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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CNBP-USP6 (FusionGDB2 ID:17624)

Fusion Gene Summary for CNBP-USP6

Fusion gene summary

Fusion gene information	Fusion gene name: CNBP-USP6
	Fusion gene ID: 17624
		Hgene	Tgene
	Gene symbol	CNBP	USP6
	Gene ID	7555	9098
	Gene name	CCHC-type zinc finger nucleic acid binding protein	ubiquitin specific peptidase 6
	Synonyms	CNBP1\|DM2\|PROMM\|RNF163\|ZCCHC22\|ZNF9	HRP1\|TRE17\|TRE2\|TRESMCR\|Tre-2\|USP6-short
	Cytomap	3q21.3	17p13.2
	Type of gene	protein-coding	protein-coding
	Description	cellular nucleic acid-binding proteinerythroid differentiation-relatedsterol regulatory element-binding proteinzinc finger protein 273zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)	ubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6
	Modification date	20200328	20200322
	UniProtAcc	P62633	USP6NL
	Ensembl transtripts involved in fusion gene	ENST00000422453, ENST00000441626, ENST00000446936, ENST00000451728, ENST00000500450, ENST00000502976, ENST00000504813,	ENST00000250066, ENST00000304328, ENST00000332776, ENST00000574788, ENST00000572429,
Fusion gene scores	* DoF score	8 X 5 X 7=280	13 X 18 X 5=1170
	# samples	12	18
	** MAII score	log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1170*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CNBP [Title/Abstract] AND USP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CNBP(128902727)-USP6(5033660), # samples:1 CNBP(128902618)-USP6(5033660), # samples:1 CNBP(128902618)-USP6(5033229), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CNBP	GO:0000122	negative regulation of transcription by RNA polymerase II	23774591
Tgene	USP6	GO:0016579	protein deubiquitination	16127172
Tgene	USP6	GO:0060627	regulation of vesicle-mediated transport	15509780

Fusion gene breakpoints across CNBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	aneurysmal bone cyst	AY624556	CNBP	chr3	128902727		USP6	chr17	5033660
ChimerKB3	.	.	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
ChimerKB3	.	.	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
ChiTaRS5.0	N/A	AY624556	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
ChiTaRS5.0	N/A	AY624557	CNBP	chr3	128902618	-	USP6	chr17	5033229	+

Top

Fusion Gene ORF analysis for CNBP-USP6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000422453	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000422453	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000422453	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000422453	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000422453	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000422453	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000422453	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000422453	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000422453	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000422453	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000422453	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000422453	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000441626	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000441626	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000441626	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000441626	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000441626	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000441626	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000441626	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000441626	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000441626	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000441626	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000441626	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000441626	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000446936	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000446936	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000446936	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000446936	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000446936	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000446936	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000446936	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000446936	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000446936	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000446936	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000446936	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000446936	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000451728	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000451728	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000451728	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000451728	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000451728	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000451728	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000451728	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000451728	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000451728	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000451728	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000451728	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000451728	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000500450	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000500450	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000500450	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000500450	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000500450	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000500450	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000500450	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000500450	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000500450	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000500450	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000500450	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000500450	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000502976	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000502976	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000502976	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000502976	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000502976	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000502976	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000502976	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000502976	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000502976	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000502976	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000502976	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000502976	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000504813	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000504813	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000504813	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000504813	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000504813	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000504813	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000504813	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000504813	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000504813	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-5UTR	ENST00000504813	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-5UTR	ENST00000504813	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-5UTR	ENST00000504813	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000422453	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000422453	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000422453	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000422453	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000422453	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000422453	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000422453	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000422453	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000441626	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000441626	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000441626	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000441626	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000441626	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000441626	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000441626	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000441626	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000446936	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000446936	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000446936	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000446936	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000446936	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000446936	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000446936	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000446936	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000451728	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000451728	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000451728	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000451728	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000451728	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000451728	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000451728	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000451728	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000500450	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000500450	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000500450	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000500450	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000500450	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000500450	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000500450	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000500450	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000502976	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000502976	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000502976	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000502976	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000502976	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000502976	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000502976	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000502976	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000504813	ENST00000250066	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000504813	ENST00000304328	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000504813	ENST00000332776	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000504813	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
5UTR-intron	ENST00000504813	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033661	+
5UTR-intron	ENST00000504813	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033660	+
5UTR-intron	ENST00000504813	ENST00000572429	CNBP	chr3	128902618	-	USP6	chr17	5033229	+
5UTR-intron	ENST00000504813	ENST00000574788	CNBP	chr3	128902618	-	USP6	chr17	5031686	+
intron-5UTR	ENST00000422453	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000422453	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000422453	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000422453	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000441626	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000441626	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000441626	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000441626	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000446936	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000446936	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000446936	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000446936	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000451728	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000451728	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000451728	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000451728	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000500450	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000500450	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000500450	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000500450	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000502976	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000502976	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000502976	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000502976	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000504813	ENST00000250066	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000504813	ENST00000304328	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000504813	ENST00000332776	CNBP	chr3	128902727		USP6	chr17	5033660
intron-5UTR	ENST00000504813	ENST00000574788	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000422453	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000441626	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000446936	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000451728	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000500450	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000502976	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660
intron-intron	ENST00000504813	ENST00000572429	CNBP	chr3	128902727		USP6	chr17	5033660

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CNBP-USP6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CNBP	chr3	128902618	-	USP6	chr17	5033230	+	7.49E-05	0.99992514
CNBP	chr3	128902618	-	USP6	chr17	5033661	+	2.43E-05	0.9999757
CNBP	chr3	128902618	-	USP6	chr17	5033230	+	7.49E-05	0.99992514
CNBP	chr3	128902618	-	USP6	chr17	5033661	+	2.43E-05	0.9999757

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNBP-USP6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:128902727/:5033660)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CNBP P62633	USP6 USP6NL
FUNCTION: Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.	828

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CNBP-USP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CNBP-USP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CNBP-USP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CNBP-USP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source