CLASRP-MAP4K1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221455ENST00000423454CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
5CDS-intronENST00000221455ENST00000589002CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
5CDS-intronENST00000391953ENST00000423454CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
5CDS-intronENST00000391953ENST00000589002CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
5CDS-intronENST00000544944ENST00000423454CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
5CDS-intronENST00000544944ENST00000589002CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000221455ENST00000396857CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000221455ENST00000586296CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000221455ENST00000589130CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000221455ENST00000591517CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000391953ENST00000396857CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000391953ENST00000586296CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000391953ENST00000589130CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000391953ENST00000591517CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000544944ENST00000396857CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000544944ENST00000586296CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000544944ENST00000589130CLASRPchr19

45543569

+MAP4K1chr19

39083977

-
In-frameENST00000544944ENST00000591517CLASRPchr19

45543569

+MAP4K1chr19

39083977

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000221455CLASRPchr1945543569+ENST00000591517MAP4K1chr1939083977-5281979835886
ENST00000221455CLASRPchr1945543569+ENST00000586296MAP4K1chr1939083977-4271979832274
ENST00000221455CLASRPchr1945543569+ENST00000589130MAP4K1chr1939083977-4251979832274
ENST00000221455CLASRPchr1945543569+ENST00000396857MAP4K1chr1939083977-4021979832274
ENST00000391953CLASRPchr1945543569+ENST00000591517MAP4K1chr1939083977-5221919235286
ENST00000391953CLASRPchr1945543569+ENST00000586296MAP4K1chr1939083977-4211919231674
ENST00000391953CLASRPchr1945543569+ENST00000589130MAP4K1chr1939083977-4191919231674
ENST00000391953CLASRPchr1945543569+ENST00000396857MAP4K1chr1939083977-3961919231674
ENST00000544944CLASRPchr1945543569+ENST00000591517MAP4K1chr1939083977-112279144871789
ENST00000544944CLASRPchr1945543569+ENST00000586296MAP4K1chr1939083977-102179144871789
ENST00000544944CLASRPchr1945543569+ENST00000589130MAP4K1chr1939083977-101979144871789
ENST00000544944CLASRPchr1945543569+ENST00000396857MAP4K1chr1939083977-99679144871789

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221455ENST00000591517CLASRPchr1945543569+MAP4K1chr1939083977-0.116242490.88375753
ENST00000221455ENST00000586296CLASRPchr1945543569+MAP4K1chr1939083977-0.082207490.9177925
ENST00000221455ENST00000589130CLASRPchr1945543569+MAP4K1chr1939083977-0.0786389260.921361
ENST00000221455ENST00000396857CLASRPchr1945543569+MAP4K1chr1939083977-0.0775642540.92243576
ENST00000391953ENST00000591517CLASRPchr1945543569+MAP4K1chr1939083977-0.104371410.89562863
ENST00000391953ENST00000586296CLASRPchr1945543569+MAP4K1chr1939083977-0.0785334560.92146647
ENST00000391953ENST00000589130CLASRPchr1945543569+MAP4K1chr1939083977-0.0752311350.92476887
ENST00000391953ENST00000396857CLASRPchr1945543569+MAP4K1chr1939083977-0.072700750.92729926
ENST00000544944ENST00000591517CLASRPchr1945543569+MAP4K1chr1939083977-0.415556430.5844436
ENST00000544944ENST00000586296CLASRPchr1945543569+MAP4K1chr1939083977-0.499614860.5003851
ENST00000544944ENST00000589130CLASRPchr1945543569+MAP4K1chr1939083977-0.489977240.5100228
ENST00000544944ENST00000396857CLASRPchr1945543569+MAP4K1chr1939083977-0.498961240.5010388

Top

Fusion Genomic Features for CLASRP-MAP4K1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CLASRP-MAP4K1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45543569/chr19:39083977)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLASRP

Q8N2M8

MAP4K1

Q92918

FUNCTION: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLASRPchr19:45543569chr19:39083977ENST00000221455+221585_64733675.0Coiled coilOntology_term=ECO:0000255
HgeneCLASRPchr19:45543569chr19:39083977ENST00000221455+221369_67333675.0Compositional biasNote=Arg-rich
HgeneCLASRPchr19:45543569chr19:39083977ENST00000221455+221377_53533675.0Compositional biasNote=Ser-rich
TgeneMAP4K1chr19:45543569chr19:39083977ENST00000396857283117_274780822.0DomainProtein kinase
TgeneMAP4K1chr19:45543569chr19:39083977ENST000003968572831495_800780822.0DomainCNH
TgeneMAP4K1chr19:45543569chr19:39083977ENST00000591517283217_274780834.0DomainProtein kinase
TgeneMAP4K1chr19:45543569chr19:39083977ENST000005915172832495_800780834.0DomainCNH
TgeneMAP4K1chr19:45543569chr19:39083977ENST00000396857283123_31780822.0Nucleotide bindingATP
TgeneMAP4K1chr19:45543569chr19:39083977ENST00000591517283223_31780834.0Nucleotide bindingATP


Top

Fusion Gene Sequence for CLASRP-MAP4K1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16957_16957_1_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000396857_length(transcript)=402nt_BP=197nt
GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC
TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG
AGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGA
CACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCC

>16957_16957_1_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000396857_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_2_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000586296_length(transcript)=427nt_BP=197nt
GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC
TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG
AGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGA
CACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCC

>16957_16957_2_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000586296_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_3_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000589130_length(transcript)=425nt_BP=197nt
GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC
TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG
AGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGA
CACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCC

>16957_16957_3_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000589130_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_4_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000591517_length(transcript)=528nt_BP=197nt
GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC
TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG
AGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCA
CGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGT
GGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCC

>16957_16957_4_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000221455_MAP4K1_chr19_39083977_ENST00000591517_length(amino acids)=86AA_BP=33

--------------------------------------------------------------
>16957_16957_5_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000396857_length(transcript)=396nt_BP=191nt
TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA
CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT
ATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCC
CAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCC

>16957_16957_5_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000396857_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_6_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000586296_length(transcript)=421nt_BP=191nt
TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA
CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT
ATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCC
CAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCC

>16957_16957_6_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000586296_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_7_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000589130_length(transcript)=419nt_BP=191nt
TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA
CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT
ATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCC
CAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCC

>16957_16957_7_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000589130_length(amino acids)=74AA_BP=33

--------------------------------------------------------------
>16957_16957_8_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000591517_length(transcript)=522nt_BP=191nt
TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA
CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT
ATGAAAAGATCCTGCTACAGGAGCTGAGAGACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCT
CGCCTCACTGCAACCTCCTCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGA
GACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCAC

>16957_16957_8_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000391953_MAP4K1_chr19_39083977_ENST00000591517_length(amino acids)=86AA_BP=33

--------------------------------------------------------------
>16957_16957_9_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000396857_length(transcript)=996nt_BP=791nt
CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC
CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC
TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG
GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA
CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT
GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG
CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA
CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC
GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAG
ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACC
TCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCATGGCATGTC

>16957_16957_9_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000396857_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>16957_16957_10_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000586296_length(transcript)=1021nt_BP=791nt
CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC
CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC
TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG
GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA
CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT
GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG
CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA
CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC
GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAG
ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACC
TCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCATGGCATGTC

>16957_16957_10_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000586296_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>16957_16957_11_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000589130_length(transcript)=1019nt_BP=791nt
CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC
CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC
TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG
GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA
CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT
GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG
CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA
CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC
GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAG
ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCCCAGCAACC
TCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCATGGCATGTC

>16957_16957_11_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000589130_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>16957_16957_12_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000591517_length(transcript)=1122nt_BP=791nt
CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC
CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC
TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG
GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA
CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT
GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG
CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA
CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC
GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCCTGCTACAGGAGCTGAGAG
ACCCTACCCTCACTTTCCGTCTGCTTGGCTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCGCCTCACTGCAACCTCCTCCTCCCAGGTT
CAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCCTGTAGTGGTGGAGACACGCCCAGTGGATGATCCTACTGCTCC
CAGCAACCTCTACATCCAGGAATGAGTCCCTAGGGGGGTGTCAGGAACTAGTCCTTGCACCCCCTCCCCCATAGACACACTAGTGGTCAT

>16957_16957_12_CLASRP-MAP4K1_CLASRP_chr19_45543569_ENST00000544944_MAP4K1_chr19_39083977_ENST00000591517_length(amino acids)=89AA_BP=

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLASRP-MAP4K1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CLASRP-MAP4K1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CLASRP-MAP4K1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource