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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT2-SLCO1A2 (FusionGDB2 ID:17752)

Fusion Gene Summary for CNOT2-SLCO1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT2-SLCO1A2
Fusion gene ID: 17752
HgeneTgene
Gene symbol

CNOT2

SLCO1A2

Gene ID

4848

6579

Gene nameCCR4-NOT transcription complex subunit 2solute carrier organic anion transporter family member 1A2
SynonymsCDC36|HSPC131|IDNADFS|NOT2|NOT2HOATP|OATP-A|OATP1A2|SLC21A3
Cytomap

12q15

12p12.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2solute carrier organic anion transporter family member 1A2OATP-1organic anion transporting polypeptide Aorganic anion-transporting polypeptide 1sodium-independent organic anion transportersolute carrier family 21 (organic anion transporter), member 3
Modification date2020031320200313
UniProtAcc

Q9NZN8

.
Ensembl transtripts involved in fusion geneENST00000229195, ENST00000418359, 
ENST00000548230, ENST00000551483, 
ENST00000390670, ENST00000452078, 
ENST00000458504, ENST00000473830, 
ENST00000307378, ENST00000537524, 
Fusion gene scores* DoF score41 X 13 X 11=58637 X 5 X 6=210
# samples 468
** MAII scorelog2(46/5863*10)=-3.6719332904521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT2 [Title/Abstract] AND SLCO1A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT2(70672054)-SLCO1A2(21445270), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check buttonFusion gene breakpoints across CNOT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLCO1A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TQ-A7RH-01ACNOT2chr12

70672054

-SLCO1A2chr12

21445270

-
ChimerDB4LGGTCGA-TQ-A7RH-01ACNOT2chr12

70672054

+SLCO1A2chr12

21445270

-


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Fusion Gene ORF analysis for CNOT2-SLCO1A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000229195ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000229195ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
5CDS-intronENST00000418359ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000229195ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000229195ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000418359ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
In-frameENST00000418359ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000548230ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000548230ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000551483ENST00000307378CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-3CDSENST00000551483ENST00000537524CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000548230ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000390670CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000452078CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000458504CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-
intron-intronENST00000551483ENST00000473830CNOT2chr12

70672054

+SLCO1A2chr12

21445270

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229195CNOT2chr1270672054+ENST00000307378SLCO1A2chr1221445270-61516275401202220
ENST00000229195CNOT2chr1270672054+ENST00000537524SLCO1A2chr1221445270-12926275401202220
ENST00000418359CNOT2chr1270672054+ENST00000307378SLCO1A2chr1221445270-60234994121074220
ENST00000418359CNOT2chr1270672054+ENST00000537524SLCO1A2chr1221445270-11644994121074220

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229195ENST00000307378CNOT2chr1270672054+SLCO1A2chr1221445270-0.0078672110.99213284
ENST00000229195ENST00000537524CNOT2chr1270672054+SLCO1A2chr1221445270-0.0101093940.9898906
ENST00000418359ENST00000307378CNOT2chr1270672054+SLCO1A2chr1221445270-0.0079464480.9920535
ENST00000418359ENST00000537524CNOT2chr1270672054+SLCO1A2chr1221445270-0.0101531060.9898469

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Fusion Genomic Features for CNOT2-SLCO1A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNOT2-SLCO1A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70672054/chr12:21445270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT2

Q9NZN8

.
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116537_545479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116572_605479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116624_670479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013537_545477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013572_605477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013624_670477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914537_545479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914572_605479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914624_670479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116514_536479671.0TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116546_571479671.0TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116606_623479671.0TransmembraneHelical%3B Name%3D12
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013514_536477580.0TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013546_571477580.0TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013606_623477580.0TransmembraneHelical%3B Name%3D12
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914514_536479671.0TransmembraneHelical%3B Name%3D10
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914546_571479671.0TransmembraneHelical%3B Name%3D11
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914606_623479671.0TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNOT2chr12:70672054chr12:21445270ENST00000229195+216437_54016541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70672054chr12:21445270ENST00000418359+317437_54016541.0RegionNote=Repressor domain
HgeneCNOT2chr12:70672054chr12:21445270ENST00000551483+17437_5400192.0RegionNote=Repressor domain
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116433_488479671.0DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013433_488477580.0DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914433_488479671.0DomainKazal-like
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116112_155479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116185_203479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000030737811161_20479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116225_242479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116268_311479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116334_353479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116378_381479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116406_513479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378111641_59479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378111681_86479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013112_155477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013185_203477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000039067010131_20477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013225_242477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013268_311477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013334_353477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013378_381477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013406_513477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670101341_59477580.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670101381_86477580.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914112_155479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914185_203479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000004520789141_20479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914225_242479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914268_311479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914334_353479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914378_381479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914406_513479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000045207891441_59479671.0Topological domainExtracellular
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000045207891481_86479671.0Topological domainCytoplasmic
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116156_184479671.0TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116204_224479671.0TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378111621_40479671.0TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116243_267479671.0TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116312_333479671.0TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116354_377479671.0TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003073781116382_405479671.0TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378111660_80479671.0TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000307378111687_111479671.0TransmembraneHelical%3B Name%3D3
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013156_184477580.0TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013204_224477580.0TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670101321_40477580.0TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013243_267477580.0TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013312_333477580.0TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013354_377477580.0TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST000003906701013382_405477580.0TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670101360_80477580.0TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000390670101387_111477580.0TransmembraneHelical%3B Name%3D3
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914156_184479671.0TransmembraneHelical%3B Name%3D4
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914204_224479671.0TransmembraneHelical%3B Name%3D5
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000045207891421_40479671.0TransmembraneHelical%3B Name%3D1
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914243_267479671.0TransmembraneHelical%3B Name%3D6
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914312_333479671.0TransmembraneHelical%3B Name%3D7
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914354_377479671.0TransmembraneHelical%3B Name%3D8
TgeneSLCO1A2chr12:70672054chr12:21445270ENST00000452078914382_405479671.0TransmembraneHelical%3B Name%3D9
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000045207891460_80479671.0TransmembraneHelical%3B Name%3D2
TgeneSLCO1A2chr12:70672054chr12:21445270ENST0000045207891487_111479671.0TransmembraneHelical%3B Name%3D3


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Fusion Gene Sequence for CNOT2-SLCO1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17752_17752_1_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000229195_SLCO1A2_chr12_21445270_ENST00000307378_length(transcript)=6151nt_BP=627nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTC
CAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTA
ATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGT
GAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTCCTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGT
TTTAAAAATCAGTAGAGATATAATAGATAACTTTTTCTTGTCTTTAAGAACCTAAAAAACCTCTTAACTCAAAATAATAAAATGTTCACT
AATGATATTTCTAAGGTATCAGTGACACTTGAGTTTTCCTAGGAGGGACATCAATAACAGCCCCCTAAAGAAGATTCTTAGAGCCAGCTT
TATTTTTATGTTGAAACAGCAATTTCCCTTAATTCATCGAAGTAAGGGTGTACTTCCTACATCTCCTTCTACTAATACTTCTAAAAATTT
TCTGTTATGAAAACCTATTTAATTCCACTAAATTTGTTCTTTGATATTGGAATTATTCAGATGCCTAAATTCTCATTCTGTTATGTGAAG
ATTTAAATATTTTATTCAAGTTTATCGCTTCCATGTGAGAGAAGCCTACATCTTCTTATTCTATTTAGGAATCGTTCTTTAACTCTTCTT
ATTCATTCTAGGCATGACTCCTATATAATAGATTACTCATAAATATACCCTCCTACTTTCAATTTTTTCTTTTCTTTATTACTCATACAT
TTGCTCAATTTGTACAGAATACTGACAAACTTAAGCAGGTTATTAAACATCATGAGGCAAAGATTGTTGGATTTTTTTTCAGTAATTCAA
ATCCAGTGACTAAAGTTTTTCTTACAAACAAGTGTCTGAATCAAAGGATGAAAGGACAATATTATAAAAACTCCAGTTCTTAAAGGCTGT
TTGTAATGTCAGATATTGTCAAAGAACCACTTTCTAAGATTCAGGACTCTTTAGACCGATGTTTATATCACCCATTGTGTCCTAAGGTAG
AACACAAACACTAATTTTCCCAAAATAATCTTAGACAATAGCTTCTGTTATGAAACAGAGGTTAGTAAAGGCTAAGGTACATATTAAAAG
CTAAATCTACTTATATTATTATTTTGTAAATTATGGATAAAATTAAAAATTGAAGGATTTTAGACATAGAAGAGGACTTATTGATTAATA
TAGGGCTTCTGGTAAAAGAGAATAGAATGAACAGACAAATACCTGTTTGTCTACTCCTTACTCTCCTTCCTGTTGAAATGACAGTCAATA
TATAAGAATGACATAAATCCCTAATGGATGAAGAGAATGGAGTAAGGAAGGGTGGGAGAAGTGGGTGTCAATACACTATGGTTATTTATG
TGTACTATAAATGGAGTGAGAGTGTCTGCAGGGATACAACAGAGTGGAGGAAGCTGAAATACAGAATATACCTAGAAGGAGCCTGGAATG
GAAGTGTGAAACTGAGTTGCCAGTTCAAAGTGTGAGTTGGTAGCTGGACAGAAAGCAGGCCAGTTAACTGAAGGACTTTGTACAGATGCT
TTACAGGTTAATATGATTTCCTAAATGATCAGATGCATCATATGAAAAAAGAAAGCAAATGAGAAGAGAAAGGCTGTATAGAACAGGTTT
AGGGGGAAGGATGAAAAGTTAAGTTTCAGTTTCATGAAGTTTGAGACTTCAACTCTGGGCATATAAAAAATAACCAAGGTTCAAACCAAG
ACTGGCTTTGAAACAAGAGAGAGGAACTAAAATCATTGGAAAGGGGGAGTTTAACTTTGATGTAGGTATGACTGCAGCAGTGAGATATCG
TATTAAGATCTGATGACATGAAATTTGGAGCCACTTCCTTTGTGGTGGGAGGAAGTGAGGAGAATGGCCTGGAAACTAAAACAAGGAGAA
GAGACTTACCTATATTCACAGAGCAGCAAGAAAAAGTAAACAGCCACTGCATGAGAAGGTTTCAGGGGAATCAGATTTTGCTGAGTGTGC
GATGGTGAAGAGAATGCTCATTTCTGAACTGGAATCTGAGCTAAAAAGAAGCAAATAGGATATATATGGAAGTTAGACTTATGGAAATTA
GAAGAAGGGGAATGAGAGATAGTTTGGAATTCTGTGGCTATTTAGGTGACTGACATAAATGGGGGCAGAGGACATAATGAGGTTAGTTCT
TACGGATTCAAGGCAGATAGTGTTGGTGAAACAGTGAGTGTCAAAATTAGGCGAGGTGGTGACTGGGCTCCCTGATGACCTCTTGTCGTG
GAGCAAAACTGAATAAGCAAAAACTTACTCAAGCTCCTGAGGCCCATTCATCATCCCTATTGATAGATTTGAGGTGATCTGAGAAAGCTG
AGTCTTGCTTTGTGGACAATTCACCCACTTGAACTCCCTCAATGGAGCATCATAGGCCCAGAGAGACATGGCTATGGACTTAGTACCTTG
GCATCACTTTTATCCCCTCATGGAGGAGATGGCATTTTACTCTGAAAACATAGGGTTCTCCTTTGACACTTCTTGGTGGGAGAAAGCAGG
TCAGAGAAAGTGGGTGTTGGAGTGCTTTGGGATCCCTCATGACCTCTTTTGTTGGTATACATGAAGCCTGGGAGTTTAGTTCTTATTCTG
AGCACTTGTACTACTCTCATGAGGGTAGAGATAATGGCATAGCGGACAGACATGGAGAAGAGAAACAAGAGAACAGGTAGTGAGAAGTCG
AGAGTCAGTAATTTTCTTACTTAATATTGTGGGGATCTTACTTAATACATAAAGTTAATGAAACTAGAAATAGTGGTTTAATATATTACT
TATAATTCAAAAATTAACCTATATTTACAGATGCTTACACAGTTTCTTTGTGAATCCACCTATGGTTTTATTTTAATTAATTTTTTATTG
CAAAGCAATGAAATGTTGCTTTGTGGAGCCAGATAGCATTACAGCAGGTAAATGGGTTTCTGCTAGATCTCCACATTATTGGGGAGATGC
TCGAAGACCTCAGAATATACACACCCTTAAGGTTCAAGGGCTGGGGTTGAGCTCTCCATAAGGAACTTTTCCTCCTCCCAGAAGGGCGAT
CATTGTGTATATAGACATGGAGACAGAACCAGAATGACTTCTGTGGGTGGAAATAGTGCCATCAGAATCATTTATTATTATGAAATAAAT
ATTATTTATCTACATTGAAAAAATACTACTCCTCCTAAAATCATTAACTTTTCCTCAGATGATTTTAAGAAATTTGAGTAATAGCACACG
AAGTGGTAAAGACCCTTAGTCTTTCTGGTATATTAGAAAAGCCTTTTAATCAGTCTCTGGAAGGACACTAGGGATTGCAGCTGAATAAAT
ATATTAAGAATAACAAATCAGTTCAACAAGGAGTAGAGTCTGAAGTGGGATTTTCCGTGGAAATTCTCTTATGTCTGTACTAACAATAAG
AAAGACAAGACAAAGACTAAGTAATTAAAGAAAAGCTCGAAATGTTTTGTAACCAAAAGCTTGAAATGTTATGTAACCAGAATGTTATGT
AACCAGAGCTGTTAGATCAGATACTGGCTGATTCATAGGTGAACGTCCTCTTTGTGGGTCCTCTCATGCATCCCCATTTTCAGAATGTAA
ATAATTTGGCTTTGTAGCCCTTCCAAAAAGGGTACTATCCCACTTCTCCTGGCATAAATCATACATTGACTGAACGTTCACCATCTAAAA
ATCACTCATGCTCCTTGAACCAAGGTGATTATCAGAGACAGCTCCTGGTAGAAGAGGTTGTAGATGTTAAAAGAGTATGATTTCTATATA
AGAAAATATAGAAATTGACAGAATGGTTCTTATTTACTGGGCCTGGAGAATTCCTGTTCTGGCATTCTTAGATCCCTCAAATTTATTACC
AAGGGGAAAAGGAAAAAGAGGCAAGTAGGCAGTAGGGTAAGCTGTTGTTTGCTTGCCAAGGAACTGGAGAGTGCAGGTTTCAAGACACCT
TGAGGAAATTCTCCTGAGCCCTTAGCCAAGAGAAGAGAGCAGAAAATGCTTTTCTGTAGAATCCCAAGAGGCATAAAAGAGGATGAGTAA
CTGGGTCCTGTGCCAAGTTCCCAACCCCTAAGCCTTCCCAACATGGAGAAACTACACCAGTGTTTAAAAGTTTCTAGGTTGGAGGAACAA
ACTTGAGCATCAAGGGCAGATGATTTGTTAACACAGTCCTGTGCAGAGGGCTCCTTCAGAAGGCATCCCCTGTGACCCAAACACAGTGAG
CACCTTCTACTTTCTGGCCTTATGCCATCAATGCATCCAGCTGCAATCTATCCTCAAACCTGGAATCCATCTCTTGACTTCCCAGCCAGA
CCACCTTCCATCCCTTCACTGTGTCCCACCCTGCCCAGAATGCATGCTGTTCTCCCAGAGTCTCATGGAAATAAGGCCTTGCACTGAAAT
AGGCTGTGGGAAACAAAAGGATAAGCAGGTCTGGACCAGTCTGTAATGGTAGCAGGTGAAAACAACTTACGGAAAAACACATGAATTCAT
TAGGAAATAAGGTGACAGATCCCCAGCTGCTGAAGAACTAGAATGTCTATTACACTCATACAATTGATGTTTTATTTTAATACACCAGAG
CTACCACACAAAACTTCCTTCCATGTGAAAGGCTCCAGATAAAATTCTGCCATCCCTCCTCTCCTCATGTCCTCCTGCTCAGACCCACCT
TCATGCCCCTAAACCAATCTGCATCATGCCTGTTTCAGAGAGTCATGGGAAGATGGGCAGTGCCTCCATTGTCACCATTCCCCACACCTC
TGCACACTTCTGCCCCTTCCCCTCTAGACGCCACAACTTCACAGTCTTACTGTTGTAAATATTCCTGCACAGTTAGTAATGATCAAATGA
TCCTGTGGTCAGAGGCCTCTTTGGCAGTGTCTTCTTACCCTTAAGAAAGGTCATGAAATCCAGAAGGGGCAACCTTTCCAGGAGAGCTTT
GGAGTCATTTCTGTGTGAGACACTATTGCATAATCCTGTAAGATTGCTTTTATATTTAAGGAATGATGTTACTTAACAAATGAACAAAAA

>17752_17752_1_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000229195_SLCO1A2_chr12_21445270_ENST00000307378_length(amino acids)=220AA_BP=28
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPG

--------------------------------------------------------------
>17752_17752_2_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000229195_SLCO1A2_chr12_21445270_ENST00000537524_length(transcript)=1292nt_BP=627nt
AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC
GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT
AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC
TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC
GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC
CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT
TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTC
CAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTA
ATGGATTCCACATGTTTACACTGGGGAACTTTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGT
GAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTCCTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGT

>17752_17752_2_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000229195_SLCO1A2_chr12_21445270_ENST00000537524_length(amino acids)=220AA_BP=28
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPG

--------------------------------------------------------------
>17752_17752_3_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000418359_SLCO1A2_chr12_21445270_ENST00000307378_length(transcript)=6023nt_BP=499nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTC
ATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCAT
TTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATT
TTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATG
TGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTT
TGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAA
AGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTTTTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTC
CTATTATATTACTTTTTTCAGAATTAGAGAACATGCTGTACAACTTAATTGTTTTAAAAATCAGTAGAGATATAATAGATAACTTTTTCT
TGTCTTTAAGAACCTAAAAAACCTCTTAACTCAAAATAATAAAATGTTCACTAATGATATTTCTAAGGTATCAGTGACACTTGAGTTTTC
CTAGGAGGGACATCAATAACAGCCCCCTAAAGAAGATTCTTAGAGCCAGCTTTATTTTTATGTTGAAACAGCAATTTCCCTTAATTCATC
GAAGTAAGGGTGTACTTCCTACATCTCCTTCTACTAATACTTCTAAAAATTTTCTGTTATGAAAACCTATTTAATTCCACTAAATTTGTT
CTTTGATATTGGAATTATTCAGATGCCTAAATTCTCATTCTGTTATGTGAAGATTTAAATATTTTATTCAAGTTTATCGCTTCCATGTGA
GAGAAGCCTACATCTTCTTATTCTATTTAGGAATCGTTCTTTAACTCTTCTTATTCATTCTAGGCATGACTCCTATATAATAGATTACTC
ATAAATATACCCTCCTACTTTCAATTTTTTCTTTTCTTTATTACTCATACATTTGCTCAATTTGTACAGAATACTGACAAACTTAAGCAG
GTTATTAAACATCATGAGGCAAAGATTGTTGGATTTTTTTTCAGTAATTCAAATCCAGTGACTAAAGTTTTTCTTACAAACAAGTGTCTG
AATCAAAGGATGAAAGGACAATATTATAAAAACTCCAGTTCTTAAAGGCTGTTTGTAATGTCAGATATTGTCAAAGAACCACTTTCTAAG
ATTCAGGACTCTTTAGACCGATGTTTATATCACCCATTGTGTCCTAAGGTAGAACACAAACACTAATTTTCCCAAAATAATCTTAGACAA
TAGCTTCTGTTATGAAACAGAGGTTAGTAAAGGCTAAGGTACATATTAAAAGCTAAATCTACTTATATTATTATTTTGTAAATTATGGAT
AAAATTAAAAATTGAAGGATTTTAGACATAGAAGAGGACTTATTGATTAATATAGGGCTTCTGGTAAAAGAGAATAGAATGAACAGACAA
ATACCTGTTTGTCTACTCCTTACTCTCCTTCCTGTTGAAATGACAGTCAATATATAAGAATGACATAAATCCCTAATGGATGAAGAGAAT
GGAGTAAGGAAGGGTGGGAGAAGTGGGTGTCAATACACTATGGTTATTTATGTGTACTATAAATGGAGTGAGAGTGTCTGCAGGGATACA
ACAGAGTGGAGGAAGCTGAAATACAGAATATACCTAGAAGGAGCCTGGAATGGAAGTGTGAAACTGAGTTGCCAGTTCAAAGTGTGAGTT
GGTAGCTGGACAGAAAGCAGGCCAGTTAACTGAAGGACTTTGTACAGATGCTTTACAGGTTAATATGATTTCCTAAATGATCAGATGCAT
CATATGAAAAAAGAAAGCAAATGAGAAGAGAAAGGCTGTATAGAACAGGTTTAGGGGGAAGGATGAAAAGTTAAGTTTCAGTTTCATGAA
GTTTGAGACTTCAACTCTGGGCATATAAAAAATAACCAAGGTTCAAACCAAGACTGGCTTTGAAACAAGAGAGAGGAACTAAAATCATTG
GAAAGGGGGAGTTTAACTTTGATGTAGGTATGACTGCAGCAGTGAGATATCGTATTAAGATCTGATGACATGAAATTTGGAGCCACTTCC
TTTGTGGTGGGAGGAAGTGAGGAGAATGGCCTGGAAACTAAAACAAGGAGAAGAGACTTACCTATATTCACAGAGCAGCAAGAAAAAGTA
AACAGCCACTGCATGAGAAGGTTTCAGGGGAATCAGATTTTGCTGAGTGTGCGATGGTGAAGAGAATGCTCATTTCTGAACTGGAATCTG
AGCTAAAAAGAAGCAAATAGGATATATATGGAAGTTAGACTTATGGAAATTAGAAGAAGGGGAATGAGAGATAGTTTGGAATTCTGTGGC
TATTTAGGTGACTGACATAAATGGGGGCAGAGGACATAATGAGGTTAGTTCTTACGGATTCAAGGCAGATAGTGTTGGTGAAACAGTGAG
TGTCAAAATTAGGCGAGGTGGTGACTGGGCTCCCTGATGACCTCTTGTCGTGGAGCAAAACTGAATAAGCAAAAACTTACTCAAGCTCCT
GAGGCCCATTCATCATCCCTATTGATAGATTTGAGGTGATCTGAGAAAGCTGAGTCTTGCTTTGTGGACAATTCACCCACTTGAACTCCC
TCAATGGAGCATCATAGGCCCAGAGAGACATGGCTATGGACTTAGTACCTTGGCATCACTTTTATCCCCTCATGGAGGAGATGGCATTTT
ACTCTGAAAACATAGGGTTCTCCTTTGACACTTCTTGGTGGGAGAAAGCAGGTCAGAGAAAGTGGGTGTTGGAGTGCTTTGGGATCCCTC
ATGACCTCTTTTGTTGGTATACATGAAGCCTGGGAGTTTAGTTCTTATTCTGAGCACTTGTACTACTCTCATGAGGGTAGAGATAATGGC
ATAGCGGACAGACATGGAGAAGAGAAACAAGAGAACAGGTAGTGAGAAGTCGAGAGTCAGTAATTTTCTTACTTAATATTGTGGGGATCT
TACTTAATACATAAAGTTAATGAAACTAGAAATAGTGGTTTAATATATTACTTATAATTCAAAAATTAACCTATATTTACAGATGCTTAC
ACAGTTTCTTTGTGAATCCACCTATGGTTTTATTTTAATTAATTTTTTATTGCAAAGCAATGAAATGTTGCTTTGTGGAGCCAGATAGCA
TTACAGCAGGTAAATGGGTTTCTGCTAGATCTCCACATTATTGGGGAGATGCTCGAAGACCTCAGAATATACACACCCTTAAGGTTCAAG
GGCTGGGGTTGAGCTCTCCATAAGGAACTTTTCCTCCTCCCAGAAGGGCGATCATTGTGTATATAGACATGGAGACAGAACCAGAATGAC
TTCTGTGGGTGGAAATAGTGCCATCAGAATCATTTATTATTATGAAATAAATATTATTTATCTACATTGAAAAAATACTACTCCTCCTAA
AATCATTAACTTTTCCTCAGATGATTTTAAGAAATTTGAGTAATAGCACACGAAGTGGTAAAGACCCTTAGTCTTTCTGGTATATTAGAA
AAGCCTTTTAATCAGTCTCTGGAAGGACACTAGGGATTGCAGCTGAATAAATATATTAAGAATAACAAATCAGTTCAACAAGGAGTAGAG
TCTGAAGTGGGATTTTCCGTGGAAATTCTCTTATGTCTGTACTAACAATAAGAAAGACAAGACAAAGACTAAGTAATTAAAGAAAAGCTC
GAAATGTTTTGTAACCAAAAGCTTGAAATGTTATGTAACCAGAATGTTATGTAACCAGAGCTGTTAGATCAGATACTGGCTGATTCATAG
GTGAACGTCCTCTTTGTGGGTCCTCTCATGCATCCCCATTTTCAGAATGTAAATAATTTGGCTTTGTAGCCCTTCCAAAAAGGGTACTAT
CCCACTTCTCCTGGCATAAATCATACATTGACTGAACGTTCACCATCTAAAAATCACTCATGCTCCTTGAACCAAGGTGATTATCAGAGA
CAGCTCCTGGTAGAAGAGGTTGTAGATGTTAAAAGAGTATGATTTCTATATAAGAAAATATAGAAATTGACAGAATGGTTCTTATTTACT
GGGCCTGGAGAATTCCTGTTCTGGCATTCTTAGATCCCTCAAATTTATTACCAAGGGGAAAAGGAAAAAGAGGCAAGTAGGCAGTAGGGT
AAGCTGTTGTTTGCTTGCCAAGGAACTGGAGAGTGCAGGTTTCAAGACACCTTGAGGAAATTCTCCTGAGCCCTTAGCCAAGAGAAGAGA
GCAGAAAATGCTTTTCTGTAGAATCCCAAGAGGCATAAAAGAGGATGAGTAACTGGGTCCTGTGCCAAGTTCCCAACCCCTAAGCCTTCC
CAACATGGAGAAACTACACCAGTGTTTAAAAGTTTCTAGGTTGGAGGAACAAACTTGAGCATCAAGGGCAGATGATTTGTTAACACAGTC
CTGTGCAGAGGGCTCCTTCAGAAGGCATCCCCTGTGACCCAAACACAGTGAGCACCTTCTACTTTCTGGCCTTATGCCATCAATGCATCC
AGCTGCAATCTATCCTCAAACCTGGAATCCATCTCTTGACTTCCCAGCCAGACCACCTTCCATCCCTTCACTGTGTCCCACCCTGCCCAG
AATGCATGCTGTTCTCCCAGAGTCTCATGGAAATAAGGCCTTGCACTGAAATAGGCTGTGGGAAACAAAAGGATAAGCAGGTCTGGACCA
GTCTGTAATGGTAGCAGGTGAAAACAACTTACGGAAAAACACATGAATTCATTAGGAAATAAGGTGACAGATCCCCAGCTGCTGAAGAAC
TAGAATGTCTATTACACTCATACAATTGATGTTTTATTTTAATACACCAGAGCTACCACACAAAACTTCCTTCCATGTGAAAGGCTCCAG
ATAAAATTCTGCCATCCCTCCTCTCCTCATGTCCTCCTGCTCAGACCCACCTTCATGCCCCTAAACCAATCTGCATCATGCCTGTTTCAG
AGAGTCATGGGAAGATGGGCAGTGCCTCCATTGTCACCATTCCCCACACCTCTGCACACTTCTGCCCCTTCCCCTCTAGACGCCACAACT
TCACAGTCTTACTGTTGTAAATATTCCTGCACAGTTAGTAATGATCAAATGATCCTGTGGTCAGAGGCCTCTTTGGCAGTGTCTTCTTAC
CCTTAAGAAAGGTCATGAAATCCAGAAGGGGCAACCTTTCCAGGAGAGCTTTGGAGTCATTTCTGTGTGAGACACTATTGCATAATCCTG

>17752_17752_3_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000418359_SLCO1A2_chr12_21445270_ENST00000307378_length(amino acids)=220AA_BP=28
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPG

--------------------------------------------------------------
>17752_17752_4_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000418359_SLCO1A2_chr12_21445270_ENST00000537524_length(transcript)=1164nt_BP=499nt
AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC
TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG
AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC
GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG
AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC
TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGTGTTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTC
ATCTGCAGTTCTTGGGCTGTGCGACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGCAGTTTCAT
TTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAATCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATT
TTGCACAAGAGTATTTGCTGGCATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACTTTGAAATG
TGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATCTACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTT
TGTTCCAGCCTTAATCATCTTAATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATAGAGACAAA
AGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTTTTGAAAGATGATGAATTGAAAACTAAATTGTAATTGTC

>17752_17752_4_CNOT2-SLCO1A2_CNOT2_chr12_70672054_ENST00000418359_SLCO1A2_chr12_21445270_ENST00000537524_length(amino acids)=220AA_BP=28
MIASGTVRKGHDSMVRTDGHTLSEKRNYQVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CNOT2-SLCO1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT2-SLCO1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT2-SLCO1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource