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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTL6A-UBL5 (FusionGDB2 ID:1738)

Fusion Gene Summary for ACTL6A-UBL5

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTL6A-UBL5
Fusion gene ID: 1738
HgeneTgene
Gene symbol

ACTL6A

UBL5

Gene ID

86

59286

Gene nameactin like 6Aubiquitin like 5
SynonymsACTL6|ARPN-BETA|Arp4|BAF53A|INO80KHUB1
Cytomap

3q26.33

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionactin-like protein 6A53 kDa BRG1-associated factor ABAF complex 53 kDa subunitBAF53BRG1-associated factor 53AINO80 complex subunit Kactin-related protein 4actin-related protein Baf53aarpNbetahArpN betaubiquitin-like protein 5beacontesticular tissue protein Li 217
Modification date2020031520200313
UniProtAcc

O96019

.
Ensembl transtripts involved in fusion geneENST00000392662, ENST00000429709, 
ENST00000450518, ENST00000467615, 
ENST00000589960, ENST00000593087, 
ENST00000358666, ENST00000586895, 
ENST00000590068, 
Fusion gene scores* DoF score7 X 6 X 5=2107 X 5 X 5=175
# samples 77
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTL6A [Title/Abstract] AND UBL5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTL6A(179292255)-UBL5(9939267), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTL6A

GO:0006338

chromatin remodeling

11726552

HgeneACTL6A

GO:0043967

histone H4 acetylation

14966270

HgeneACTL6A

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across ACTL6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBL5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1743ACTL6Achr3

179292255

+UBL5chr19

9939267

+


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Fusion Gene ORF analysis for ACTL6A-UBL5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000392662ENST00000589960ACTL6Achr3

179292255

+UBL5chr19

9939267

+
5CDS-intronENST00000392662ENST00000593087ACTL6Achr3

179292255

+UBL5chr19

9939267

+
5CDS-intronENST00000429709ENST00000589960ACTL6Achr3

179292255

+UBL5chr19

9939267

+
5CDS-intronENST00000429709ENST00000593087ACTL6Achr3

179292255

+UBL5chr19

9939267

+
5CDS-intronENST00000450518ENST00000589960ACTL6Achr3

179292255

+UBL5chr19

9939267

+
5CDS-intronENST00000450518ENST00000593087ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000392662ENST00000358666ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000392662ENST00000586895ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000392662ENST00000590068ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000429709ENST00000358666ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000429709ENST00000586895ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000429709ENST00000590068ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000450518ENST00000358666ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000450518ENST00000586895ACTL6Achr3

179292255

+UBL5chr19

9939267

+
In-frameENST00000450518ENST00000590068ACTL6Achr3

179292255

+UBL5chr19

9939267

+
intron-3CDSENST00000467615ENST00000358666ACTL6Achr3

179292255

+UBL5chr19

9939267

+
intron-3CDSENST00000467615ENST00000586895ACTL6Achr3

179292255

+UBL5chr19

9939267

+
intron-3CDSENST00000467615ENST00000590068ACTL6Achr3

179292255

+UBL5chr19

9939267

+
intron-intronENST00000467615ENST00000589960ACTL6Achr3

179292255

+UBL5chr19

9939267

+
intron-intronENST00000467615ENST00000593087ACTL6Achr3

179292255

+UBL5chr19

9939267

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000429709ACTL6Achr3179292255+ENST00000586895UBL5chr199939267+961689159854231
ENST00000429709ACTL6Achr3179292255+ENST00000358666UBL5chr199939267+962689159854231
ENST00000429709ACTL6Achr3179292255+ENST00000590068UBL5chr199939267+962689159854231
ENST00000450518ACTL6Achr3179292255+ENST00000586895UBL5chr199939267+811539189704171
ENST00000450518ACTL6Achr3179292255+ENST00000358666UBL5chr199939267+812539189704171
ENST00000450518ACTL6Achr3179292255+ENST00000590068UBL5chr199939267+812539189704171
ENST00000392662ACTL6Achr3179292255+ENST00000586895UBL5chr199939267+969697347862171
ENST00000392662ACTL6Achr3179292255+ENST00000358666UBL5chr199939267+970697347862171
ENST00000392662ACTL6Achr3179292255+ENST00000590068UBL5chr199939267+970697347862171

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000429709ENST00000586895ACTL6Achr3179292255+UBL5chr199939267+0.0019288580.99807113
ENST00000429709ENST00000358666ACTL6Achr3179292255+UBL5chr199939267+0.0019663610.9980336
ENST00000429709ENST00000590068ACTL6Achr3179292255+UBL5chr199939267+0.0019663610.9980336
ENST00000450518ENST00000586895ACTL6Achr3179292255+UBL5chr199939267+0.0039005530.9960995
ENST00000450518ENST00000358666ACTL6Achr3179292255+UBL5chr199939267+0.0039566830.9960433
ENST00000450518ENST00000590068ACTL6Achr3179292255+UBL5chr199939267+0.0039566830.9960433
ENST00000392662ENST00000586895ACTL6Achr3179292255+UBL5chr199939267+0.003825140.9961748
ENST00000392662ENST00000358666ACTL6Achr3179292255+UBL5chr199939267+0.0038937720.9961062
ENST00000392662ENST00000590068ACTL6Achr3179292255+UBL5chr199939267+0.0038937720.9961062

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Fusion Genomic Features for ACTL6A-UBL5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTL6Achr3179292255+UBL5chr199939267+1.61E-060.99999845
ACTL6Achr3179292255+UBL5chr199939267+1.61E-060.99999845

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACTL6A-UBL5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:179292255/chr19:9939267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTL6A

O96019

.
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBL5chr3:179292255chr19:9939267ENST00000358666151_731874.0DomainNote=Ubiquitin-like
TgeneUBL5chr3:179292255chr19:9939267ENST00000586895151_731874.0DomainNote=Ubiquitin-like
TgeneUBL5chr3:179292255chr19:9939267ENST00000590068151_731874.0DomainNote=Ubiquitin-like


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Fusion Gene Sequence for ACTL6A-UBL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1738_1738_1_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000358666_length(transcript)=970nt_BP=697nt
GCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTA
TCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTAGCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCG
GCGGCGTGTACGGGGGAGGTGAGTGAGTGCGGCCGGACGAGAGAGCGCGCCTTTTCGGCGTGTGGGATGAAGTTGGAGCCCTTGTTTTTG
ACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAA
GAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTG
TTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCT
ACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGA
CAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACC
TTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTC
TGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCC

>1738_1738_1_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000358666_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------
>1738_1738_2_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000586895_length(transcript)=969nt_BP=697nt
GCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTA
TCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTAGCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCG
GCGGCGTGTACGGGGGAGGTGAGTGAGTGCGGCCGGACGAGAGAGCGCGCCTTTTCGGCGTGTGGGATGAAGTTGGAGCCCTTGTTTTTG
ACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAA
GAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTG
TTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCT
ACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGA
CAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACC
TTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTC
TGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCC

>1738_1738_2_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000586895_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------
>1738_1738_3_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000590068_length(transcript)=970nt_BP=697nt
GCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTA
TCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTAGCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCG
GCGGCGTGTACGGGGGAGGTGAGTGAGTGCGGCCGGACGAGAGAGCGCGCCTTTTCGGCGTGTGGGATGAAGTTGGAGCCCTTGTTTTTG
ACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAA
GAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTG
TTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCT
ACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGA
CAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACC
TTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTC
TGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCC

>1738_1738_3_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000392662_UBL5_chr19_9939267_ENST00000590068_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------
>1738_1738_4_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000358666_length(transcript)=962nt_BP=689nt
AGACTTAGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCC
TGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTATCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTA
GCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCGGCGGCGTGTACGGGGGAGATGAAGTTGGAGCCCTTGTTTTTGACATTGGA
TCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAAGAGATGAC
GGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTGTTCCGAGG
GAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCTACAAAATG
CATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGACAGAGTTA
ATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACCTTAAGAAG
CTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTCTGGGGGAC
TATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCCCATCCTCA

>1738_1738_4_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000358666_length(amino acids)=231AA_BP=177
MQSLRQLALRVGVAPAAAMSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDT
NALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTATDD

--------------------------------------------------------------
>1738_1738_5_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000586895_length(transcript)=961nt_BP=689nt
AGACTTAGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCC
TGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTATCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTA
GCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCGGCGGCGTGTACGGGGGAGATGAAGTTGGAGCCCTTGTTTTTGACATTGGA
TCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAAGAGATGAC
GGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTGTTCCGAGG
GAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCTACAAAATG
CATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGACAGAGTTA
ATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACCTTAAGAAG
CTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTCTGGGGGAC
TATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCCCATCCTCA

>1738_1738_5_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000586895_length(amino acids)=231AA_BP=177
MQSLRQLALRVGVAPAAAMSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDT
NALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTATDD

--------------------------------------------------------------
>1738_1738_6_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000590068_length(transcript)=962nt_BP=689nt
AGACTTAGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCC
TGAGGTGGGTGGCGGTGGAAGTTAAGGGAGTCAGGGGCTATCGCTCCTCGAGACTCGCAGTCGCGGCCACTGCAGTCACTTCGCCAGTTA
GCCCTTAGGGTAGGAGTCGCGCCGGCAGCAGCCATGAGCGGCGGCGTGTACGGGGGAGATGAAGTTGGAGCCCTTGTTTTTGACATTGGA
TCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACAGCTATTGGTATGGTGGTAGAAAGAGATGAC
GGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTACATAGATACTAATGCTCTGCGTGTTCCGAGG
GAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTCCAAGCTATTTTGGATCATACCTACAAAATG
CATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACTAGAGCAAAGAGAGAGAAACTGACAGAGTTA
ATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCCACGGATGATACCATCGGGGACCTTAAGAAG
CTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACGATTTTTAAGGACCACGTGTCTCTGGGGGAC
TATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATCTTCCTGCCCCGCTTTCCTCTCCCATCCTCA

>1738_1738_6_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000429709_UBL5_chr19_9939267_ENST00000590068_length(amino acids)=231AA_BP=177
MQSLRQLALRVGVAPAAAMSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDT
NALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTATDD

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>1738_1738_7_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000358666_length(transcript)=812nt_BP=539nt
AGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGAT
GAAGTTGGAGCCCTTGTTTTTGACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACA
GCTATTGGTATGGTGGTAGAAAGAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTAC
ATAGATACTAATGCTCTGCGTGTTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTC
CAAGCTATTTTGGATCATACCTACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACT
AGAGCAAAGAGAGAGAAACTGACAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCC
ACGGATGATACCATCGGGGACCTTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACG
ATTTTTAAGGACCACGTGTCTCTGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATC
TTCCTGCCCCGCTTTCCTCTCCCATCCTCATCCCCCACACTGGGATAGATGCTTGTTTGTAAAAACTCACCTTAATAAAGACTTAGATGT

>1738_1738_7_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000358666_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------
>1738_1738_8_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000586895_length(transcript)=811nt_BP=539nt
AGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGAT
GAAGTTGGAGCCCTTGTTTTTGACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACA
GCTATTGGTATGGTGGTAGAAAGAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTAC
ATAGATACTAATGCTCTGCGTGTTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTC
CAAGCTATTTTGGATCATACCTACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACT
AGAGCAAAGAGAGAGAAACTGACAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCC
ACGGATGATACCATCGGGGACCTTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACG
ATTTTTAAGGACCACGTGTCTCTGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATC
TTCCTGCCCCGCTTTCCTCTCCCATCCTCATCCCCCACACTGGGATAGATGCTTGTTTGTAAAAACTCACCTTAATAAAGACTTAGATGT

>1738_1738_8_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000586895_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------
>1738_1738_9_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000590068_length(transcript)=812nt_BP=539nt
AGGCCTGGACCCTAGTGATTGGCTGATAGGAGGAGCCAGCAAGTGTGGCTGAGCTCCGGGGTGTGTGGACGCCGCTTTGTTGCCTGAGAT
GAAGTTGGAGCCCTTGTTTTTGACATTGGATCCTATACTGTGAGAGCTGGTTATGCTGGTGAGGACTGCCCCAAGGTGGATTTTCCTACA
GCTATTGGTATGGTGGTAGAAAGAGATGACGGAAGCACATTAATGGAAATAGATGGCGATAAAGGCAAACAAGGCGGTCCCACCTACTAC
ATAGATACTAATGCTCTGCGTGTTCCGAGGGAGAATATGGAGGCCATTTCACCTCTAAAAAATGGGATGGTTGAAGACTGGGATAGTTTC
CAAGCTATTTTGGATCATACCTACAAAATGCATGTCAAATCAGAAGCCAGTCTCCATCCTGTTCTCATGTCAGAGGCACCGTGGAATACT
AGAGCAAAGAGAGAGAAACTGACAGAGTTAATGTTTGAACACTACAACATCCCTGCCTTCTTCCTTTGCAAAACTGCAGTTTTGACAGCC
ACGGATGATACCATCGGGGACCTTAAGAAGCTGATTGCAGCCCAAACTGGTACCCGTTGGAACAAGATTGTCCTGAAGAAGTGGTACACG
ATTTTTAAGGACCACGTGTCTCTGGGGGACTATGAAATCCACGATGGGATGAACCTGGAGCTTTATTATCAATAGATGAGAATCCTCATC
TTCCTGCCCCGCTTTCCTCTCCCATCCTCATCCCCCACACTGGGATAGATGCTTGTTTGTAAAAACTCACCTTAATAAAGACTTAGATGT

>1738_1738_9_ACTL6A-UBL5_ACTL6A_chr3_179292255_ENST00000450518_UBL5_chr19_9939267_ENST00000590068_length(amino acids)=171AA_BP=117
MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACTL6A-UBL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTL6A-UBL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTL6A-UBL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource