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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLN6-FBXL17 (FusionGDB2 ID:17240)

Fusion Gene Summary for CLN6-FBXL17

check button Fusion gene summary
Fusion gene informationFusion gene name: CLN6-FBXL17
Fusion gene ID: 17240
HgeneTgene
Gene symbol

CLN6

FBXL17

Gene ID

54982

64839

Gene nameCLN6 transmembrane ER proteinF-box and leucine rich repeat protein 17
SynonymsCLN4A|HsT18960|nclfFBXO13|Fbl17|Fbx13
Cytomap

15q23

5q21.3

Type of geneprotein-codingprotein-coding
Descriptionceroid-lipofuscinosis neuronal protein 6ceroid-lipofuscinosis neuronal 6 late infantileceroid-lipofuscinosis, neuronal 6, late infantileF-box/LRR-repeat protein 17F-box only protein 13
Modification date2020032820200313
UniProtAcc.

Q9UF56

Ensembl transtripts involved in fusion geneENST00000418702, ENST00000569336, 
ENST00000249806, ENST00000564752, 
ENST00000565471, ENST00000566347, 
ENST00000538696, 		ENST00000359660, 
ENST00000496714, ENST00000542267, 
Fusion gene scores* DoF score12 X 7 X 9=75614 X 13 X 5=910
# samples 1213
** MAII scorelog2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLN6 [Title/Abstract] AND FBXL17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLN6(68521840)-FBXL17(107684231), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBXL17

GO:0000209

protein polyubiquitination

27234298

TgeneFBXL17

GO:0006515

protein quality control for misfolded or incompletely synthesized proteins

30190310

TgeneFBXL17

GO:0016567

protein ubiquitination

24035498|30190310

TgeneFBXL17

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

24035498|27234298

TgeneFBXL17

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

30190310


check buttonFusion gene breakpoints across CLN6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXL17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4402-01ACLN6chr15

68521840

-FBXL17chr5

107684231

-


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Fusion Gene ORF analysis for CLN6-FBXL17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000418702ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
5UTR-3CDSENST00000418702ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
5UTR-3CDSENST00000418702ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
5UTR-3CDSENST00000569336ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
5UTR-3CDSENST00000569336ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
5UTR-3CDSENST00000569336ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000249806ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000249806ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000249806ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000564752ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000564752ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000564752ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000565471ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000565471ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000565471ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000566347ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000566347ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
In-frameENST00000566347ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-
intron-3CDSENST00000538696ENST00000359660CLN6chr15

68521840

-FBXL17chr5

107684231

-
intron-3CDSENST00000538696ENST00000496714CLN6chr15

68521840

-FBXL17chr5

107684231

-
intron-3CDSENST00000538696ENST00000542267CLN6chr15

68521840

-FBXL17chr5

107684231

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000249806CLN6chr1568521840-ENST00000359660FBXL17chr5107684231-3658241145972275
ENST00000249806CLN6chr1568521840-ENST00000542267FBXL17chr5107684231-3648241145972275
ENST00000249806CLN6chr1568521840-ENST00000496714FBXL17chr5107684231-36322411451005286
ENST00000565471CLN6chr1568521840-ENST00000359660FBXL17chr5107684231-358717074901275
ENST00000565471CLN6chr1568521840-ENST00000542267FBXL17chr5107684231-357717074901275
ENST00000565471CLN6chr1568521840-ENST00000496714FBXL17chr5107684231-356117074934286
ENST00000566347CLN6chr1568521840-ENST00000359660FBXL17chr5107684231-3634217121948275
ENST00000566347CLN6chr1568521840-ENST00000542267FBXL17chr5107684231-3624217121948275
ENST00000566347CLN6chr1568521840-ENST00000496714FBXL17chr5107684231-3608217121981286
ENST00000564752CLN6chr1568521840-ENST00000359660FBXL17chr5107684231-3625208112939275
ENST00000564752CLN6chr1568521840-ENST00000542267FBXL17chr5107684231-3615208112939275
ENST00000564752CLN6chr1568521840-ENST00000496714FBXL17chr5107684231-3599208112972286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000249806ENST00000359660CLN6chr1568521840-FBXL17chr5107684231-0.0012222110.9987778
ENST00000249806ENST00000542267CLN6chr1568521840-FBXL17chr5107684231-0.001036810.99896324
ENST00000249806ENST00000496714CLN6chr1568521840-FBXL17chr5107684231-0.0035445170.99645555
ENST00000565471ENST00000359660CLN6chr1568521840-FBXL17chr5107684231-0.001197120.9988029
ENST00000565471ENST00000542267CLN6chr1568521840-FBXL17chr5107684231-0.0010149670.998985
ENST00000565471ENST00000496714CLN6chr1568521840-FBXL17chr5107684231-0.0036309750.996369
ENST00000566347ENST00000359660CLN6chr1568521840-FBXL17chr5107684231-0.0012152340.9987847
ENST00000566347ENST00000542267CLN6chr1568521840-FBXL17chr5107684231-0.0010311010.99896896
ENST00000566347ENST00000496714CLN6chr1568521840-FBXL17chr5107684231-0.0036158140.99638414
ENST00000564752ENST00000359660CLN6chr1568521840-FBXL17chr5107684231-0.0012108780.99878913
ENST00000564752ENST00000542267CLN6chr1568521840-FBXL17chr5107684231-0.0010273790.99897265
ENST00000564752ENST00000496714CLN6chr1568521840-FBXL17chr5107684231-0.0036308790.9963691

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Fusion Genomic Features for CLN6-FBXL17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CLN6-FBXL17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:68521840/chr5:107684231)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBXL17

Q9UF56

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBXL17chr15:68521840chr5:107684231ENST0000035966029216_23660304.0Compositional biasNote=Gly-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST000003596602990_15160304.0Compositional biasNote=Ala-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST0000049671417216_23660315.0Compositional biasNote=Gly-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST000004967141790_15160315.0Compositional biasNote=Ala-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST0000035966029318_36560304.0DomainF-box
TgeneFBXL17chr15:68521840chr5:107684231ENST0000049671417318_36560315.0DomainF-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-17111_13127312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-17179_19927312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-17204_22427312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-17225_24527312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-17260_28027312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-1756_7627312.0TransmembraneHelical
HgeneCLN6chr15:68521840chr5:107684231ENST00000249806-1781_10127312.0TransmembraneHelical
TgeneFBXL17chr15:68521840chr5:107684231ENST000003596602925_2860304.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr15:68521840chr5:107684231ENST000003596602929_8660304.0Compositional biasNote=Pro-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST000004967141725_2860315.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr15:68521840chr5:107684231ENST000004967141729_8660315.0Compositional biasNote=Pro-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST0000054226729216_236458702.0Compositional biasNote=Gly-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST000005422672925_28458702.0Compositional biasNote=Poly-Arg
TgeneFBXL17chr15:68521840chr5:107684231ENST000005422672929_86458702.0Compositional biasNote=Pro-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST000005422672990_151458702.0Compositional biasNote=Ala-rich
TgeneFBXL17chr15:68521840chr5:107684231ENST0000054226729318_365458702.0DomainF-box


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Fusion Gene Sequence for CLN6-FBXL17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17240_17240_1_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000359660_length(transcript)=3658nt_BP=241nt
GTCCGCAGCCCCGCCTGTTCCTCCCGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCC
GCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGC
AGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGA
TATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCA
GGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGT
CACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGT
GATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGC
AAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGAC
AATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTT
GGGGCTGATGAGATGTGATAAAGTCAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCA
GGACTGCAAGAGGACCTTGGAGAGAGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTA
GTCCACTGGGATCATTCAGCAGAGCAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGT
GTGTTCAAGTATGTGTATTTGTGTCTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTC
TTAGAAATTAAAGATTATGAAAGCCACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATA
GAGTCAAAAAATTGGATGTATTATTTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATG
AATTGTGCACTTCTACTGATGATGACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCAC
ATCTACACCAGGGCTCTGATCTACTCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGG
CACTGCCTAACTCCGTGTATCCTCGGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTT
GTTATATAGAGGCAACAGTCTGAACTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAA
ATATTTTAGTTGGTTTTATGTTAACATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACT
AATCTTAGCATTGAAGCCACCAATGTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAA
TTATTAAAGTCTATTTCTGAGATACGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTT
GTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAA
AGATCTATTGCTAGCTAATATATGAGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCAT
TTCTTTGTTTAATTAAGGATTGCCAGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAAT
TAATTCATAATAGGGACTCAGGCTCAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGT
GATTATCTTTCACAGTAGAACTAGAAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGT
CTTTAACAGATATACTGAGGTTTGAGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTA
CATTTGAATGCCATTTACTGATTTCTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGC
ATTTTTGTTTTAATCCCAATCGGTTAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAAT
TTGAAGGGAATAAAATTTGTGTAAGAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATA
TCCACTTCCCCACCACTGAAATATCTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAA
TAGTAGCTTGAGTGAATATGCAAAAGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCC
ATCTATGATATAGATGGTACCATTTCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTAT
AATTGATTTTTTTAAATGTTGCATTGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGAC
TTGCACTTATTCTCTAAAATGTTGACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGT
AGAAATACCATATCCAGCCTCAAAGCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTG
GTCCTGTGATGGTTGTTGAATGTGTTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTT
TTGCTTAGAATGTCATAAATACATGTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGA
CTATGAAATATATTGCTGTAGTGGAAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGT

>17240_17240_1_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000359660_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_2_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000496714_length(transcript)=3632nt_BP=241nt
GTCCGCAGCCCCGCCTGTTCCTCCCGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCC
GCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGC
AGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGA
TATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCA
GGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGT
CACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGT
GATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGC
AAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGAC
AATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTT
GGGGCTGATGAGATGTGATAAAGTAAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATATCC
TCTCTCCTTCTCTATCTCCACCCCCGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTGCC
TGCTTTTGTAAACTAATCTGAGATTATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATATA
CATAGTCAACTAGAGTTTGGCATCCTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCTAA
CCGTAAAATTGTATTCTGGGTTTCAAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAATTT
TGGTACTGAACATCTATGTATTCTGGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACATCA
GATGCCACTCCCAGCACATGATAAGAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAG
GAAATGGTGTAGCATTTAACGTGGGACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACATT
GGGAGGCCAAGGCAGAAGGATCACTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTCCC
CCAACAAAAAAAAATTAGCCAGGCATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTCAA
GAGGCCGAGGTTGCAGTGAGCCGTGATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAAAA
CCTATACTGGACACCAGGCACTCCACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTTGC
ATTGTGAAGGGGAGAAAATGGAGGCTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGTCT
GTATCCAGTGCTGCTGGCACAACCCAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCTCA
GAAAGTGCCGCCATCTTGTACTAATTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAACT
AAATAGACACGCCATTCAAAGGGCATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCTTT
GTGATTTTTTGTTAATTGGCTAATTCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAGAG
AAATGTTATTATATATTCTCAGCCCAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTCCC
ACAAATCTTTCCACTAACCAACCTAATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCATA
GGCATAGTCCTCTAGAAACAGGAATCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGCTA
CCAAAATGTACACATTCATACATATGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGATCA
GCTCCATCTTCGGAGATACACTGTAGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATTTT
GCTGATTTTTAGTTAAGAAATGGGTTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTATC
CCTGAGGGTTTTAGCCCTTTTCCTGGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACGAC
GCCGTCTGGTCAGAGCCTGCTGCAGTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTCAG
AGCCAAACACGAGAGGCTCTGTGAGGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCTTG
TTGGTTTAGTTGGATGGAAATCTAAAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATCAA
GATTCAAAGGAAGATATGAGTAACAAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGGGC
TTTGCACTTACTAGTTGTGTCACCGCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTACCT
ATCTTGTAGAATTGTGAGCATGTGAATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTGAT
TAGTCTTATCATCCATATCATTATATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAATTATATTGCCTACTATCCCA

>17240_17240_2_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000496714_length(amino acids)=286AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMSYPLSFSISTPVYYILYIHFI

--------------------------------------------------------------
>17240_17240_3_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000542267_length(transcript)=3648nt_BP=241nt
GTCCGCAGCCCCGCCTGTTCCTCCCGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCC
GCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGC
AGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGA
TATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCA
GGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGT
CACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGT
GATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGC
AAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGAC
AATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTT
GGGGCTGATGAGATGTGATAAAGTCAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCA
GGACTGCAAGAGGACCTTGGAGAGAGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTA
GTCCACTGGGATCATTCAGCAGAGCAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGT
GTGTTCAAGTATGTGTATTTGTGTCTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTC
TTAGAAATTAAAGATTATGAAAGCCACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATA
GAGTCAAAAAATTGGATGTATTATTTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATG
AATTGTGCACTTCTACTGATGATGACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCAC
ATCTACACCAGGGCTCTGATCTACTCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGG
CACTGCCTAACTCCGTGTATCCTCGGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTT
GTTATATAGAGGCAACAGTCTGAACTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAA
ATATTTTAGTTGGTTTTATGTTAACATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACT
AATCTTAGCATTGAAGCCACCAATGTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAA
TTATTAAAGTCTATTTCTGAGATACGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTT
GTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAA
AGATCTATTGCTAGCTAATATATGAGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCAT
TTCTTTGTTTAATTAAGGATTGCCAGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAAT
TAATTCATAATAGGGACTCAGGCTCAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGT
GATTATCTTTCACAGTAGAACTAGAAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGT
CTTTAACAGATATACTGAGGTTTGAGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTA
CATTTGAATGCCATTTACTGATTTCTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGC
ATTTTTGTTTTAATCCCAATCGGTTAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAAT
TTGAAGGGAATAAAATTTGTGTAAGAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATA
TCCACTTCCCCACCACTGAAATATCTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAA
TAGTAGCTTGAGTGAATATGCAAAAGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCC
ATCTATGATATAGATGGTACCATTTCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTAT
AATTGATTTTTTTAAATGTTGCATTGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGAC
TTGCACTTATTCTCTAAAATGTTGACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGT
AGAAATACCATATCCAGCCTCAAAGCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTG
GTCCTGTGATGGTTGTTGAATGTGTTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTT
TTGCTTAGAATGTCATAAATACATGTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGA
CTATGAAATATATTGCTGTAGTGGAAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGT

>17240_17240_3_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000249806_FBXL17_chr5_107684231_ENST00000542267_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_4_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000359660_length(transcript)=3625nt_BP=208nt
CGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCT
CGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGC
AGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGA
TGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAA
AGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCT
AAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAG
CTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTT
GGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGA
AATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTCAACGAAGT
GACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAGAGCCTATCA
GATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAGCAGAGGAGA
ATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGTCTTGTTTGC
ATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGCCACAAACTT
TTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTATTTTGAGCTT
CTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATGACTACAGCA
GAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTACTCTAGATCG
TTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTCGGGTGGCCA
ACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAACTCTCCTGG
CCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAACATTGTGTT
AGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAATGTAATTAAT
GGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATACGAGAGGGT
AGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAA
CAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATGAGTTAAGAA
AGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCCAGCTTCAGT
TAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCTCAAATAACT
GTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAGAAACAAAAC
CCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTGAGTTTCACT
TTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTTCTAATGATT
CTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGTTAGGAAAAT
CTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAAGAAAAAAGC
TGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATATCTTATTTCA
CAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAAAGTTTAATT
TTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATTTCAGTTCAA
AGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCATTGTTTGAAT
CTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTGACTAATCCA
GAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAAGCATTAATC
TCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTGTTCTCATTA
GATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACATGTGAACACG
TTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGGAAAATTCTG
GTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGTTTCTATATTTCCGTGAATCTTTGACCTTGCAGT

>17240_17240_4_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000359660_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_5_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000496714_length(transcript)=3599nt_BP=208nt
CGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCT
CGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGC
AGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGA
TGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAA
AGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCT
AAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAG
CTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTT
GGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGA
AATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTAAGAGTTGA
CTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATATCCTCTCTCCTTCTCTATCTCCACCCCCGTGTATTA
TATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTGCCTGCTTTTGTAAACTAATCTGAGATTATCTTTGT
ATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATATACATAGTCAACTAGAGTTTGGCATCCTATTCATA
AGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCTAACCGTAAAATTGTATTCTGGGTTTCAAGTTTCCA
GCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAATTTTGGTACTGAACATCTATGTATTCTGGCCATTCG
GGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACATCAGATGCCACTCCCAGCACATGATAAGAAGTGGTT
CCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAGGAAATGGTGTAGCATTTAACGTGGGACCCTTTG
AAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGAAGGATCACTTGAGCCCA
GGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTCCCCCAACAAAAAAAAATTAGCCAGGCATAATGGCA
CACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTCAAGAGGCCGAGGTTGCAGTGAGCCGTGATTGTGCC
GCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAAAACCTATACTGGACACCAGGCACTCCACAGGTGTT
TTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTTGCATTGTGAAGGGGAGAAAATGGAGGCTCAGAAAG
ACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGTCTGTATCCAGTGCTGCTGGCACAACCCAGGGGGCA
GTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCTCAGAAAGTGCCGCCATCTTGTACTAATTTACACAT
GTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAACTAAATAGACACGCCATTCAAAGGGCATGCATCTT
CTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCTTTGTGATTTTTTGTTAATTGGCTAATTCTTTTCTC
CAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAGAGAAATGTTATTATATATTCTCAGCCCAGCCCAGA
AGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTCCCACAAATCTTTCCACTAACCAACCTAATGCCGCT
GCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCATAGGCATAGTCCTCTAGAAACAGGAATCAATGACA
GCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGCTACCAAAATGTACACATTCATACATATGTGTCCGC
AGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGATCAGCTCCATCTTCGGAGATACACTGTAGAAGTTGT
ATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATTTTGCTGATTTTTAGTTAAGAAATGGGTTATTTTCT
ACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTATCCCTGAGGGTTTTAGCCCTTTTCCTGGGCTGCCT
CTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACGACGCCGTCTGGTCAGAGCCTGCTGCAGTGCAGCCC
AGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTCAGAGCCAAACACGAGAGGCTCTGTGAGGATGGAAG
ACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCTTGTTGGTTTAGTTGGATGGAAATCTAAAGTAGCTA
TTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATCAAGATTCAAAGGAAGATATGAGTAACAAAGAAAAG
AAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGGGCTTTGCACTTACTAGTTGTGTCACCGCGGGCAGT
TACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTACCTATCTTGTAGAATTGTGAGCATGTGAATGAGTTA
ACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTGATTAGTCTTATCATCCATATCATTATATTAACCTG

>17240_17240_5_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000496714_length(amino acids)=286AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMSYPLSFSISTPVYYILYIHFI

--------------------------------------------------------------
>17240_17240_6_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000542267_length(transcript)=3615nt_BP=208nt
CGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCT
CGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGC
AGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGA
TGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAA
AGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCT
AAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAG
CTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTT
GGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGA
AATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTCAACGAAGT
GACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAGAGCCTATCA
GATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAGCAGAGGAGA
ATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGTCTTGTTTGC
ATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGCCACAAACTT
TTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTATTTTGAGCTT
CTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATGACTACAGCA
GAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTACTCTAGATCG
TTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTCGGGTGGCCA
ACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAACTCTCCTGG
CCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAACATTGTGTT
AGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAATGTAATTAAT
GGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATACGAGAGGGT
AGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAA
CAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATGAGTTAAGAA
AGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCCAGCTTCAGT
TAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCTCAAATAACT
GTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAGAAACAAAAC
CCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTGAGTTTCACT
TTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTTCTAATGATT
CTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGTTAGGAAAAT
CTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAAGAAAAAAGC
TGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATATCTTATTTCA
CAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAAAGTTTAATT
TTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATTTCAGTTCAA
AGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCATTGTTTGAAT
CTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTGACTAATCCA
GAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAAGCATTAATC
TCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTGTTCTCATTA
GATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACATGTGAACACG
TTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGGAAAATTCTG
GTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGTTTCTATATTTCCGTGAATCTTTGACCTTGCAGT

>17240_17240_6_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000564752_FBXL17_chr5_107684231_ENST00000542267_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_7_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000359660_length(transcript)=3587nt_BP=170nt
GGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATG
GAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAA
AATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAAT
TACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAG
GCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTG
AACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACA
GGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCA
TTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCA
GCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTCAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCA
CCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAGAGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCT
AGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAGCAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTT
AACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGTCTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCA
AGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGCCACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAA
AAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTATTTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGC
CTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATGACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCA
CATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTACTCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGT
AGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTCGGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAA
TAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAACTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAAT
GCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAACATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATAT
TTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAATGTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATT
ATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATACGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGT
AGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACT
AGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATGAGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTAC
ACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCCAGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGA
TTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCTCAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAG
CCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAGAAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTG
AATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTGAGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGT
AAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTTCTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTC
AACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGTTAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTA
AATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAAGAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATT
GAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATATCTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTAT
AAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAAAGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAA
GACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATTTCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTC
AAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCATTGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGG
GTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTGACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGG
TACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAAGCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAA
AAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTGTTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGC
AATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACATGTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAAC
AGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGGAAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAA

>17240_17240_7_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000359660_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_8_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000496714_length(transcript)=3561nt_BP=170nt
GGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATG
GAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAA
AATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAAT
TACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAG
GCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTG
AACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACA
GGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCA
TTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCA
GCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTAAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTA
ATAGCTTGATGTCATATCCTCTCTCCTTCTCTATCTCCACCCCCGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTA
TAGCTATGCATTGTTTGCCTGCTTTTGTAAACTAATCTGAGATTATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGA
AAGAAAAAGTAATCATATACATAGTCAACTAGAGTTTGGCATCCTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAAC
TGCAATTTGCAGGGTCTAACCGTAAAATTGTATTCTGGGTTTCAAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTT
TTTCACAAGTGTGTAATTTTGGTACTGAACATCTATGTATTCTGGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATT
TGCATCTCCCCATACATCAGATGCCACTCCCAGCACATGATAAGAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGG
GATGTGAGCATGAGTTTAGGAAATGGTGTAGCATTTAACGTGGGACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACA
CCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGAAGGATCACTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCT
GTCTCTATCCCCCTCTCCCCCAACAAAAAAAAATTAGCCAGGCATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGG
GAGGATCACCTGAGCTCAAGAGGCCGAGGTTGCAGTGAGCCGTGATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGT
CCCAAACAAACAAAAAAAACCTATACTGGACACCAGGCACTCCACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGT
CTAAGAAATAGTTATTTGCATTGTGAAGGGGAGAAAATGGAGGCTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCA
TGCCGGGTCTTTGGAGTCTGTATCCAGTGCTGCTGGCACAACCCAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTC
CAGTTCAGATACTTGCTCAGAAAGTGCCGCCATCTTGTACTAATTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCT
AGCAAAATAATGTGAAACTAAATAGACACGCCATTCAAAGGGCATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCC
CAAAGCTCTTGTGTCCTTTGTGATTTTTTGTTAATTGGCTAATTCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGC
CAGCTAGTTATGTTTAGAGAAATGTTATTATATATTCTCAGCCCAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATC
CGGGGCTTGCGAGTCTCCCACAAATCTTTCCACTAACCAACCTAATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACA
AGTTAAAGGGTCCACCATAGGCATAGTCCTCTAGAAACAGGAATCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACA
TGAATGCTAACTAAAGCTACCAAAATGTACACATTCATACATATGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAAT
CTTTAGATGGTTAAGATCAGCTCCATCTTCGGAGATACACTGTAGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACAT
ATTTGCTGACCAGCATTTTGCTGATTTTTAGTTAAGAAATGGGTTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAG
TATTCAGATTAGCTGTATCCCTGAGGGTTTTAGCCCTTTTCCTGGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAAC
CCATTGGCTCCAGCACGACGCCGTCTGGTCAGAGCCTGCTGCAGTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCT
CAGACTTAAAGCAGCTCAGAGCCAAACACGAGAGGCTCTGTGAGGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTT
GCACAGAAAAGCCTGCTTGTTGGTTTAGTTGGATGGAAATCTAAAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCA
GATTTTAAGTTACCATCAAGATTCAAAGGAAGATATGAGTAACAAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAG
TTCAGGTTCAGATCTGGGCTTTGCACTTACTAGTTGTGTCACCGCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAAT
GAGGATGATACTAGTACCTATCTTGTAGAATTGTGAGCATGTGAATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATAT
AAAATGCTCTGTTACTGATTAGTCTTATCATCCATATCATTATATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAAT

>17240_17240_8_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000496714_length(amino acids)=286AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMSYPLSFSISTPVYYILYIHFI

--------------------------------------------------------------
>17240_17240_9_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000542267_length(transcript)=3577nt_BP=170nt
GGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATG
GAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAA
AATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAAGATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAAT
TACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCAGTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAG
GCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCTAACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTG
AACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAAAAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACA
GGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGAGCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCA
TTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATGGTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCA
GCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGTCAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCA
CCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAGAGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCT
AGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAGCAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTT
AACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGTCTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCA
AGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGCCACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAA
AAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTATTTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGC
CTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATGACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCA
CATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTACTCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGT
AGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTCGGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAA
TAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAACTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAAT
GCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAACATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATAT
TTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAATGTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATT
ATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATACGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGT
AGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGGGTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACT
AGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATGAGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTAC
ACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCCAGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGA
TTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCTCAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAG
CCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAGAAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTG
AATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTGAGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGT
AAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTTCTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTC
AACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGTTAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTA
AATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAAGAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATT
GAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATATCTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTAT
AAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAAAGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAA
GACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATTTCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTC
AAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCATTGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGG
GTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTGACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGG
TACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAAGCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAA
AAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTGTTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGC
AATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACATGTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAAC
AGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGGAAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAA

>17240_17240_9_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000565471_FBXL17_chr5_107684231_ENST00000542267_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_10_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000359660_length(transcript)=3634nt_BP=217nt
CGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGG
TCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCC
CAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAA
GATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCA
GTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCT
AACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAA
AAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGA
GCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATG
GTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGT
CAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAG
AGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAG
CAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGT
CTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGC
CACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTAT
TTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATG
ACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTAC
TCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTC
GGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAA
CTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAA
CATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAAT
GTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATA
CGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGG
GTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATG
AGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCC
AGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCT
CAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAG
AAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTG
AGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTT
CTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGT
TAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAA
GAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATAT
CTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAA
AGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATT
TCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCAT
TGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTG
ACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAA
GCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTG
TTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACAT
GTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGG
AAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGTTTCTATATTTCCGTGAATCTTTGA

>17240_17240_10_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000359660_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------
>17240_17240_11_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000496714_length(transcript)=3608nt_BP=217nt
CGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGG
TCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCC
CAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAA
GATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCA
GTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCT
AACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAA
AAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGA
GCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATG
GTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGT
AAGAGTTGACTATCAAGTTGTTTGCTTTCTACATATCAGTATAGTTAATAGCTTGATGTCATATCCTCTCTCCTTCTCTATCTCCACCCC
CGTGTATTATATATTATATATACATTTTATATGTATATATGCAATTATAGCTATGCATTGTTTGCCTGCTTTTGTAAACTAATCTGAGAT
TATCTTTGTATTTCCCCACTTAATAATGAATTTTGTGCTTAAGTAGAAAGAAAAAGTAATCATATACATAGTCAACTAGAGTTTGGCATC
CTATTCATAAGTCCATGGACCAAAATGTAAAAGATTACATGACAAACTGCAATTTGCAGGGTCTAACCGTAAAATTGTATTCTGGGTTTC
AAGTTTCCAGCAACAGTAAAGGTGGAAAGAACAGTGCCAAATTGGTTTTTCACAAGTGTGTAATTTTGGTACTGAACATCTATGTATTCT
GGCCATTCGGGACCAACAAAGGGCCAGTAAGGGGGTATGTGGGAATTTGCATCTCCCCATACATCAGATGCCACTCCCAGCACATGATAA
GAAGTGGTTCCAGAGGTCCTGGTGGAAGGCCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAGGAAATGGTGTAGCATTTAACGTGG
GACCCTTTGAAGACTGAGAAAACAGATAATAAAAATCTATACTGACACCTGTAATCCCAGCACATTGGGAGGCCAAGGCAGAAGGATCAC
TTGAGCCCAGGAATTTGAGACCAGCCTGGACAACATGGGAAAACCCTGTCTCTATCCCCCTCTCCCCCAACAAAAAAAAATTAGCCAGGC
ATAATGGCACACACCTGTAGTCCCAGCTACTCGGGAAGCTAAGGTGGGAGGATCACCTGAGCTCAAGAGGCCGAGGTTGCAGTGAGCCGT
GATTGTGCCGCAACCACCTCAGCCTGGATGACGGAGCACGACTGTGTCCCAAACAAACAAAAAAAACCTATACTGGACACCAGGCACTCC
ACAGGTGTTTTCTTCTTTGTTTATTCCATGTTTTACCTATAACAAGTCTAAGAAATAGTTATTTGCATTGTGAAGGGGAGAAAATGGAGG
CTCAGAAAGACCAGTCAGTGGCCCCAGGATACTCTGGCAAGACTTCATGCCGGGTCTTTGGAGTCTGTATCCAGTGCTGCTGGCACAACC
CAGGGGGCAGTCTGTGGCCACGGGGACTGCTTCCCTTGGAAAAGGTCCAGTTCAGATACTTGCTCAGAAAGTGCCGCCATCTTGTACTAA
TTTACACATGTGTGCTACTTTTGTAAATGGTGATTAGGAACAAATCTAGCAAAATAATGTGAAACTAAATAGACACGCCATTCAAAGGGC
ATGCATCTTCTAAATGTAGCAAATGTGGGGGCAAATGAAGTATGGCCCAAAGCTCTTGTGTCCTTTGTGATTTTTTGTTAATTGGCTAAT
TCTTTTCTCCAAACACTTTAGAATCCCAACTTATACGAGACCTTTGCCAGCTAGTTATGTTTAGAGAAATGTTATTATATATTCTCAGCC
CAGCCCAGAAGCGACTTACTTTGTAACTAAGCAACAGCACTGAGATCCGGGGCTTGCGAGTCTCCCACAAATCTTTCCACTAACCAACCT
AATGCCGCTGCTAACCCTGCCACTTTAAAATGACTTCTTTTAAGACAAGTTAAAGGGTCCACCATAGGCATAGTCCTCTAGAAACAGGAA
TCAATGACAGCAGAACTCCTCAGCTTCCAGCAGAAGGAACTGCCACATGAATGCTAACTAAAGCTACCAAAATGTACACATTCATACATA
TGTGTCCGCAGCCATTCTCAGAAATTGTCATATTTCTAACCTGTAATCTTTAGATGGTTAAGATCAGCTCCATCTTCGGAGATACACTGT
AGAAGTTGTATGTTACAGTTACTACAGGAGAATGTTATTCCAGACATATTTGCTGACCAGCATTTTGCTGATTTTTAGTTAAGAAATGGG
TTATTTTCTACCCAAATGCAAATTAGTCCAAAATTAAATAGAGACAGTATTCAGATTAGCTGTATCCCTGAGGGTTTTAGCCCTTTTCCT
GGGCTGCCTCTGAATCCTTTCTCTAACCAGAGAGCCACTCTGAGAACCCATTGGCTCCAGCACGACGCCGTCTGGTCAGAGCCTGCTGCA
GTGCAGCCCAGGGAGATGCTGGACCCAGCCTTGCTGTCTGGCTTCCTCAGACTTAAAGCAGCTCAGAGCCAAACACGAGAGGCTCTGTGA
GGATGGAAGACAGTTCCAAACCACACACAAAGCACAAGTAAAGCCTTGCACAGAAAAGCCTGCTTGTTGGTTTAGTTGGATGGAAATCTA
AAGTAGCTATTCAGTTTTCAGATTTTGTATCATGCCATCCATCTCCAGATTTTAAGTTACCATCAAGATTCAAAGGAAGATATGAGTAAC
AAAGAAAAGAAATTAGTAGCAACGGTATGGTCTGCGGAGAGCCAGAGTTCAGGTTCAGATCTGGGCTTTGCACTTACTAGTTGTGTCACC
GCGGGCAGTTACTAACCTCTCAGTGCCTGTTCCCTCGTTTGCAAAATGAGGATGATACTAGTACCTATCTTGTAGAATTGTGAGCATGTG
AATGAGTTAACATACATAAAGCACTTAGAATAATGTCTATTATATATAAAATGCTCTGTTACTGATTAGTCTTATCATCCATATCATTAT
ATTAACCTGTGTTGTGATACTGGAATTTTCCAATGAGAAAAAAAAATTATATTGCCTACTATCCCATTTTGAAAGACAATTAAAAAGAAA

>17240_17240_11_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000496714_length(amino acids)=286AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVVCFLHISIVNSLMSYPLSFSISTPVYYILYIHFI

--------------------------------------------------------------
>17240_17240_12_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000542267_length(transcript)=3624nt_BP=217nt
CGAGGGCCGCGCGCTCTCGCCGGCCCGCCCCGAACCGCCCCGCGCTGGGAATTTGCGGCGGCCTCCGCCGGGGCAGCCGAGCTGAACCGG
TCTCTTCCTCGGAAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCC
CAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGCTGGGCTCAAAATGCAGAGAACTCAAAGATATTCATTTCGGCCAGTGTTACAA
GATCTCAGATGAAGGCATGATCGTCATAGCTAAGGGCTGTCTGAAATTACAAAGGATATACATGCAGGAAAACAAATTAGTGACAGATCA
GTCAGTGAAAGCATTTGCTGAACACTGTCCTGAGCTTCAATATGTAGGCTTCATGGGTTGTTCAGTCACTTCTAAAGGAGTCATTCACCT
AACCAAGCTAAGAAACCTTTCCAGCTTGGACCTACGTCATATCACTGAACTGGATAATGAAACCGTGATGGAAATTGTCAAGAGGTGCAA
AAATCTTAGCTCTCTCAATCTCTGTCTGAACTGGATCATAAATGACAGGTGTGTGGAGGTCATTGCAAAGGAAGGACAAAACCTGAAAGA
GCTATATTTGGTGTCCTGTAAAATCACAGATTATGCACTGATAGCCATTGGGCGATACAGCATGACAATAGAGACTGTGGATGTCGGATG
GTGTAAAGAAATCACAGACCAAGGAGCCACCCTGATTGCACAGAGCAGCAAGTCTCTGAGATATTTGGGGCTGATGAGATGTGATAAAGT
CAACGAAGTGACGGTGGAACAGCTGGTGCAGCAGTACCCCCACATCACCTTCAGCACCGTCCTGCAGGACTGCAAGAGGACCTTGGAGAG
AGCCTATCAGATGGGCTGGACCCCCAACATGTCTGCCGCCTCCTCCTAGCGCTCCTGCCTCGCCTAGTCCACTGGGATCATTCAGCAGAG
CAGAGGAGAATTGTACATTTGGGGAGCTGATCTCTCGGAAGGGTTTTAACTGTCACCTGTCTGTGTGTGTTCAAGTATGTGTATTTGTGT
CTTGTTTGCATACTGCATACCAAAAGTGCAGTTGTCATTTGTTCCCAAGTGAGCTGGCTTTTTTTCTTAGAAATTAAAGATTATGAAAGC
CACAAACTTTTTAGTTTTTAACTTCAAAGGCTTCTTTCTCTTTAAAAAAAAATTATTTTTAATATAGAGTCAAAAAATTGGATGTATTAT
TTTGAGCTTCTAATTGCTGCCACTTGGAGATGTCCAAGTAAGAAGGCCTTCTTTTTACATGGGATGAATTGTGCACTTCTACTGATGATG
ACTACAGCAGAAGTGATGTTATACGTACAGGCACTTACACTCTCTCACATATTCACACGTGTGCACATCTACACCAGGGCTCTGATCTAC
TCTAGATCGTTTCCTGACAGAGAAGCCTTCTTCCAGGCCACTAAGGTAGCATGTTATCCACTGTGGCACTGCCTAACTCCGTGTATCCTC
GGGTGGCCAACTTGCTATCTGGTGGGTGACTTGGGGACTAGAAAGAATAAAGCCTTTTCTAAATTTGTTATATAGAGGCAACAGTCTGAA
CTCTCCTGGCCAGCTCACGAAAGTTAATTATACATTATTCTACAAATGCATTCTGTTGAGCACTAAATATTTTAGTTGGTTTTATGTTAA
CATTGTGTTAGCTTTTATTTCCTGGATAGTAACTGGTCAGGATATATTTTAATGATATTTGAAACTAATCTTAGCATTGAAGCCACCAAT
GTAATTAATGGTGTGCAGTTATTTTAAAAACTACAGATCATTTCATTATTTTCTTAATTTTGGTAATTATTAAAGTCTATTTCTGAGATA
CGAGAGGGTAGTCACATTAATAGAAGATTCATGAGTGAGATATAAGTAGACAATCTTTCTACTGTTGTTGCTCTTTTTGCTTTGCTTTGG
GTTCTTGAACAGGTTTTTTGGATATATGCATGTTGTCATTTTGGACTAGTTCTCATGCTACTGCAAAGATCTATTGCTAGCTAATATATG
AGTTAAGAAAGAAAATTAGAAAATCTGTTCATTGAAATTCTGTTTACACTTGTCAGAAATAAGCATTTCTTTGTTTAATTAAGGATTGCC
AGCTTCAGTTAAGACAAGACCTATCAGTAAATGAATATATGTTTTGATTTAACACATCTTTACAATTAATTCATAATAGGGACTCAGGCT
CAAATAACTGTTCCTGTGTCTAGATTTATAATGAGGACATCAGGGAGCCTTTTTAAGCTAAAGAGTGATTATCTTTCACAGTAGAACTAG
AAACAAAACCCTAACTTGTGAAGTTGCTATTTATTTTTCCCTGAGTGAATATAACTGTTATTTGGTCTTTAACAGATATACTGAGGTTTG
AGTTTCACTTTCTTTAAGTCTCACATTGCTAACATGACATTAGCTGTAAGAAACAAGATAGCTTTACATTTGAATGCCATTTACTGATTT
CTAATGATTCTCTTTTTTTGTAAACAACTGTTTCCTTTGATTATGTCAACATGTTTCTGATGTGGCATTTTTGTTTTAATCCCAATCGGT
TAGGAAAATCTAGTCAGTAAGCGCCATGAGTATTCTTCCCATAACTAAATGGGTTTCTAATTTAATTTGAAGGGAATAAAATTTGTGTAA
GAAAAAAGCTGTTTAACATTAATAAACTATATTTCTTCTTACACATTGAACTGTATCATTTTCATATCCACTTCCCCACCACTGAAATAT
CTTATTTCACAATATTTTAACTGATTTTTAATCCAAAACTAATTTATAAGACAGTATGTATAGTAATAGTAGCTTGAGTGAATATGCAAA
AGTTTAATTTTTATATATGTCATACTATATTTTAAATAGTTAAAAAAGACAAAAGAAGGGAGAGCCATCTATGATATAGATGGTACCATT
TCAGTTCAAAGTTGTAATAACCTTTGGAGTGTTACAGTTTGGTTGTCAAATGGTTTCAGAATGTATAATTGATTTTTTTAAATGTTGCAT
TGTTTGAATCTAAAGTACAGCACTATAACATGCTTTAGCTTGGGGGGGTGGGGGTGGGGTGGGGACTTGCACTTATTCTCTAAAATGTTG
ACTAATCCAGAAAGCCTGATGCAACATAATCTGGAAAACTGCTTTGGTACATTTGTAGAAATCCGTAGAAATACCATATCCAGCCTCAAA
GCATTAATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAACAGCCAGAAAAAAGCATCACCTTGAGTGGTCCTGTGATGGTTGTTGAATGTG
TTCTCATTAGATGCTTTGAAATGAGGCTTAAAATAATTTTTCTGGGCAATATAGAGTTTCTTTTTTTTGCTTAGAATGTCATAAATACAT
GTGAACACGTTTAATGCAGGGCTTTTTATTCTCTCCAAAATGTCAACAGTATTTTCAGAATAAAGACTATGAAATATATTGCTGTAGTGG
AAAATTCTGGTCCTTTGTCTTTAATGTCTTTTTGAGTGGATAAAGAAAATTCACCCGGTTTGTAGTTTCTATATTTCCGTGAATCTTTGA

>17240_17240_12_CLN6-FBXL17_CLN6_chr15_68521840_ENST00000566347_FBXL17_chr5_107684231_ENST00000542267_length(amino acids)=275AA_BP=31
MRGSHGGDAEAAAPGSDGRPRRAAGRLLPAGQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCP
ELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITD
YALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CLN6-FBXL17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLN6-FBXL17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLN6-FBXL17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource