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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COASY-COASY (FusionGDB2 ID:17960)

Fusion Gene Summary for COASY-COASY

check button Fusion gene summary
Fusion gene informationFusion gene name: COASY-COASY
Fusion gene ID: 17960
HgeneTgene
Gene symbol

COASY

COASY

Gene ID

80347

80347

Gene nameCoenzyme A synthaseCoenzyme A synthase
SynonymsDPCK|NBIA6|NBP|PCH12|PPAT|UKR1|pOV-2DPCK|NBIA6|NBP|PCH12|PPAT|UKR1|pOV-2
Cytomap

17q21.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionbifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinasebifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
Modification date2020031320200313
UniProtAcc

Q13057

Q13057

Ensembl transtripts involved in fusion geneENST00000393818, ENST00000420359, 
ENST00000421097, ENST00000449624, 
ENST00000588757, ENST00000590958, 
ENST00000393818, ENST00000420359, 
ENST00000421097, ENST00000449624, 
ENST00000588757, ENST00000590958, 
Fusion gene scores* DoF score9 X 9 X 8=6483 X 3 X 1=9
# samples 143
** MAII scorelog2(14/648*10)=-2.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COASY [Title/Abstract] AND COASY [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOASY(40716721)-COASY(40716816), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOASY

GO:0015937

coenzyme A biosynthetic process

11923312

TgeneCOASY

GO:0015937

coenzyme A biosynthetic process

11923312


check buttonFusion gene breakpoints across COASY (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COASY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG120370COASYchr17

40716721

-COASYchr17

40716816

+
ChiTaRS5.0N/ABQ212022COASYchr17

40716721

-COASYchr17

40716816

+


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Fusion Gene ORF analysis for COASY-COASY

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000393818ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000393818ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000393818ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000393818ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000393818ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000393818ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000420359ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000421097ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000449624ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000588757ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000393818COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000420359COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000421097COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000449624COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000588757COASYchr17

40716721

-COASYchr17

40716816

+
intron-intronENST00000590958ENST00000590958COASYchr17

40716721

-COASYchr17

40716816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for COASY-COASY


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for COASY-COASY


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40716721/:40716816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COASY

Q13057

COASY

Q13057

FUNCTION: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}.FUNCTION: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for COASY-COASY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for COASY-COASY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COASY-COASY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COASY-COASY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource