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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CLYBL-ARGLU1 (FusionGDB2 ID:17476)

Fusion Gene Summary for CLYBL-ARGLU1

Fusion gene summary

Fusion gene information	Fusion gene name: CLYBL-ARGLU1
	Fusion gene ID: 17476
		Hgene	Tgene
	Gene symbol	CLYBL	ARGLU1
	Gene ID	171425	55082
	Gene name	citramalyl-CoA lyase	arginine and glutamate rich 1
	Synonyms	CLB	-
	Cytomap	13q32.3	13q33.3
	Type of gene	protein-coding	protein-coding
	Description	citramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthase	arginine and glutamate-rich protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q8N0X4	Q9NWB6
	Ensembl transtripts involved in fusion gene	ENST00000339105, ENST00000376354, ENST00000376355, ENST00000376360, ENST00000444838,	ENST00000375926, ENST00000472226, ENST00000400198,
Fusion gene scores	* DoF score	7 X 8 X 4=224	8 X 7 X 3=168
	# samples	8	8
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CLYBL [Title/Abstract] AND ARGLU1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CLYBL(100259011)-ARGLU1(107212005), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLYBL	GO:0070207	protein homotrimerization	29056341
Hgene	CLYBL	GO:0106064	regulation of cobalamin metabolic process	29056341

Fusion gene breakpoints across CLYBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARGLU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	135N	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-

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Fusion Gene ORF analysis for CLYBL-ARGLU1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000339105	ENST00000375926	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-5UTR	ENST00000376354	ENST00000375926	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-5UTR	ENST00000376355	ENST00000375926	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-5UTR	ENST00000376360	ENST00000375926	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-5UTR	ENST00000444838	ENST00000375926	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-intron	ENST00000339105	ENST00000472226	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-intron	ENST00000376354	ENST00000472226	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-intron	ENST00000376355	ENST00000472226	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-intron	ENST00000376360	ENST00000472226	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
5CDS-intron	ENST00000444838	ENST00000472226	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
In-frame	ENST00000339105	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
In-frame	ENST00000376354	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
In-frame	ENST00000376355	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
In-frame	ENST00000376360	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-
In-frame	ENST00000444838	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376355	CLYBL	chr13	100259011	+	ENST00000400198	ARGLU1	chr13	107212005	-	2891	93	31	567	178
ENST00000444838	CLYBL	chr13	100259011	+	ENST00000400198	ARGLU1	chr13	107212005	-	2887	89	27	563	178
ENST00000376360	CLYBL	chr13	100259011	+	ENST00000400198	ARGLU1	chr13	107212005	-	2887	89	27	563	178
ENST00000376354	CLYBL	chr13	100259011	+	ENST00000400198	ARGLU1	chr13	107212005	-	2866	68	6	542	178
ENST00000339105	CLYBL	chr13	100259011	+	ENST00000400198	ARGLU1	chr13	107212005	-	2860	62	0	536	178

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376355	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-	0.000121493	0.9998785
ENST00000444838	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-	9.68E-05	0.9999032
ENST00000376360	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-	9.68E-05	0.9999032
ENST00000376354	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-	9.60E-05	0.9999039
ENST00000339105	ENST00000400198	CLYBL	chr13	100259011	+	ARGLU1	chr13	107212005	-	0.000136007	0.999864

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Fusion Genomic Features for CLYBL-ARGLU1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CLYBL-ARGLU1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:100259011/chr13:107212005)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLYBL Q8N0X4	ARGLU1 Q9NWB6
FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269\|PubMed:24334609, ECO:0000269\|PubMed:29056341}.	FUNCTION: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. {ECO:0000269\|PubMed:21454576}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLYBL

chr13:100259011

chr13:107212005

ENST00000339105

272_273

361.0

Region

Substrate binding

Hgene

CLYBL

chr13:100259011

chr13:107212005

ENST00000376354

272_273

307.0

Region

Substrate binding

Hgene

CLYBL

chr13:100259011

chr13:107212005

ENST00000376355

272_273

1839.6666666666667

Region

Substrate binding

Hgene

CLYBL

chr13:100259011

chr13:107212005

ENST00000376360

272_273

341.0

Region

Substrate binding

Tgene

ARGLU1

chr13:100259011

chr13:107212005

ENST00000400198

3_74

115

274.0

Compositional bias

Note=Arg-rich

Tgene

ARGLU1

chr13:100259011

chr13:107212005

ENST00000400198

97_251

115

274.0

Compositional bias

Note=Glu-rich

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Fusion Gene Sequence for CLYBL-ARGLU1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17476_17476_1_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000339105_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2860nt_BP=62nt
ATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAAAAACTC
ATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATTGAACGA
GAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAGCTTGCC
GCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCAGAAGCA
CAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAACGACAA
CGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGATTAAATT
GCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTTGTTTTT
TTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCACTAAGT
CAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAGAGCAGA
TCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATAATGCTG
GTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACTGGACCT
ATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACTCTGATA
CAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTGTAAATA
AATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGTGGTTCA
CTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTAAATATA
CTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGAAAGACT
AACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGGCTAGAA
AAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGCTAAGAT
GGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTTTTTTGC
ATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTATTAAAAC
ATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCCCAATAT
TTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATGCTAGGA
AAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAAAGGTAG
AATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAGAATATA
GGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTTTGGTGA
AGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGTATCTAA
AGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATATGGTGTG
AAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTGCTTGGT
AACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAATGTAGT
AATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATGTTCCCT
AATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTATTTTTAT

>17476_17476_1_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000339105_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_2_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376354_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2866nt_BP=68nt
GGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTTCGACAGCAAGAAATAGAAGAA
AAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTGGAGAAAAGGAAGGATGAAATT
GAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTCGAGCGACAGAGACAAGCTGAG
CTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAAGAGAATAACCGAAAAATTGCA
GAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAAAGGATGAAACTAGAACAAGAA
CGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCCTTCTCATTAAAAACCCAGGAT
TAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAGTGGTTTTTTGTTTTTGTTTTT
GTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTTTTTTTTTTTTTTTTCCTTCCA
CTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTCTATATTAGTGGTCTGAGGAAG
AGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTATACTCTGTTTGCTACATCATA
ATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTGGGAAATTCCCAGGGTATTACT
GGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGGTAAGGAAACAGTTGGTCAACT
CTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATCAAACCAGCATTCCCCATTGTG
TAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTTATGTTAAGTCTTAAAGAGGGT
GGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAACATAGGGTTTATATGTACATTA
AATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATGGCATCAGTGTTACCTTTAAGA
AAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATCACAAAGTATACTTAATAAAGG
CTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGCTTTATACTGTCAAAAAAAGGC
TAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAACTTTATGAATTTTTTTTTTTT
TTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACATATGTTTAAGTATACTGGTAT
TAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGAGAAAATATTTTTATTTTTGCC
CAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGTAGATTATTTTGTGTGTGCATG
CTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAAAATCAGTTTAAAGATCTTTAA
AGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATCAAACATTTTATTTTCCTAAAG
AATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTTTTTTTTCAATGTAACTTTTTT
TGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTATACAAGTGTTCAAAACATTGT
ATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTTAAGTTTCTTACTGCCACATAT
GGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGAGATGTTGAAATTGTTCCTGTG
CTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCAGTCTTTAATGTGCTGCAACAA
TGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCCAGTCTATTAGAAGTTAAGATG
TTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGAATTAAGTATGACTTTGTTTAT

>17476_17476_2_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376354_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_3_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376355_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2891nt_BP=93nt
AGGCAAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAG
GCTTCGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGA
ACTGGAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGA
ACTCGAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACT
GGAAGAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGA
GGAAAGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACT
GTCCTTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTT
GAAGTGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCC
CTTTTTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGG
ATTCTATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGA
GTTATACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGC
ATTGGGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATA
CAGGTAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAA
AATCAAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAA
TGTTATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTT
TAACATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCA
AATGGCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTAT
TATCACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACT
TAGCTTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATT
TGAACTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTT
AACATATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAG
TAGAGAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAA
TGGTAGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAAT
ATAAAATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAA
AATCAAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTT
TTTTTTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGT
TCTATACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTT
TTTTAAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCA
GTGAGATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCA
TCCAGTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTC
CCCCAGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTA
TAGAATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAA

>17476_17476_3_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376355_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_4_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376360_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2887nt_BP=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTT
CGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTG
GAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTC
GAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAA
GAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCC
TTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAG
TGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTT
TTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTC
TATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTG
GGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGG
TAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATC
AAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTT
ATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATG
GCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATC
ACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGC
TTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAA
CTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGA
GAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGT
AGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAA
AATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATC
AAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTA
TACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTT
AAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGA
GATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCA
GTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGA
ATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAACCTT

>17476_17476_4_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000376360_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------
>17476_17476_5_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000444838_ARGLU1_chr13_107212005_ENST00000400198_length(transcript)=2887nt_BP=89nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTT
CGACAGCAAGAAATAGAAGAAAAACTCATCGAGGAAGAAACAGCACGAAGAGTAGAAGAATTGGTAGCAAAAAGGGTGGAGGAAGAACTG
GAGAAAAGGAAGGATGAAATTGAACGAGAAGTTCTCCGAAGGGTGGAGGAAGCCAAACGCATCATGGAAAAGCAGTTGCTCGAAGAACTC
GAGCGACAGAGACAAGCTGAGCTTGCCGCACAAAAAGCTAGAGAGGAGGAAGAACGTGCAAAACGTGAGGAGCTAGAGCGAATACTGGAA
GAGAATAACCGAAAAATTGCAGAAGCACAAGCCAAACTGGCCGAAGAACAGTTGAGAATTGTTGAAGAACAAAGAAAGATTCATGAGGAA
AGGATGAAACTAGAACAAGAACGACAACGTCAACAAAAAGAAGAACAAAAAATTATCCTGGGCAAGGGGAAGTCCAGGCCAAAACTGTCC
TTCTCATTAAAAACCCAGGATTAAATTGCAAACTCTGAACTTTTTACAAAGAAAAATGGAAAAACTTTGTATGGTAGCTTCATGTTGAAG
TGGTTTTTTGTTTTTGTTTTTGTTTTTTTAATTTGTAAAATCTGGAAAGTTAGCTTGTTCTAATAGGGGCTATGCTCTGCAATTCCCTTT
TTTTTTTTTTTTTTCCTTCCACTAAGTCAAATCCTTATCAGATCATTGTTGTATTCTAAGGAGTGACGTATTTTTCACCTGTTTGGATTC
TATATTAGTGGTCTGAGGAAGAGCAGATCACATTGTAAAACTATGGATGGTCTGATAAGGCTTTTACTGACCCCACTGACTTCAGAGTTA
TACTCTGTTTGCTACATCATAATGCTGGTTTTGCTGACTTTTTGTTTTTTTATATATTTATAAAAAAAGAAAAAGTTGGTGATTGCATTG
GGAAATTCCCAGGGTATTACTGGACCTATGTGGTGTATTGTTAAACCAGTGTCCTTGTGATACTGTTGCTCTTGATGTTCCTGATACAGG
TAAGGAAACAGTTGGTCAACTCTGATACAAAGTATATATACAGTTCAGTATTGTCTCTGTTCATTTTGTTTTTATTTCATTGACAAAATC
AAACCAGCATTCCCCATTGTGTAAATAAATGATTTTGCTGAATAAAGTAAAGTCTTAAATTCATATGTTGAAGCAATTTTTTTTAATGTT
ATGTTAAGTCTTAAAGAGGGTGGTTCACTTTTTGATGGTCAACCATTTAGAAGTCTTAGAACTATATTTCCTCTTGTTTATACTTTTAAC
ATAGGGTTTATATGTACATTAAATATACTTGTGAATTAGTATTTAATGGCTATTTTTACAAATATCAACTTTATGCTGATAGAGCAAATG
GCATCAGTGTTACCTTTAAGAAAGACTAACAACATCCAGAAGATTTAAATTCTCAAACCTGTGCCTCTGTTTTAGGATATAAGTATTATC
ACAAAGTATACTTAATAAAGGCTAGAAAAATGCTTTTAAATTATGGAATCTGAGATCGTTTTCAGAGTGGGCCATCAGAAAGAACTTAGC
TTTATACTGTCAAAAAAAGGCTAAGATGGTCGAGTCATTTTCATTGTGTAGTGTACTTGCACGTTTATTTTTAGGACAAACACATTTGAA
CTTTATGAATTTTTTTTTTTTTTTTGCATGTGAAATCTTATGAATGGCTTTCATTTTATACACTAGAATCTGCCTCATTTACTCTTAACA
TATGTTTAAGTATACTGGTATTAAAACATTCAAGAAAAGGATATTGATCTAAAATGCTACCTGAGATGCATAAACATGTCATCAAGTAGA
GAAAATATTTTTATTTTTGCCCAATATTTTTTAGACAGTTTGATTATTCTTAAAAATTGAAAACATAAGCTAAAGAGATGACTAAATGGT
AGATTATTTTGTGTGTGCATGCTAGGAAAAATGCTGTTGCTTTAGTTTTGAGCTCTTCAATGAGTCTAATTGTGGTAAGGAACAATATAA
AATCAGTTTAAAGATCTTTAAAGGTAGAATTTTAAATAGGCATGAAATATAGTGAGAACTTTTAGTAAACATACTACTTACTCTAAAATC
AAACATTTTATTTTCCTAAAGAATATAGGTTGCCAAAAAATATTTTATCTCTAAATATAGGTTAGCTGTAATTATTTCATGAATTTTTTT
TTTTTTCAATGTAACTTTTTTTGGTGAAGATTCATGGTTCCTAAGTTCTGTATTCAAGTTTTTGGAAATGTTTATTTAAAAACTGTTCTA
TACAAGTGTTCAAAACATTGTATCTAAAGAGAGTAGCCTGGACTTAAAATATTTGAAATCAGCTTATGCGTGCCTTTTAATTTTTTTTTT
AAGTTTCTTACTGCCACATATGGTGTGAAGTGACAGTAAGTTGCTTAATGACATCCTGCAGTATCTGCTTGCTTTTGGAGACTCCAGTGA
GATGTTGAAATTGTTCCTGTGCTTGGTAACTACTTTCCTCTGCCAGGCTATGGGAAAGAGGATGTAATTGTGAATAATATACACCATCCA
GTCTTTAATGTGCTGCAACAATGTAGTAATTTGTTTTTTTCATTTGTTCCCACTGCCTTTGTGTACATAGAAAACTTAAAAATTTCCCCC
AGTCTATTAGAAGTTAAGATGTTCCCTAATTTATTAAATATGCCTTTATTCACAATTTGTTTTTTTAGGTTATTCTTAATGCATTATAGA
ATTAAGTATGACTTTGTTTATTTTTATTACAGTATGTAGTTATTGACATATTGTGGTTTGCAGAATTATCAATTGTATAAACTAAACCTT

>17476_17476_5_CLYBL-ARGLU1_CLYBL_chr13_100259011_ENST00000444838_ARGLU1_chr13_107212005_ENST00000400198_length(amino acids)=178AA_BP=21
MALRLLRRAARGAAAAALLRLRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLYBL-ARGLU1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CLYBL-ARGLU1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CLYBL-ARGLU1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source