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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNOT8-MTX2 (FusionGDB2 ID:17794)

Fusion Gene Summary for CNOT8-MTX2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNOT8-MTX2
Fusion gene ID: 17794
HgeneTgene
Gene symbol

CNOT8

MTX2

Gene ID

9337

10651

Gene nameCCR4-NOT transcription complex subunit 8metaxin 2
SynonymsCAF1|CALIF|Caf1b|POP2|hCAF1-
Cytomap

5q33.2

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionCCR4-NOT transcription complex subunit 8CAF1-like proteinCAF2CALIFpCCR4-associated factor 8PGK promoter directed over productionmetaxin-2mitochondrial outer membrane import complex protein 2
Modification date2020031320200327
UniProtAcc

Q9UFF9

O75431

Ensembl transtripts involved in fusion geneENST00000521402, ENST00000285896, 
ENST00000403027, ENST00000517876, 
ENST00000519404, ENST00000520671, 
ENST00000521450, ENST00000521583, 
ENST00000523698, ENST00000524105, 
ENST00000249442, ENST00000392529, 
ENST00000443241, 
Fusion gene scores* DoF score11 X 9 X 5=49511 X 5 X 8=440
# samples 1012
** MAII scorelog2(10/495*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNOT8 [Title/Abstract] AND MTX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNOT8(154242955)-MTX2(177202221), # samples:1
Anticipated loss of major functional domain due to fusion event.CNOT8-MTX2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CNOT8-MTX2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CNOT8-MTX2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNOT8

GO:0043928

exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

20065043


check buttonFusion gene breakpoints across CNOT8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR188441CNOT8chr5

154242955

+MTX2chr2

177202221

+


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Fusion Gene ORF analysis for CNOT8-MTX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521402ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
3UTR-3CDSENST00000521402ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
3UTR-3CDSENST00000521402ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
Frame-shiftENST00000285896ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
Frame-shiftENST00000403027ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
Frame-shiftENST00000517876ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
Frame-shiftENST00000519404ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000285896ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000285896ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000403027ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000403027ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000517876ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000517876ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000519404ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
In-frameENST00000519404ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000520671ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000520671ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000520671ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521450ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521450ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521450ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521583ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521583ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000521583ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000523698ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000523698ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000523698ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000524105ENST00000249442CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000524105ENST00000392529CNOT8chr5

154242955

+MTX2chr2

177202221

+
intron-3CDSENST00000524105ENST00000443241CNOT8chr5

154242955

+MTX2chr2

177202221

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000517876CNOT8chr5154242955+ENST00000392529MTX2chr2177202221+1119593134436100
ENST00000517876CNOT8chr5154242955+ENST00000443241MTX2chr2177202221+780593134436100
ENST00000403027CNOT8chr5154242955+ENST00000392529MTX2chr2177202221+1015489206069
ENST00000403027CNOT8chr5154242955+ENST00000443241MTX2chr2177202221+676489206069
ENST00000285896CNOT8chr5154242955+ENST00000392529MTX2chr2177202221+93841240458359
ENST00000285896CNOT8chr5154242955+ENST00000443241MTX2chr2177202221+59941240458359
ENST00000519404CNOT8chr5154242955+ENST00000392529MTX2chr2177202221+83230629847759
ENST00000519404CNOT8chr5154242955+ENST00000443241MTX2chr2177202221+49330629847759

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000517876ENST00000392529CNOT8chr5154242955+MTX2chr2177202221+0.72786930.27213076
ENST00000517876ENST00000443241CNOT8chr5154242955+MTX2chr2177202221+0.303970520.6960295
ENST00000403027ENST00000392529CNOT8chr5154242955+MTX2chr2177202221+0.508151770.49184826
ENST00000403027ENST00000443241CNOT8chr5154242955+MTX2chr2177202221+0.162938150.8370619
ENST00000285896ENST00000392529CNOT8chr5154242955+MTX2chr2177202221+0.54281890.45718113
ENST00000285896ENST00000443241CNOT8chr5154242955+MTX2chr2177202221+0.051869180.9481308
ENST00000519404ENST00000392529CNOT8chr5154242955+MTX2chr2177202221+0.422548150.5774519
ENST00000519404ENST00000443241CNOT8chr5154242955+MTX2chr2177202221+0.08598140.91401863

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Fusion Genomic Features for CNOT8-MTX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CNOT8chr5154242955+MTX2chr2177202220+5.15E-050.9999485
CNOT8chr5154242955+MTX2chr2177202220+5.15E-050.9999485

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CNOT8-MTX2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:154242955/chr2:177202221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNOT8

Q9UFF9

MTX2

O75431

FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.FUNCTION: Involved in transport of proteins into the mitochondrion. {ECO:0000269|PubMed:10381257}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CNOT8-MTX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17794_17794_1_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000285896_MTX2_chr2_177202221_ENST00000392529_length(transcript)=938nt_BP=412nt
GGGTAGAGTGGTGCCGTCCGGTTGTTTGGTGGGAGGCACGTAAGACCGCTCTGGGCACGGGGGCGCTCACCTCACTGGCTCGTTCGGTTC
TAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGCT
CGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGA
AGACGACTTCTCAGGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGA
AGAGATGAGGAAGATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTAT
ACACCATTCTTACCACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTG
AACAGCACTATTTTGAAGATCGTGGTAAAGGCAGGCTGTCATAGAGTTATGTGTTAGTCTCAGGAGTCTTAACTTTTGAAATATGTTTTA
CTTGAATGTTACATTAGATATTGGTGTCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAATTATATAATGTATCTTATGTAT
GTGCTTTATATTGTTATTTGTGTATACATTAAAATAATTCTGAATTATTTAATCTGATATGTTGTATTCTGTATCTTGAAATTTTTGTTT
CCTTGAAACATGCATGCATTTAAAAATAAAGCTTAAACAACTGTATGGATGTTACATTTACTTTCTTTTGATTTTTCTGAAAGTCATTCA

>17794_17794_1_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000285896_MTX2_chr2_177202221_ENST00000392529_length(amino acids)=59AA_BP=3

--------------------------------------------------------------
>17794_17794_2_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000285896_MTX2_chr2_177202221_ENST00000443241_length(transcript)=599nt_BP=412nt
GGGTAGAGTGGTGCCGTCCGGTTGTTTGGTGGGAGGCACGTAAGACCGCTCTGGGCACGGGGGCGCTCACCTCACTGGCTCGTTCGGTTC
TAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGCT
CGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGA
AGACGACTTCTCAGGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGA
AGAGATGAGGAAGATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTAT
ACACCATTCTTACCACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTG

>17794_17794_2_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000285896_MTX2_chr2_177202221_ENST00000443241_length(amino acids)=59AA_BP=3

--------------------------------------------------------------
>17794_17794_3_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000403027_MTX2_chr2_177202221_ENST00000392529_length(transcript)=1015nt_BP=489nt
AGAGAGCAGGCGAGTCGGGCGGATCGGGTGGGTAGAGTGGTGCCGTCCGGTTGTTTGGTGGGAGGCACGTAAGACCGCTCTGGGCACGGG
GGCGCTCACCTCACTGGCTCGTTCGGTTCTAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGT
CGGGGAGTCAGCCCGCCAGCCCGCCAGCTCGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGGTAAGCGGGCCTGCGCTT
ACCGGAAAGAGGAGCGTAAGATGAAAGAGTATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGAAGACGACTTCTCA
GGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGAAGAGATGAGGAAG
ATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTATACACCATTCTTAC
CACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTGAACAGCACTATTT
TGAAGATCGTGGTAAAGGCAGGCTGTCATAGAGTTATGTGTTAGTCTCAGGAGTCTTAACTTTTGAAATATGTTTTACTTGAATGTTACA
TTAGATATTGGTGTCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAATTATATAATGTATCTTATGTATGTGCTTTATATTG
TTATTTGTGTATACATTAAAATAATTCTGAATTATTTAATCTGATATGTTGTATTCTGTATCTTGAAATTTTTGTTTCCTTGAAACATGC
ATGCATTTAAAAATAAAGCTTAAACAACTGTATGGATGTTACATTTACTTTCTTTTGATTTTTCTGAAAGTCATTCACTGAATTTTACAC

>17794_17794_3_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000403027_MTX2_chr2_177202221_ENST00000392529_length(amino acids)=69AA_BP=

--------------------------------------------------------------
>17794_17794_4_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000403027_MTX2_chr2_177202221_ENST00000443241_length(transcript)=676nt_BP=489nt
AGAGAGCAGGCGAGTCGGGCGGATCGGGTGGGTAGAGTGGTGCCGTCCGGTTGTTTGGTGGGAGGCACGTAAGACCGCTCTGGGCACGGG
GGCGCTCACCTCACTGGCTCGTTCGGTTCTAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGT
CGGGGAGTCAGCCCGCCAGCCCGCCAGCTCGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGGTAAGCGGGCCTGCGCTT
ACCGGAAAGAGGAGCGTAAGATGAAAGAGTATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGAAGACGACTTCTCA
GGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGAAGAGATGAGGAAG
ATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTATACACCATTCTTAC
CACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTGAACAGCACTATTT

>17794_17794_4_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000403027_MTX2_chr2_177202221_ENST00000443241_length(amino acids)=69AA_BP=

--------------------------------------------------------------
>17794_17794_5_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000517876_MTX2_chr2_177202221_ENST00000392529_length(transcript)=1119nt_BP=593nt
GAGGACCAAAATGGAGGAGTAAGAATCATGATTAAATTGAGCGAGCGCAACTAATCACGCGAAGAGGGCCGCAGGCGGGCCGTCTTCCGC
AAGCGTGCTTCCAGGCCTCCACTCCCCACCTATTCGGCGGCACCCTGTTACTTCTGCTCCTGCGCGCTGCTTCCCGCGACCTCACAGGCA
GAGCGAACACGCACGGAGTCGCAGGGGCGCGCAAAGGGGGAGGAGCGGGCGTGACCAGGCGCGCGCGCGCGTCTGGAGTGACTCTAGAGA
GCAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGC
TCGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTG
AAGACGACTTCTCAGGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAG
AAGAGATGAGGAAGATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTA
TACACCATTCTTACCACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATT
GAACAGCACTATTTTGAAGATCGTGGTAAAGGCAGGCTGTCATAGAGTTATGTGTTAGTCTCAGGAGTCTTAACTTTTGAAATATGTTTT
ACTTGAATGTTACATTAGATATTGGTGTCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAATTATATAATGTATCTTATGTA
TGTGCTTTATATTGTTATTTGTGTATACATTAAAATAATTCTGAATTATTTAATCTGATATGTTGTATTCTGTATCTTGAAATTTTTGTT
TCCTTGAAACATGCATGCATTTAAAAATAAAGCTTAAACAACTGTATGGATGTTACATTTACTTTCTTTTGATTTTTCTGAAAGTCATTC

>17794_17794_5_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000517876_MTX2_chr2_177202221_ENST00000392529_length(amino acids)=100AA_BP=
MLLLLLRAASRDLTGRANTHGVAGARKGGGAGVTRRARASGVTLESRSRSGVEGKELRARGCRRRRRGVSPPARQLVSPPASASRALSVP

--------------------------------------------------------------
>17794_17794_6_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000517876_MTX2_chr2_177202221_ENST00000443241_length(transcript)=780nt_BP=593nt
GAGGACCAAAATGGAGGAGTAAGAATCATGATTAAATTGAGCGAGCGCAACTAATCACGCGAAGAGGGCCGCAGGCGGGCCGTCTTCCGC
AAGCGTGCTTCCAGGCCTCCACTCCCCACCTATTCGGCGGCACCCTGTTACTTCTGCTCCTGCGCGCTGCTTCCCGCGACCTCACAGGCA
GAGCGAACACGCACGGAGTCGCAGGGGCGCGCAAAGGGGGAGGAGCGGGCGTGACCAGGCGCGCGCGCGCGTCTGGAGTGACTCTAGAGA
GCAGGAGCAGATCCGGGGTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGC
TCGTCAGCCCGCCAGCCAGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTG
AAGACGACTTCTCAGGTTTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAG
AAGAGATGAGGAAGATCCGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTA
TACACCATTCTTACCACACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATT

>17794_17794_6_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000517876_MTX2_chr2_177202221_ENST00000443241_length(amino acids)=100AA_BP=
MLLLLLRAASRDLTGRANTHGVAGARKGGGAGVTRRARASGVTLESRSRSGVEGKELRARGCRRRRRGVSPPARQLVSPPASASRALSVP

--------------------------------------------------------------
>17794_17794_7_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000519404_MTX2_chr2_177202221_ENST00000392529_length(transcript)=832nt_BP=306nt
GTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGCTCGTCAGCCCGCCAGCC
AGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGAAGACGACTTCTCAGGT
TTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGAAGAGATGAGGAAGATC
CGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTATACACCATTCTTACCAC
ACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTGAACAGCACTATTTTGA
AGATCGTGGTAAAGGCAGGCTGTCATAGAGTTATGTGTTAGTCTCAGGAGTCTTAACTTTTGAAATATGTTTTACTTGAATGTTACATTA
GATATTGGTGTCAGAATTTTAAAACCAAATTACTGCTTTTTGAAACCTCAAATTATATAATGTATCTTATGTATGTGCTTTATATTGTTA
TTTGTGTATACATTAAAATAATTCTGAATTATTTAATCTGATATGTTGTATTCTGTATCTTGAAATTTTTGTTTCCTTGAAACATGCATG
CATTTAAAAATAAAGCTTAAACAACTGTATGGATGTTACATTTACTTTCTTTTGATTTTTCTGAAAGTCATTCACTGAATTTTACACATG

>17794_17794_7_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000519404_MTX2_chr2_177202221_ENST00000392529_length(amino acids)=59AA_BP=3

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>17794_17794_8_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000519404_MTX2_chr2_177202221_ENST00000443241_length(transcript)=493nt_BP=306nt
GTAGAGGGAAAAGAGCTCCGGGCCAGGGGCTGCCGTCGCCGCCGTCGGGGAGTCAGCCCGCCAGCCCGCCAGCTCGTCAGCCCGCCAGCC
AGCGCTTCGCGGGCCCTGTCGGTCCCGATCAGACCAAACATTGTCTGGCTTGCACTGTAAAACTAGTTAGCTGAAGACGACTTCTCAGGT
TTCTTCAGGATGCCTGCAGCACTTGTGGAGAATAGCCAGGTTATCTGTGAAGTGTGGGCCAGTAATCTAGAAGAAGAGATGAGGAAGATC
CGAGAAATCGTGCTCAGTTACAGTTATATTGCCATGGCCTACTGAACTTGACGCACTGGTATTTGGCCATCTATACACCATTCTTACCAC
ACAATTGACAAATGATGAACTTTCTGAGAAGGTGAAAAACTATAGCAACCTCCTTGCTTTCTGTAGGAGAATTGAACAGCACTATTTTGA

>17794_17794_8_CNOT8-MTX2_CNOT8_chr5_154242955_ENST00000519404_MTX2_chr2_177202221_ENST00000443241_length(amino acids)=59AA_BP=3

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Fusion Gene PPI Analysis for CNOT8-MTX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNOT8-MTX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNOT8-MTX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource