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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CLN3-POGZ (FusionGDB2 ID:17233)

Fusion Gene Summary for CLN3-POGZ

Fusion gene summary

Fusion gene information	Fusion gene name: CLN3-POGZ
	Fusion gene ID: 17233
		Hgene	Tgene
	Gene symbol	CLN3	POGZ
	Gene ID	1201	23126
	Gene name	CLN3 lysosomal/endosomal transmembrane protein, battenin	pogo transposable element derived with ZNF domain
	Synonyms	BTN1\|BTS\|JNCL	MRD37\|WHSUS\|ZNF280E\|ZNF635\|ZNF635m
	Cytomap	16p12.1	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	batteninCLN3, batteninbatten disease proteinceroid-lipofuscinosis, neuronal 3	pogo transposable element with ZNF domainputative protein product of Nbla00003zinc finger protein 280Ezinc finger protein 635
	Modification date	20200328	20200327
	UniProtAcc	Q13286	.
	Ensembl transtripts involved in fusion gene	ENST00000333496, ENST00000354630, ENST00000355477, ENST00000357076, ENST00000357806, ENST00000357857, ENST00000359984, ENST00000360019, ENST00000395653, ENST00000535392, ENST00000565316, ENST00000567160, ENST00000567963, ENST00000568224, ENST00000569430,	ENST00000271715, ENST00000361398, ENST00000368863, ENST00000392723, ENST00000409503, ENST00000491586, ENST00000531094, ENST00000540984,
Fusion gene scores	* DoF score	5 X 4 X 3=60	7 X 5 X 3=105
	# samples	5	8
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/105*10)=-0.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CLN3 [Title/Abstract] AND POGZ [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CLN3(28481293)-POGZ(151375200), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLN3	GO:0015809	arginine transport	16251196
Hgene	CLN3	GO:0035752	lysosomal lumen pH elevation	10924275
Hgene	CLN3	GO:0042987	amyloid precursor protein catabolic process	10924275

Fusion gene breakpoints across CLN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POGZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA747265	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+

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Fusion Gene ORF analysis for CLN3-POGZ

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000333496	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000333496	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000354630	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000355477	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357076	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357806	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000357857	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000359984	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000360019	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000395653	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000535392	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000565316	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567160	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000567963	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000568224	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000271715	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000361398	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000368863	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000392723	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000409503	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000491586	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000531094	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+
intron-intron	ENST00000569430	ENST00000540984	CLN3	chr16	28481293	-	POGZ	chr1	151375200	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CLN3-POGZ

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CLN3-POGZ

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:28481293/:151375200)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLN3 Q13286	.
FUNCTION: Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10924275, PubMed:18817525, PubMed:18317235, PubMed:22261744, PubMed:15471887, PubMed:20850431). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:10924275, PubMed:18817525). Moreover regulates CTSD activity in response to osmotic stress (PubMed:23840424, PubMed:28390177). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:18317235). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:20850431). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (By similarity). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (By similarity). Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:17482562). {ECO:0000250\|UniProtKB:Q61124, ECO:0000269\|PubMed:10924275, ECO:0000269\|PubMed:15471887, ECO:0000269\|PubMed:17482562, ECO:0000269\|PubMed:18317235, ECO:0000269\|PubMed:18817525, ECO:0000269\|PubMed:20850431, ECO:0000269\|PubMed:22261744, ECO:0000269\|PubMed:23840424, ECO:0000269\|PubMed:28390177}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CLN3-POGZ

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CLN3-POGZ

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CLN3-POGZ

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CLN3-POGZ

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source