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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CNOT1-STK38L (FusionGDB2 ID:17721)

Fusion Gene Summary for CNOT1-STK38L

Fusion gene summary

Fusion gene information	Fusion gene name: CNOT1-STK38L
	Fusion gene ID: 17721
		Hgene	Tgene
	Gene symbol	CNOT1	STK38L
	Gene ID	23019	23012
	Gene name	CCR4-NOT transcription complex subunit 1	serine/threonine kinase 38 like
	Synonyms	AD-005\|CDC39\|HPE12\|NOT1\|NOT1H	NDR2
	Cytomap	16q21	12p11.23
	Type of gene	protein-coding	protein-coding
	Description	CCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog	serine/threonine-protein kinase 38-likeNDR2 protein kinasenuclear Dbf2-related 2nuclear Dbf2-related kinase 2
	Modification date	20200322	20200313
	UniProtAcc	A5YKK6	.
	Ensembl transtripts involved in fusion gene	ENST00000317147, ENST00000441024, ENST00000569240, ENST00000245138, ENST00000569732,	ENST00000539577, ENST00000389032,
Fusion gene scores	* DoF score	19 X 17 X 11=3553	10 X 6 X 8=480
	# samples	21	11
	** MAII score	log2(21/3553*10)=-4.0805764556651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CNOT1 [Title/Abstract] AND STK38L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CNOT1(58594115)-STK38L(27461271), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CNOT1	GO:0000122	negative regulation of transcription by RNA polymerase II	16778766
Hgene	CNOT1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly	21976065
Hgene	CNOT1	GO:0017148	negative regulation of translation	24736845
Hgene	CNOT1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	16778766
Hgene	CNOT1	GO:0035195	gene silencing by miRNA	23172285\|24768540
Hgene	CNOT1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	16778766
Hgene	CNOT1	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	23644599
Tgene	STK38L	GO:0006468	protein phosphorylation	15037617\|15067004
Tgene	STK38L	GO:0035556	intracellular signal transduction	15067004

Fusion gene breakpoints across CNOT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STK38L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A43J	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+

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Fusion Gene ORF analysis for CNOT1-STK38L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000317147	ENST00000539577	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
5CDS-intron	ENST00000441024	ENST00000539577	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
5CDS-intron	ENST00000569240	ENST00000539577	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
In-frame	ENST00000317147	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
In-frame	ENST00000441024	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
In-frame	ENST00000569240	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
intron-3CDS	ENST00000245138	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
intron-3CDS	ENST00000569732	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
intron-intron	ENST00000245138	ENST00000539577	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+
intron-intron	ENST00000569732	ENST00000539577	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000317147	CNOT1	chr16	58594115	-	ENST00000389032	STK38L	chr12	27461271	+	7176	2463	312	3671	1119
ENST00000569240	CNOT1	chr16	58594115	-	ENST00000389032	STK38L	chr12	27461271	+	7124	2411	260	3619	1119
ENST00000441024	CNOT1	chr16	58594115	-	ENST00000389032	STK38L	chr12	27461271	+	7128	2415	264	3623	1119

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000317147	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+	0.000158536	0.99984145
ENST00000569240	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+	0.000150855	0.9998491
ENST00000441024	ENST00000389032	CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+	0.000151355	0.9998486

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Fusion Genomic Features for CNOT1-STK38L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+	5.37E-05	0.99994624
CNOT1	chr16	58594115	-	STK38L	chr12	27461271	+	5.37E-05	0.99994624

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNOT1-STK38L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:58594115/chr12:27461271)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CNOT1 A5YKK6	.
FUNCTION: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269\|PubMed:10637334, ECO:0000269\|PubMed:16778766, ECO:0000269\|PubMed:21278420, ECO:0000269\|PubMed:21976065, ECO:0000269\|PubMed:21984185, ECO:0000269\|PubMed:22367759, ECO:0000269\|PubMed:23644599, ECO:0000269\|PubMed:27558897, ECO:0000269\|PubMed:32354837}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

153_157

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

181_185

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

223_227

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

570_574

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

153_157

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

181_185

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

223_227

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

570_574

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

153_157

710

2372.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

181_185

710

2372.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

223_227

710

2372.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

570_574

710

2372.0

Motif

Note=LXXLL

Tgene

STK38L

chr16:58594115

chr12:27461271

ENST00000389032

384_453

465.0

Domain

AGC-kinase C-terminal

Tgene

STK38L

chr16:58594115

chr12:27461271

ENST00000389032

90_383

465.0

Domain

Protein kinase

Tgene

STK38L

chr16:58594115

chr12:27461271

ENST00000389032

96_104

465.0

Nucleotide binding

ATP

Tgene

STK38L

chr16:58594115

chr12:27461271

ENST00000389032

63_88

465.0

Region

S100B binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

1333_1350

710

2377.0

Compositional bias

Note=Thr-rich

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

1333_1350

710

1552.0

Compositional bias

Note=Thr-rich

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

1333_1350

710

2372.0

Compositional bias

Note=Thr-rich

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

1639_1643

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

1942_1946

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000317147

2096_2100

710

2377.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

1639_1643

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

1942_1946

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000441024

2096_2100

710

1552.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

1639_1643

710

2372.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

1942_1946

710

2372.0

Motif

Note=LXXLL

Hgene

CNOT1

chr16:58594115

chr12:27461271

ENST00000569240

2096_2100

710

2372.0

Motif

Note=LXXLL

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Fusion Gene Sequence for CNOT1-STK38L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17721_17721_1_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000317147_STK38L_chr12_27461271_ENST00000389032_length(transcript)=7176nt_BP=2463nt
GAAATGGGAACGGGGAGGGGAAAGGCCGCGACGTGAGCGCGCGACCTCCGGCGCCATTTTGTAGAGAAACAAGCGGAGTTAACCGAAGAG
GGGGTCGAGGAGAGCCGGAGTCGGGGACCCAGGAGTTTCCTGTGTCCAGCGCTGCCGGAGCCGCCTGAGGTGCCATGTTTCAGAACAGAG
TAAGACCCCTGGTAAAGAAGAACTGAAGATATTATACAGATACCAGATATAGCCTAATTACAAAGAAAGCATTAACCTGCCTCTGAGGTG
ACTAAAGGGGAATAATGGTGATTTTGCGCCGGGCTCGGCCGCCTGCTTCCGCCCCAACCAGCAATGAATCTTGACTCGCTCTCGCTGGCC
TTGTCTCAAATCAGCTACCTGGTGGACAATTTAACCAAGAAAAATTACCGAGCCAGCCAGCAGGAAATACAGCATATTGTGAATCGGCAC
GGTCCTGAGGCAGACAGGCATTTATTACGCTGCCTATTTTCGCATGTGGATTTCAGTGGCGATGGTAAAAGCAGTGGCAAAGATTTCCAT
CAGACTCAGTTTCTGATTCAGGAGTGTGCGTTGCTGATTACAAAGCCAAATTTTATCTCGACGCTGTCCTATGCCATTGATAATCCATTG
CACTATCAGAAGAGTTTAAAGCCTGCACCCCACTTATTTGCCCAGCTGAGTAAAGTGCTCAAATTAAGCAAAGTACAAGAGGTAATTTTT
GGCCTTGCCCTGTTGAATTCTTCCAGCTCAGATCTTAGAGGTTTCGCTGCCCAGTTTATCAAACAGAAGCTTCCAGATCTTCTGCGTTCT
TACATTGACGCAGACGTCAGTGGAAATCAAGAAGGTGGCTTCCAAGATATAGCAATAGAGGTCCTACACCTCCTCCTCTCCCATCTCCTC
TTTGGGCAGAAGGGAGCCTTTGGAGTTGGACAAGAACAGATAGACGCTTTTCTTAAGACGCTGCGCAGAGATTTTCCCCAAGAACGCTGT
CCCGTGGTGCTCGCACCACTTTTATACCCTGAAAAACGGGACATTCTAATGGACAGGATCCTGCCTGATTCCGGAGGGGTAGCTAAAACC
ATGATGGAGAGCTCTTTGGCTGATTTCATGCAAGAAGTAGGCTATGGCTTTTGTGCAAGTATTGAAGAATGTCGCAATATAATCGTGCAG
TTTGGTGTTCGGGAGGTCACAGCTGCCCAGGTTGCAAGGGTTTTGGGAATGATGGCTCGAACTCATTCAGGATTAACAGATGGCATTCCA
TTACAGAGTATTTCTGCTCCGGGCAGTGGGATCTGGAGTGATGGGAAAGATAAAAGTGATGGAGCACAGGCACACACATGGAATGTAGAA
GTCTTGATTGACGTTCTTAAAGAACTGAATCCAAGTTTGAATTTCAAGGAAGTAACTTATGAACTGGACCATCCTGGATTTCAAATTCGT
GACAGTAAAGGACTTCATAATGTGGTTTATGGCATTCAGAGGGGTTTGGGTATGGAAGTGTTCCCAGTAGACCTCATATATAGACCTTGG
AAACATGCTGAAGGCCAGCTCTCCTTCATTCAACATTCCCTTATAAATCCAGAGATCTTCTGTTTTGCTGACTATCCCTGTCATACTGTT
GCCACTGATATTCTGAAAGCACCACCAGAGGATGACAATCGAGAAATTGCCACATGGAAGAGCTTGGATTTGATTGAATCTCTGCTGAGG
CTTGCAGAGGTTGGGCAGTATGAGCAAGTCAAACAGCTCTTCAGCTTCCCTATCAAACACTGTCCAGACATGCTGGTATTGGCCTTACTA
CAAATTAACACCTCTTGGCATACCTTGCGCCATGAACTTATCTCCACTCTGATGCCAATTTTCCTTGGAAACCATCCTAACTCAGCTATT
ATTTTGCACTATGCATGGCATGGGCAGGGACAGTCTCCCTCAATTCGCCAACTTATCATGCATGCAATGGCAGAATGGTACATGAGAGGG
GAGCAGTATGATCAGGCCAAATTGTCTCGAATACTTGATGTGGCCCAGGACTTGAAGGCCTTGTCAATGCTGCTAAATGGTACTCCATTT
GCCTTTGTTATTGACCTTGCTGCACTTGCTTCACGTCGTGAATACCTCAAACTTGATAAGTGGCTCACAGATAAAATTCGAGAGCATGGG
GAGCCTTTTATCCAGGCGTGTATGACTTTTTTAAAGAGACGGTGTCCTTCTATTTTGGGCGGACTTGCCCCAGAAAAAGACCAGCCCAAA
AGTGCTCAACTTCCTCCAGAAACTTTGGCGACAATGTTGGCCTGTCTGCAAGCTTGTGCAGGGAGTGTTTCTCAGGAGCTATCAGAAACT
ATCCTCACCATGGTAGCCAATTGCAGTAATGTTATGAATAAGGCCAGACAACCACCACCTGGAGTTATGCCAAAAGGACGTCCTCCTAGT
GCTAGCAGCTTAGATGCCATTTCTCCTGTTCAGAAAAAGTTACGTCGATCACAACACGCTCGCAAAGAAACAGAGTTCTTACGGCTCAAA
AGGACCAGACTTGGCTTGGATGACTTTGAGTCTCTGAAAGTTATAGGAAGAGGAGCTTTTGGAGAGGTGCGGTTGGTCCAGAAGAAAGAT
ACAGGCCATATCTATGCAATGAAGATATTGAGAAAGTCTGATATGCTTGAAAAAGAGCAGGTGGCCCATATCCGAGCAGAAAGAGATATT
TTGGTAGAAGCAGATGGTGCCTGGGTGGTGAAGATGTTTTACAGTTTTCAGGATAAGAGGAATCTTTATCTAATCATGGAATTTCTCCCT
GGAGGTGACATGATGACATTGCTAATGAAGAAAGACACCTTGACAGAAGAGGAAACACAGTTCTACATTTCAGAGACTGTTCTGGCAATA
GATGCGATCCACCAGTTGGGTTTCATCCATCGGGATATTAAGCCAGACAACCTTTTATTGGATGCCAAGGGTCATGTAAAATTATCTGAT
TTTGGTTTATGTACGGGATTAAAGAAAGCTCACAGGACTGAATTTTATAGAAATCTCACACACAACCCACCAAGTGACTTCTCATTTCAG
AACATGAACTCAAAGAGGAAAGCAGAAACTTGGAAGAAGAACAGGAGACAACTGGCATATTCCACAGTTGGGACACCAGATTACATTGCT
CCAGAAGTATTCATGCAGACTGGTTACAACAAATTGTGTGACTGGTGGTCTTTGGGAGTGATTATGTATGAAATGCTAATAGGATATCCA
CCTTTCTGCTCTGAAACACCTCAAGAAACGTACAGAAAAGTGATGAACTGGAAAGAAACTCTGGTATTTCCTCCAGAGGTACCTATATCT
GAGAAAGCCAAGGACTTAATTCTCAGATTTTGTATTGATTCTGAAAACAGAATTGGAAATAGTGGAGTAGAAGAAATAAAAGGTCATCCC
TTTTTTGAAGGTGTCGACTGGGAGCACATAAGGGAAAGGCCAGCAGCAATCCCTATAGAAATCAAAAGCATTGATGATACTTCAAATTTT
GATGACTTCCCTGAATCTGATATTTTACAACCAGTGCCAAATACCACAGAACCGGACTACAAATCCAAAGACTGGGTTTTTCTCAATTAT
ACCTATAAAAGGTTTGAAGGGTTGACTCAACGTGGCTCTATCCCCACCTACATGAAAGCTGGGAAGTTATGAATGAAGATAACATTCACC
CATAACCAAGAGAACTCAGGTAGCTGCATCACCAGGCTTGCTTGGCGTAGATAACAATACACTGAAATACTCCTGAAGATGGTGGTGCTT
ATTGACTACAAGAGGAAATTCTACAGGATTAGGATTTCTAAGACTACTATAGGAATTGGTTGGCAGTGCCAGCTGGCTCTTTTTTTTAAT
ATTTTATTATTTTTGTTAACTTTATTATATGAAGGTACTGGAATAAAAGGAACAGACATCCCTTTCTAACTGCACTGCCTACATGCGTAT
TAAGGTCCATTCTGCCTGTGTGTGCTGTGGCTTTGAACTGTAACACCTCTAATCAATTCAGGAGAAACACATATCATTTAAAGCAACATA
GGCTAACCTGTAGGTAACACTGCAGTATTGATGTTTTACTGCAAATCTTATGGGTCTAGATAATCAGTAAAAGCCATCTTCCATAGTTGG
TGTTAGAACATTGCCCTATTGGTTTGGACATCTGTAGAATATATATGAAGACAATTTCTGTAATGGTTTTAAGAGATTTAAAAAGAAATT
CACTGGTTCTTTACAAAATAGAATTTATCATCAAGTTATTACACAAACTTCACAGTAAGGAGTGACAAGTTTATAATAAGGAAGACAAAG
TTTAACACCTTCACTCAAGCACTCCACTAATATATTTACGTTGCATTCAGAAATACTGATGACCTTCATATACGTAGTCTGTATACTCAT
AGGGAGATGTACTGTATTATATAACATGTAAAGTTGATTTTCTTGTGACAAGAGAACTTCTTTTTTTAACAAGAGGACATGGCATTATTT
TAATTTGATTATGGTGAGTTGAATTTAAGACATGACCATGAAGGCTGCTTGTAGAATTAGTGTATTTTTATTAAACTATTTTTTTAAATG
TCAAACTTCTATCATGTAAATGGACTTATAGAGAACAAAAAGCTATTTACTTTGGTTTTCTAGAAAGTTGTTACATATCATGGCTGGTTA
ACTTTTATTTCTTTTGATGAAAATTTTTCCTTTGATAGTACTTGTATTATTGTGCCATTATTTTCTTATGCTCCAAATGTACCAAAGATC
TTGAACAGAGTGGATGTTCACAACTGAGTAGAATTTTCCTTTCCTGTGGGCATGCTGTATTCAGACCTGACAGATCTTTGATAGAGGTCA
GCTTATTAAAGGGCAATATTGTTCTTGTTTAGCTACATCACTGTGGTGAATATAGATGGAATTAAGGAAGTAAATGCAGGCCAGGGGGTT
GTGATGAGAGGATAGGGGAGATAATATCAGCATCAAATTCTTTGGGTATCTCTCTAAGAATTAAATAATCTTTTCTAGCTTAATATTTTA
ATTCTAATTCAAACAACTCTGAGGTTTTGGTTTCATTAGTAATAGTTGAGGAATAATATACTAGCAAAGAATGGCCTAATGTTTGTCATA
ACTGTTAATGGATGAAATTTTTTAAAGATACAACCATGATAACCATTATAAATGATCTATGATCAAAATCTAAAGTGATGAATTATTTGT
AGGAATGTCTTCCTAATGGGGAAGAATTGCATAGGAGCATTATGCAAATCTACACAAGCTTTTATAAATGTTGCTGCTGGGTAGCTCCAC
AGTGTTTCATAAGGCCATCCTGTTTCCCCCAACTCCCCCATTTTTGGTTTGTTTCTTTTTAAATATTTGTTGAGTACTTACGTGTTTATC
TAACAGTTCACTTCCATTTTTCTAGTCTGGATTTTTTGAGTATTTAGGAAAGAGAGCTATTAAAAACTGGGGATTTCTCAATGTGACTAA
CTCTAATTTTTCTAATTATAACTGCCTTTAATTAACATAATATTAACTTTTGCTGAGGTTTATGAGATTTTCTCACCCCACATCGCTCCC
CTTTTTTTAAAAAGGACTGTTTTGCTAGTGTGATAATGAATAGGTAAGATATGAGATAATTGCAACATTGTCTAGTTCTAGTATGGTAAC
TATTCTTGAAATGGTATTGAAAAATACCGTTAATTCAAATTGACAGAGATTGATAAAAAGAAACTGATTTACCTAAGTTTACTTTTTAAT
TGCATAATAGAGCATTTTTTGTTTTGAGTTCCCTCATTCTTATTACCAGAAAGAGCTTGCAAATAGTTTTACTTTCTTGGCACTGGAAGG
GTAGTTCTGGAAAGCTACTTTGTTGAGAGTCTCATTCTTCCCTGGAGTTAATAGAGTGATTCACAATCTTTGGGGTTTTCTCCTCATCAA
AAGCATTTCTTAAGTGCCTATCTAAAAGCAATTAAAGACTGTGTCTGCCCTTTAGAAGCTAAGAATTTGATTCATGATGCAAATTAACTA
GATAATTTGCAAAGTACCCTTGAGATTGAATTTTCTCTATTATATATTTCCCATATTTCAGGTGAATAATTTAATTTAAATGACAAAACC
CTATCTAGTCAACTGGGCATAATGACATTTTCTTTAAATTAGACTCTATTTTGAATTAAAAGAGTTTTATTATAAACCGTGTGTTTTTGG
TTTTTCTAAGTATATAGAAAGCTTGTATAATTCAGATTTATCAATTTCCTGATTTAATGTAGACTTTGACTTTTTTATTAAAAACCTTTG
TATTAAAGCAAGTTATGTTATTTTTCTTTTATGCATTTATTACTAACATAGCTTTAAATCTTTAAATGTATTGAAGCATTGTGCTGTCTG
AAAATAAGGAATTGCTTATAAACCAGCCACTTCTGAATACAATATGTAGCTGATTTAATAAGCTAGTTAGTGAATGGAAAATAAGTGTGG
AGTATTAAAAATGTTCTTTGGTTGGTAAGGCCTAAGATAGGGTTTCATTTATTTCTATACTTTTTCTGTTTTTTAAACACCTGCATATTT
TTATGTAAATCTCTAAATTTAAAATATTTTAAGTACATTTATTTTTGGTGTTTTATTGTATAAAACCTTAGACAATCAATCAGTCAGTCT
TTACTGACAGGAGCAGCAGCTATCTGTCTTTTGCTGATCTACAAATAAATGAATTGAGAATTTAGTCCATAGAGGTCCCTGGCTACCAAA
CACATTCTCCTTTGAATTGTTAAAATTCAGAACATTCAAAATAACTGTTTTGCTACAACCCATGATTATTTTCCTGTTGTGTTTATTTAA
ATTTACTTTCTCTTTAGAAGTGCACTTATTTCTGAAAAATCTTAATGAAACAAACGCTTAGAACAAATATAAATATGAGACACTTGGGAC
TACTAGAGATATTTTAGATTTTTATGAAAAAAATGTGAGGGGATATTGCTGCTTTAAAAAGGAATAAAGTAATAAAAATATATCTCAGCT
ATTTTTTTAAAGCAATATAATTCAGCAATTGTCTAGAAAAGTAATCATGAGGCTACTGAGTTTGGTGTTCAGTTACTGAGTTTCAAAAAT

>17721_17721_1_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000317147_STK38L_chr12_27461271_ENST00000389032_length(amino acids)=1119AA_BP=717
MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT
KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF
QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG
YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN
FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR
EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS
IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR
CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL
RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY
SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE
FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV
MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN

--------------------------------------------------------------
>17721_17721_2_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000441024_STK38L_chr12_27461271_ENST00000389032_length(transcript)=7128nt_BP=2415nt
CGGCGCCATTTTGTAGAGAAACAAGCGGAGTTAACCGAAGAGGGGGTCGAGGAGAGCCGGAGTCGGGGACCCAGGAGTTTCCTGTGTCCA
GCGCTGCCGGAGCCGCCTGAGGTGCCATGTTTCAGAACAGAGTAAGACCCCTGGTAAAGAAGAACTGAAGATATTATACAGATACCAGAT
ATAGCCTAATTACAAAGAAAGCATTAACCTGCCTCTGAGGTGACTAAAGGGGAATAATGGTGATTTTGCGCCGGGCTCGGCCGCCTGCTT
CCGCCCCAACCAGCAATGAATCTTGACTCGCTCTCGCTGGCCTTGTCTCAAATCAGCTACCTGGTGGACAATTTAACCAAGAAAAATTAC
CGAGCCAGCCAGCAGGAAATACAGCATATTGTGAATCGGCACGGTCCTGAGGCAGACAGGCATTTATTACGCTGCCTATTTTCGCATGTG
GATTTCAGTGGCGATGGTAAAAGCAGTGGCAAAGATTTCCATCAGACTCAGTTTCTGATTCAGGAGTGTGCGTTGCTGATTACAAAGCCA
AATTTTATCTCGACGCTGTCCTATGCCATTGATAATCCATTGCACTATCAGAAGAGTTTAAAGCCTGCACCCCACTTATTTGCCCAGCTG
AGTAAAGTGCTCAAATTAAGCAAAGTACAAGAGGTAATTTTTGGCCTTGCCCTGTTGAATTCTTCCAGCTCAGATCTTAGAGGTTTCGCT
GCCCAGTTTATCAAACAGAAGCTTCCAGATCTTCTGCGTTCTTACATTGACGCAGACGTCAGTGGAAATCAAGAAGGTGGCTTCCAAGAT
ATAGCAATAGAGGTCCTACACCTCCTCCTCTCCCATCTCCTCTTTGGGCAGAAGGGAGCCTTTGGAGTTGGACAAGAACAGATAGACGCT
TTTCTTAAGACGCTGCGCAGAGATTTTCCCCAAGAACGCTGTCCCGTGGTGCTCGCACCACTTTTATACCCTGAAAAACGGGACATTCTA
ATGGACAGGATCCTGCCTGATTCCGGAGGGGTAGCTAAAACCATGATGGAGAGCTCTTTGGCTGATTTCATGCAAGAAGTAGGCTATGGC
TTTTGTGCAAGTATTGAAGAATGTCGCAATATAATCGTGCAGTTTGGTGTTCGGGAGGTCACAGCTGCCCAGGTTGCAAGGGTTTTGGGA
ATGATGGCTCGAACTCATTCAGGATTAACAGATGGCATTCCATTACAGAGTATTTCTGCTCCGGGCAGTGGGATCTGGAGTGATGGGAAA
GATAAAAGTGATGGAGCACAGGCACACACATGGAATGTAGAAGTCTTGATTGACGTTCTTAAAGAACTGAATCCAAGTTTGAATTTCAAG
GAAGTAACTTATGAACTGGACCATCCTGGATTTCAAATTCGTGACAGTAAAGGACTTCATAATGTGGTTTATGGCATTCAGAGGGGTTTG
GGTATGGAAGTGTTCCCAGTAGACCTCATATATAGACCTTGGAAACATGCTGAAGGCCAGCTCTCCTTCATTCAACATTCCCTTATAAAT
CCAGAGATCTTCTGTTTTGCTGACTATCCCTGTCATACTGTTGCCACTGATATTCTGAAAGCACCACCAGAGGATGACAATCGAGAAATT
GCCACATGGAAGAGCTTGGATTTGATTGAATCTCTGCTGAGGCTTGCAGAGGTTGGGCAGTATGAGCAAGTCAAACAGCTCTTCAGCTTC
CCTATCAAACACTGTCCAGACATGCTGGTATTGGCCTTACTACAAATTAACACCTCTTGGCATACCTTGCGCCATGAACTTATCTCCACT
CTGATGCCAATTTTCCTTGGAAACCATCCTAACTCAGCTATTATTTTGCACTATGCATGGCATGGGCAGGGACAGTCTCCCTCAATTCGC
CAACTTATCATGCATGCAATGGCAGAATGGTACATGAGAGGGGAGCAGTATGATCAGGCCAAATTGTCTCGAATACTTGATGTGGCCCAG
GACTTGAAGGCCTTGTCAATGCTGCTAAATGGTACTCCATTTGCCTTTGTTATTGACCTTGCTGCACTTGCTTCACGTCGTGAATACCTC
AAACTTGATAAGTGGCTCACAGATAAAATTCGAGAGCATGGGGAGCCTTTTATCCAGGCGTGTATGACTTTTTTAAAGAGACGGTGTCCT
TCTATTTTGGGCGGACTTGCCCCAGAAAAAGACCAGCCCAAAAGTGCTCAACTTCCTCCAGAAACTTTGGCGACAATGTTGGCCTGTCTG
CAAGCTTGTGCAGGGAGTGTTTCTCAGGAGCTATCAGAAACTATCCTCACCATGGTAGCCAATTGCAGTAATGTTATGAATAAGGCCAGA
CAACCACCACCTGGAGTTATGCCAAAAGGACGTCCTCCTAGTGCTAGCAGCTTAGATGCCATTTCTCCTGTTCAGAAAAAGTTACGTCGA
TCACAACACGCTCGCAAAGAAACAGAGTTCTTACGGCTCAAAAGGACCAGACTTGGCTTGGATGACTTTGAGTCTCTGAAAGTTATAGGA
AGAGGAGCTTTTGGAGAGGTGCGGTTGGTCCAGAAGAAAGATACAGGCCATATCTATGCAATGAAGATATTGAGAAAGTCTGATATGCTT
GAAAAAGAGCAGGTGGCCCATATCCGAGCAGAAAGAGATATTTTGGTAGAAGCAGATGGTGCCTGGGTGGTGAAGATGTTTTACAGTTTT
CAGGATAAGAGGAATCTTTATCTAATCATGGAATTTCTCCCTGGAGGTGACATGATGACATTGCTAATGAAGAAAGACACCTTGACAGAA
GAGGAAACACAGTTCTACATTTCAGAGACTGTTCTGGCAATAGATGCGATCCACCAGTTGGGTTTCATCCATCGGGATATTAAGCCAGAC
AACCTTTTATTGGATGCCAAGGGTCATGTAAAATTATCTGATTTTGGTTTATGTACGGGATTAAAGAAAGCTCACAGGACTGAATTTTAT
AGAAATCTCACACACAACCCACCAAGTGACTTCTCATTTCAGAACATGAACTCAAAGAGGAAAGCAGAAACTTGGAAGAAGAACAGGAGA
CAACTGGCATATTCCACAGTTGGGACACCAGATTACATTGCTCCAGAAGTATTCATGCAGACTGGTTACAACAAATTGTGTGACTGGTGG
TCTTTGGGAGTGATTATGTATGAAATGCTAATAGGATATCCACCTTTCTGCTCTGAAACACCTCAAGAAACGTACAGAAAAGTGATGAAC
TGGAAAGAAACTCTGGTATTTCCTCCAGAGGTACCTATATCTGAGAAAGCCAAGGACTTAATTCTCAGATTTTGTATTGATTCTGAAAAC
AGAATTGGAAATAGTGGAGTAGAAGAAATAAAAGGTCATCCCTTTTTTGAAGGTGTCGACTGGGAGCACATAAGGGAAAGGCCAGCAGCA
ATCCCTATAGAAATCAAAAGCATTGATGATACTTCAAATTTTGATGACTTCCCTGAATCTGATATTTTACAACCAGTGCCAAATACCACA
GAACCGGACTACAAATCCAAAGACTGGGTTTTTCTCAATTATACCTATAAAAGGTTTGAAGGGTTGACTCAACGTGGCTCTATCCCCACC
TACATGAAAGCTGGGAAGTTATGAATGAAGATAACATTCACCCATAACCAAGAGAACTCAGGTAGCTGCATCACCAGGCTTGCTTGGCGT
AGATAACAATACACTGAAATACTCCTGAAGATGGTGGTGCTTATTGACTACAAGAGGAAATTCTACAGGATTAGGATTTCTAAGACTACT
ATAGGAATTGGTTGGCAGTGCCAGCTGGCTCTTTTTTTTAATATTTTATTATTTTTGTTAACTTTATTATATGAAGGTACTGGAATAAAA
GGAACAGACATCCCTTTCTAACTGCACTGCCTACATGCGTATTAAGGTCCATTCTGCCTGTGTGTGCTGTGGCTTTGAACTGTAACACCT
CTAATCAATTCAGGAGAAACACATATCATTTAAAGCAACATAGGCTAACCTGTAGGTAACACTGCAGTATTGATGTTTTACTGCAAATCT
TATGGGTCTAGATAATCAGTAAAAGCCATCTTCCATAGTTGGTGTTAGAACATTGCCCTATTGGTTTGGACATCTGTAGAATATATATGA
AGACAATTTCTGTAATGGTTTTAAGAGATTTAAAAAGAAATTCACTGGTTCTTTACAAAATAGAATTTATCATCAAGTTATTACACAAAC
TTCACAGTAAGGAGTGACAAGTTTATAATAAGGAAGACAAAGTTTAACACCTTCACTCAAGCACTCCACTAATATATTTACGTTGCATTC
AGAAATACTGATGACCTTCATATACGTAGTCTGTATACTCATAGGGAGATGTACTGTATTATATAACATGTAAAGTTGATTTTCTTGTGA
CAAGAGAACTTCTTTTTTTAACAAGAGGACATGGCATTATTTTAATTTGATTATGGTGAGTTGAATTTAAGACATGACCATGAAGGCTGC
TTGTAGAATTAGTGTATTTTTATTAAACTATTTTTTTAAATGTCAAACTTCTATCATGTAAATGGACTTATAGAGAACAAAAAGCTATTT
ACTTTGGTTTTCTAGAAAGTTGTTACATATCATGGCTGGTTAACTTTTATTTCTTTTGATGAAAATTTTTCCTTTGATAGTACTTGTATT
ATTGTGCCATTATTTTCTTATGCTCCAAATGTACCAAAGATCTTGAACAGAGTGGATGTTCACAACTGAGTAGAATTTTCCTTTCCTGTG
GGCATGCTGTATTCAGACCTGACAGATCTTTGATAGAGGTCAGCTTATTAAAGGGCAATATTGTTCTTGTTTAGCTACATCACTGTGGTG
AATATAGATGGAATTAAGGAAGTAAATGCAGGCCAGGGGGTTGTGATGAGAGGATAGGGGAGATAATATCAGCATCAAATTCTTTGGGTA
TCTCTCTAAGAATTAAATAATCTTTTCTAGCTTAATATTTTAATTCTAATTCAAACAACTCTGAGGTTTTGGTTTCATTAGTAATAGTTG
AGGAATAATATACTAGCAAAGAATGGCCTAATGTTTGTCATAACTGTTAATGGATGAAATTTTTTAAAGATACAACCATGATAACCATTA
TAAATGATCTATGATCAAAATCTAAAGTGATGAATTATTTGTAGGAATGTCTTCCTAATGGGGAAGAATTGCATAGGAGCATTATGCAAA
TCTACACAAGCTTTTATAAATGTTGCTGCTGGGTAGCTCCACAGTGTTTCATAAGGCCATCCTGTTTCCCCCAACTCCCCCATTTTTGGT
TTGTTTCTTTTTAAATATTTGTTGAGTACTTACGTGTTTATCTAACAGTTCACTTCCATTTTTCTAGTCTGGATTTTTTGAGTATTTAGG
AAAGAGAGCTATTAAAAACTGGGGATTTCTCAATGTGACTAACTCTAATTTTTCTAATTATAACTGCCTTTAATTAACATAATATTAACT
TTTGCTGAGGTTTATGAGATTTTCTCACCCCACATCGCTCCCCTTTTTTTAAAAAGGACTGTTTTGCTAGTGTGATAATGAATAGGTAAG
ATATGAGATAATTGCAACATTGTCTAGTTCTAGTATGGTAACTATTCTTGAAATGGTATTGAAAAATACCGTTAATTCAAATTGACAGAG
ATTGATAAAAAGAAACTGATTTACCTAAGTTTACTTTTTAATTGCATAATAGAGCATTTTTTGTTTTGAGTTCCCTCATTCTTATTACCA
GAAAGAGCTTGCAAATAGTTTTACTTTCTTGGCACTGGAAGGGTAGTTCTGGAAAGCTACTTTGTTGAGAGTCTCATTCTTCCCTGGAGT
TAATAGAGTGATTCACAATCTTTGGGGTTTTCTCCTCATCAAAAGCATTTCTTAAGTGCCTATCTAAAAGCAATTAAAGACTGTGTCTGC
CCTTTAGAAGCTAAGAATTTGATTCATGATGCAAATTAACTAGATAATTTGCAAAGTACCCTTGAGATTGAATTTTCTCTATTATATATT
TCCCATATTTCAGGTGAATAATTTAATTTAAATGACAAAACCCTATCTAGTCAACTGGGCATAATGACATTTTCTTTAAATTAGACTCTA
TTTTGAATTAAAAGAGTTTTATTATAAACCGTGTGTTTTTGGTTTTTCTAAGTATATAGAAAGCTTGTATAATTCAGATTTATCAATTTC
CTGATTTAATGTAGACTTTGACTTTTTTATTAAAAACCTTTGTATTAAAGCAAGTTATGTTATTTTTCTTTTATGCATTTATTACTAACA
TAGCTTTAAATCTTTAAATGTATTGAAGCATTGTGCTGTCTGAAAATAAGGAATTGCTTATAAACCAGCCACTTCTGAATACAATATGTA
GCTGATTTAATAAGCTAGTTAGTGAATGGAAAATAAGTGTGGAGTATTAAAAATGTTCTTTGGTTGGTAAGGCCTAAGATAGGGTTTCAT
TTATTTCTATACTTTTTCTGTTTTTTAAACACCTGCATATTTTTATGTAAATCTCTAAATTTAAAATATTTTAAGTACATTTATTTTTGG
TGTTTTATTGTATAAAACCTTAGACAATCAATCAGTCAGTCTTTACTGACAGGAGCAGCAGCTATCTGTCTTTTGCTGATCTACAAATAA
ATGAATTGAGAATTTAGTCCATAGAGGTCCCTGGCTACCAAACACATTCTCCTTTGAATTGTTAAAATTCAGAACATTCAAAATAACTGT
TTTGCTACAACCCATGATTATTTTCCTGTTGTGTTTATTTAAATTTACTTTCTCTTTAGAAGTGCACTTATTTCTGAAAAATCTTAATGA
AACAAACGCTTAGAACAAATATAAATATGAGACACTTGGGACTACTAGAGATATTTTAGATTTTTATGAAAAAAATGTGAGGGGATATTG
CTGCTTTAAAAAGGAATAAAGTAATAAAAATATATCTCAGCTATTTTTTTAAAGCAATATAATTCAGCAATTGTCTAGAAAAGTAATCAT
GAGGCTACTGAGTTTGGTGTTCAGTTACTGAGTTTCAAAAATGTTTTGGTGGCATGAGGACAAAATTTCATTGAAGGTAAGATAAGAATA

>17721_17721_2_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000441024_STK38L_chr12_27461271_ENST00000389032_length(amino acids)=1119AA_BP=717
MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT
KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF
QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG
YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN
FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR
EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS
IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR
CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL
RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY
SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE
FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV
MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN

--------------------------------------------------------------
>17721_17721_3_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000569240_STK38L_chr12_27461271_ENST00000389032_length(transcript)=7124nt_BP=2411nt
GCCATTTTGTAGAGAAACAAGCGGAGTTAACCGAAGAGGGGGTCGAGGAGAGCCGGAGTCGGGGACCCAGGAGTTTCCTGTGTCCAGCGC
TGCCGGAGCCGCCTGAGGTGCCATGTTTCAGAACAGAGTAAGACCCCTGGTAAAGAAGAACTGAAGATATTATACAGATACCAGATATAG
CCTAATTACAAAGAAAGCATTAACCTGCCTCTGAGGTGACTAAAGGGGAATAATGGTGATTTTGCGCCGGGCTCGGCCGCCTGCTTCCGC
CCCAACCAGCAATGAATCTTGACTCGCTCTCGCTGGCCTTGTCTCAAATCAGCTACCTGGTGGACAATTTAACCAAGAAAAATTACCGAG
CCAGCCAGCAGGAAATACAGCATATTGTGAATCGGCACGGTCCTGAGGCAGACAGGCATTTATTACGCTGCCTATTTTCGCATGTGGATT
TCAGTGGCGATGGTAAAAGCAGTGGCAAAGATTTCCATCAGACTCAGTTTCTGATTCAGGAGTGTGCGTTGCTGATTACAAAGCCAAATT
TTATCTCGACGCTGTCCTATGCCATTGATAATCCATTGCACTATCAGAAGAGTTTAAAGCCTGCACCCCACTTATTTGCCCAGCTGAGTA
AAGTGCTCAAATTAAGCAAAGTACAAGAGGTAATTTTTGGCCTTGCCCTGTTGAATTCTTCCAGCTCAGATCTTAGAGGTTTCGCTGCCC
AGTTTATCAAACAGAAGCTTCCAGATCTTCTGCGTTCTTACATTGACGCAGACGTCAGTGGAAATCAAGAAGGTGGCTTCCAAGATATAG
CAATAGAGGTCCTACACCTCCTCCTCTCCCATCTCCTCTTTGGGCAGAAGGGAGCCTTTGGAGTTGGACAAGAACAGATAGACGCTTTTC
TTAAGACGCTGCGCAGAGATTTTCCCCAAGAACGCTGTCCCGTGGTGCTCGCACCACTTTTATACCCTGAAAAACGGGACATTCTAATGG
ACAGGATCCTGCCTGATTCCGGAGGGGTAGCTAAAACCATGATGGAGAGCTCTTTGGCTGATTTCATGCAAGAAGTAGGCTATGGCTTTT
GTGCAAGTATTGAAGAATGTCGCAATATAATCGTGCAGTTTGGTGTTCGGGAGGTCACAGCTGCCCAGGTTGCAAGGGTTTTGGGAATGA
TGGCTCGAACTCATTCAGGATTAACAGATGGCATTCCATTACAGAGTATTTCTGCTCCGGGCAGTGGGATCTGGAGTGATGGGAAAGATA
AAAGTGATGGAGCACAGGCACACACATGGAATGTAGAAGTCTTGATTGACGTTCTTAAAGAACTGAATCCAAGTTTGAATTTCAAGGAAG
TAACTTATGAACTGGACCATCCTGGATTTCAAATTCGTGACAGTAAAGGACTTCATAATGTGGTTTATGGCATTCAGAGGGGTTTGGGTA
TGGAAGTGTTCCCAGTAGACCTCATATATAGACCTTGGAAACATGCTGAAGGCCAGCTCTCCTTCATTCAACATTCCCTTATAAATCCAG
AGATCTTCTGTTTTGCTGACTATCCCTGTCATACTGTTGCCACTGATATTCTGAAAGCACCACCAGAGGATGACAATCGAGAAATTGCCA
CATGGAAGAGCTTGGATTTGATTGAATCTCTGCTGAGGCTTGCAGAGGTTGGGCAGTATGAGCAAGTCAAACAGCTCTTCAGCTTCCCTA
TCAAACACTGTCCAGACATGCTGGTATTGGCCTTACTACAAATTAACACCTCTTGGCATACCTTGCGCCATGAACTTATCTCCACTCTGA
TGCCAATTTTCCTTGGAAACCATCCTAACTCAGCTATTATTTTGCACTATGCATGGCATGGGCAGGGACAGTCTCCCTCAATTCGCCAAC
TTATCATGCATGCAATGGCAGAATGGTACATGAGAGGGGAGCAGTATGATCAGGCCAAATTGTCTCGAATACTTGATGTGGCCCAGGACT
TGAAGGCCTTGTCAATGCTGCTAAATGGTACTCCATTTGCCTTTGTTATTGACCTTGCTGCACTTGCTTCACGTCGTGAATACCTCAAAC
TTGATAAGTGGCTCACAGATAAAATTCGAGAGCATGGGGAGCCTTTTATCCAGGCGTGTATGACTTTTTTAAAGAGACGGTGTCCTTCTA
TTTTGGGCGGACTTGCCCCAGAAAAAGACCAGCCCAAAAGTGCTCAACTTCCTCCAGAAACTTTGGCGACAATGTTGGCCTGTCTGCAAG
CTTGTGCAGGGAGTGTTTCTCAGGAGCTATCAGAAACTATCCTCACCATGGTAGCCAATTGCAGTAATGTTATGAATAAGGCCAGACAAC
CACCACCTGGAGTTATGCCAAAAGGACGTCCTCCTAGTGCTAGCAGCTTAGATGCCATTTCTCCTGTTCAGAAAAAGTTACGTCGATCAC
AACACGCTCGCAAAGAAACAGAGTTCTTACGGCTCAAAAGGACCAGACTTGGCTTGGATGACTTTGAGTCTCTGAAAGTTATAGGAAGAG
GAGCTTTTGGAGAGGTGCGGTTGGTCCAGAAGAAAGATACAGGCCATATCTATGCAATGAAGATATTGAGAAAGTCTGATATGCTTGAAA
AAGAGCAGGTGGCCCATATCCGAGCAGAAAGAGATATTTTGGTAGAAGCAGATGGTGCCTGGGTGGTGAAGATGTTTTACAGTTTTCAGG
ATAAGAGGAATCTTTATCTAATCATGGAATTTCTCCCTGGAGGTGACATGATGACATTGCTAATGAAGAAAGACACCTTGACAGAAGAGG
AAACACAGTTCTACATTTCAGAGACTGTTCTGGCAATAGATGCGATCCACCAGTTGGGTTTCATCCATCGGGATATTAAGCCAGACAACC
TTTTATTGGATGCCAAGGGTCATGTAAAATTATCTGATTTTGGTTTATGTACGGGATTAAAGAAAGCTCACAGGACTGAATTTTATAGAA
ATCTCACACACAACCCACCAAGTGACTTCTCATTTCAGAACATGAACTCAAAGAGGAAAGCAGAAACTTGGAAGAAGAACAGGAGACAAC
TGGCATATTCCACAGTTGGGACACCAGATTACATTGCTCCAGAAGTATTCATGCAGACTGGTTACAACAAATTGTGTGACTGGTGGTCTT
TGGGAGTGATTATGTATGAAATGCTAATAGGATATCCACCTTTCTGCTCTGAAACACCTCAAGAAACGTACAGAAAAGTGATGAACTGGA
AAGAAACTCTGGTATTTCCTCCAGAGGTACCTATATCTGAGAAAGCCAAGGACTTAATTCTCAGATTTTGTATTGATTCTGAAAACAGAA
TTGGAAATAGTGGAGTAGAAGAAATAAAAGGTCATCCCTTTTTTGAAGGTGTCGACTGGGAGCACATAAGGGAAAGGCCAGCAGCAATCC
CTATAGAAATCAAAAGCATTGATGATACTTCAAATTTTGATGACTTCCCTGAATCTGATATTTTACAACCAGTGCCAAATACCACAGAAC
CGGACTACAAATCCAAAGACTGGGTTTTTCTCAATTATACCTATAAAAGGTTTGAAGGGTTGACTCAACGTGGCTCTATCCCCACCTACA
TGAAAGCTGGGAAGTTATGAATGAAGATAACATTCACCCATAACCAAGAGAACTCAGGTAGCTGCATCACCAGGCTTGCTTGGCGTAGAT
AACAATACACTGAAATACTCCTGAAGATGGTGGTGCTTATTGACTACAAGAGGAAATTCTACAGGATTAGGATTTCTAAGACTACTATAG
GAATTGGTTGGCAGTGCCAGCTGGCTCTTTTTTTTAATATTTTATTATTTTTGTTAACTTTATTATATGAAGGTACTGGAATAAAAGGAA
CAGACATCCCTTTCTAACTGCACTGCCTACATGCGTATTAAGGTCCATTCTGCCTGTGTGTGCTGTGGCTTTGAACTGTAACACCTCTAA
TCAATTCAGGAGAAACACATATCATTTAAAGCAACATAGGCTAACCTGTAGGTAACACTGCAGTATTGATGTTTTACTGCAAATCTTATG
GGTCTAGATAATCAGTAAAAGCCATCTTCCATAGTTGGTGTTAGAACATTGCCCTATTGGTTTGGACATCTGTAGAATATATATGAAGAC
AATTTCTGTAATGGTTTTAAGAGATTTAAAAAGAAATTCACTGGTTCTTTACAAAATAGAATTTATCATCAAGTTATTACACAAACTTCA
CAGTAAGGAGTGACAAGTTTATAATAAGGAAGACAAAGTTTAACACCTTCACTCAAGCACTCCACTAATATATTTACGTTGCATTCAGAA
ATACTGATGACCTTCATATACGTAGTCTGTATACTCATAGGGAGATGTACTGTATTATATAACATGTAAAGTTGATTTTCTTGTGACAAG
AGAACTTCTTTTTTTAACAAGAGGACATGGCATTATTTTAATTTGATTATGGTGAGTTGAATTTAAGACATGACCATGAAGGCTGCTTGT
AGAATTAGTGTATTTTTATTAAACTATTTTTTTAAATGTCAAACTTCTATCATGTAAATGGACTTATAGAGAACAAAAAGCTATTTACTT
TGGTTTTCTAGAAAGTTGTTACATATCATGGCTGGTTAACTTTTATTTCTTTTGATGAAAATTTTTCCTTTGATAGTACTTGTATTATTG
TGCCATTATTTTCTTATGCTCCAAATGTACCAAAGATCTTGAACAGAGTGGATGTTCACAACTGAGTAGAATTTTCCTTTCCTGTGGGCA
TGCTGTATTCAGACCTGACAGATCTTTGATAGAGGTCAGCTTATTAAAGGGCAATATTGTTCTTGTTTAGCTACATCACTGTGGTGAATA
TAGATGGAATTAAGGAAGTAAATGCAGGCCAGGGGGTTGTGATGAGAGGATAGGGGAGATAATATCAGCATCAAATTCTTTGGGTATCTC
TCTAAGAATTAAATAATCTTTTCTAGCTTAATATTTTAATTCTAATTCAAACAACTCTGAGGTTTTGGTTTCATTAGTAATAGTTGAGGA
ATAATATACTAGCAAAGAATGGCCTAATGTTTGTCATAACTGTTAATGGATGAAATTTTTTAAAGATACAACCATGATAACCATTATAAA
TGATCTATGATCAAAATCTAAAGTGATGAATTATTTGTAGGAATGTCTTCCTAATGGGGAAGAATTGCATAGGAGCATTATGCAAATCTA
CACAAGCTTTTATAAATGTTGCTGCTGGGTAGCTCCACAGTGTTTCATAAGGCCATCCTGTTTCCCCCAACTCCCCCATTTTTGGTTTGT
TTCTTTTTAAATATTTGTTGAGTACTTACGTGTTTATCTAACAGTTCACTTCCATTTTTCTAGTCTGGATTTTTTGAGTATTTAGGAAAG
AGAGCTATTAAAAACTGGGGATTTCTCAATGTGACTAACTCTAATTTTTCTAATTATAACTGCCTTTAATTAACATAATATTAACTTTTG
CTGAGGTTTATGAGATTTTCTCACCCCACATCGCTCCCCTTTTTTTAAAAAGGACTGTTTTGCTAGTGTGATAATGAATAGGTAAGATAT
GAGATAATTGCAACATTGTCTAGTTCTAGTATGGTAACTATTCTTGAAATGGTATTGAAAAATACCGTTAATTCAAATTGACAGAGATTG
ATAAAAAGAAACTGATTTACCTAAGTTTACTTTTTAATTGCATAATAGAGCATTTTTTGTTTTGAGTTCCCTCATTCTTATTACCAGAAA
GAGCTTGCAAATAGTTTTACTTTCTTGGCACTGGAAGGGTAGTTCTGGAAAGCTACTTTGTTGAGAGTCTCATTCTTCCCTGGAGTTAAT
AGAGTGATTCACAATCTTTGGGGTTTTCTCCTCATCAAAAGCATTTCTTAAGTGCCTATCTAAAAGCAATTAAAGACTGTGTCTGCCCTT
TAGAAGCTAAGAATTTGATTCATGATGCAAATTAACTAGATAATTTGCAAAGTACCCTTGAGATTGAATTTTCTCTATTATATATTTCCC
ATATTTCAGGTGAATAATTTAATTTAAATGACAAAACCCTATCTAGTCAACTGGGCATAATGACATTTTCTTTAAATTAGACTCTATTTT
GAATTAAAAGAGTTTTATTATAAACCGTGTGTTTTTGGTTTTTCTAAGTATATAGAAAGCTTGTATAATTCAGATTTATCAATTTCCTGA
TTTAATGTAGACTTTGACTTTTTTATTAAAAACCTTTGTATTAAAGCAAGTTATGTTATTTTTCTTTTATGCATTTATTACTAACATAGC
TTTAAATCTTTAAATGTATTGAAGCATTGTGCTGTCTGAAAATAAGGAATTGCTTATAAACCAGCCACTTCTGAATACAATATGTAGCTG
ATTTAATAAGCTAGTTAGTGAATGGAAAATAAGTGTGGAGTATTAAAAATGTTCTTTGGTTGGTAAGGCCTAAGATAGGGTTTCATTTAT
TTCTATACTTTTTCTGTTTTTTAAACACCTGCATATTTTTATGTAAATCTCTAAATTTAAAATATTTTAAGTACATTTATTTTTGGTGTT
TTATTGTATAAAACCTTAGACAATCAATCAGTCAGTCTTTACTGACAGGAGCAGCAGCTATCTGTCTTTTGCTGATCTACAAATAAATGA
ATTGAGAATTTAGTCCATAGAGGTCCCTGGCTACCAAACACATTCTCCTTTGAATTGTTAAAATTCAGAACATTCAAAATAACTGTTTTG
CTACAACCCATGATTATTTTCCTGTTGTGTTTATTTAAATTTACTTTCTCTTTAGAAGTGCACTTATTTCTGAAAAATCTTAATGAAACA
AACGCTTAGAACAAATATAAATATGAGACACTTGGGACTACTAGAGATATTTTAGATTTTTATGAAAAAAATGTGAGGGGATATTGCTGC
TTTAAAAAGGAATAAAGTAATAAAAATATATCTCAGCTATTTTTTTAAAGCAATATAATTCAGCAATTGTCTAGAAAAGTAATCATGAGG
CTACTGAGTTTGGTGTTCAGTTACTGAGTTTCAAAAATGTTTTGGTGGCATGAGGACAAAATTTCATTGAAGGTAAGATAAGAATAAAAA

>17721_17721_3_CNOT1-STK38L_CNOT1_chr16_58594115_ENST00000569240_STK38L_chr12_27461271_ENST00000389032_length(amino acids)=1119AA_BP=717
MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT
KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF
QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG
YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN
FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR
EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS
IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR
CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL
RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY
SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE
FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV
MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN

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Fusion Gene PPI Analysis for CNOT1-STK38L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000317147	-	17	49	1090_1605	710.0	2377.0	CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000441024	-	17	31	1090_1605	710.0	1552.0	CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000569240	-	17	49	1090_1605	710.0	2372.0	CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000317147	-	17	49	800_1015	710.0	2377.0	ZFP36
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000441024	-	17	31	800_1015	710.0	1552.0	ZFP36
Hgene	CNOT1	chr16:58594115	chr12:27461271	ENST00000569240	-	17	49	800_1015	710.0	2372.0	ZFP36

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CNOT1-STK38L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CNOT1-STK38L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source