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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT2-NUP107 (FusionGDB2 ID:17743)

Fusion Gene Summary for CNOT2-NUP107

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2-NUP107
Fusion gene ID: 17743
HgeneTgene
Gene symbol

CNOT2

NUP107

Gene ID

4848

57122

Gene nameCCR4-NOT transcription complex subunit 2nucleoporin 107
SynonymsCDC36|HSPC131|IDNADFS|NOT2|NOT2HNPHS11|NUP84|ODG6|ODG6; GAMOS7
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2nuclear pore complex protein Nup107nucleoporin 107kDa
Modification date2020031320200313
UniProtAcc

Q9NZN8

P57740

Ensembl transtripts involved in fusion geneENST00000548230, ENST00000229195, 
ENST00000418359, ENST00000551483, 
ENST00000229179, ENST00000378905, 
ENST00000539906, ENST00000401003, 
Fusion gene scores* DoF score41 X 13 X 11=586327 X 22 X 9=5346
# samples 4637
** MAII scorelog2(46/5863*10)=-3.6719332904521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/5346*10)=-3.85286266172677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT2 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT2(70637260)-NUP107(69090599), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523

TgeneNUP107

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across CNOT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08F-01ACNOT2chr12

70637260

-NUP107chr12

69090599

+
ChimerDB4BRCATCGA-A8-A08F-01ACNOT2chr12

70637260

+NUP107chr12

69090599

+
ChimerDB4BRCATCGA-A8-A08FCNOT2chr12

70637260

+NUP107chr12

69090598

+
ChimerDB4STADTCGA-FP-7998-01ACNOT2chr12

70724249

-NUP107chr12

69082742

+


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Fusion Gene ORF analysis for CNOT2-NUP107

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000548230ENST00000229179CNOT2chr12

70724249

-NUP107chr12

69082742

+
3UTR-5UTRENST00000548230ENST00000378905CNOT2chr12

70724249

-NUP107chr12

69082742

+
3UTR-5UTRENST00000548230ENST00000539906CNOT2chr12

70724249

-NUP107chr12

69082742

+
3UTR-intronENST00000548230ENST00000401003CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-5UTRENST00000229195ENST00000378905CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-5UTRENST00000229195ENST00000539906CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-5UTRENST00000418359ENST00000378905CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-5UTRENST00000418359ENST00000539906CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-intronENST00000229195ENST00000401003CNOT2chr12

70724249

-NUP107chr12

69082742

+
5CDS-intronENST00000418359ENST00000401003CNOT2chr12

70724249

-NUP107chr12

69082742

+
5UTR-3CDSENST00000229195ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-3CDSENST00000229195ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-3CDSENST00000418359ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-3CDSENST00000418359ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-5UTRENST00000229195ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-5UTRENST00000229195ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-5UTRENST00000229195ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-5UTRENST00000229195ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-5UTRENST00000418359ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-5UTRENST00000418359ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-5UTRENST00000418359ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-5UTRENST00000418359ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-intronENST00000229195ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-intronENST00000229195ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090598

+
5UTR-intronENST00000418359ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090599

+
5UTR-intronENST00000418359ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090598

+
In-frameENST00000229195ENST00000229179CNOT2chr12

70724249

-NUP107chr12

69082742

+
In-frameENST00000418359ENST00000229179CNOT2chr12

70724249

-NUP107chr12

69082742

+
intron-3CDSENST00000548230ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-3CDSENST00000548230ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-3CDSENST00000551483ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-3CDSENST00000551483ENST00000229179CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-3CDSENST00000551483ENST00000229179CNOT2chr12

70724249

-NUP107chr12

69082742

+
intron-5UTRENST00000548230ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-5UTRENST00000548230ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-5UTRENST00000548230ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-5UTRENST00000548230ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-5UTRENST00000551483ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-5UTRENST00000551483ENST00000378905CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-5UTRENST00000551483ENST00000378905CNOT2chr12

70724249

-NUP107chr12

69082742

+
intron-5UTRENST00000551483ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-5UTRENST00000551483ENST00000539906CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-5UTRENST00000551483ENST00000539906CNOT2chr12

70724249

-NUP107chr12

69082742

+
intron-intronENST00000548230ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-intronENST00000548230ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-intronENST00000551483ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090599

+
intron-intronENST00000551483ENST00000401003CNOT2chr12

70637260

+NUP107chr12

69090598

+
intron-intronENST00000551483ENST00000401003CNOT2chr12

70724249

-NUP107chr12

69082742

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229195CNOT2chr1270724249-ENST00000229179NUP107chr1269082742+4461114854039171125
ENST00000418359CNOT2chr1270724249-ENST00000229179NUP107chr1269082742+4333102041237891125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229195ENST00000229179CNOT2chr1270724249-NUP107chr1269082742+0.0003480030.999652
ENST00000418359ENST00000229179CNOT2chr1270724249-NUP107chr1269082742+0.0003130950.99968696

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Fusion Genomic Features for CNOT2-NUP107


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CNOT2chr1270637260+NUP107chr1269090598+9.72E-080.9999999
CNOT2chr1270637260+NUP107chr1269090598+9.72E-080.9999999
CNOT2chr1270637260+NUP107chr1269090598+9.72E-080.9999999
CNOT2chr1270637260+NUP107chr1269090598+9.72E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CNOT2-NUP107


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70637260/chr12:69090599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

NUP107

P57740

FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT2chr12:70724249chr12:69082742ENST00000229195-616437_540189541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70724249chr12:69082742ENST00000418359-717437_540189541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70724249chr12:69082742ENST00000551483-17437_5400192.0RegionNote=Repressor domain


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Fusion Gene Sequence for CNOT2-NUP107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17743_17743_1_CNOT2-NUP107_CNOT2_chr12_70724249_ENST00000229195_NUP107_chr12_69082742_ENST00000229179_length(transcript)=4461nt_BP=1148nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
ACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGTAGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCT
TCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGCATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGG
CAACAAAGTGCACTAGGCCTTCCAATGAGGGGGATGAGCAACAATACCCCTCAGTTAAATCGCAGCTTATCACAAGGCACTCAGTTACCG
AGCCACGTCACGCCAACAACAGGGGTACCAACAATGTCACTTCACACGCCTCCATCTCCAAGCAGGGGTATTTTGCCTATGAATCCTAGG
AATATGATGAACCACTCCCAGGTTGGTCAGGGCATTGGAATTCCTAGCAGGACAAATAGCATGAGCAGTTCAGGGTTAGGTAGCCCCAAC
AGAAGCTCGCCAAGCATAATATGTATGCCAAAGCAGCAGCCTTCTCGACAGCCTTTTACTGTGAACAGGAGTGGCTTTGGAGAGATATCA
TCCCCTGTAATCCGGGAGGCAGAGGTGACACGGACTGCACGGAAACAGAGTGCTCAGAAAAGAGTTTTACTTCAGGCATCTCAAGATGAA
AATTTTGGTAATACTACACCAAGAAACCAGGTTATCCCTCGAACTCCTAGCTCATTTCGACAGCCTTTTACCCCAACAAGCCGAAGCTTA
CTAAGGCAGCCAGATATTTCCTGCATTCTTGGAACAGGAGGGAAGTCGCCCCGACTTACGCAGTCTTCAGGGTTCTTTGGAAATCTCTCC
ATGGTTACTAATCTGGATGACAGTAACTGGGCAGCTGCATTTTCATCACAGCGTTCCGGGCTGTTCACAAACACAGAGCCCCACAGTATA
ACAGAAGATGTAACTATCAGTGCTGTTATGTTACGTGAGGATGATCCTGGAGAAGCTGCATCCATGAGTATGTTTTCTGATTTCCTGCAG
TCTTTTCTGAAGCACTCTTCGAGTACAGTTTTTGATCTTGTGGAAGAGTATGAAAACATCTGTGGTAGTCAGGTGAATATACTGAGTAAA
ATAGTGAGTCGAGCAACACCTGGACTTCAAAAATTTTCAAAAACAGCCAGTATGCTCTGGCTTCTTCAACAGGAGATGGTCACATGGAGG
CTGCTGGCTTCTTTGTATAGAGACAGAATACAGTCTGCATTAGAAGAGGAAAGTGTATTCGCAGTTACTGCTGTTAATGCCAGTGAAAAA
ACAGTTGTGGAAGCGTTATTTCAGAGGGATTCACTTGTTCGACAAAGTCAGCTGGTGGTAGATTGGTTAGAGAGTATTGCCAAAGATGAA
ATTGGAGAATTTTCTGATAATATTGAGTTTTATGCAAAATCAGTATATTGGGAAAATACTCTGCATACCTTAAAACAACGGCAGCTGACT
TCTTACGTTGGAAGTGTTCGTCCGCTTGTCACTGAATTGGACCCTGATGCTCCCATAAGACAGAAAATGCCCCTTGATGATCTGGATAGA
GAAGATGAAGTTAGATTACTCAAATATCTCTTTACTCTAATCCGTGCTGGAATGACAGAAGAGGCACAACGACTCTGTAAACGCTGTGGT
CAAGCATGGAGAGCTGCAACACTTGAAGGCTGGAAACTGTACCATGACCCTAATGTTAATGGAGGAACAGAATTAGAACCTGTTGAAGGG
AATCCATATAGACGCATTTGGAAAATAAGTTGCTGGAGAATGGCAGAAGATGAGCTTTTTAATAGATACGAGAGAGCAATTTATGCAGCT
TTAAGTGGGAATCTTAAGCAGCTGCTTCCTGTCTGTGACACCTGGGAAGACACAGTTTGGGCCTACTTCCGGGTGATGGTGGACAGTCTG
GTAGAACAGGAGATCCAGACATCAGTAGCAACTCTGGATGAAACTGAAGAACTCCCTAGAGAATATCTGGGAGCAAACTGGACGTTAGAA
AAGGTTTTTGAGGAACTTCAAGCTACTGACAAAAAGAGAGTTCTGGAAGAGAATCAAGAACATTATCATATAGTTCAAAAGTTTCTTATC
CTGGGAGACATTGATGGTTTGATGGATGAGTTTAGCAAATGGCTTTCCAAAAGCAGAAACAATCTACCTGGACACCTGCTTCGCTTTATG
ACTCACCTTATTTTGTTTTTCCGTACTCTGGGACTACAGACCAAGGAGGAAGTTTCTATTGAAGTTTTAAAGACATACATACAGCTTTTA
ATAAGAGAGAAACATACAAATCTTATAGCATTTTATACCTGTCATTTGCCTCAAGACCTAGCTGTTGCCCAGTATGCATTATTTTTGGAA
AGTGTTACAGAATTTGAACAGCGCCACCATTGCCTGGAGTTGGCTAAAGAAGCAGATTTGGATGTTGCAACAATAACAAAAACTGTAGTT
GAGAATATTCGAAAGAAAGATAATGGTGAATTTAGTCATCATGACCTGGCCCCAGCCCTAGATACTGGCACTACTGAGGAGGATCGTTTA
AAAATTGATGTAATTGACTGGTTGGTATTTGACCCAGCGCAGAGGGCAGAAGCACTGAAACAAGGCAATGCAATTATGAGAAAATTCTTG
GCATCAAAAAAGCACGAAGCTGCAAAAGAAGTATTTGTGAAAATTCCTCAGGATTCTATAGCAGAAATCTATAATCAGTGCGAGGAACAA
GGAATGGAAAGTCCACTTCCTGCTGAAGATGATAATGCTATCCGAGAACATTTGTGCATCAGAGCTTATTTGGAAGCCCATGAAACCTTT
AATGAGTGGTTTAAGCATATGAATTCAGTTCCACAAAAACCTGCTTTGATACCTCAACCAACTTTTACTGAGAAAGTGGCTCATGAACAC
AAAGAAAAGAAATATGAAATGGATTTTGGTATTTGGAAAGGGCATTTGGATGCCCTAACTGCTGATGTGAAGGAGAAAATGTATAACGTC
TTGTTGTTTGTTGATGGAGGGTGGATGGTGGATGTTAGAGAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGA
AAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATG
GTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATG
CTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGT
TTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATAT
TATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTA
CAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTT
AAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTA
AAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTT

>17743_17743_1_CNOT2-NUP107_CNOT2_chr12_70724249_ENST00000229195_NUP107_chr12_69082742_ENST00000229179_length(amino acids)=1125AA_BP=202
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPN
RSSPSIICMPKQQPSRQPFTVNRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGNTTPRNQVIPRTPSSFRQPFTPTSRSL
LRQPDISCILGTGGKSPRLTQSSGFFGNLSMVTNLDDSNWAAAFSSQRSGLFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQ
SFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEEESVFAVTAVNASEK
TVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFSDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDR
EDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAA
LSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLI
LGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLE
SVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFL
ASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEH
KEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADM

--------------------------------------------------------------
>17743_17743_2_CNOT2-NUP107_CNOT2_chr12_70724249_ENST00000418359_NUP107_chr12_69082742_ENST00000229179_length(transcript)=4333nt_BP=1020nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGACAAACAGCATGTTTGGTGCTTCAAGAAAGAAGTTTGT
AGAGGGGGTCGACAGTGACTACCATGACGAAAACATGTACTACAGCCAGTCTTCTATGTTTCCACATCGGTCAGAAAAAGATATGCTGGC
ATCACCATCTACATCAGGTCAGCTGTCTCAGTTTGGGGCAAGTTTATACGGGCAACAAAGTGCACTAGGCCTTCCAATGAGGGGGATGAG
CAACAATACCCCTCAGTTAAATCGCAGCTTATCACAAGGCACTCAGTTACCGAGCCACGTCACGCCAACAACAGGGGTACCAACAATGTC
ACTTCACACGCCTCCATCTCCAAGCAGGGGTATTTTGCCTATGAATCCTAGGAATATGATGAACCACTCCCAGGTTGGTCAGGGCATTGG
AATTCCTAGCAGGACAAATAGCATGAGCAGTTCAGGGTTAGGTAGCCCCAACAGAAGCTCGCCAAGCATAATATGTATGCCAAAGCAGCA
GCCTTCTCGACAGCCTTTTACTGTGAACAGGAGTGGCTTTGGAGAGATATCATCCCCTGTAATCCGGGAGGCAGAGGTGACACGGACTGC
ACGGAAACAGAGTGCTCAGAAAAGAGTTTTACTTCAGGCATCTCAAGATGAAAATTTTGGTAATACTACACCAAGAAACCAGGTTATCCC
TCGAACTCCTAGCTCATTTCGACAGCCTTTTACCCCAACAAGCCGAAGCTTACTAAGGCAGCCAGATATTTCCTGCATTCTTGGAACAGG
AGGGAAGTCGCCCCGACTTACGCAGTCTTCAGGGTTCTTTGGAAATCTCTCCATGGTTACTAATCTGGATGACAGTAACTGGGCAGCTGC
ATTTTCATCACAGCGTTCCGGGCTGTTCACAAACACAGAGCCCCACAGTATAACAGAAGATGTAACTATCAGTGCTGTTATGTTACGTGA
GGATGATCCTGGAGAAGCTGCATCCATGAGTATGTTTTCTGATTTCCTGCAGTCTTTTCTGAAGCACTCTTCGAGTACAGTTTTTGATCT
TGTGGAAGAGTATGAAAACATCTGTGGTAGTCAGGTGAATATACTGAGTAAAATAGTGAGTCGAGCAACACCTGGACTTCAAAAATTTTC
AAAAACAGCCAGTATGCTCTGGCTTCTTCAACAGGAGATGGTCACATGGAGGCTGCTGGCTTCTTTGTATAGAGACAGAATACAGTCTGC
ATTAGAAGAGGAAAGTGTATTCGCAGTTACTGCTGTTAATGCCAGTGAAAAAACAGTTGTGGAAGCGTTATTTCAGAGGGATTCACTTGT
TCGACAAAGTCAGCTGGTGGTAGATTGGTTAGAGAGTATTGCCAAAGATGAAATTGGAGAATTTTCTGATAATATTGAGTTTTATGCAAA
ATCAGTATATTGGGAAAATACTCTGCATACCTTAAAACAACGGCAGCTGACTTCTTACGTTGGAAGTGTTCGTCCGCTTGTCACTGAATT
GGACCCTGATGCTCCCATAAGACAGAAAATGCCCCTTGATGATCTGGATAGAGAAGATGAAGTTAGATTACTCAAATATCTCTTTACTCT
AATCCGTGCTGGAATGACAGAAGAGGCACAACGACTCTGTAAACGCTGTGGTCAAGCATGGAGAGCTGCAACACTTGAAGGCTGGAAACT
GTACCATGACCCTAATGTTAATGGAGGAACAGAATTAGAACCTGTTGAAGGGAATCCATATAGACGCATTTGGAAAATAAGTTGCTGGAG
AATGGCAGAAGATGAGCTTTTTAATAGATACGAGAGAGCAATTTATGCAGCTTTAAGTGGGAATCTTAAGCAGCTGCTTCCTGTCTGTGA
CACCTGGGAAGACACAGTTTGGGCCTACTTCCGGGTGATGGTGGACAGTCTGGTAGAACAGGAGATCCAGACATCAGTAGCAACTCTGGA
TGAAACTGAAGAACTCCCTAGAGAATATCTGGGAGCAAACTGGACGTTAGAAAAGGTTTTTGAGGAACTTCAAGCTACTGACAAAAAGAG
AGTTCTGGAAGAGAATCAAGAACATTATCATATAGTTCAAAAGTTTCTTATCCTGGGAGACATTGATGGTTTGATGGATGAGTTTAGCAA
ATGGCTTTCCAAAAGCAGAAACAATCTACCTGGACACCTGCTTCGCTTTATGACTCACCTTATTTTGTTTTTCCGTACTCTGGGACTACA
GACCAAGGAGGAAGTTTCTATTGAAGTTTTAAAGACATACATACAGCTTTTAATAAGAGAGAAACATACAAATCTTATAGCATTTTATAC
CTGTCATTTGCCTCAAGACCTAGCTGTTGCCCAGTATGCATTATTTTTGGAAAGTGTTACAGAATTTGAACAGCGCCACCATTGCCTGGA
GTTGGCTAAAGAAGCAGATTTGGATGTTGCAACAATAACAAAAACTGTAGTTGAGAATATTCGAAAGAAAGATAATGGTGAATTTAGTCA
TCATGACCTGGCCCCAGCCCTAGATACTGGCACTACTGAGGAGGATCGTTTAAAAATTGATGTAATTGACTGGTTGGTATTTGACCCAGC
GCAGAGGGCAGAAGCACTGAAACAAGGCAATGCAATTATGAGAAAATTCTTGGCATCAAAAAAGCACGAAGCTGCAAAAGAAGTATTTGT
GAAAATTCCTCAGGATTCTATAGCAGAAATCTATAATCAGTGCGAGGAACAAGGAATGGAAAGTCCACTTCCTGCTGAAGATGATAATGC
TATCCGAGAACATTTGTGCATCAGAGCTTATTTGGAAGCCCATGAAACCTTTAATGAGTGGTTTAAGCATATGAATTCAGTTCCACAAAA
ACCTGCTTTGATACCTCAACCAACTTTTACTGAGAAAGTGGCTCATGAACACAAAGAAAAGAAATATGAAATGGATTTTGGTATTTGGAA
AGGGCATTTGGATGCCCTAACTGCTGATGTGAAGGAGAAAATGTATAACGTCTTGTTGTTTGTTGATGGAGGGTGGATGGTGGATGTTAG
AGAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATAC
GATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTC
TAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAAT
TCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTT
TTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTT
CTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAA
ATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAA
GCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACA
TAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAGCAAACTTCCTATCAAAATAAGAGCATATAAA

>17743_17743_2_CNOT2-NUP107_CNOT2_chr12_70724249_ENST00000418359_NUP107_chr12_69082742_ENST00000229179_length(amino acids)=1125AA_BP=202
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYG
QQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPN
RSSPSIICMPKQQPSRQPFTVNRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGNTTPRNQVIPRTPSSFRQPFTPTSRSL
LRQPDISCILGTGGKSPRLTQSSGFFGNLSMVTNLDDSNWAAAFSSQRSGLFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQ
SFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEEESVFAVTAVNASEK
TVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFSDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDR
EDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAA
LSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLI
LGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLE
SVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFL
ASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEH
KEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADM

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Fusion Gene PPI Analysis for CNOT2-NUP107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT2-NUP107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT2-NUP107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource