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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT2-MBD4 (FusionGDB2 ID:17742)

Fusion Gene Summary for CNOT2-MBD4

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2-MBD4
Fusion gene ID: 17742
HgeneTgene
Gene symbol

CNOT2

MBD4

Gene ID

4848

8930

Gene nameCCR4-NOT transcription complex subunit 2methyl-CpG binding domain 4, DNA glycosylase
SynonymsCDC36|HSPC131|IDNADFS|NOT2|NOT2HMED1
Cytomap

12q15

3q21.3

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1meth
Modification date2020031320200313
UniProtAcc

Q9NZN8

O95243

Ensembl transtripts involved in fusion geneENST00000229195, ENST00000418359, 
ENST00000548230, ENST00000551483, 
ENST00000509587, ENST00000249910, 
ENST00000393278, ENST00000429544, 
ENST00000503197, ENST00000507208, 
Fusion gene scores* DoF score41 X 13 X 11=58632 X 1 X 2=4
# samples 462
** MAII scorelog2(46/5863*10)=-3.6719332904521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: CNOT2 [Title/Abstract] AND MBD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT2(70713144)-MBD4(129152979), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check buttonFusion gene breakpoints across CNOT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MBD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB37-01ACNOT2chr12

70713144

+MBD4chr3

129152979

-


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Fusion Gene ORF analysis for CNOT2-MBD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000229195ENST00000509587CNOT2chr12

70713144

+MBD4chr3

129152979

-
5CDS-5UTRENST00000418359ENST00000509587CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000229195ENST00000249910CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000229195ENST00000393278CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000229195ENST00000429544CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000229195ENST00000503197CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000229195ENST00000507208CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000418359ENST00000249910CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000418359ENST00000393278CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000418359ENST00000429544CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000418359ENST00000503197CNOT2chr12

70713144

+MBD4chr3

129152979

-
In-frameENST00000418359ENST00000507208CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000548230ENST00000249910CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000548230ENST00000393278CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000548230ENST00000429544CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000548230ENST00000503197CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000548230ENST00000507208CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000551483ENST00000249910CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000551483ENST00000393278CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000551483ENST00000429544CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000551483ENST00000503197CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-3CDSENST00000551483ENST00000507208CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-5UTRENST00000548230ENST00000509587CNOT2chr12

70713144

+MBD4chr3

129152979

-
intron-5UTRENST00000551483ENST00000509587CNOT2chr12

70713144

+MBD4chr3

129152979

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229195CNOT2chr1270713144+ENST00000429544MBD4chr3129152979-19168175401358272
ENST00000229195CNOT2chr1270713144+ENST00000249910MBD4chr3129152979-19108175401358272
ENST00000229195CNOT2chr1270713144+ENST00000503197MBD4chr3129152979-15418175401238232
ENST00000229195CNOT2chr1270713144+ENST00000393278MBD4chr3129152979-13748175401358272
ENST00000229195CNOT2chr1270713144+ENST00000507208MBD4chr3129152979-16088175401334264
ENST00000418359CNOT2chr1270713144+ENST00000429544MBD4chr3129152979-17886894121230272
ENST00000418359CNOT2chr1270713144+ENST00000249910MBD4chr3129152979-17826894121230272
ENST00000418359CNOT2chr1270713144+ENST00000503197MBD4chr3129152979-14136894121110232
ENST00000418359CNOT2chr1270713144+ENST00000393278MBD4chr3129152979-12466894121230272
ENST00000418359CNOT2chr1270713144+ENST00000507208MBD4chr3129152979-14806894121206264

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229195ENST00000429544CNOT2chr1270713144+MBD4chr3129152979-0.0038398530.99616015
ENST00000229195ENST00000249910CNOT2chr1270713144+MBD4chr3129152979-0.0038195240.99618053
ENST00000229195ENST00000503197CNOT2chr1270713144+MBD4chr3129152979-0.0063594770.9936405
ENST00000229195ENST00000393278CNOT2chr1270713144+MBD4chr3129152979-0.005654710.9943453
ENST00000229195ENST00000507208CNOT2chr1270713144+MBD4chr3129152979-0.0045469550.995453
ENST00000418359ENST00000429544CNOT2chr1270713144+MBD4chr3129152979-0.004116090.9958839
ENST00000418359ENST00000249910CNOT2chr1270713144+MBD4chr3129152979-0.0040948950.99590504
ENST00000418359ENST00000503197CNOT2chr1270713144+MBD4chr3129152979-0.0069142480.99308574
ENST00000418359ENST00000393278CNOT2chr1270713144+MBD4chr3129152979-0.00620360.99379647
ENST00000418359ENST00000507208CNOT2chr1270713144+MBD4chr3129152979-0.0048415030.9951585

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Fusion Genomic Features for CNOT2-MBD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNOT2-MBD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70713144/chr3:129152979)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

MBD4

O95243

FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.FUNCTION: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT2chr12:70713144chr3:129152979ENST00000229195+416437_54079541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70713144chr3:129152979ENST00000418359+517437_54079541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70713144chr3:129152979ENST00000551483+17437_5400192.0RegionNote=Repressor domain
TgeneMBD4chr12:70713144chr3:129152979ENST000002499102876_148400581.0DomainMBD
TgeneMBD4chr12:70713144chr3:129152979ENST000003932781776_14882263.0DomainMBD
TgeneMBD4chr12:70713144chr3:129152979ENST000004295442876_148394575.0DomainMBD
TgeneMBD4chr12:70713144chr3:129152979ENST000005031972876_148400541.0DomainMBD


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Fusion Gene Sequence for CNOT2-MBD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17742_17742_1_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000249910_length(transcript)=1910nt_BP=817nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAAAGATACCATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGC
CCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAG
CTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGCAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCT
GAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAG
TTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTT
TGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCACAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGT
CTATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTATGCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTC
CAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTAGTGTGTGTGCTTTCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAAT
GTGTTTGAACATGTTTTGAGATTTTTTTAAAATAAATTATTATTTGACAACAATCCAAAAAAAATACGGCTTTTCCAATGATGAAATATA
ATCAGAAGATGAAAAATAGTTCTAAACTATCAATAATACAAAGCAAATTTCTATCAGCCTTGCTAAAGCTAGGGGCCCACTAAATATTTT
TATCGGCTAGGCGTGGTGGTGCATGCCTGTAATCTCGGAAGGCTGAGGCAGGAGGATCATTTGAGCTCATGAGGGCCCAGGAGGTCAAGG
CTTCAGTGAGCCATGATCATGCCACTGCACTCCAGTCTGGATGACAGAGAGAGACCCTGTCTCAAAAAATATATATTTAAAAAATAAAAA

>17742_17742_1_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000249910_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_2_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000393278_length(transcript)=1374nt_BP=817nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAAAGATACCATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGC
CCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAG
CTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGCAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCT
GAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAG
TTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTT
TGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCACAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGT

>17742_17742_2_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000393278_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_3_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000429544_length(transcript)=1916nt_BP=817nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAAAGATACCATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGC
CCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAG
CTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGCAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCT
GAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAG
TTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTT
TGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCACAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGT
CTATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTATGCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTC
CAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTAGTGTGTGTGCTTTCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAAT
GTGTTTGAACATGTTTTGAGATTTTTTTAAAATAAATTATTATTTGACAACAATCCAAAAAAAATACGGCTTTTCCAATGATGAAATATA
ATCAGAAGATGAAAAATAGTTCTAAACTATCAATAATACAAAGCAAATTTCTATCAGCCTTGCTAAAGCTAGGGGCCCACTAAATATTTT
TATCGGCTAGGCGTGGTGGTGCATGCCTGTAATCTCGGAAGGCTGAGGCAGGAGGATCATTTGAGCTCATGAGGGCCCAGGAGGTCAAGG
CTTCAGTGAGCCATGATCATGCCACTGCACTCCAGTCTGGATGACAGAGAGAGACCCTGTCTCAAAAAATATATATTTAAAAAATAAAAA

>17742_17742_3_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000429544_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_4_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000503197_length(transcript)=1541nt_BP=817nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAAAGATACCATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGC
CCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAG
CTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGCAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCT
GAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAG
TTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGAGCTTCATGGGATTGGTGCACCCTGAAGACCACAAATTAAATAAATA
TCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGTCTATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTATGCATAGCTTTGCACT
TCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTCCAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTAGTGTGTGTGCTTTCT
TAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAATGTGTTTGAACATGTTTTGAGATTTTTTTAAAATAAATTATTATTTGACAACAA

>17742_17742_4_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000503197_length(amino acids)=232AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA

--------------------------------------------------------------
>17742_17742_5_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000507208_length(transcript)=1608nt_BP=817nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAAAGATACCATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGC
CCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAG
CTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGCAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCT
GAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAG
TTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTT
TGTGTCAATGAGTGGAAGCAGGTGAGGCTCACTCCCATCCATAATTCAGCACATTTGGTCTCTGAGGCAAAATAAGTCCACCATTATGGT
TAAGACTATTTATTGGATACAAATGCTATTACAGTCACAAACAATTGTGTTCCTGGCTGCGGGGAAGCGGGTGGCATGTGGGTTTTGGGG
TTTTTGATCAGTAGGCGCTCCCAAGTCCACAAAGACCAGTCCAGCGGCGTGGCCTCTGACTCATCTCCAGTGGTTTGTCACCTCTGGCCC

>17742_17742_5_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000229195_MBD4_chr3_129152979_ENST00000507208_length(amino acids)=264AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA

--------------------------------------------------------------
>17742_17742_6_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000249910_length(transcript)=1782nt_BP=689nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAAAGATACCATCCCACGAACACAGATAGAAAG
AAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCC
TCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGG
CAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGA
ACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAGTTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCC
AATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTTTGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCA
CAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGTCTATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTAT
GCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTCCAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTA
GTGTGTGTGCTTTCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAATGTGTTTGAACATGTTTTGAGATTTTTTTAAAATAAATT
ATTATTTGACAACAATCCAAAAAAAATACGGCTTTTCCAATGATGAAATATAATCAGAAGATGAAAAATAGTTCTAAACTATCAATAATA
CAAAGCAAATTTCTATCAGCCTTGCTAAAGCTAGGGGCCCACTAAATATTTTTATCGGCTAGGCGTGGTGGTGCATGCCTGTAATCTCGG
AAGGCTGAGGCAGGAGGATCATTTGAGCTCATGAGGGCCCAGGAGGTCAAGGCTTCAGTGAGCCATGATCATGCCACTGCACTCCAGTCT

>17742_17742_6_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000249910_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_7_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000393278_length(transcript)=1246nt_BP=689nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAAAGATACCATCCCACGAACACAGATAGAAAG
AAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCC
TCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGG
CAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGA
ACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAGTTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCC
AATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTTTGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCA

>17742_17742_7_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000393278_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_8_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000429544_length(transcript)=1788nt_BP=689nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAAAGATACCATCCCACGAACACAGATAGAAAG
AAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCC
TCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGG
CAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGA
ACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAGTTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCC
AATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTTTGTGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCA
CAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGTCTATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTAT
GCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTCCAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTA
GTGTGTGTGCTTTCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAATGTGTTTGAACATGTTTTGAGATTTTTTTAAAATAAATT
ATTATTTGACAACAATCCAAAAAAAATACGGCTTTTCCAATGATGAAATATAATCAGAAGATGAAAAATAGTTCTAAACTATCAATAATA
CAAAGCAAATTTCTATCAGCCTTGCTAAAGCTAGGGGCCCACTAAATATTTTTATCGGCTAGGCGTGGTGGTGCATGCCTGTAATCTCGG
AAGGCTGAGGCAGGAGGATCATTTGAGCTCATGAGGGCCCAGGAGGTCAAGGCTTCAGTGAGCCATGATCATGCCACTGCACTCCAGTCT

>17742_17742_8_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000429544_length(amino acids)=272AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA
EVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLS

--------------------------------------------------------------
>17742_17742_9_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000503197_length(transcript)=1413nt_BP=689nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAAAGATACCATCCCACGAACACAGATAGAAAG
AAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCC
TCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGG
CAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGA
ACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAGTTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCC
AATTGAGCTTCATGGGATTGGTGCACCCTGAAGACCACAAATTAAATAAATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGTC
TATCTTAAACTCTGCAGCTTTCAAGCTCATCTGTTATGCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCAACCACCTTTCC
AGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTAGTGTGTGTGCTTTCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAATG

>17742_17742_9_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000503197_length(amino acids)=232AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA

--------------------------------------------------------------
>17742_17742_10_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000507208_length(transcript)=1480nt_BP=689nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAAAGATACCATCCCACGAACACAGATAGAAAG
AAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAACAAAGAAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAATGGACACCTCC
TCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGGAAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGG
CAAAATGGCAATACCTGTGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGAGAGATGTGTCAGA
ACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTGTCAAGTTCTCAGATGAATACCTGACAAAGCAGTGGAAGTATCC
AATTGAGCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTTTGTGTCAATGAGTGGAAGCAGGTGAGGCTCACTCCCAT
CCATAATTCAGCACATTTGGTCTCTGAGGCAAAATAAGTCCACCATTATGGTTAAGACTATTTATTGGATACAAATGCTATTACAGTCAC
AAACAATTGTGTTCCTGGCTGCGGGGAAGCGGGTGGCATGTGGGTTTTGGGGTTTTTGATCAGTAGGCGCTCCCAAGTCCACAAAGACCA
GTCCAGCGGCGTGGCCTCTGACTCATCTCCAGTGGTTTGTCACCTCTGGCCCTGTTCCTGTCATTCCCTATTTGTGTGCTATCTCTAAGC

>17742_17742_10_CNOT2-MBD4_CNOT2_chr12_70713144_ENST00000418359_MBD4_chr3_129152979_ENST00000507208_length(amino acids)=264AA_BP=93
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQKDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CNOT2-MBD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT2-MBD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT2-MBD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource