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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CLSTN2-PCOLCE2 (FusionGDB2 ID:17355) |
Fusion Gene Summary for CLSTN2-PCOLCE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLSTN2-PCOLCE2 | Fusion gene ID: 17355 | Hgene | Tgene | Gene symbol | CLSTN2 | PCOLCE2 | Gene ID | 64084 | 26577 |
| Gene name | calsyntenin 2 | procollagen C-endopeptidase enhancer 2 | |
| Synonyms | ALC-GAMMA|CDHR13|CS2|CSTN2|alcagamma | PCPE2 | |
| Cytomap | 3q23 | 3q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calsyntenin-2alcadein gammacadherin-related family member 13 | procollagen C-endopeptidase enhancer 2procollagen C-proteinase enhancer 2procollagen COOH-terminal proteinase enhancer 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9H4D0 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000458420, | ENST00000295992, ENST00000485766, ENST00000461818, | |
| Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 1 X 2 X 1=2 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/105*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: CLSTN2 [Title/Abstract] AND PCOLCE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CLSTN2(140285052)-PCOLCE2(142539887), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across CLSTN2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PCOLCE2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A0CL-01A | CLSTN2 | chr3 | 140285051 | + | PCOLCE2 | chr3 | 142539886 | - |
| ChimerDB4 | BRCA | TCGA-A2-A0CL-01A | CLSTN2 | chr3 | 140285052 | + | PCOLCE2 | chr3 | 142539887 | - |
| ChimerDB4 | BRCA | TCGA-A2-A0CL-01A | CLSTN2 | chr3 | 140285501 | + | PCOLCE2 | chr3 | 142539886 | - |
| ChimerDB4 | BRCA | TCGA-A2-A0CL-01A | CLSTN2 | chr3 | 140285502 | + | PCOLCE2 | chr3 | 142539887 | - |
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Fusion Gene ORF analysis for CLSTN2-PCOLCE2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000458420 | ENST00000295992 | CLSTN2 | chr3 | 140285501 | + | PCOLCE2 | chr3 | 142539886 | - |
| 3UTR-3CDS | ENST00000458420 | ENST00000295992 | CLSTN2 | chr3 | 140285502 | + | PCOLCE2 | chr3 | 142539887 | - |
| 3UTR-3CDS | ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285501 | + | PCOLCE2 | chr3 | 142539886 | - |
| 3UTR-3CDS | ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285502 | + | PCOLCE2 | chr3 | 142539887 | - |
| 3UTR-intron | ENST00000458420 | ENST00000461818 | CLSTN2 | chr3 | 140285501 | + | PCOLCE2 | chr3 | 142539886 | - |
| 3UTR-intron | ENST00000458420 | ENST00000461818 | CLSTN2 | chr3 | 140285502 | + | PCOLCE2 | chr3 | 142539887 | - |
| 5CDS-intron | ENST00000458420 | ENST00000461818 | CLSTN2 | chr3 | 140285051 | + | PCOLCE2 | chr3 | 142539886 | - |
| 5CDS-intron | ENST00000458420 | ENST00000461818 | CLSTN2 | chr3 | 140285052 | + | PCOLCE2 | chr3 | 142539887 | - |
| Frame-shift | ENST00000458420 | ENST00000295992 | CLSTN2 | chr3 | 140285051 | + | PCOLCE2 | chr3 | 142539886 | - |
| Frame-shift | ENST00000458420 | ENST00000295992 | CLSTN2 | chr3 | 140285052 | + | PCOLCE2 | chr3 | 142539887 | - |
| In-frame | ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285051 | + | PCOLCE2 | chr3 | 142539886 | - |
| In-frame | ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285052 | + | PCOLCE2 | chr3 | 142539887 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000458420 | CLSTN2 | chr3 | 140285052 | + | ENST00000485766 | PCOLCE2 | chr3 | 142539887 | - | 14419 | 14044 | 172 | 2880 | 902 |
| ENST00000458420 | CLSTN2 | chr3 | 140285051 | + | ENST00000485766 | PCOLCE2 | chr3 | 142539886 | - | 14420 | 14045 | 172 | 2949 | 925 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285052 | + | PCOLCE2 | chr3 | 142539887 | - | 0.00030867 | 0.99969137 |
| ENST00000458420 | ENST00000485766 | CLSTN2 | chr3 | 140285051 | + | PCOLCE2 | chr3 | 142539886 | - | 0.000270983 | 0.999729 |
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Fusion Genomic Features for CLSTN2-PCOLCE2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CLSTN2-PCOLCE2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:140285052/chr3:142539887) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLSTN2 | . |
| FUNCTION: May modulate calcium-mediated postsynaptic signals. {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 889_929 | 0 | 956.0 | Compositional bias | Note=Glu-rich (highly acidic) |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 889_929 | 0 | 956.0 | Compositional bias | Note=Glu-rich (highly acidic) |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 161_280 | 0 | 956.0 | Domain | Cadherin 2 |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 44_160 | 0 | 956.0 | Domain | Cadherin 1 |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 161_280 | 0 | 956.0 | Domain | Cadherin 2 |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 44_160 | 0 | 956.0 | Domain | Cadherin 1 |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 21_831 | 0 | 956.0 | Topological domain | Extracellular |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 853_955 | 0 | 956.0 | Topological domain | Cytoplasmic |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 21_831 | 0 | 956.0 | Topological domain | Extracellular |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 853_955 | 0 | 956.0 | Topological domain | Cytoplasmic |
| Hgene | CLSTN2 | chr3:140285051 | chr3:142539886 | ENST00000458420 | + | 1 | 17 | 832_852 | 0 | 956.0 | Transmembrane | Helical |
| Hgene | CLSTN2 | chr3:140285052 | chr3:142539887 | ENST00000458420 | + | 1 | 17 | 832_852 | 0 | 956.0 | Transmembrane | Helical |
| Tgene | PCOLCE2 | chr3:140285051 | chr3:142539886 | ENST00000295992 | 6 | 9 | 154_268 | 316 | 416.0 | Domain | CUB 2 | |
| Tgene | PCOLCE2 | chr3:140285051 | chr3:142539886 | ENST00000295992 | 6 | 9 | 297_415 | 316 | 416.0 | Domain | NTR | |
| Tgene | PCOLCE2 | chr3:140285051 | chr3:142539886 | ENST00000295992 | 6 | 9 | 33_144 | 316 | 416.0 | Domain | CUB 1 | |
| Tgene | PCOLCE2 | chr3:140285052 | chr3:142539887 | ENST00000295992 | 6 | 9 | 154_268 | 316 | 416.0 | Domain | CUB 2 | |
| Tgene | PCOLCE2 | chr3:140285052 | chr3:142539887 | ENST00000295992 | 6 | 9 | 297_415 | 316 | 416.0 | Domain | NTR | |
| Tgene | PCOLCE2 | chr3:140285052 | chr3:142539887 | ENST00000295992 | 6 | 9 | 33_144 | 316 | 416.0 | Domain | CUB 1 |
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Fusion Gene Sequence for CLSTN2-PCOLCE2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >17355_17355_1_CLSTN2-PCOLCE2_CLSTN2_chr3_140285051_ENST00000458420_PCOLCE2_chr3_142539886_ENST00000485766_length(transcript)=14420nt_BP=14045nt AGTGAGCGCGGCTGCTGCCGGCGAGCTAGCGGCGCAGCGGCGGGAACCCGAGGCCGAGCGCCGCGGCGGCAGCGCTAGAAGCGCACCCAT CGGGCACGGCGAGGCGGCCCACGGTGCGGCAGGCACCGGGAGGCGAGAGCCGGCGCGGACAGTAGGCGGCGGCTGCAGCTCGTTGGCGGC TGCTGCGAGGATGCTGCCTGGGCGGCTGTGCTGGGTGCCGCTCCTGCTGGCGCTGGGCGTGGGGAGCGGCAGCGGCGGTGGCGGGGACAG CCGGCAGCGCCGCCTCCTCGCGGCTAAAGTCAATAAGCACAAGCCATGGATCGAGACTTCATATCATGGAGTCATAACTGAGAACAATGA CACAGTCATTTTGGACCCACCACTGGTAGCCCTGGATAAAGATGCACCGGTTCCTTTTGCAGGGGAAATCTGTGCGTTCAAGATCCATGG CCAGGAGCTGCCCTTTGAGGCTGTGGTGCTCAACAAGACATCAGGAGAGGGCCGGCTCCGTGCCAAGAGCCCCATTGACTGTGAGTTGCA GAAGGAGTACACATTCATCATCCAGGCCTATGACTGTGGTGCTGGGCCCCACGAGACAGCCTGGAAAAAGTCACACAAGGCCGTGGTCCA TATACAGGTGAAGGATGTCAACGAGTTTGCTCCCACCTTCAAAGAGCCAGCCTACAAGGCTGTTGTGACGGAGGGCAAGATCTATGACAG CATTCTGCAGGTGGAGGCCATTGACGAGGACTGCTCCCCACAGTACAGCCAGATCTGCAACTATGAAATCGTCACCACAGATGTGCCTTT TGCCATCGACAGAAATGGCAACATCAGGAACACTGAGAAGCTGAGCTATGACAAACAACACCAGTATGAGATCCTGGTGACCGCCTACGA CTGTGGACAGAAGCCCGCTGCTCAGGACACCCTGGTGCAGGTGGATGTGAAGCCAGTTTGCAAGCCTGGCTGGCAAGACTGGACCAAGAG GATTGAGTACCAGCCTGGCTCCGGGAGCATGCCCCTGTTCCCCAGCATCCACCTGGAGACGTGCGATGGAGCCGTGTCTTCCCTCCAGAT CGTCACAGAGCTGCAGACTAATTACATTGGGAAGGGTTGTGACCGGGAGACCTACTCTGAGAAATCCCTTCAAAAGTTATGTGGAGCCTC CTCTGGCATCATTGACCTCTTGCCATCCCCTAGCGCTGCCACCAACTGGACTGCAGGACTGCTGGTGGACAGCAGTGAGATGATCTTCAA GTTTGACGGCAGGCAGGGTGCCAAAGTCCCCGATGGGATTGTGCCCAAGAACCTGACCGATCAGTTCACCATCACCATGTGGATGAAACA CGGCCCCAGCCCTGGTGTGAGAGCCGAGAAGGAAACCATCCTCTGCAACTCAGACAAAACCGAAATGAACCGGCATCACTATGCCCTGTA TGTGCACAACTGCCGCCTCGTCTTTCTCTTGCGGAAGGACTTCGACCAGGCTGACACCTTTCGCCCCGCGGAGTTCCACTGGAAGCTGGA TCAGATTTGTGACAAAGAGTGGCACTACTATGTCATCAATGTGGAGTTTCCTGTGGTAACCTTATACATGGATGGAGCAACATATGAACC ATACCTGGTGACCAACGACTGGCCCATTCATCCATCTCACATAGCCATGCAACTCACAGTCGGCGCTTGTTGGCAAGGAGGAGAAGTCAC CAAACCACAGTTTGCTCAGTTCTTTCATGGAAGCCTGGCCAGTCTCACCATCCGCCCTGGCAAAATGGAAAGCCAGAAGGTGATCTCCTG CCTGCAGGCCTGCAAGGAAGGGCTGGACATTAATTCCTTGGAAAGCCTTGGCCAAGGAATAAAGTATCACTTCAACCCCTCGCAGTCCAT CCTGGTGATGGAAGGTGACGACATTGGGAACATTAACCGTGCTCTCCAGAAAGTCTCCTACATCAACTCCAGGCAGTTCCCAACGGCGGG TGTGCGGCGCCTCAAAGTATCCTCCAAAGTCCAGTGCTTTGGGGAAGACGTATGCATCAGTATCCCTGAGGTAGATGCCTATGTGATGGT CCTCCAGGCCATCGAGCCCCGGATCACCCTCCGGGGCACAGACCACTTCTGGAGACCTGCTGCCCAGTTTGAAAGTGCCAGGGGAGTGAC CCTCTTCCCTGATATCAAGATTGTGAGCACCTTCGCCAAAACCGAAGCCCCCGGGGACGTGAAAACCACAGACCCCAAATCAGAAGTCTT AGAGGAAATGCTTCATAACTTAGATTTCTGTGACATTTTGGTGATCGGAGGGGACTTGGACCCAAGGCAGGAGTGCTTGGAGCTCAACCA CAGTGAGCTCCACCAACGACACCTGGATGCCACTAATTCTACTGCAGGCTACTCCATCTACGGTGTGGGCTCCATGAGCCGCTATGAGCA GGTGCTACATCACATCCGCTACCGCAACTGGCGTCCGGCTTCCCTTGAGGCCCGGCGTTTCCGGATTAAGTGCTCAGAACTCAATGGGCG CTACACTAGCAATGAGTTCAACTTGGAGGTCAGCATCCTTCATGAAGACCAAGTCTCAGATAAGGAGCATGTCAATCATCTGATTGTGCA GCCTCCCTTCCTCCAGTCTGTCCATCATCCTGAGTCCCGGAGTAGCATCCAGCACAGTTCAGTGGTCCCAAGCATTGCCACAGTGGTCAT CATCATCTCCGTGTGCATGCTTGTGTTTGTCGTGGCCATGGGTGTGTACCGGGTCCGGATCGCCCACCAGCACTTCATCCAGGAGACTGA GGCTGCCAAGGAATCTGAGATGGACTGGGACGATTCTGCGCTGACTATCACAGTCAACCCCATGGAGGGCAAGCCCAGCTGGAGTGGGAT GACTCCACCCTCCCCTACTAGTGCCCAGGGGTCTGCTGCCTGGCCCACATGTCCCTTTTGTAAACCCTGACCCAGTGTATGCCCATGTCT ATCATACCTCACCTCTGATGTCTGTGACATGTCTGGGAAGGCCTTCTCCAGCTTCCTGGAGCCCACCCTTTAAGCCTTGGGCACTCCCTG TGTTTCATCCATGGGGAAGTTCCAAGAAGCCCAGCATGGCCATCAGTGAGGACTTCAGGGTAGACTTTGTCCTGTAGCCTCCACTTCTGC CCTAAGTTCCCCAGCATCCTGACTACCTGTCTGCAGAGTTTGCCTTTGTTTTTTCCTGCAGGGAAGAAGGCCCACCTTTGTGTCACTCAC CTCCCCAGGCTCAGAGTCCCCAAGGCCCTGGGGTTCCAACTCACTGTGCGTCTCCTCCACACAGACCAGTAGGTTCTCCTATGCTGACTC CAGGTTGCTTCATACAAGGAGGGTGGTTGAACTTCACACACGTAAGGTCTTAGTGCTTAACAGTTTAAAGGAAAGTCCTTGTTGAGGCAG AACTAAGTTTACAGGGAAAGGTACACACATTCTCTCTCTCTCTCTCTCTCTGTCTATCTAGTTCCCCAGCTTGGAGAGCCTTTCCCCTTG CTTCTTTCTGAGGCCATATAAGCTTATAAGAAAAGTCCCAAACCAAGAATAGGTCCTTGGCCACAAGCAGGGTCTGATCCCCCATCAGAG CTATCTGAGCCTGCCTGTCTGGGCACCTGCTGCAACCATGCAGCTACCCTGCCAGGGGCACTCAGCAAACAGAACCACAGGGCCCAGGAG GCATTCCACACAGGCACTGCCCCAGGACAACACAACAAGGACAGTCACAACAAGGACAACAAGGACACAACACAACACACAACAAGGACA GTCACAACAAGCCTAGAGCCAGAAAGCAGATGGAAATGCTAATGAGGTCAAACGTAGGCTTCATGGTGGGTGGAGTGGGGGTGGCTGGGC TCCCCCAGGACAGAGGGGACCCTGAGGTTGGCAAGGCTCTCACCACTCAGCCTTATGGTCCCTTATCTCCTATCTTCCCTCTTGAGAAAA TACACGCTTTCTGCATGTATTAGAAACGCACGAGCTCCACCAAGTCTACAATGAAAGTTTGAAATTTAACTGCAAGGAATTAGAAGCATA TTTGCAATCATTGCAGCTTCTTCTTTCTTCTGCTCATAAAAGGAGGAACACTTTAGATAGAGGGCAAATATATCTGAAAACCTAATTTCT TTCTTTTTTTGATAAGGAAATCTTTTCCATCTCCATCCTAACATGCACAACCTGTGAAGAGAATTGTTTCTATAGTAACTGGTCTGTGAT CTTTTGTGGCCAAGAGAATAGCAGGCAAGAATTAGGGCCTTGACAGAATTTCCACGAAGCTCTGAGAACATGTTTGTTTCGAATGTCTGA TTCCTCTTTGTCATCAATGTGTATGCTCTGTCCCCATCCTTCACTCCTCCTCAAGCTCACACCAATTGGTTTGGCACAGGCACAGAGCTG GTCCCTAGTTAAGTGGCATTTATGTTAAAAAAAAATAGTTCAGAATCTCAGCCTTTTCTTTGTGTCATCAAAACAGCTTAAGAAGGGGAC TACTGCCAATGTCCTCTAGTCTGACCTCCACCCAGGGAGGACCCATGGCAGGTCTTTTCAACTTTCTGATTCATGAGAACAACCTTGTGA AGCTTTTCCCACCTCCTAAAGTGTTTTCTGCATCTGTTCCTTCCTTTGGACCTCACAACAAATCCTGTGAAGTAACTGAGACATCTGTTG TTAGATACATTTTTGTGATGAGTAAACTGAGGCTTCGTGATTCAATGTCTTGTTCAGAGTCATTCAAAAGTATAGACAAGACCAGTCTCC CCAACTTCCACTCCTGGTGCAGGATTCTACTTATGTTCATAGGTATGCACCTAACAGACACTGCTGCAAACCTACTATGTGCTAAGCATC CTACCAATAGCTGTGAGAAAAAGAAAAGCTGAATAAGATAAGCTCCTTCCCTACATTATATTTGCAGACGGGAAATAAACAGGCCTAGAA ATTACACAAGAGACAAATGAAGAGGAAGAGAAGTCACAAGAGAAGAAGGATGCGGTCACAAACTTAACCAGTGCTCTTATTTTTCCCTTC TCAGGGAAAAACACCAGAAGAAGCTGGGGTTTTATATTCATTGGATGGAAACAGATATTTCTCCTGGGAATTCTCCCAACCAAATAGCCC TTTTCTATTAGGCTGTGTCTGTACATCCACAAGAGGAAAGTCTATAGGACTGATTAGTTTTCACAATCCCATTTAAATAAAAAAAAGATC TTTAGTTGGGCATTTAGGAGCAACTGAATTCTCCCAAAATTGTGGCAGCAAAAAGAACACTTCATATGCTTAAAACCCATTCTTTTTGAA TTAGATTTTGATTTTAAATATTTAAGTCTGGTGTTTGTGAGAACACTTTTCTCTTTGCTCAGTCTTTTCGATCTGGTTGGGTAGGGAAGG TGTTCCTCATGCTCTCTGGGTGGCTGCCTTATTCATAGTTGAGAGAGCTGTTAGGTAAAATCTTTATATGTGTTGGGGTTTTTTTGGTAG GGGGGGTAGCAGGTAAAGGTGGCCCATGGCTAGGGCAGCAAAGATGAATAATTTGAGGAAGCATTTGGTTGGTGGACTCATTTGCAGAGA AACAGTGGTGACAACAAATCAGAGCTGTTTCCCTCAACTCTGGCTATAAGAGGTCATTCTCTGCATGTCAGCTACAAAGATCAGGCACTT GAATGAATCCGCTGGGTTGGCAGGCATTGGTCATCTTCGCAACACCCTCTTCCTCACCATGGATGAGAACAAGACGGGAGTGGTTATATC CCAGTAACAGAAGCTTTGGGAGGTATCCAGGTGAGCAGGGTAATGTGGCTTGCCCTCCCCCAGATATTCTGATCCCAAGAAAAAGGTGTC ATTAATCAGTCTGGCATTTTCCACCCTCCATATGCTGGCATCCAGGAACCAAAACCCCTGAAGGCCTAGACACCCTATGACCTCTAACTG AGATGTTGGCAGCCAGGCAGATGCAGGCTCATGTCCAGGAGGAACTGCTGACTGGTTTGGCCACAGCCCAGTTCATTGCTTGTCTTGCCA AGTGGACAACCAGATTCTGCCTTCCTGAGCTTGAAAATAGGCTACAACTCTCAGGTGATTCAGATGACATGGAGGAGAAGTTGGAGGAGA AGATTGAAATGCTTAAATCCCAGTGCAGAATGAGTTGCTTCAGTGGAGTAAAGCAACCGGCTAGTTGGTAGCCTGCCTTAAAAAATACTA AACATATATCATCATACATTTGATCAAATGCTGTAAGCACAGCCAAGGCCCAAATTCATCTAGATACCAAAAATGTGATTTCAGTGAAAT CTCTTTTCATTGCCGCTTTCTTTTGTTGTTGTTTGTTTTTTGAGCCAGAGTCTTGCTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACA ATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGAGTTTCCTGCCTCAGACTCCCGAGTAGCTGGGATTACAGGCATCCACCAC CATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGCTTCACCGTGTTGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCTG CCCACCTTGGCCTCCAAGGTAATGAGATTATAGGAGTGAGCCACCGCACCCAGCCCTCATTACCACTTTCTTGAATTTACTCAATCATCC TATCAAGCAGGGTTTAGACCAACATCTTTGCATTTAATAAGGGCTCTACTTTGTATACATGGACCATCCAGTGAGAGAGCTGGGGGTGGT GAGAAGCAATGTCCCCCATTCCTATATGTCAGGTGTCAGCAAACTATCTGTAAAGAGGCAAATAGTAAATATTTTGGGCTTTGTGAGCCA TTTGGTACCTGTCACAGAATAGTCAGCCCTCCATATCTGAGGTTTCCAAATCCATGGATTCAACCAACCTTGAATCAAAAATATTTGGGA AAAAATGTATAGTTGCAACTGACCTGAACATATTCTTTTTTTCATTATTATTCCTTGAACAATACAGTTTAACAGGATTTACATAGCATT TACACTGTATTAGGTATTATAAGTAACCTAGAGATGATTTGAAGAACACAGGAAGTTGTGCATAGGCTATATGCAAATACTATGCATTTT ATATAAAGGAATTGAACATCTGTGGATTTTGGTGTCCGAGGGGAGTTCTGGAACCAATCCCCTACAGATACTGAGGGATGACTGTACTCA GCTCTCCTATTGTAGCATGAAAACAGACAATACGTACAACAAATGAATGTTTCAATACAACTTTATCTAGTTTCCATAAAACAATTTAAA AACACTAAAAAAGCAGGCAGTTTGGATTTATGTAATTTTCATATCTTTTTTTACCCTTTTGATTTACATTTTTAATAATTTAAAAATATA AAAACCTTCCTCAGCCCACAGGCCATACGAAAATTAGCAGCCAGCTAGATTTGGCCCAAGGCCAAAGTTTGGCAACCCGTACCATACACC ATGGAAGTTAGCCTTCCACCTCAGGAGAAAGCAAGCTGCTCTCATAAGCCTCTCACCAACTACCCAGTAGTCTTTGCCTCCAAACTGAAC AACAGGAAAAAGTGCCATAGTTTTTAATTAAGCTGTTTTAAAAGTCCATGTTCCGGGGGAAAACAAAAAAGAAACAAACAAAACACTTGT TATTTGCTGAACTGACAAACTGACAGATATTCCACGAGAGTTGAAAGCCTTGGATCGAGGTGATTGCCTGGTTACTGAGTGCTAACTCCA CTGAGGCAAGTGTTAGCCCCCCAAGGCTCAGTGCCTTCCCAGCACAGCTCAGCCCATAATGATCTCTGAGCAGGAGTGTTCATTATCTCA GACTGATTTTCATTTCAGCCCTACTCTTGCCATTGCTCTAAAAATGATCCTAAAGACTTGTGACTGTTTGAATCAATAGCAACATCATCA GTAGAAAGCCCGACCAAGCACACTTCGAAATTAGCAATCTTCTTGGCTCTATGGCTCAATATCAGCAAGAAGAAAAAAAGACAACTTTTT TTTTAATCATCCCCACATTTAAATTAACCAAATAGTTTTTACAAAAAAGTAGGTAAGTGGGTTTAATTCTTTGAAAGTATTTGCCAGTGA AAAGTAGATGATTTTTAGGTAAGATAACGTTTAGGCCTCTGGGGGATCCCCAAAGCCTTCTGCAATGTACTCTGGCAGGCTATGAATGGT ACAGGATTCTGCATCTATATGAGACATTTATTGAGGCTGACAAGCAAAAGCCCTTGGCACAATTTAATTTTCACATAACCACTTTCCATT GTCCAGCTGCAGGCAAAAGAAATGAGCAATGAAAGTTTTGAAGTCTACCCCAGTACCCTCATTTCCTGTCTTTATTTCCTTTACTTTATA GATGTATTCTATACCTGCTATGTAGATAATGCTCTAGTTTTCCCTTTAGTGCCAACTGGAAAAGGAGAGTTGGCTTTACAGGGGCTGTGG ATTAAGAGCCAGGCTTCATTCCATCCCAGGGAGACAAAAAGAGACAGAAGAAGTTACCTCCAGCAGCACCCCAGAAAGCTGACAGATATT CCCTGTATGCAGGTAGTAAACAGATGGGAGTCTGTGTTTGCAGCTATGTTCAGTGTAATTCAGCAGACCTTCACTGGGCACTTGTGATGG GTCAGGCCCTGTGCCAGCAACAGGGGAAGGGAGGATGAACAAGGCATGTTTCCCTGACCATGAGGAGCTCTTGGCCTGTGAGCTGTTGGG ATGTCCCTTTGTGGTGTTGGAAGCTGTGCACGAGCAGTCAGGACTTTGGGGACAGAAGTTTAGTGTTAGGGAGGCAGGGTAACTTGCTTT GACAGCTACCCACCCTAAGTCAGATGACAGGTGTAATTCTAGGGGCCCTGATATGCATCACTGAGGCAGACTGAGGAGCTCTCCAGGGAA GTAGGCAATATTTCCCTGAATATTCCTCAATTCCAATCAAGGCTGACTCAGTTCACTTATGGATGAAAGCCAGTTACCCTGCCCACTGGG CAGAAATAACATGGTTGACAGCTGACATTCAGAGAAAATAAGACAGAAGCAGTCCTTAAATATAAACAGCAGCCAGGTGGACCTGGAAAT TTAGGAAGGGTGATGCAGGTAGAGGGGCCAGCAGGAGCCAAGTCTCAAAAGGCACAAGCCAGACTGATGCAAGGGAGCCCTCCTGAGGCC CAACATCAGAGCTGAAGATCTAAGGAGGGCCCACCTCCACGAGACCTGCTGAGGGCTTACATTTGGTGCTGAGGAGCAGTGGTTCCCTGG GCCAGCTGCATCACCTGGGAACATGTGAGAAGTGCATATTCTTGGGCCCCACCCCAGACCTACTGAATGAGAAGCTCTGGAGGCAGGCAG TCTGTGATTTAATGAGCTTTCTGACACACACTAAAGTTTGAGAACCACTGATGCAGAGGATGAGGAGATGACTTGAGCTGGCATCGGGAA GAACTGACTATTAACTAACAAGGTAAAATCAATGACTAGTGCAGTGAGGGTGCCAAAGCAAACCACCCCCAGCCCCCATCCTGGGCCTTT TTGGCTCCAGTTTATACTCACTGAAGCAGTGGTTTCAAGGAACCTTGGTCCTAGTCCGCATCCTTCACCTGCCCTTGGGCATGAGACAAT TCCTGCCTGCCTGCCCCTTCTATCCTAGAGAGAGAGACTGCCCAGGAGAGGCTGCCATGAGGTCACTCATCCCCAGGAAGGCCACCTGCC AGGTTTCTGTAAGCTGAGCAGCCTCTTCGAGGGCCATATTTTGTGGAGAAACACTGAAACTGCAGCAGTGACCCTGGTCACTAGGAGAGC TGCTTTCTACACAGCCTGTATGCTGGTGGAGACACCCAGGGCCTGGCAGAGTGTGGAGGGGGTCATTTAAGGACGTTGCCAGGTTGCCGC AGCACTGCTCTGTTTGTTTGTAATGAGACTGGGGCATGCAGCATCACAATTCAAACACTGAATTGCTTGGGGAATGGATGGCCTTCCTTG GAAGGGCAGTAACTCATTCTGGATGTTACTAAAAGTAGAAAACAAAAATCCAAAAACAAACCTACAGCCTCATTTACAATTAGAATCTGT CTGGGCCTTCTGATTTCTAAAGTCTGTGAGGCTGCCAGGATTCACCAATTCTCCTTTCCCCTGAGGCCCAGCAACTATTGATTTATAGCT TAAACTCTGTGAAGGTCCACAGACCTTTGAAAGGAACTTGCTGGTACTTTGTCAGTCGTGTACACCTAACTGACTCCTCCTACGAGGTAC AGTCTCCTCATACAAGGGGTTTTGAGATGGAGAGTCAGAGGGCCAGGGCCCTGGGCTTTGGGGTGGAAGGACAGAAGAGTAGCAGTCTAG GAAAGGGACTAGACATGTAGCCTAGGAAAACTAGCACCATCTGTTGAGTTCTGAAGAACCCAGATTCTCTCCTGCTCACAGCCTCAGCAG TCTTTTCAGAGTCCTCCTGAATGGCCCAAAGACACCCCTGTTTCTGGGGAACAGAAGGGAGCTGGTACCTCTGGACCATTGAGGCAACAC CTCCCCAGAGGCAGGACCCCGCCCCCATGAGAACATGCAGTTGAATGATGTGGTGCCTGGCCAGGACCTTGGAAAACGTGGCCATGTGAG ACTAGTATAGATCTCCAACTATTGCTGCCTCTGCTGATATGGCCACCTCCTTAAGGTAAGAAGACTACCGACTTAGCTATTGTGGCACCA CGGGAGCCTAGCACTGCACCTGGCCCATGACATGTGTGCCACAAATGTTGAATTGAATTGAATCCCAGAGATCACTTGACCTCAGTGAAG GGACTGGGTTTGAAGAATTAAGACCCCCCAGTGGAGAAAGCCTCCTCCAACTTCCTTCTCGGTTTGTGAGTCAAGGTCCTTTGTAAAATC AGATCGACGAGGGTGGAAGTGCAGTGAACAGAGGACAACATTTGTGATGCACGTGGGAGAAAACAGGAGTGGGGTTGTTTGGGGACTACC CCTTCCTAGCTATAGTCAGTAAATGGAGCCCCTAAGCAAGGAGCAGGGGTAGATGTGCCTGGGTGAGGCCTGCTTGCTCCACCGTCGAGG TCATGGGCAGCATCCCAACTGAGGAGAGAAAACCCTAATTTGTTAATGACCCAGCCTTGTGCTGCTCTCCAGTTCCTTTCATCAGATTTA CTGCAGAGCAGATTCATCAACATGAAGTTCAATTCCCAGTAGACTAATGAAAAGAGGGCAACAGACTTGAGAAGAGCCAAAATGCAGACA GTGTGTATTAATCACAGACAACAGAAACGTGTTAGCTTTAATGTCTGTTTGCTTTTATCTTGAAATGAAAATGCATCTCTGTTACCTGGA CCCTTTTTACTGCACATTTCAGAACAGAAATGGGACACCCACACACGTATTGAGGGTCCTTTTCCCCGGCAGGAGGAGCTACCAGAGAAA TGAGCCCACATTTTGTGTGCAGAGAGAATCAACCCACAGGTCTCAGCTGCAGACTCCAGCACCTCTGCAGAGAAGGCAGGCAAAGGGATG AGGAGGTAGCATCTCCTCTTCAGAAGGATTCATAAGGGCCTCTGTGAGGAGGGCCTTGCTTGTGCCTGTGGGTCATGGATGTTAATATAA AGGCTCATCCACCCTTGGTGGCAAAAGTGCATCCATCCTGGCCAATATAGAACACTCACATCTGGAGCCCACGCCCACCCACCTCCAGCT CCTCTACATGGCTGCAAGAGCATGGCTGATGTGTGGGATTCAGAAGAGGTCTGCTCATGTTCACTAGCCAAACTTTAGGTGGTGTGATAC AGCAAAAAGCTTTTTTTGTTTTTCTGTTTTTGTTTTGTTTTTGGCGTGGAGGAGAAATTTAGACTTGAAAGTCAGGGCTGATCACTCAAA AAGTAAGATAGGAGATATTGAGGGAAAATGTGACTCATAGTTGGAGAGGAAACAGGAGAGTGGGTACAAGTGACAGCACCAGGAACAACC CCCTCCCCCAGATGCCAAAGCATTGCTCTGTATCTAAAGATGCATCCAAGTTTGCAAAAAATTATGGGTAAATCTGGCCATGTGACCAAA GAGGCAGTCAAATCAATTGCTTCCAAAGTCAGAGCTGTTTGAAGGTGATCAGCTCTTAATTGAACTAGTCATGATGAATCAATCCAACTG ACTGCATCCAGTCTGACCTCGGTGGTTTCCATAAAGGGTTGTTGATGTCCTGAGCTGGACAGGGTGGGCAGGAGGTTGAAGAAAACCAGT TGGTGAGTATAGAAAAGAAATTGCATGTAGAAGTTGTTTGTTCTCAAAGAAATCTGTAGGTGTTAGAGCTGGGTTTGTTATGTTATTGTC AGGGACATTATAATATTGGTAAGGAGGAGAGAATGATTTGGTAGGGGTATTCGAGAAATTTGAGTACAAAATATAAATTATCAGAGATGA GTAGGCTATGGACAGCTGATTATATATATGTGTGTGTGTGTATATGTGTGCATATATGTGTACATATACACATACCCCAAAGCCATATAC ATATCTATAATACAGAAGTAAGAATAAAGTCATAAGTACCAGCATATTTTAAATCCTTAGAAGCACTGGTTGGGATGTTACATGTTTTTT CACTGTTGTTGTTTACCGTTAGCTCTCAAAGCAGTGGGAATAGTGCTTGGCACATAGTAGGAGTTTGGTAAACATTTGGAAATTGAAGAC CCAGCTTATCACTCCTTCATAGAGACTCAGTAGTATGAGTATACCCCAAATTGAATGAGCCACAGAGAAATGCATCCAGCCACACTCCCT CTTAGCTGAGGAGAAGCCTCTGTGAATCCACAGATTCCATGCAATATTCAGCCAGCCGCAGACACAAGGTCTGGCTCCCTTGTCGTGAGA GTGAAGGCATGCTGCACACAGTGGGTTTGCATGCACCTAGACTGCATCTGCTGAACACCCAACAGCTGTTTCTACAAGCTAAAGTTGTAG CTTCTCTCTACCACTGTCTAAAGCTGTAGCTTGTCTCTACTATTGTCTCTACACCGTTGCCCAAACACTTGGTATAATGCTATTGAATTT TTCACCTCCAGGCATGATTTTGTAACCAATGTAAAGGTTCTGGGTTCAGCCAGTCTAAAAAGTCTAATAATTTCTTCTCTCAGTCCTTCC CTTCTCCCTTGTCTGGAGCTGCCACCGCCATTTAAAAGTGTTGGACGCTGTTTATTCCCAGCTTCTCAACCTCAGTGTGTGTGGGAAAGG CCTGAAAGAGAGAGGTATGTTTTCTCTCCTCCAGAGTCTCTGTGGTGTTGACACAGCAGAGAGAGGAGGGGGAGCAGCCTCGTCTTGCAG AATCACCTTCAATCACTGCTACTGTCTGGGCCATTACTGCCAGTCTGGCCGGTGTCTCCCACAGTGGATGGCTTTGCCTCCAGCGGTGGA CCAGTGTGTACCTGACATGTATCAGACTTCTGAGCTCTTCAAGCTGCCTCAAAGAATGAATCTTTTTAGTCTAGAAAATGTGTTTATTTG ATAAATATACTATTGTGTATGAGTGTGAAACAATGCAGACTTTGGAGTATCTCATTAGAAGGACTGTATGAATTTATAGAAAATTGAATC TAATTTCAGAAGAGCGCACTGTCTTCTCAGTCAACAAGGTTGCCCAGCCACAGAGGGTCAGAGAAAATGTCCTTTCCCCTCCCCACTCCT TTTCATAGAATCCTCTCTCAGGCCTAACTGAGCTGTCATATCCAATTCAGACTGACACAGAGTGAGGGGCGCTGAGAGTCTCTATGTATA TAAAGATATAGGAAGAAAATAAGGATCATCACAGGAATCTGTTGGGCTTCTCCCCATGACTGTGATCTTACCCATGTTTGAATCACAAAC TTTAAATTTATAATAATTATGATTCTTGCAGTTTTCAAGTAATTTGTTAAATGCCTATTCAACACAGACAGATTTTTATTTTCAGCTGTG GCTTGTAAATGCCTACAAACTGATTCATGTTGGTGGTCGTTATGACACTTTCTGTGAATTGGTGAATAAATATGATTTTAGAATTTCACA GTAAATATTAGCCGGCACTGTTATCACAACCATCACTCGCGATGGGAGTTTGCACGCCACAGTCTCGATCATCAACATCTACAAAGAGGG AAATTTGGCGATTCAGCAGGCGGGCAAGAACATGAGTGCCAGGCTGACTGTCGTCTGCAAGCAGTGCCCTCTCCTCAGAAGAGGTCTAAA TTACATTATTATGGGCCAAGTAGGTGAAGATGGGCGAGGCAAAATCATGCCAAACAGCTTTATCATGATGTTCAAGACCAAGAATCAGAA GCTCCTGGATGCCTTAAAAAATAAGCAATGTTAACAGTGAACTGTGTCCATTTAAGCTGTATTCTGCCATTGCCTTTGAAAGATCTATGT >17355_17355_1_CLSTN2-PCOLCE2_CLSTN2_chr3_140285051_ENST00000458420_PCOLCE2_chr3_142539886_ENST00000485766_length(amino acids)=925AA_BP= MAAAARMLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFK IHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKI YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDW TKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEM IFKFDGRQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHW KLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKV ISCLQACKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAY VMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLE LNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNEFNLEVSILHEDQVSDKEHVNHL IVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEGKPSW -------------------------------------------------------------- >17355_17355_2_CLSTN2-PCOLCE2_CLSTN2_chr3_140285052_ENST00000458420_PCOLCE2_chr3_142539887_ENST00000485766_length(transcript)=14419nt_BP=14044nt AGTGAGCGCGGCTGCTGCCGGCGAGCTAGCGGCGCAGCGGCGGGAACCCGAGGCCGAGCGCCGCGGCGGCAGCGCTAGAAGCGCACCCAT CGGGCACGGCGAGGCGGCCCACGGTGCGGCAGGCACCGGGAGGCGAGAGCCGGCGCGGACAGTAGGCGGCGGCTGCAGCTCGTTGGCGGC TGCTGCGAGGATGCTGCCTGGGCGGCTGTGCTGGGTGCCGCTCCTGCTGGCGCTGGGCGTGGGGAGCGGCAGCGGCGGTGGCGGGGACAG CCGGCAGCGCCGCCTCCTCGCGGCTAAAGTCAATAAGCACAAGCCATGGATCGAGACTTCATATCATGGAGTCATAACTGAGAACAATGA CACAGTCATTTTGGACCCACCACTGGTAGCCCTGGATAAAGATGCACCGGTTCCTTTTGCAGGGGAAATCTGTGCGTTCAAGATCCATGG CCAGGAGCTGCCCTTTGAGGCTGTGGTGCTCAACAAGACATCAGGAGAGGGCCGGCTCCGTGCCAAGAGCCCCATTGACTGTGAGTTGCA GAAGGAGTACACATTCATCATCCAGGCCTATGACTGTGGTGCTGGGCCCCACGAGACAGCCTGGAAAAAGTCACACAAGGCCGTGGTCCA TATACAGGTGAAGGATGTCAACGAGTTTGCTCCCACCTTCAAAGAGCCAGCCTACAAGGCTGTTGTGACGGAGGGCAAGATCTATGACAG CATTCTGCAGGTGGAGGCCATTGACGAGGACTGCTCCCCACAGTACAGCCAGATCTGCAACTATGAAATCGTCACCACAGATGTGCCTTT TGCCATCGACAGAAATGGCAACATCAGGAACACTGAGAAGCTGAGCTATGACAAACAACACCAGTATGAGATCCTGGTGACCGCCTACGA CTGTGGACAGAAGCCCGCTGCTCAGGACACCCTGGTGCAGGTGGATGTGAAGCCAGTTTGCAAGCCTGGCTGGCAAGACTGGACCAAGAG GATTGAGTACCAGCCTGGCTCCGGGAGCATGCCCCTGTTCCCCAGCATCCACCTGGAGACGTGCGATGGAGCCGTGTCTTCCCTCCAGAT CGTCACAGAGCTGCAGACTAATTACATTGGGAAGGGTTGTGACCGGGAGACCTACTCTGAGAAATCCCTTCAAAAGTTATGTGGAGCCTC CTCTGGCATCATTGACCTCTTGCCATCCCCTAGCGCTGCCACCAACTGGACTGCAGGACTGCTGGTGGACAGCAGTGAGATGATCTTCAA GTTTGACGGCAGGCAGGGTGCCAAAGTCCCCGATGGGATTGTGCCCAAGAACCTGACCGATCAGTTCACCATCACCATGTGGATGAAACA CGGCCCCAGCCCTGGTGTGAGAGCCGAGAAGGAAACCATCCTCTGCAACTCAGACAAAACCGAAATGAACCGGCATCACTATGCCCTGTA TGTGCACAACTGCCGCCTCGTCTTTCTCTTGCGGAAGGACTTCGACCAGGCTGACACCTTTCGCCCCGCGGAGTTCCACTGGAAGCTGGA TCAGATTTGTGACAAAGAGTGGCACTACTATGTCATCAATGTGGAGTTTCCTGTGGTAACCTTATACATGGATGGAGCAACATATGAACC ATACCTGGTGACCAACGACTGGCCCATTCATCCATCTCACATAGCCATGCAACTCACAGTCGGCGCTTGTTGGCAAGGAGGAGAAGTCAC CAAACCACAGTTTGCTCAGTTCTTTCATGGAAGCCTGGCCAGTCTCACCATCCGCCCTGGCAAAATGGAAAGCCAGAAGGTGATCTCCTG CCTGCAGGCCTGCAAGGAAGGGCTGGACATTAATTCCTTGGAAAGCCTTGGCCAAGGAATAAAGTATCACTTCAACCCCTCGCAGTCCAT CCTGGTGATGGAAGGTGACGACATTGGGAACATTAACCGTGCTCTCCAGAAAGTCTCCTACATCAACTCCAGGCAGTTCCCAACGGCGGG TGTGCGGCGCCTCAAAGTATCCTCCAAAGTCCAGTGCTTTGGGGAAGACGTATGCATCAGTATCCCTGAGGTAGATGCCTATGTGATGGT CCTCCAGGCCATCGAGCCCCGGATCACCCTCCGGGGCACAGACCACTTCTGGAGACCTGCTGCCCAGTTTGAAAGTGCCAGGGGAGTGAC CCTCTTCCCTGATATCAAGATTGTGAGCACCTTCGCCAAAACCGAAGCCCCCGGGGACGTGAAAACCACAGACCCCAAATCAGAAGTCTT AGAGGAAATGCTTCATAACTTAGATTTCTGTGACATTTTGGTGATCGGAGGGGACTTGGACCCAAGGCAGGAGTGCTTGGAGCTCAACCA CAGTGAGCTCCACCAACGACACCTGGATGCCACTAATTCTACTGCAGGCTACTCCATCTACGGTGTGGGCTCCATGAGCCGCTATGAGCA GGTGCTACATCACATCCGCTACCGCAACTGGCGTCCGGCTTCCCTTGAGGCCCGGCGTTTCCGGATTAAGTGCTCAGAACTCAATGGGCG CTACACTAGCAATGAGTTCAACTTGGAGGTCAGCATCCTTCATGAAGACCAAGTCTCAGATAAGGAGCATGTCAATCATCTGATTGTGCA GCCTCCCTTCCTCCAGTCTGTCCATCATCCTGAGTCCCGGAGTAGCATCCAGCACAGTTCAGTGGTCCCAAGCATTGCCACAGTGGTCAT CATCATCTCCGTGTGCATGCTTGTGTTTGTCGTGGCCATGGGTGTGTACCGGGTCCGGATCGCCCACCAGCACTTCATCCAGGAGACTGA GGCTGCCAAGGAATCTGAGATGGACTGGGACGATTCTGCGCTGACTATCACAGTCAACCCCATGGAGGCAAGCCCAGCTGGAGTGGGATG ACTCCACCCTCCCCTACTAGTGCCCAGGGGTCTGCTGCCTGGCCCACATGTCCCTTTTGTAAACCCTGACCCAGTGTATGCCCATGTCTA TCATACCTCACCTCTGATGTCTGTGACATGTCTGGGAAGGCCTTCTCCAGCTTCCTGGAGCCCACCCTTTAAGCCTTGGGCACTCCCTGT GTTTCATCCATGGGGAAGTTCCAAGAAGCCCAGCATGGCCATCAGTGAGGACTTCAGGGTAGACTTTGTCCTGTAGCCTCCACTTCTGCC CTAAGTTCCCCAGCATCCTGACTACCTGTCTGCAGAGTTTGCCTTTGTTTTTTCCTGCAGGGAAGAAGGCCCACCTTTGTGTCACTCACC TCCCCAGGCTCAGAGTCCCCAAGGCCCTGGGGTTCCAACTCACTGTGCGTCTCCTCCACACAGACCAGTAGGTTCTCCTATGCTGACTCC AGGTTGCTTCATACAAGGAGGGTGGTTGAACTTCACACACGTAAGGTCTTAGTGCTTAACAGTTTAAAGGAAAGTCCTTGTTGAGGCAGA ACTAAGTTTACAGGGAAAGGTACACACATTCTCTCTCTCTCTCTCTCTCTGTCTATCTAGTTCCCCAGCTTGGAGAGCCTTTCCCCTTGC TTCTTTCTGAGGCCATATAAGCTTATAAGAAAAGTCCCAAACCAAGAATAGGTCCTTGGCCACAAGCAGGGTCTGATCCCCCATCAGAGC TATCTGAGCCTGCCTGTCTGGGCACCTGCTGCAACCATGCAGCTACCCTGCCAGGGGCACTCAGCAAACAGAACCACAGGGCCCAGGAGG CATTCCACACAGGCACTGCCCCAGGACAACACAACAAGGACAGTCACAACAAGGACAACAAGGACACAACACAACACACAACAAGGACAG TCACAACAAGCCTAGAGCCAGAAAGCAGATGGAAATGCTAATGAGGTCAAACGTAGGCTTCATGGTGGGTGGAGTGGGGGTGGCTGGGCT CCCCCAGGACAGAGGGGACCCTGAGGTTGGCAAGGCTCTCACCACTCAGCCTTATGGTCCCTTATCTCCTATCTTCCCTCTTGAGAAAAT ACACGCTTTCTGCATGTATTAGAAACGCACGAGCTCCACCAAGTCTACAATGAAAGTTTGAAATTTAACTGCAAGGAATTAGAAGCATAT TTGCAATCATTGCAGCTTCTTCTTTCTTCTGCTCATAAAAGGAGGAACACTTTAGATAGAGGGCAAATATATCTGAAAACCTAATTTCTT TCTTTTTTTGATAAGGAAATCTTTTCCATCTCCATCCTAACATGCACAACCTGTGAAGAGAATTGTTTCTATAGTAACTGGTCTGTGATC TTTTGTGGCCAAGAGAATAGCAGGCAAGAATTAGGGCCTTGACAGAATTTCCACGAAGCTCTGAGAACATGTTTGTTTCGAATGTCTGAT TCCTCTTTGTCATCAATGTGTATGCTCTGTCCCCATCCTTCACTCCTCCTCAAGCTCACACCAATTGGTTTGGCACAGGCACAGAGCTGG TCCCTAGTTAAGTGGCATTTATGTTAAAAAAAAATAGTTCAGAATCTCAGCCTTTTCTTTGTGTCATCAAAACAGCTTAAGAAGGGGACT ACTGCCAATGTCCTCTAGTCTGACCTCCACCCAGGGAGGACCCATGGCAGGTCTTTTCAACTTTCTGATTCATGAGAACAACCTTGTGAA GCTTTTCCCACCTCCTAAAGTGTTTTCTGCATCTGTTCCTTCCTTTGGACCTCACAACAAATCCTGTGAAGTAACTGAGACATCTGTTGT TAGATACATTTTTGTGATGAGTAAACTGAGGCTTCGTGATTCAATGTCTTGTTCAGAGTCATTCAAAAGTATAGACAAGACCAGTCTCCC CAACTTCCACTCCTGGTGCAGGATTCTACTTATGTTCATAGGTATGCACCTAACAGACACTGCTGCAAACCTACTATGTGCTAAGCATCC TACCAATAGCTGTGAGAAAAAGAAAAGCTGAATAAGATAAGCTCCTTCCCTACATTATATTTGCAGACGGGAAATAAACAGGCCTAGAAA TTACACAAGAGACAAATGAAGAGGAAGAGAAGTCACAAGAGAAGAAGGATGCGGTCACAAACTTAACCAGTGCTCTTATTTTTCCCTTCT CAGGGAAAAACACCAGAAGAAGCTGGGGTTTTATATTCATTGGATGGAAACAGATATTTCTCCTGGGAATTCTCCCAACCAAATAGCCCT TTTCTATTAGGCTGTGTCTGTACATCCACAAGAGGAAAGTCTATAGGACTGATTAGTTTTCACAATCCCATTTAAATAAAAAAAAGATCT TTAGTTGGGCATTTAGGAGCAACTGAATTCTCCCAAAATTGTGGCAGCAAAAAGAACACTTCATATGCTTAAAACCCATTCTTTTTGAAT TAGATTTTGATTTTAAATATTTAAGTCTGGTGTTTGTGAGAACACTTTTCTCTTTGCTCAGTCTTTTCGATCTGGTTGGGTAGGGAAGGT GTTCCTCATGCTCTCTGGGTGGCTGCCTTATTCATAGTTGAGAGAGCTGTTAGGTAAAATCTTTATATGTGTTGGGGTTTTTTTGGTAGG GGGGGTAGCAGGTAAAGGTGGCCCATGGCTAGGGCAGCAAAGATGAATAATTTGAGGAAGCATTTGGTTGGTGGACTCATTTGCAGAGAA ACAGTGGTGACAACAAATCAGAGCTGTTTCCCTCAACTCTGGCTATAAGAGGTCATTCTCTGCATGTCAGCTACAAAGATCAGGCACTTG AATGAATCCGCTGGGTTGGCAGGCATTGGTCATCTTCGCAACACCCTCTTCCTCACCATGGATGAGAACAAGACGGGAGTGGTTATATCC CAGTAACAGAAGCTTTGGGAGGTATCCAGGTGAGCAGGGTAATGTGGCTTGCCCTCCCCCAGATATTCTGATCCCAAGAAAAAGGTGTCA TTAATCAGTCTGGCATTTTCCACCCTCCATATGCTGGCATCCAGGAACCAAAACCCCTGAAGGCCTAGACACCCTATGACCTCTAACTGA GATGTTGGCAGCCAGGCAGATGCAGGCTCATGTCCAGGAGGAACTGCTGACTGGTTTGGCCACAGCCCAGTTCATTGCTTGTCTTGCCAA GTGGACAACCAGATTCTGCCTTCCTGAGCTTGAAAATAGGCTACAACTCTCAGGTGATTCAGATGACATGGAGGAGAAGTTGGAGGAGAA GATTGAAATGCTTAAATCCCAGTGCAGAATGAGTTGCTTCAGTGGAGTAAAGCAACCGGCTAGTTGGTAGCCTGCCTTAAAAAATACTAA ACATATATCATCATACATTTGATCAAATGCTGTAAGCACAGCCAAGGCCCAAATTCATCTAGATACCAAAAATGTGATTTCAGTGAAATC TCTTTTCATTGCCGCTTTCTTTTGTTGTTGTTTGTTTTTTGAGCCAGAGTCTTGCTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAA TCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGAGTTTCCTGCCTCAGACTCCCGAGTAGCTGGGATTACAGGCATCCACCACC ATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGCTTCACCGTGTTGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCTGC CCACCTTGGCCTCCAAGGTAATGAGATTATAGGAGTGAGCCACCGCACCCAGCCCTCATTACCACTTTCTTGAATTTACTCAATCATCCT ATCAAGCAGGGTTTAGACCAACATCTTTGCATTTAATAAGGGCTCTACTTTGTATACATGGACCATCCAGTGAGAGAGCTGGGGGTGGTG AGAAGCAATGTCCCCCATTCCTATATGTCAGGTGTCAGCAAACTATCTGTAAAGAGGCAAATAGTAAATATTTTGGGCTTTGTGAGCCAT TTGGTACCTGTCACAGAATAGTCAGCCCTCCATATCTGAGGTTTCCAAATCCATGGATTCAACCAACCTTGAATCAAAAATATTTGGGAA AAAATGTATAGTTGCAACTGACCTGAACATATTCTTTTTTTCATTATTATTCCTTGAACAATACAGTTTAACAGGATTTACATAGCATTT ACACTGTATTAGGTATTATAAGTAACCTAGAGATGATTTGAAGAACACAGGAAGTTGTGCATAGGCTATATGCAAATACTATGCATTTTA TATAAAGGAATTGAACATCTGTGGATTTTGGTGTCCGAGGGGAGTTCTGGAACCAATCCCCTACAGATACTGAGGGATGACTGTACTCAG CTCTCCTATTGTAGCATGAAAACAGACAATACGTACAACAAATGAATGTTTCAATACAACTTTATCTAGTTTCCATAAAACAATTTAAAA ACACTAAAAAAGCAGGCAGTTTGGATTTATGTAATTTTCATATCTTTTTTTACCCTTTTGATTTACATTTTTAATAATTTAAAAATATAA AAACCTTCCTCAGCCCACAGGCCATACGAAAATTAGCAGCCAGCTAGATTTGGCCCAAGGCCAAAGTTTGGCAACCCGTACCATACACCA TGGAAGTTAGCCTTCCACCTCAGGAGAAAGCAAGCTGCTCTCATAAGCCTCTCACCAACTACCCAGTAGTCTTTGCCTCCAAACTGAACA ACAGGAAAAAGTGCCATAGTTTTTAATTAAGCTGTTTTAAAAGTCCATGTTCCGGGGGAAAACAAAAAAGAAACAAACAAAACACTTGTT ATTTGCTGAACTGACAAACTGACAGATATTCCACGAGAGTTGAAAGCCTTGGATCGAGGTGATTGCCTGGTTACTGAGTGCTAACTCCAC TGAGGCAAGTGTTAGCCCCCCAAGGCTCAGTGCCTTCCCAGCACAGCTCAGCCCATAATGATCTCTGAGCAGGAGTGTTCATTATCTCAG ACTGATTTTCATTTCAGCCCTACTCTTGCCATTGCTCTAAAAATGATCCTAAAGACTTGTGACTGTTTGAATCAATAGCAACATCATCAG TAGAAAGCCCGACCAAGCACACTTCGAAATTAGCAATCTTCTTGGCTCTATGGCTCAATATCAGCAAGAAGAAAAAAAGACAACTTTTTT TTTAATCATCCCCACATTTAAATTAACCAAATAGTTTTTACAAAAAAGTAGGTAAGTGGGTTTAATTCTTTGAAAGTATTTGCCAGTGAA AAGTAGATGATTTTTAGGTAAGATAACGTTTAGGCCTCTGGGGGATCCCCAAAGCCTTCTGCAATGTACTCTGGCAGGCTATGAATGGTA CAGGATTCTGCATCTATATGAGACATTTATTGAGGCTGACAAGCAAAAGCCCTTGGCACAATTTAATTTTCACATAACCACTTTCCATTG TCCAGCTGCAGGCAAAAGAAATGAGCAATGAAAGTTTTGAAGTCTACCCCAGTACCCTCATTTCCTGTCTTTATTTCCTTTACTTTATAG ATGTATTCTATACCTGCTATGTAGATAATGCTCTAGTTTTCCCTTTAGTGCCAACTGGAAAAGGAGAGTTGGCTTTACAGGGGCTGTGGA TTAAGAGCCAGGCTTCATTCCATCCCAGGGAGACAAAAAGAGACAGAAGAAGTTACCTCCAGCAGCACCCCAGAAAGCTGACAGATATTC CCTGTATGCAGGTAGTAAACAGATGGGAGTCTGTGTTTGCAGCTATGTTCAGTGTAATTCAGCAGACCTTCACTGGGCACTTGTGATGGG TCAGGCCCTGTGCCAGCAACAGGGGAAGGGAGGATGAACAAGGCATGTTTCCCTGACCATGAGGAGCTCTTGGCCTGTGAGCTGTTGGGA TGTCCCTTTGTGGTGTTGGAAGCTGTGCACGAGCAGTCAGGACTTTGGGGACAGAAGTTTAGTGTTAGGGAGGCAGGGTAACTTGCTTTG ACAGCTACCCACCCTAAGTCAGATGACAGGTGTAATTCTAGGGGCCCTGATATGCATCACTGAGGCAGACTGAGGAGCTCTCCAGGGAAG TAGGCAATATTTCCCTGAATATTCCTCAATTCCAATCAAGGCTGACTCAGTTCACTTATGGATGAAAGCCAGTTACCCTGCCCACTGGGC AGAAATAACATGGTTGACAGCTGACATTCAGAGAAAATAAGACAGAAGCAGTCCTTAAATATAAACAGCAGCCAGGTGGACCTGGAAATT TAGGAAGGGTGATGCAGGTAGAGGGGCCAGCAGGAGCCAAGTCTCAAAAGGCACAAGCCAGACTGATGCAAGGGAGCCCTCCTGAGGCCC AACATCAGAGCTGAAGATCTAAGGAGGGCCCACCTCCACGAGACCTGCTGAGGGCTTACATTTGGTGCTGAGGAGCAGTGGTTCCCTGGG CCAGCTGCATCACCTGGGAACATGTGAGAAGTGCATATTCTTGGGCCCCACCCCAGACCTACTGAATGAGAAGCTCTGGAGGCAGGCAGT CTGTGATTTAATGAGCTTTCTGACACACACTAAAGTTTGAGAACCACTGATGCAGAGGATGAGGAGATGACTTGAGCTGGCATCGGGAAG AACTGACTATTAACTAACAAGGTAAAATCAATGACTAGTGCAGTGAGGGTGCCAAAGCAAACCACCCCCAGCCCCCATCCTGGGCCTTTT TGGCTCCAGTTTATACTCACTGAAGCAGTGGTTTCAAGGAACCTTGGTCCTAGTCCGCATCCTTCACCTGCCCTTGGGCATGAGACAATT CCTGCCTGCCTGCCCCTTCTATCCTAGAGAGAGAGACTGCCCAGGAGAGGCTGCCATGAGGTCACTCATCCCCAGGAAGGCCACCTGCCA GGTTTCTGTAAGCTGAGCAGCCTCTTCGAGGGCCATATTTTGTGGAGAAACACTGAAACTGCAGCAGTGACCCTGGTCACTAGGAGAGCT GCTTTCTACACAGCCTGTATGCTGGTGGAGACACCCAGGGCCTGGCAGAGTGTGGAGGGGGTCATTTAAGGACGTTGCCAGGTTGCCGCA GCACTGCTCTGTTTGTTTGTAATGAGACTGGGGCATGCAGCATCACAATTCAAACACTGAATTGCTTGGGGAATGGATGGCCTTCCTTGG AAGGGCAGTAACTCATTCTGGATGTTACTAAAAGTAGAAAACAAAAATCCAAAAACAAACCTACAGCCTCATTTACAATTAGAATCTGTC TGGGCCTTCTGATTTCTAAAGTCTGTGAGGCTGCCAGGATTCACCAATTCTCCTTTCCCCTGAGGCCCAGCAACTATTGATTTATAGCTT AAACTCTGTGAAGGTCCACAGACCTTTGAAAGGAACTTGCTGGTACTTTGTCAGTCGTGTACACCTAACTGACTCCTCCTACGAGGTACA GTCTCCTCATACAAGGGGTTTTGAGATGGAGAGTCAGAGGGCCAGGGCCCTGGGCTTTGGGGTGGAAGGACAGAAGAGTAGCAGTCTAGG AAAGGGACTAGACATGTAGCCTAGGAAAACTAGCACCATCTGTTGAGTTCTGAAGAACCCAGATTCTCTCCTGCTCACAGCCTCAGCAGT CTTTTCAGAGTCCTCCTGAATGGCCCAAAGACACCCCTGTTTCTGGGGAACAGAAGGGAGCTGGTACCTCTGGACCATTGAGGCAACACC TCCCCAGAGGCAGGACCCCGCCCCCATGAGAACATGCAGTTGAATGATGTGGTGCCTGGCCAGGACCTTGGAAAACGTGGCCATGTGAGA CTAGTATAGATCTCCAACTATTGCTGCCTCTGCTGATATGGCCACCTCCTTAAGGTAAGAAGACTACCGACTTAGCTATTGTGGCACCAC GGGAGCCTAGCACTGCACCTGGCCCATGACATGTGTGCCACAAATGTTGAATTGAATTGAATCCCAGAGATCACTTGACCTCAGTGAAGG GACTGGGTTTGAAGAATTAAGACCCCCCAGTGGAGAAAGCCTCCTCCAACTTCCTTCTCGGTTTGTGAGTCAAGGTCCTTTGTAAAATCA GATCGACGAGGGTGGAAGTGCAGTGAACAGAGGACAACATTTGTGATGCACGTGGGAGAAAACAGGAGTGGGGTTGTTTGGGGACTACCC CTTCCTAGCTATAGTCAGTAAATGGAGCCCCTAAGCAAGGAGCAGGGGTAGATGTGCCTGGGTGAGGCCTGCTTGCTCCACCGTCGAGGT CATGGGCAGCATCCCAACTGAGGAGAGAAAACCCTAATTTGTTAATGACCCAGCCTTGTGCTGCTCTCCAGTTCCTTTCATCAGATTTAC TGCAGAGCAGATTCATCAACATGAAGTTCAATTCCCAGTAGACTAATGAAAAGAGGGCAACAGACTTGAGAAGAGCCAAAATGCAGACAG TGTGTATTAATCACAGACAACAGAAACGTGTTAGCTTTAATGTCTGTTTGCTTTTATCTTGAAATGAAAATGCATCTCTGTTACCTGGAC CCTTTTTACTGCACATTTCAGAACAGAAATGGGACACCCACACACGTATTGAGGGTCCTTTTCCCCGGCAGGAGGAGCTACCAGAGAAAT GAGCCCACATTTTGTGTGCAGAGAGAATCAACCCACAGGTCTCAGCTGCAGACTCCAGCACCTCTGCAGAGAAGGCAGGCAAAGGGATGA GGAGGTAGCATCTCCTCTTCAGAAGGATTCATAAGGGCCTCTGTGAGGAGGGCCTTGCTTGTGCCTGTGGGTCATGGATGTTAATATAAA GGCTCATCCACCCTTGGTGGCAAAAGTGCATCCATCCTGGCCAATATAGAACACTCACATCTGGAGCCCACGCCCACCCACCTCCAGCTC CTCTACATGGCTGCAAGAGCATGGCTGATGTGTGGGATTCAGAAGAGGTCTGCTCATGTTCACTAGCCAAACTTTAGGTGGTGTGATACA GCAAAAAGCTTTTTTTGTTTTTCTGTTTTTGTTTTGTTTTTGGCGTGGAGGAGAAATTTAGACTTGAAAGTCAGGGCTGATCACTCAAAA AGTAAGATAGGAGATATTGAGGGAAAATGTGACTCATAGTTGGAGAGGAAACAGGAGAGTGGGTACAAGTGACAGCACCAGGAACAACCC CCTCCCCCAGATGCCAAAGCATTGCTCTGTATCTAAAGATGCATCCAAGTTTGCAAAAAATTATGGGTAAATCTGGCCATGTGACCAAAG AGGCAGTCAAATCAATTGCTTCCAAAGTCAGAGCTGTTTGAAGGTGATCAGCTCTTAATTGAACTAGTCATGATGAATCAATCCAACTGA CTGCATCCAGTCTGACCTCGGTGGTTTCCATAAAGGGTTGTTGATGTCCTGAGCTGGACAGGGTGGGCAGGAGGTTGAAGAAAACCAGTT GGTGAGTATAGAAAAGAAATTGCATGTAGAAGTTGTTTGTTCTCAAAGAAATCTGTAGGTGTTAGAGCTGGGTTTGTTATGTTATTGTCA GGGACATTATAATATTGGTAAGGAGGAGAGAATGATTTGGTAGGGGTATTCGAGAAATTTGAGTACAAAATATAAATTATCAGAGATGAG TAGGCTATGGACAGCTGATTATATATATGTGTGTGTGTGTATATGTGTGCATATATGTGTACATATACACATACCCCAAAGCCATATACA TATCTATAATACAGAAGTAAGAATAAAGTCATAAGTACCAGCATATTTTAAATCCTTAGAAGCACTGGTTGGGATGTTACATGTTTTTTC ACTGTTGTTGTTTACCGTTAGCTCTCAAAGCAGTGGGAATAGTGCTTGGCACATAGTAGGAGTTTGGTAAACATTTGGAAATTGAAGACC CAGCTTATCACTCCTTCATAGAGACTCAGTAGTATGAGTATACCCCAAATTGAATGAGCCACAGAGAAATGCATCCAGCCACACTCCCTC TTAGCTGAGGAGAAGCCTCTGTGAATCCACAGATTCCATGCAATATTCAGCCAGCCGCAGACACAAGGTCTGGCTCCCTTGTCGTGAGAG TGAAGGCATGCTGCACACAGTGGGTTTGCATGCACCTAGACTGCATCTGCTGAACACCCAACAGCTGTTTCTACAAGCTAAAGTTGTAGC TTCTCTCTACCACTGTCTAAAGCTGTAGCTTGTCTCTACTATTGTCTCTACACCGTTGCCCAAACACTTGGTATAATGCTATTGAATTTT TCACCTCCAGGCATGATTTTGTAACCAATGTAAAGGTTCTGGGTTCAGCCAGTCTAAAAAGTCTAATAATTTCTTCTCTCAGTCCTTCCC TTCTCCCTTGTCTGGAGCTGCCACCGCCATTTAAAAGTGTTGGACGCTGTTTATTCCCAGCTTCTCAACCTCAGTGTGTGTGGGAAAGGC CTGAAAGAGAGAGGTATGTTTTCTCTCCTCCAGAGTCTCTGTGGTGTTGACACAGCAGAGAGAGGAGGGGGAGCAGCCTCGTCTTGCAGA ATCACCTTCAATCACTGCTACTGTCTGGGCCATTACTGCCAGTCTGGCCGGTGTCTCCCACAGTGGATGGCTTTGCCTCCAGCGGTGGAC CAGTGTGTACCTGACATGTATCAGACTTCTGAGCTCTTCAAGCTGCCTCAAAGAATGAATCTTTTTAGTCTAGAAAATGTGTTTATTTGA TAAATATACTATTGTGTATGAGTGTGAAACAATGCAGACTTTGGAGTATCTCATTAGAAGGACTGTATGAATTTATAGAAAATTGAATCT AATTTCAGAAGAGCGCACTGTCTTCTCAGTCAACAAGGTTGCCCAGCCACAGAGGGTCAGAGAAAATGTCCTTTCCCCTCCCCACTCCTT TTCATAGAATCCTCTCTCAGGCCTAACTGAGCTGTCATATCCAATTCAGACTGACACAGAGTGAGGGGCGCTGAGAGTCTCTATGTATAT AAAGATATAGGAAGAAAATAAGGATCATCACAGGAATCTGTTGGGCTTCTCCCCATGACTGTGATCTTACCCATGTTTGAATCACAAACT TTAAATTTATAATAATTATGATTCTTGCAGTTTTCAAGTAATTTGTTAAATGCCTATTCAACACAGACAGATTTTTATTTTCAGCTGTGG CTTGTAAATGCCTACAAACTGATTCATGTTGGTGGTCGTTATGACACTTTCTGTGAATTGGTGAATAAATATGATTTTAGAATTTCACAG TAAATATTAGCCGGCACTGTTATCACAACCATCACTCGCGATGGGAGTTTGCACGCCACAGTCTCGATCATCAACATCTACAAAGAGGGA AATTTGGCGATTCAGCAGGCGGGCAAGAACATGAGTGCCAGGCTGACTGTCGTCTGCAAGCAGTGCCCTCTCCTCAGAAGAGGTCTAAAT TACATTATTATGGGCCAAGTAGGTGAAGATGGGCGAGGCAAAATCATGCCAAACAGCTTTATCATGATGTTCAAGACCAAGAATCAGAAG CTCCTGGATGCCTTAAAAAATAAGCAATGTTAACAGTGAACTGTGTCCATTTAAGCTGTATTCTGCCATTGCCTTTGAAAGATCTATGTT >17355_17355_2_CLSTN2-PCOLCE2_CLSTN2_chr3_140285052_ENST00000458420_PCOLCE2_chr3_142539887_ENST00000485766_length(amino acids)=902AA_BP= MAAAARMLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFK IHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKI YDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDW TKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEM IFKFDGRQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHW KLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKV ISCLQACKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVSSKVQCFGEDVCISIPEVDAY VMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLE LNHSELHQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSNEFNLEVSILHEDQVSDKEHVNHL IVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEASPAG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CLSTN2-PCOLCE2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CLSTN2-PCOLCE2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CLSTN2-PCOLCE2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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