Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CLYBL-UBAC2 (FusionGDB2 ID:17481)

Fusion Gene Summary for CLYBL-UBAC2

Fusion gene summary

Fusion gene information	Fusion gene name: CLYBL-UBAC2
	Fusion gene ID: 17481
		Hgene	Tgene
	Gene symbol	CLYBL	UBAC2
	Gene ID	171425	337867
	Gene name	citramalyl-CoA lyase	UBA domain containing 2
	Synonyms	CLB	PHGDHL1
	Cytomap	13q32.3	13q32.3
	Type of gene	protein-coding	protein-coding
	Description	citramalyl-CoA lyase, mitochondrial(3S)-malyl-CoA thioesterasebeta-methylmalate synthasecitrate lyase beta likecitrate lyase subunit beta-like protein, mitochondrialmalate synthase	ubiquitin-associated domain-containing protein 2RP11-178C10.1UBA domain-containing protein 2phosphoglycerate dehydrogenase like 1phosphoglycerate dehydrogenase-like protein 1
	Modification date	20200313	20200320
	UniProtAcc	Q8N0X4	.
	Ensembl transtripts involved in fusion gene	ENST00000339105, ENST00000376354, ENST00000376355, ENST00000376360, ENST00000444838,	ENST00000460562, ENST00000376440, ENST00000403766,
Fusion gene scores	* DoF score	7 X 8 X 4=224	9 X 10 X 6=540
	# samples	8	11
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CLYBL [Title/Abstract] AND UBAC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBAC2(99890808)-CLYBL(100543572), # samples:2 UBAC2(99970323)-CLYBL(100425078), # samples:2 CLYBL(100425264)-UBAC2(100020041), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLYBL	GO:0070207	protein homotrimerization	29056341
Hgene	CLYBL	GO:0106064	regulation of cobalamin metabolic process	29056341
Tgene	UBAC2	GO:0070972	protein localization to endoplasmic reticulum	23297223

Fusion gene breakpoints across CLYBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBAC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-A5GH-01A	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+

Top

Fusion Gene ORF analysis for CLYBL-UBAC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000339105	ENST00000460562	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
5CDS-3UTR	ENST00000376354	ENST00000460562	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
5CDS-3UTR	ENST00000376355	ENST00000460562	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
5CDS-3UTR	ENST00000376360	ENST00000460562	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
5CDS-3UTR	ENST00000444838	ENST00000460562	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000339105	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000339105	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376354	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376354	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376355	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376355	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376360	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000376360	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000444838	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+
In-frame	ENST00000444838	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376355	CLYBL	chr13	100425264	-	ENST00000403766	UBAC2	chr13	100020041	+	713	280	31	507	158
ENST00000376355	CLYBL	chr13	100425264	-	ENST00000376440	UBAC2	chr13	100020041	+	1600	280	31	507	158
ENST00000444838	CLYBL	chr13	100425264	-	ENST00000403766	UBAC2	chr13	100020041	+	709	276	27	503	158
ENST00000444838	CLYBL	chr13	100425264	-	ENST00000376440	UBAC2	chr13	100020041	+	1596	276	27	503	158
ENST00000376360	CLYBL	chr13	100425264	-	ENST00000403766	UBAC2	chr13	100020041	+	709	276	27	503	158
ENST00000376360	CLYBL	chr13	100425264	-	ENST00000376440	UBAC2	chr13	100020041	+	1596	276	27	503	158
ENST00000376354	CLYBL	chr13	100425264	-	ENST00000403766	UBAC2	chr13	100020041	+	688	255	6	482	158
ENST00000376354	CLYBL	chr13	100425264	-	ENST00000376440	UBAC2	chr13	100020041	+	1575	255	6	482	158
ENST00000339105	CLYBL	chr13	100425264	-	ENST00000403766	UBAC2	chr13	100020041	+	682	249	0	476	158
ENST00000339105	CLYBL	chr13	100425264	-	ENST00000376440	UBAC2	chr13	100020041	+	1569	249	0	476	158

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376355	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.003051262	0.9969488
ENST00000376355	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.002065253	0.9979348
ENST00000444838	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.003486387	0.99651366
ENST00000444838	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.002191637	0.9978084
ENST00000376360	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.003486387	0.99651366
ENST00000376360	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.002191637	0.9978084
ENST00000376354	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.003221843	0.9967782
ENST00000376354	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.002604201	0.99739575
ENST00000339105	ENST00000403766	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.003169168	0.9968309
ENST00000339105	ENST00000376440	CLYBL	chr13	100425264	-	UBAC2	chr13	100020041	+	0.002461159	0.9975388

Top

Fusion Genomic Features for CLYBL-UBAC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CLYBL-UBAC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:99890808/chr13:100543572)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLYBL Q8N0X4	.
FUNCTION: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). {ECO:0000269\|PubMed:24334609, ECO:0000269\|PubMed:29056341}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

304_344

234

310.0

Domain

UBA

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

304_344

269

345.0

Domain

UBA

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLYBL

chr13:100425264

chr13:100020041

ENST00000339105

272_273

361.0

Region

Substrate binding

Hgene

CLYBL

chr13:100425264

chr13:100020041

ENST00000376354

272_273

307.0

Region

Substrate binding

Hgene

CLYBL

chr13:100425264

chr13:100020041

ENST00000376355

272_273

1839.6666666666667

Region

Substrate binding

Hgene

CLYBL

chr13:100425264

chr13:100020041

ENST00000376360

272_273

341.0

Region

Substrate binding

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

113_125

234

310.0

Topological domain

Cytoplasmic

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

147_163

234

310.0

Topological domain

Extracellular

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

185_344

234

310.0

Topological domain

Cytoplasmic

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

36_91

234

310.0

Topological domain

Extracellular

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

113_125

269

345.0

Topological domain

Cytoplasmic

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

147_163

269

345.0

Topological domain

Extracellular

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

185_344

269

345.0

Topological domain

Cytoplasmic

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

36_91

269

345.0

Topological domain

Extracellular

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

126_146

234

310.0

Transmembrane

Helical

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

164_184

234

310.0

Transmembrane

Helical

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000376440

92_112

234

310.0

Transmembrane

Helical

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

126_146

269

345.0

Transmembrane

Helical

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

164_184

269

345.0

Transmembrane

Helical

Tgene

UBAC2

chr13:100425264

chr13:100020041

ENST00000403766

92_112

269

345.0

Transmembrane

Helical

Top

Fusion Gene Sequence for CLYBL-UBAC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17481_17481_1_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000339105_UBAC2_chr13_100020041_ENST00000376440_length(transcript)=1569nt_BP=249nt
ATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTGAAAGCGTCTCTAGCAGCTGATATCCCC
AGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAAATAAAG
AAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGGGAGGAATGATCAATTGGAAT
CGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAGCCAGCAGCGCCCCCTCTAGAAGTTTCT
GAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTGAGAGCTTCAAACAATGACCTCAATGTC
GCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCCGAGTGACAGTGCGTGGTCCCCACCATC
AGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCACCGCACCCCTGCCCTCAACCGCAAGACT
GTTGCCGTTTTAGTGTGGAGATAAGTTTGCCATTACATTAGCATGTATTTTCTATCTATATTTTTTATTGGGCATTTTCCCTAGGTTGGA
GAGTCAGCACTCGTTTTGAATGTGTTTAAAATGCATTAAAATGGAAGATTTCTGCAGGCAGTTGAATGGCACTCCAGATGGGGAATTGCT
GTAACCCTCTTACTGTAACATGTCATCTCCTGCGTCGTGATGGGGAGAGGGTAATGTTACTTCACAAAGGACATGTCAGATCCTTCTTCA
TGGACTTTTTTAGTTACTGTTTTTTCTCTCAAACTTGTTTTCGAATCTCCTGGGAGTGAGGGAGAAACAGGGAGCTGAATCCTCCCCCAA
GCTGTTCCAGGCCAGAGGACTCTGCAGTACCTTCTCCTACATCTAGTAACAAAGAATGGTGATAACCATGCACTGGTTCAAGGTTCTGGA
GTTCTCCATGAAACTTGGGTTAATTTTGCTCAGAGTATCCAGAGTTAGCCACTAGGCTGCGGGTGAAATGGGATGGAGAAGAACAACAGC
AGGCTTCCTGGAGCCACATGGGCTGACTAGGGCACTCTGTGGCTGGCCTGGCATGGGCTCAGCCCAGGAAGAGGAGAAACGATCCCTTGC
CTGCCCCTCCCTGTGGCAGGGCTAACTGCCTGGCCCTCCTGGCTCGCAGCCAGCCAGCCCCCTGGCAGCAGGTTCTCCTCAGGGCTTGGG
TCTTCAACCTGTGGCGACAGGAGGCAGGGCAGACTGTGGAGGACAGGATGCAGGTCAGGGAGAGGGAAGGCAGGGGTGGACCGCCATGAG
CATGAAAAGACCCGAAGCAAGTTGACTCTTGCAATGTGCAACTGTTATGTTCTGCAAAATGAGCAACGATGTATCAAATTGATGCAAATT

>17481_17481_1_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000339105_UBAC2_chr13_100020041_ENST00000376440_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_2_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000339105_UBAC2_chr13_100020041_ENST00000403766_length(transcript)=682nt_BP=249nt
ATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTGAAAGCGTCTCTAGCAGCTGATATCCCC
AGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAAATAAAG
AAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGGGAGGAATGATCAATTGGAAT
CGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAGCCAGCAGCGCCCCCTCTAGAAGTTTCT
GAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTGAGAGCTTCAAACAATGACCTCAATGTC
GCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCCGAGTGACAGTGCGTGGTCCCCACCATC
AGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCACCGCACCCCTGCCCTCAACCGCAAGACT

>17481_17481_2_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000339105_UBAC2_chr13_100020041_ENST00000403766_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_3_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376354_UBAC2_chr13_100020041_ENST00000376440_length(transcript)=1575nt_BP=255nt
GGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTGAAAGCGTCTCTAGCAGCTGAT
ATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAA
ATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGGGAGGAATGATCAAT
TGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAGCCAGCAGCGCCCCCTCTAGAA
GTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTGAGAGCTTCAAACAATGACCTC
AATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCCGAGTGACAGTGCGTGGTCCCC
ACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCACCGCACCCCTGCCCTCAACCGC
AAGACTGTTGCCGTTTTAGTGTGGAGATAAGTTTGCCATTACATTAGCATGTATTTTCTATCTATATTTTTTATTGGGCATTTTCCCTAG
GTTGGAGAGTCAGCACTCGTTTTGAATGTGTTTAAAATGCATTAAAATGGAAGATTTCTGCAGGCAGTTGAATGGCACTCCAGATGGGGA
ATTGCTGTAACCCTCTTACTGTAACATGTCATCTCCTGCGTCGTGATGGGGAGAGGGTAATGTTACTTCACAAAGGACATGTCAGATCCT
TCTTCATGGACTTTTTTAGTTACTGTTTTTTCTCTCAAACTTGTTTTCGAATCTCCTGGGAGTGAGGGAGAAACAGGGAGCTGAATCCTC
CCCCAAGCTGTTCCAGGCCAGAGGACTCTGCAGTACCTTCTCCTACATCTAGTAACAAAGAATGGTGATAACCATGCACTGGTTCAAGGT
TCTGGAGTTCTCCATGAAACTTGGGTTAATTTTGCTCAGAGTATCCAGAGTTAGCCACTAGGCTGCGGGTGAAATGGGATGGAGAAGAAC
AACAGCAGGCTTCCTGGAGCCACATGGGCTGACTAGGGCACTCTGTGGCTGGCCTGGCATGGGCTCAGCCCAGGAAGAGGAGAAACGATC
CCTTGCCTGCCCCTCCCTGTGGCAGGGCTAACTGCCTGGCCCTCCTGGCTCGCAGCCAGCCAGCCCCCTGGCAGCAGGTTCTCCTCAGGG
CTTGGGTCTTCAACCTGTGGCGACAGGAGGCAGGGCAGACTGTGGAGGACAGGATGCAGGTCAGGGAGAGGGAAGGCAGGGGTGGACCGC
CATGAGCATGAAAAGACCCGAAGCAAGTTGACTCTTGCAATGTGCAACTGTTATGTTCTGCAAAATGAGCAACGATGTATCAAATTGATG

>17481_17481_3_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376354_UBAC2_chr13_100020041_ENST00000376440_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_4_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376354_UBAC2_chr13_100020041_ENST00000403766_length(transcript)=688nt_BP=255nt
GGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTGAAAGCGTCTCTAGCAGCTGAT
ATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAA
ATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAACAAAAAGGGAGGAATGATCAAT
TGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAGCCAGCAGCGCCCCCTCTAGAA
GTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTGAGAGCTTCAAACAATGACCTC
AATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCCGAGTGACAGTGCGTGGTCCCC
ACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCACCGCACCCCTGCCCTCAACCGC

>17481_17481_4_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376354_UBAC2_chr13_100020041_ENST00000403766_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_5_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376355_UBAC2_chr13_100020041_ENST00000376440_length(transcript)=1600nt_BP=280nt
AGGCAAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAG
GCTGAAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTA
TGTACCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGC
AAACAAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTC
TGAGCCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGC
CCTGAGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGC
AGCCGAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTT
CCACCGCACCCCTGCCCTCAACCGCAAGACTGTTGCCGTTTTAGTGTGGAGATAAGTTTGCCATTACATTAGCATGTATTTTCTATCTAT
ATTTTTTATTGGGCATTTTCCCTAGGTTGGAGAGTCAGCACTCGTTTTGAATGTGTTTAAAATGCATTAAAATGGAAGATTTCTGCAGGC
AGTTGAATGGCACTCCAGATGGGGAATTGCTGTAACCCTCTTACTGTAACATGTCATCTCCTGCGTCGTGATGGGGAGAGGGTAATGTTA
CTTCACAAAGGACATGTCAGATCCTTCTTCATGGACTTTTTTAGTTACTGTTTTTTCTCTCAAACTTGTTTTCGAATCTCCTGGGAGTGA
GGGAGAAACAGGGAGCTGAATCCTCCCCCAAGCTGTTCCAGGCCAGAGGACTCTGCAGTACCTTCTCCTACATCTAGTAACAAAGAATGG
TGATAACCATGCACTGGTTCAAGGTTCTGGAGTTCTCCATGAAACTTGGGTTAATTTTGCTCAGAGTATCCAGAGTTAGCCACTAGGCTG
CGGGTGAAATGGGATGGAGAAGAACAACAGCAGGCTTCCTGGAGCCACATGGGCTGACTAGGGCACTCTGTGGCTGGCCTGGCATGGGCT
CAGCCCAGGAAGAGGAGAAACGATCCCTTGCCTGCCCCTCCCTGTGGCAGGGCTAACTGCCTGGCCCTCCTGGCTCGCAGCCAGCCAGCC
CCCTGGCAGCAGGTTCTCCTCAGGGCTTGGGTCTTCAACCTGTGGCGACAGGAGGCAGGGCAGACTGTGGAGGACAGGATGCAGGTCAGG
GAGAGGGAAGGCAGGGGTGGACCGCCATGAGCATGAAAAGACCCGAAGCAAGTTGACTCTTGCAATGTGCAACTGTTATGTTCTGCAAAA

>17481_17481_5_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376355_UBAC2_chr13_100020041_ENST00000376440_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_6_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376355_UBAC2_chr13_100020041_ENST00000403766_length(transcript)=713nt_BP=280nt
AGGCAAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAG
GCTGAAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTA
TGTACCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGC
AAACAAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTC
TGAGCCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGC
CCTGAGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGC
AGCCGAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTT

>17481_17481_6_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376355_UBAC2_chr13_100020041_ENST00000403766_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_7_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376360_UBAC2_chr13_100020041_ENST00000376440_length(transcript)=1596nt_BP=276nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTG
AAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTA
CCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAAC
AAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAG
CCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTG
AGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCC
GAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCAC
CGCACCCCTGCCCTCAACCGCAAGACTGTTGCCGTTTTAGTGTGGAGATAAGTTTGCCATTACATTAGCATGTATTTTCTATCTATATTT
TTTATTGGGCATTTTCCCTAGGTTGGAGAGTCAGCACTCGTTTTGAATGTGTTTAAAATGCATTAAAATGGAAGATTTCTGCAGGCAGTT
GAATGGCACTCCAGATGGGGAATTGCTGTAACCCTCTTACTGTAACATGTCATCTCCTGCGTCGTGATGGGGAGAGGGTAATGTTACTTC
ACAAAGGACATGTCAGATCCTTCTTCATGGACTTTTTTAGTTACTGTTTTTTCTCTCAAACTTGTTTTCGAATCTCCTGGGAGTGAGGGA
GAAACAGGGAGCTGAATCCTCCCCCAAGCTGTTCCAGGCCAGAGGACTCTGCAGTACCTTCTCCTACATCTAGTAACAAAGAATGGTGAT
AACCATGCACTGGTTCAAGGTTCTGGAGTTCTCCATGAAACTTGGGTTAATTTTGCTCAGAGTATCCAGAGTTAGCCACTAGGCTGCGGG
TGAAATGGGATGGAGAAGAACAACAGCAGGCTTCCTGGAGCCACATGGGCTGACTAGGGCACTCTGTGGCTGGCCTGGCATGGGCTCAGC
CCAGGAAGAGGAGAAACGATCCCTTGCCTGCCCCTCCCTGTGGCAGGGCTAACTGCCTGGCCCTCCTGGCTCGCAGCCAGCCAGCCCCCT
GGCAGCAGGTTCTCCTCAGGGCTTGGGTCTTCAACCTGTGGCGACAGGAGGCAGGGCAGACTGTGGAGGACAGGATGCAGGTCAGGGAGA
GGGAAGGCAGGGGTGGACCGCCATGAGCATGAAAAGACCCGAAGCAAGTTGACTCTTGCAATGTGCAACTGTTATGTTCTGCAAAATGAG

>17481_17481_7_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376360_UBAC2_chr13_100020041_ENST00000376440_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_8_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376360_UBAC2_chr13_100020041_ENST00000403766_length(transcript)=709nt_BP=276nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTG
AAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTA
CCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAAC
AAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAG
CCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTG
AGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCC
GAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCAC

>17481_17481_8_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000376360_UBAC2_chr13_100020041_ENST00000403766_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_9_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000444838_UBAC2_chr13_100020041_ENST00000376440_length(transcript)=1596nt_BP=276nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTG
AAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTA
CCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAAC
AAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAG
CCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTG
AGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCC
GAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCAC
CGCACCCCTGCCCTCAACCGCAAGACTGTTGCCGTTTTAGTGTGGAGATAAGTTTGCCATTACATTAGCATGTATTTTCTATCTATATTT
TTTATTGGGCATTTTCCCTAGGTTGGAGAGTCAGCACTCGTTTTGAATGTGTTTAAAATGCATTAAAATGGAAGATTTCTGCAGGCAGTT
GAATGGCACTCCAGATGGGGAATTGCTGTAACCCTCTTACTGTAACATGTCATCTCCTGCGTCGTGATGGGGAGAGGGTAATGTTACTTC
ACAAAGGACATGTCAGATCCTTCTTCATGGACTTTTTTAGTTACTGTTTTTTCTCTCAAACTTGTTTTCGAATCTCCTGGGAGTGAGGGA
GAAACAGGGAGCTGAATCCTCCCCCAAGCTGTTCCAGGCCAGAGGACTCTGCAGTACCTTCTCCTACATCTAGTAACAAAGAATGGTGAT
AACCATGCACTGGTTCAAGGTTCTGGAGTTCTCCATGAAACTTGGGTTAATTTTGCTCAGAGTATCCAGAGTTAGCCACTAGGCTGCGGG
TGAAATGGGATGGAGAAGAACAACAGCAGGCTTCCTGGAGCCACATGGGCTGACTAGGGCACTCTGTGGCTGGCCTGGCATGGGCTCAGC
CCAGGAAGAGGAGAAACGATCCCTTGCCTGCCCCTCCCTGTGGCAGGGCTAACTGCCTGGCCCTCCTGGCTCGCAGCCAGCCAGCCCCCT
GGCAGCAGGTTCTCCTCAGGGCTTGGGTCTTCAACCTGTGGCGACAGGAGGCAGGGCAGACTGTGGAGGACAGGATGCAGGTCAGGGAGA
GGGAAGGCAGGGGTGGACCGCCATGAGCATGAAAAGACCCGAAGCAAGTTGACTCTTGCAATGTGCAACTGTTATGTTCTGCAAAATGAG

>17481_17481_9_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000444838_UBAC2_chr13_100020041_ENST00000376440_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------
>17481_17481_10_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000444838_UBAC2_chr13_100020041_ENST00000403766_length(transcript)=709nt_BP=276nt
AAAGGGCGGGGCGCGCGCGTCGGGAAGATGGCGCTACGTCTGCTGCGGAGGGCGGCGCGCGGAGCTGCGGCGGCGGCGCTGCTGAGGCTG
AAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAAGTACATCCCCCGGAGGGCAGTGCTTTATGTA
CCTGGAAATGATGAAAAGAAAATAAAGAAGATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAAC
AAAAAGGGAGGAATGATCAATTGGAATCGTCTTTTTCCTCCTTTACGTCAGCGACAAAACGTAAACTATCAGGGCGGTCGGCAGTCTGAG
CCAGCAGCGCCCCCTCTAGAAGTTTCTGAGGAACAGGTCGCCCGGCTCATGGAGATGGGATTTTCCAGAGGTGATGCTTTGGAAGCCCTG
AGAGCTTCAAACAATGACCTCAATGTCGCCACCAACTTCCTGCTGCAGCACTGATAGTCCCAGGCCAACACTGGGACCGGACCGGCAGCC
GAGTGACAGTGCGTGGTCCCCACCATCAGATCAGCCCGGGGACCGAGCATCTCTGGTGCTGATGTTCTTGTGGGAAGAGGGAGGTTCCAC

>17481_17481_10_CLYBL-UBAC2_CLYBL_chr13_100425264_ENST00000444838_UBAC2_chr13_100020041_ENST00000403766_length(amino acids)=158AA_BP=83
MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKGGMINWN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLYBL-UBAC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CLYBL-UBAC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CLYBL-UBAC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source