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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLASRP-PPP1R37 (FusionGDB2 ID:16960)

Fusion Gene Summary for CLASRP-PPP1R37

check button Fusion gene summary
Fusion gene informationFusion gene name: CLASRP-PPP1R37
Fusion gene ID: 16960
HgeneTgene
Gene symbol

CLASRP

PPP1R37

Gene ID

11129

284352

Gene nameCLK4 associating serine/arginine rich proteinprotein phosphatase 1 regulatory subunit 37
SynonymsCLASP|SFRS16|SWAP2LRRC68
Cytomap

19q13.32

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionCLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2protein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68
Modification date2020031320200313
UniProtAcc

Q8N2M8

O75864

Ensembl transtripts involved in fusion geneENST00000221455, ENST00000391953, 
ENST00000544944, 		ENST00000496125, 
ENST00000221462, ENST00000421905, 
Fusion gene scores* DoF score16 X 12 X 9=17286 X 4 X 4=96
# samples 177
** MAII scorelog2(17/1728*10)=-3.34549656602577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLASRP [Title/Abstract] AND PPP1R37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPPP1R37(45596785)-CLASRP(45570594), # samples:2
CLASRP(45543569)-PPP1R37(45648465), # samples:2
Anticipated loss of major functional domain due to fusion event.CLASRP-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP1R37-CLASRP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R37

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across CLASRP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP1R37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8361-01ACLASRPchr19

45543569

+PPP1R37chr19

45648352

+
ChimerDB4STADTCGA-BR-8361-01ACLASRPchr19

45543569

+PPP1R37chr19

45648465

+


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Fusion Gene ORF analysis for CLASRP-PPP1R37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221455ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
5CDS-intronENST00000221455ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
5CDS-intronENST00000391953ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
5CDS-intronENST00000391953ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
5CDS-intronENST00000544944ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
5CDS-intronENST00000544944ENST00000496125CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000221455ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000221455ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000221455ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000221455ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000391953ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000391953ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000391953ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000391953ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000544944ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000544944ENST00000221462CLASRPchr19

45543569

+PPP1R37chr19

45648465

+
Frame-shiftENST00000544944ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648352

+
Frame-shiftENST00000544944ENST00000421905CLASRPchr19

45543569

+PPP1R37chr19

45648465

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CLASRP-PPP1R37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLASRPchr1945543569+PPP1R37chr1945648351+7.74E-050.99992263
CLASRPchr1945543569+PPP1R37chr1945648351+7.74E-050.99992263

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CLASRP-PPP1R37


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45596785/:45570594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLASRP

Q8N2M8

PPP1R37

O75864

FUNCTION: Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}.FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CLASRP-PPP1R37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CLASRP-PPP1R37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLASRP-PPP1R37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLASRP-PPP1R37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource