Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:COBLL1-GRB14 (FusionGDB2 ID:17978)

Fusion Gene Summary for COBLL1-GRB14

Fusion gene summary

Fusion gene information	Fusion gene name: COBLL1-GRB14
	Fusion gene ID: 17978
		Hgene	Tgene
	Gene symbol	COBLL1	GRB14
	Gene ID	22837	2888
	Gene name	cordon-bleu WH2 repeat protein like 1	growth factor receptor bound protein 14
	Synonyms	COBLR1	-
	Cytomap	2q24.3	2q24.3
	Type of gene	protein-coding	protein-coding
	Description	cordon-bleu protein-like 1COBL-like 1	growth factor receptor-bound protein 14GRB14 adapter protein
	Modification date	20200313	20200313
	UniProtAcc	Q53SF7	Q14449
	Ensembl transtripts involved in fusion gene	ENST00000194871, ENST00000342193, ENST00000375458, ENST00000392717, ENST00000409184, ENST00000491126,	ENST00000497306, ENST00000263915, ENST00000543549,
Fusion gene scores	* DoF score	11 X 7 X 8=616	5 X 7 X 4=140
	# samples	16	9
	** MAII score	log2(16/616*10)=-1.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/140*10)=-0.637429920615292 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: COBLL1 [Title/Abstract] AND GRB14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	COBLL1(165697666)-GRB14(165404326), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across COBLL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GRB14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BC-4073-01B	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-

Top

Fusion Gene ORF analysis for COBLL1-GRB14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000194871	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5CDS-intron	ENST00000342193	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5CDS-intron	ENST00000375458	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5CDS-intron	ENST00000392717	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5CDS-intron	ENST00000409184	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5UTR-3CDS	ENST00000491126	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5UTR-3CDS	ENST00000491126	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
5UTR-intron	ENST00000491126	ENST00000497306	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000194871	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000194871	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000392717	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000392717	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000409184	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
Frame-shift	ENST00000409184	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
In-frame	ENST00000342193	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
In-frame	ENST00000342193	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
In-frame	ENST00000375458	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-
In-frame	ENST00000375458	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375458	COBLL1	chr2	165697666	-	ENST00000263915	GRB14	chr2	165404326	-	1782	263	344	1561	405
ENST00000375458	COBLL1	chr2	165697666	-	ENST00000543549	GRB14	chr2	165404326	-	1775	263	344	1561	405
ENST00000342193	COBLL1	chr2	165697666	-	ENST00000263915	GRB14	chr2	165404326	-	1776	257	338	1555	405
ENST00000342193	COBLL1	chr2	165697666	-	ENST00000543549	GRB14	chr2	165404326	-	1769	257	338	1555	405

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375458	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-	0.007956084	0.9920439
ENST00000375458	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-	0.008060798	0.99193925
ENST00000342193	ENST00000263915	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-	0.00763126	0.99236876
ENST00000342193	ENST00000543549	COBLL1	chr2	165697666	-	GRB14	chr2	165404326	-	0.007798226	0.9922018

Top

Fusion Genomic Features for COBLL1-GRB14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for COBLL1-GRB14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:165697666/chr2:165404326)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COBLL1 Q53SF7	GRB14 Q14449
	FUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269\|PubMed:15210700, ECO:0000269\|PubMed:19648926}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GRB14

chr2:165697666

chr2:165404326

ENST00000263915

106_192

108

541.0

Domain

Ras-associating

Tgene

GRB14

chr2:165697666

chr2:165404326

ENST00000263915

234_342

108

541.0

Domain

Tgene

GRB14

chr2:165697666

chr2:165404326

ENST00000263915

439_535

108

541.0

Domain

SH2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000342193

1081_1101

1167.0

Domain

WH2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000375458

1081_1101

1129.0

Domain

WH2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000392717

1081_1101

1205.0

Domain

WH2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000409184

1081_1101

1167.0

Domain

WH2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000342193

291_296

1167.0

Motif

Note=KKRRAP 1

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000342193

360_365

1167.0

Motif

Note=KKRRAP 2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000375458

291_296

1129.0

Motif

Note=KKRRAP 1

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000375458

360_365

1129.0

Motif

Note=KKRRAP 2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000392717

291_296

1205.0

Motif

Note=KKRRAP 1

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000392717

360_365

1205.0

Motif

Note=KKRRAP 2

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000409184

291_296

1167.0

Motif

Note=KKRRAP 1

Hgene

COBLL1

chr2:165697666

chr2:165404326

ENST00000409184

360_365

1167.0

Motif

Note=KKRRAP 2

Top

Fusion Gene Sequence for COBLL1-GRB14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>17978_17978_1_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000342193_GRB14_chr2_165404326_ENST00000263915_length(transcript)=1776nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATTAAAGTAT
ACAGTGAAGATGAAACCAGCAGGGCTTTAGATGTACCCAGTGACATAACGGCTCGAGATGTTTGTCAGCTGTTGATCCTGAAGAATCATT
ACATTGATGACCACAGCTGGACCCTTTTTGAGCACCTGCCTCACATAGGTGTAGAAAGAACAATAGAAGACCACGAACTGGTGATTGAAG
TGCTATCCAACTGGGGGATAGAAGAAGAAAACAAACTATACTTTAGAAAAAATTATGCCAAATATGAGTTCTTTAAAAACCCAATGTATT
TTTTTCCAGAGCATATGGTATCTTTTGCAACTGAAACCAATGGTGAAATATCCCCCACACAGATTTTGCAGATGTTTCTGAGTTCAAGCA
CATATCCTGAAATTCATGGTTTCTTACATGCGAAAGAACAGGGAAAGAAGTCTTGGAAAAAAATTTACTTTTTTCTAAGAAGATCTGGTT
TATATTTTTCTACTAAAGGAACATCAAAGGAACCGCGGCATTTGCAGTTTTTCAGCGAATTTGGCAATAGTGATATTTATGTGTCACTGG
CAGGCAAAAAAAAACATGGAGCACCGACTAACTATGGATTCTGCTTTAAGCCTAACAAAGCGGGAGGGCCCCGAGACCTGAAAATGCTCT
GTGCAGAAGAAGAGCAGAGTAGGACGTGCTGGGTGACCGCGATTAGATTGCTTAAGTATGGCATGCAGCTGTACCAGAATTATATGCATC
CATATCAAGGTAGAAGTGGCTGCAGTTCACAGAGCATATCACCTATGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCTCAG
GCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTTTAC
GCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACCACA
AAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACCCCA
AAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACACAC
TGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGAAAC
ATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAGACC
ATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGCAAA

>17978_17978_1_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000342193_GRB14_chr2_165404326_ENST00000263915_length(amino acids)=405AA_BP=
MLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQIL
QMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGG
PRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLA
WRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED

--------------------------------------------------------------
>17978_17978_2_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000342193_GRB14_chr2_165404326_ENST00000543549_length(transcript)=1769nt_BP=257nt
CGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCGGGCTCT
TGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACGCGCCGC
CTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATTAAAGTAT
ACAGTGAAGATGAAACCAGCAGGGCTTTAGATGTACCCAGTGACATAACGGCTCGAGATGTTTGTCAGCTGTTGATCCTGAAGAATCATT
ACATTGATGACCACAGCTGGACCCTTTTTGAGCACCTGCCTCACATAGGTGTAGAAAGAACAATAGAAGACCACGAACTGGTGATTGAAG
TGCTATCCAACTGGGGGATAGAAGAAGAAAACAAACTATACTTTAGAAAAAATTATGCCAAATATGAGTTCTTTAAAAACCCAATGTATT
TTTTTCCAGAGCATATGGTATCTTTTGCAACTGAAACCAATGGTGAAATATCCCCCACACAGATTTTGCAGATGTTTCTGAGTTCAAGCA
CATATCCTGAAATTCATGGTTTCTTACATGCGAAAGAACAGGGAAAGAAGTCTTGGAAAAAAATTTACTTTTTTCTAAGAAGATCTGGTT
TATATTTTTCTACTAAAGGAACATCAAAGGAACCGCGGCATTTGCAGTTTTTCAGCGAATTTGGCAATAGTGATATTTATGTGTCACTGG
CAGGCAAAAAAAAACATGGAGCACCGACTAACTATGGATTCTGCTTTAAGCCTAACAAAGCGGGAGGGCCCCGAGACCTGAAAATGCTCT
GTGCAGAAGAAGAGCAGAGTAGGACGTGCTGGGTGACCGCGATTAGATTGCTTAAGTATGGCATGCAGCTGTACCAGAATTATATGCATC
CATATCAAGGTAGAAGTGGCTGCAGTTCACAGAGCATATCACCTATGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACTTCTCAG
GCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGATGTTTAC
GCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTCACCACA
AAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTAACCCCA
AAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCCACACAC
TGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGTTGAAAC
ATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAAAAGACC
ATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATAAGCAAA

>17978_17978_2_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000342193_GRB14_chr2_165404326_ENST00000543549_length(amino acids)=405AA_BP=
MLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQIL
QMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGG
PRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLA
WRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED

--------------------------------------------------------------
>17978_17978_3_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000375458_GRB14_chr2_165404326_ENST00000263915_length(transcript)=1782nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATTA
AAGTATACAGTGAAGATGAAACCAGCAGGGCTTTAGATGTACCCAGTGACATAACGGCTCGAGATGTTTGTCAGCTGTTGATCCTGAAGA
ATCATTACATTGATGACCACAGCTGGACCCTTTTTGAGCACCTGCCTCACATAGGTGTAGAAAGAACAATAGAAGACCACGAACTGGTGA
TTGAAGTGCTATCCAACTGGGGGATAGAAGAAGAAAACAAACTATACTTTAGAAAAAATTATGCCAAATATGAGTTCTTTAAAAACCCAA
TGTATTTTTTTCCAGAGCATATGGTATCTTTTGCAACTGAAACCAATGGTGAAATATCCCCCACACAGATTTTGCAGATGTTTCTGAGTT
CAAGCACATATCCTGAAATTCATGGTTTCTTACATGCGAAAGAACAGGGAAAGAAGTCTTGGAAAAAAATTTACTTTTTTCTAAGAAGAT
CTGGTTTATATTTTTCTACTAAAGGAACATCAAAGGAACCGCGGCATTTGCAGTTTTTCAGCGAATTTGGCAATAGTGATATTTATGTGT
CACTGGCAGGCAAAAAAAAACATGGAGCACCGACTAACTATGGATTCTGCTTTAAGCCTAACAAAGCGGGAGGGCCCCGAGACCTGAAAA
TGCTCTGTGCAGAAGAAGAGCAGAGTAGGACGTGCTGGGTGACCGCGATTAGATTGCTTAAGTATGGCATGCAGCTGTACCAGAATTATA
TGCATCCATATCAAGGTAGAAGTGGCTGCAGTTCACAGAGCATATCACCTATGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACT
TCTCAGGCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGAT
GTTTACGCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTC
ACCACAAAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTA
ACCCCAAAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCC
ACACACTGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGT
TGAAACATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAA
AAGACCATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATA

>17978_17978_3_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000375458_GRB14_chr2_165404326_ENST00000263915_length(amino acids)=405AA_BP=
MLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQIL
QMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGG
PRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLA
WRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED

--------------------------------------------------------------
>17978_17978_4_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000375458_GRB14_chr2_165404326_ENST00000543549_length(transcript)=1775nt_BP=263nt
CGGCGGCGGCGCCCGCGGGCTGGGAGCCGGGGCCCGCAGGTGGAAGCGCACCCGGGAGGCGGGCCGGCCGGGGCTGGAGCGGCTCGGGCG
GGCTCTTGACGCTCAGCCAGCTTCGCTCCGGCCTCGGGAAGGCGCGCGTCCCGCCCTGACCCGCCGGCCTCTCCCACCCCAGCAGTGACG
CGCCGCCTGGGAGCTGGAGCCCGCGCAGCGCCCCGCAGGGCGATGGACGGCCGAACCCCGCGCCCGCAGGACGCCCCAGCCAGGTGATTA
AAGTATACAGTGAAGATGAAACCAGCAGGGCTTTAGATGTACCCAGTGACATAACGGCTCGAGATGTTTGTCAGCTGTTGATCCTGAAGA
ATCATTACATTGATGACCACAGCTGGACCCTTTTTGAGCACCTGCCTCACATAGGTGTAGAAAGAACAATAGAAGACCACGAACTGGTGA
TTGAAGTGCTATCCAACTGGGGGATAGAAGAAGAAAACAAACTATACTTTAGAAAAAATTATGCCAAATATGAGTTCTTTAAAAACCCAA
TGTATTTTTTTCCAGAGCATATGGTATCTTTTGCAACTGAAACCAATGGTGAAATATCCCCCACACAGATTTTGCAGATGTTTCTGAGTT
CAAGCACATATCCTGAAATTCATGGTTTCTTACATGCGAAAGAACAGGGAAAGAAGTCTTGGAAAAAAATTTACTTTTTTCTAAGAAGAT
CTGGTTTATATTTTTCTACTAAAGGAACATCAAAGGAACCGCGGCATTTGCAGTTTTTCAGCGAATTTGGCAATAGTGATATTTATGTGT
CACTGGCAGGCAAAAAAAAACATGGAGCACCGACTAACTATGGATTCTGCTTTAAGCCTAACAAAGCGGGAGGGCCCCGAGACCTGAAAA
TGCTCTGTGCAGAAGAAGAGCAGAGTAGGACGTGCTGGGTGACCGCGATTAGATTGCTTAAGTATGGCATGCAGCTGTACCAGAATTATA
TGCATCCATATCAAGGTAGAAGTGGCTGCAGTTCACAGAGCATATCACCTATGAGAAGTATATCAGAGAATTCCCTGGTAGCAATGGACT
TCTCAGGCCAGAAAAGCAGAGTTATAGAAAATCCCACTGAAGCCCTTTCAGTTGCGGTTGAAGAAGGACTCGCTTGGAGGAAAAAAGGAT
GTTTACGCCTGGGCACTCACGGTAGCCCCACTGCCTCTTCACAGAGCTCTGCCACAAACATGGCTATCCACCGGTCCCAGCCATGGTTTC
ACCACAAAATTTCTAGAGATGAGGCTCAGCGATTGATTATTCAGCAAGGACTTGTGGATGGAGTTTTCTTGGTACGGGATAGTCAGAGTA
ACCCCAAAACTTTCGTACTGTCAATGAGTCATGGACAAAAAATAAAGCACTTTCAAATTATACCAGTAGAAGATGACGGTGAAATGTTCC
ACACACTGGATGATGGCCACACAAGATTTACAGATCTAATACAGCTGGTGGAGTTCTATCAACTCAATAAGGGCGTTCTTCCTTGCAAGT
TGAAACATTATTGTGCTAGGATTGCTCTCTAGACAAGCCAGAAGTGACTTATTAAACTATTGAAGGAAAAGGACTCAAGAAAAATAATAA
AAGACCATAAATAAGGGCGAAAACATTACCATGTGAAAAGAATGTATTTCACCTGCAAGTTACAAAAAAATAGTTTGTGCATTGCAAATA

>17978_17978_4_COBLL1-GRB14_COBLL1_chr2_165697666_ENST00000375458_GRB14_chr2_165404326_ENST00000543549_length(amino acids)=405AA_BP=
MLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQIL
QMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGG
PRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLA
WRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for COBLL1-GRB14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for COBLL1-GRB14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for COBLL1-GRB14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source