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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT2-GRM7 (FusionGDB2 ID:17736)

Fusion Gene Summary for CNOT2-GRM7

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2-GRM7
Fusion gene ID: 17736
HgeneTgene
Gene symbol

CNOT2

GRM7

Gene ID

4848

2917

Gene nameCCR4-NOT transcription complex subunit 2glutamate metabotropic receptor 7
SynonymsCDC36|HSPC131|IDNADFS|NOT2|NOT2HGLUR7|GPRC1G|MGLU7|MGLUR7|PPP1R87
Cytomap

12q15

3p26.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2metabotropic glutamate receptor 7glutamate receptor, metabotropic 7protein phosphatase 1, regulatory subunit 87
Modification date2020031320200313
UniProtAcc

Q9NZN8

Q14831

Ensembl transtripts involved in fusion geneENST00000229195, ENST00000418359, 
ENST00000551483, ENST00000548230, 
ENST00000357716, ENST00000389336, 
ENST00000402647, ENST00000403881, 
ENST00000458641, ENST00000486284, 
Fusion gene scores* DoF score41 X 13 X 11=586312 X 9 X 7=756
# samples 4611
** MAII scorelog2(46/5863*10)=-3.6719332904521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/756*10)=-2.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT2 [Title/Abstract] AND GRM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT2(70747714)-GRM7(7709548), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523

TgeneGRM7

GO:0007196

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

9473604

TgeneGRM7

GO:0007268

chemical synaptic transmission

9473604


check buttonFusion gene breakpoints across CNOT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP431029CNOT2chr12

70747714

+GRM7chr3

7709548

+


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Fusion Gene ORF analysis for CNOT2-GRM7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000229195ENST00000357716CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000229195ENST00000389336CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000229195ENST00000402647CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000229195ENST00000403881CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000229195ENST00000458641CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000229195ENST00000486284CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000357716CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000389336CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000402647CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000403881CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000458641CNOT2chr12

70747714

+GRM7chr3

7709548

+
3UTR-intronENST00000418359ENST00000486284CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000357716CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000389336CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000402647CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000403881CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000458641CNOT2chr12

70747714

+GRM7chr3

7709548

+
5CDS-intronENST00000551483ENST00000486284CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000357716CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000389336CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000402647CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000403881CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000458641CNOT2chr12

70747714

+GRM7chr3

7709548

+
intron-intronENST00000548230ENST00000486284CNOT2chr12

70747714

+GRM7chr3

7709548

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CNOT2-GRM7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNOT2-GRM7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:70747714/:7709548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

GRM7

Q14831

FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CNOT2-GRM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CNOT2-GRM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT2-GRM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT2-GRM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource