FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CMC2-FER (FusionGDB2 ID:17510)

Fusion Gene Summary for CMC2-FER

check button Fusion gene summary
Fusion gene informationFusion gene name: CMC2-FER
Fusion gene ID: 17510
HgeneTgene
Gene symbol

CMC2

FER

Gene ID

56942

2241

Gene nameC-X9-C motif containing 2FER tyrosine kinase
Synonyms2310061C15Rik|C16orf61|DC13PPP1R74|TYK3|p94-Fer
Cytomap

16q23.2

5q21.3

Type of geneprotein-codingprotein-coding
DescriptionCOX assembly mitochondrial protein 2 homologC-x(9)-C motif containing 2tyrosine-protein kinase Ferfeline encephalitis virus-related kinase FERfer (fps/fes related) tyrosine kinasefujinami poultry sarcoma/Feline sarcoma-related protein Ferphosphoprotein NCP94protein phosphatase 1, regulatory subunit 74proto-oncogene c-F
Modification date2020031320200320
UniProtAcc

Q9NRP2

PRG3

Ensembl transtripts involved in fusion geneENST00000219400, ENST00000486645, 
ENST00000562713, ENST00000564174, 
ENST00000565108, ENST00000565925, 
ENST00000570195, ENST00000564249, 
ENST00000565914, ENST00000566231, 
ENST00000281092, ENST00000438717, 
ENST00000502752, ENST00000536402, 
Fusion gene scores* DoF score7 X 5 X 3=1059 X 13 X 4=468
# samples 712
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/468*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMC2 [Title/Abstract] AND FER [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCMC2(81040338)-FER(108219096), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFER

GO:0007260

tyrosine phosphorylation of STAT protein

19147545

TgeneFER

GO:0010591

regulation of lamellipodium assembly

19738202

TgeneFER

GO:0018108

peptidyl-tyrosine phosphorylation

12972546|19738202

TgeneFER

GO:0046777

protein autophosphorylation

7623846


check buttonFusion gene breakpoints across CMC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FER (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-8462CMC2chr16

81040338

-FERchr5

108219096

+


Top

Fusion Gene ORF analysis for CMC2-FER

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000219400ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000219400ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000219400ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000219400ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000486645ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000486645ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000486645ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000486645ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000562713ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000562713ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000562713ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000562713ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000564174ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000564174ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000564174ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000564174ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565108ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565108ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565108ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565108ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565925ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565925ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565925ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000565925ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000570195ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000570195ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000570195ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
5UTR-intronENST00000570195ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000564249ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000564249ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000564249ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000564249ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000565914ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000565914ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000565914ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000565914ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000566231ENST00000281092CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000566231ENST00000438717CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000566231ENST00000502752CMC2chr16

81040338

-FERchr5

108219096

+
intron-intronENST00000566231ENST00000536402CMC2chr16

81040338

-FERchr5

108219096

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CMC2-FER


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CMC2chr1681040338-FERchr5108219096+8.34E-080.9999999
CMC2chr1681040338-FERchr5108219096+8.34E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CMC2-FER


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81040338/:108219096)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMC2

Q9NRP2

FER

PRG3

FUNCTION: May be involved in cytochrome c oxidase biogenesis. {ECO:0000250}.225

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CMC2-FER


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CMC2-FER


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CMC2-FER


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CMC2-FER


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource