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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTR2-SMC4 (FusionGDB2 ID:1835)

Fusion Gene Summary for ACTR2-SMC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR2-SMC4
Fusion gene ID: 1835
HgeneTgene
Gene symbol

ACTR2

SMC4

Gene ID

10097

10051

Gene nameactin related protein 2structural maintenance of chromosomes 4
SynonymsARP2CAP-C|CAPC|SMC-4|SMC4L1
Cytomap

2p14

3q25.33

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2ARP2 actin related protein 2 homologactin-like protein 2structural maintenance of chromosomes protein 4SMC protein 4SMC4 structural maintenance of chromosomes 4-like 1chromosome-associated polypeptide C
Modification date2020032720200313
UniProtAcc

P61160

.
Ensembl transtripts involved in fusion geneENST00000476840, ENST00000260641, 
ENST00000377982, ENST00000542850, 
ENST00000344722, ENST00000357388, 
ENST00000360111, ENST00000462787, 
ENST00000469762, ENST00000470240, 
Fusion gene scores* DoF score8 X 8 X 5=3204 X 3 X 4=48
# samples 94
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR2 [Title/Abstract] AND SMC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTR2(65467096)-SMC4(160129708), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTR2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539|17220302|29925947

HgeneACTR2

GO:0045944

positive regulation of transcription by RNA polymerase II

17220302

HgeneACTR2

GO:1905168

positive regulation of double-strand break repair via homologous recombination

29925947

HgeneACTR2

GO:2001032

regulation of double-strand break repair via nonhomologous end joining

29925947

TgeneSMC4

GO:0007076

mitotic chromosome condensation

11136719


check buttonFusion gene breakpoints across ACTR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315395ACTR2chr2

65467096

+SMC4chr3

160129708

+


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Fusion Gene ORF analysis for ACTR2-SMC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476840ENST00000344722ACTR2chr2

65467096

+SMC4chr3

160129708

+
3UTR-3CDSENST00000476840ENST00000357388ACTR2chr2

65467096

+SMC4chr3

160129708

+
3UTR-3CDSENST00000476840ENST00000360111ACTR2chr2

65467096

+SMC4chr3

160129708

+
3UTR-3CDSENST00000476840ENST00000462787ACTR2chr2

65467096

+SMC4chr3

160129708

+
3UTR-3CDSENST00000476840ENST00000469762ACTR2chr2

65467096

+SMC4chr3

160129708

+
3UTR-3UTRENST00000476840ENST00000470240ACTR2chr2

65467096

+SMC4chr3

160129708

+
5CDS-3UTRENST00000260641ENST00000470240ACTR2chr2

65467096

+SMC4chr3

160129708

+
5CDS-3UTRENST00000377982ENST00000470240ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3CDSENST00000542850ENST00000344722ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3CDSENST00000542850ENST00000357388ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3CDSENST00000542850ENST00000360111ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3CDSENST00000542850ENST00000462787ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3CDSENST00000542850ENST00000469762ACTR2chr2

65467096

+SMC4chr3

160129708

+
5UTR-3UTRENST00000542850ENST00000470240ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000260641ENST00000344722ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000260641ENST00000357388ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000260641ENST00000360111ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000260641ENST00000462787ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000260641ENST00000469762ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000377982ENST00000344722ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000377982ENST00000357388ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000377982ENST00000360111ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000377982ENST00000462787ACTR2chr2

65467096

+SMC4chr3

160129708

+
In-frameENST00000377982ENST00000469762ACTR2chr2

65467096

+SMC4chr3

160129708

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000260641ACTR2chr265467096+ENST00000357388SMC4chr3160129708+464931613034951121
ENST00000260641ACTR2chr265467096+ENST00000360111SMC4chr3160129708+446431613033211063
ENST00000260641ACTR2chr265467096+ENST00000469762SMC4chr3160129708+359731613034951121
ENST00000260641ACTR2chr265467096+ENST00000462787SMC4chr3160129708+350331613033211063
ENST00000260641ACTR2chr265467096+ENST00000344722SMC4chr3160129708+464031613034951121
ENST00000377982ACTR2chr265467096+ENST00000357388SMC4chr3160129708+45652324634111121
ENST00000377982ACTR2chr265467096+ENST00000360111SMC4chr3160129708+43802324632371063
ENST00000377982ACTR2chr265467096+ENST00000469762SMC4chr3160129708+35132324634111121
ENST00000377982ACTR2chr265467096+ENST00000462787SMC4chr3160129708+34192324632371063
ENST00000377982ACTR2chr265467096+ENST00000344722SMC4chr3160129708+45562324634111121

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260641ENST00000357388ACTR2chr265467096+SMC4chr3160129708+0.0004271250.9995728
ENST00000260641ENST00000360111ACTR2chr265467096+SMC4chr3160129708+0.0006296550.9993704
ENST00000260641ENST00000469762ACTR2chr265467096+SMC4chr3160129708+0.0009245760.9990754
ENST00000260641ENST00000462787ACTR2chr265467096+SMC4chr3160129708+0.001224720.9987753
ENST00000260641ENST00000344722ACTR2chr265467096+SMC4chr3160129708+0.0004256550.99957436
ENST00000377982ENST00000357388ACTR2chr265467096+SMC4chr3160129708+0.0003984920.99960154
ENST00000377982ENST00000360111ACTR2chr265467096+SMC4chr3160129708+0.0005840310.999416
ENST00000377982ENST00000469762ACTR2chr265467096+SMC4chr3160129708+0.0009078720.9990921
ENST00000377982ENST00000462787ACTR2chr265467096+SMC4chr3160129708+0.0011752960.99882466
ENST00000377982ENST00000344722ACTR2chr265467096+SMC4chr3160129708+0.0003971560.99960285

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Fusion Genomic Features for ACTR2-SMC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACTR2chr265467096+SMC4chr3160129707+2.82E-070.99999976
ACTR2chr265467096+SMC4chr3160129707+2.82E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACTR2-SMC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:65467096/chr3:160129708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR2

P61160

.
FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMC4chr2:65467096chr3:160129708ENST000003447223231109_11292291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000344722323272_5882291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000344722323767_10202291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST000003573884241109_11292291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000357388424272_5882291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000357388424767_10202291289.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST000003601114231109_11292291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000360111423272_5882291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000360111423767_10202291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST000004627873221109_11292291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000462787322272_5882291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST00000462787322767_10202291231.0Coiled coilOntology_term=ECO:0000255
TgeneSMC4chr2:65467096chr3:160129708ENST000003447223231191_12262291289.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC4chr2:65467096chr3:160129708ENST000003573884241191_12262291289.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC4chr2:65467096chr3:160129708ENST000003601114231191_12262291231.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC4chr2:65467096chr3:160129708ENST000004627873221191_12262291231.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC4chr2:65467096chr3:160129708ENST00000344722323613_7272291289.0DomainNote=SMC hinge
TgeneSMC4chr2:65467096chr3:160129708ENST00000357388424613_7272291289.0DomainNote=SMC hinge
TgeneSMC4chr2:65467096chr3:160129708ENST00000360111423613_7272291231.0DomainNote=SMC hinge
TgeneSMC4chr2:65467096chr3:160129708ENST00000462787322613_7272291231.0DomainNote=SMC hinge

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTR2chr2:65467096chr3:160129708ENST00000260641+29160_16253395.0Nucleotide bindingATP
HgeneACTR2chr2:65467096chr3:160129708ENST00000260641+29214_21853395.0Nucleotide bindingATP
HgeneACTR2chr2:65467096chr3:160129708ENST00000260641+29305_31053395.0Nucleotide bindingATP
HgeneACTR2chr2:65467096chr3:160129708ENST00000377982+210160_16253400.0Nucleotide bindingATP
HgeneACTR2chr2:65467096chr3:160129708ENST00000377982+210214_21853400.0Nucleotide bindingATP
HgeneACTR2chr2:65467096chr3:160129708ENST00000377982+210305_31053400.0Nucleotide bindingATP
TgeneSMC4chr2:65467096chr3:160129708ENST0000034472232318_232291289.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000034472232366_712291289.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000035738842418_232291289.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000035738842466_712291289.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000036011142318_232291231.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000036011142366_712291231.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000046278732218_232291231.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST0000046278732266_712291231.0Compositional biasNote=Poly-Pro
TgeneSMC4chr2:65467096chr3:160129708ENST00000344722323113_1202291289.0Nucleotide bindingATP
TgeneSMC4chr2:65467096chr3:160129708ENST00000357388424113_1202291289.0Nucleotide bindingATP
TgeneSMC4chr2:65467096chr3:160129708ENST00000360111423113_1202291231.0Nucleotide bindingATP
TgeneSMC4chr2:65467096chr3:160129708ENST00000462787322113_1202291231.0Nucleotide bindingATP


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Fusion Gene Sequence for ACTR2-SMC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1835_1835_1_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000344722_length(transcript)=4640nt_BP=316nt
AGCTAAATGACGGGCGGAGCCCGGCGGCGGCTTCCGGTCGGGGGAAAAAAGTTGGGCCGAAGGAGGGGCCGGGAAGACGCAAGAGGAAGA
AGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAGGAAGGT
GGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAG
ACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGGCCAGAC
TGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCGGAGAGT
TGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAAAAACAT
AGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAAACGAAT
TGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAATGAAAGC
TAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGA
TTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAAAGAAAA
GGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGA
GAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGAGAAAGA
ACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAA
TACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAGAGATAT
AGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTTTAAAAG
TTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGCAATAAT
TCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATC
ATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAATATTGG
AGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATT
TGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGC
CACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGACTGGTGG
TGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACAGTTGCA
AAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACGAGAAAT
GAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACTTGAAGC
TAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGCTGTGGC
TGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGA
CAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAGAAACCT
TCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAG
TCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAATCTGCT
TCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGATGGTCA
CATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTATTGAAGA
GATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCGGTGTCA
TGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAAAATTAC
TTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAATAACAAA
TAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGAAGGAAT
CATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGCTTTAGT
ATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCATTGTTGC
ATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACTTATTGG
AATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATGCTGAAG
ATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAACTAGATC
ATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTACAAAAATATGACA
ATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAGGCAAAG
TCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAATCTTGGA
TAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGTAAACCA
GTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGAGAGCCA
GTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAGTAAGAT
GGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGATAGTTTC
AACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAAGTAAGA
TACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAAGTTGGC
AACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGAATTAAT
TAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGTAAAAAT

>1835_1835_1_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000344722_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

--------------------------------------------------------------
>1835_1835_2_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000357388_length(transcript)=4649nt_BP=316nt
AGCTAAATGACGGGCGGAGCCCGGCGGCGGCTTCCGGTCGGGGGAAAAAAGTTGGGCCGAAGGAGGGGCCGGGAAGACGCAAGAGGAAGA
AGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAGGAAGGT
GGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAG
ACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGGCCAGAC
TGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCGGAGAGT
TGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAAAAACAT
AGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAAACGAAT
TGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAATGAAAGC
TAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGA
TTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAAAGAAAA
GGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGA
GAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGAGAAAGA
ACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAA
TACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAGAGATAT
AGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTTTAAAAG
TTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGCAATAAT
TCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATC
ATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAATATTGG
AGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATT
TGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGC
CACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGACTGGTGG
TGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACAGTTGCA
AAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACGAGAAAT
GAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACTTGAAGC
TAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGCTGTGGC
TGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGA
CAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAGAAACCT
TCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAG
TCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAATCTGCT
TCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGATGGTCA
CATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTATTGAAGA
GATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCGGTGTCA
TGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAAAATTAC
TTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAATAACAAA
TAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGAAGGAAT
CATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGCTTTAGT
ATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCATTGTTGC
ATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACTTATTGG
AATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATGCTGAAG
ATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAACTAGATC
ATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTACAAAAATATGACA
ATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAGGCAAAG
TCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAATCTTGGA
TAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGTAAACCA
GTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGAGAGCCA
GTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAGTAAGAT
GGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGATAGTTTC
AACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAAGTAAGA
TACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAAGTTGGC
AACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGAATTAAT
TAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGTAAAAAT

>1835_1835_2_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000357388_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

--------------------------------------------------------------
>1835_1835_3_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000360111_length(transcript)=4464nt_BP=316nt
AGCTAAATGACGGGCGGAGCCCGGCGGCGGCTTCCGGTCGGGGGAAAAAAGTTGGGCCGAAGGAGGGGCCGGGAAGACGCAAGAGGAAGA
AGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAGGAAGGT
GGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAG
ACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGGCCAGAC
TGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCGGAGAGT
TGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAAAAACAT
AGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAAACGAAT
TGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAATGAAAGC
TAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGA
TTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAAAGAAAA
GGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGA
GAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGAGAAAGA
ACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAA
TACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAGAGATAT
AGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTTTAAAAG
TTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGCAATAAT
TCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATC
ATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAATATTGG
AGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATT
TGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGC
CACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGACTGGTGG
TGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACAGTTGCA
AAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACGAGAAAT
GAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACTTGAAGC
TAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGCTGTGGC
TGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGA
CAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAGAAACCT
TCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAG
TCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTAT
TGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCG
GTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAA
AATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAAT
AACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGA
AGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGC
TTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCAT
TGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACT
TATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATG
CTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAAC
TAGATCATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTACAAAAAT
ATGACAATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAG
GCAAAGTCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAAT
CTTGGATAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGT
AAACCAGTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGA
GAGCCAGTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAG
TAAGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGAT
AGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAA
GTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAA
GTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGA
ATTAATTAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGT

>1835_1835_3_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000360111_length(amino acids)=1063AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYE
DLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPL

--------------------------------------------------------------
>1835_1835_4_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000462787_length(transcript)=3503nt_BP=316nt
AGCTAAATGACGGGCGGAGCCCGGCGGCGGCTTCCGGTCGGGGGAAAAAAGTTGGGCCGAAGGAGGGGCCGGGAAGACGCAAGAGGAAGA
AGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAGGAAGGT
GGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAG
ACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGGCCAGAC
TGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCGGAGAGT
TGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAAAAACAT
AGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAAACGAAT
TGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAATGAAAGC
TAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGA
TTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAAAGAAAA
GGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGA
GAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGAGAAAGA
ACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAA
TACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAGAGATAT
AGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTTTAAAAG
TTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGCAATAAT
TCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATC
ATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAATATTGG
AGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATT
TGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGC
CACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGACTGGTGG
TGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACAGTTGCA
AAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACGAGAAAT
GAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACTTGAAGC
TAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGCTGTGGC
TGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGA
CAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAGAAACCT
TCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAG
TCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTAT
TGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCG
GTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAA
AATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAAT
AACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGA
AGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGC
TTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCAT
TGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACT
TATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATG
CTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAAC

>1835_1835_4_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000462787_length(amino acids)=1063AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYE
DLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPL

--------------------------------------------------------------
>1835_1835_5_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000469762_length(transcript)=3597nt_BP=316nt
AGCTAAATGACGGGCGGAGCCCGGCGGCGGCTTCCGGTCGGGGGAAAAAAGTTGGGCCGAAGGAGGGGCCGGGAAGACGCAAGAGGAAGA
AGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAGGAAGGT
GGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAG
ACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGGCCAGAC
TGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCGGAGAGT
TGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAAAAACAT
AGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAAACGAAT
TGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAATGAAAGC
TAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACAGCTAGA
TTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAAAGAAAA
GGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGAAAAAGA
GAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGAGAAAGA
ACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCGTCATAA
TACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAGAGATAT
AGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTTTAAAAG
TTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGCAATAAT
TCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGCTATATC
ATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAATATTGG
AGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCGTTTATT
TGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGATCAAGC
CACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGACTGGTGG
TGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACAGTTGCA
AAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACGAGAAAT
GAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACTTGAAGC
TAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGCTGTGGC
TGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCAACAAGA
CAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAGAAACCT
TCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCTGAAAAG
TCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAATCTGCT
TCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGATGGTCA
CATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTATTGAAGA
GATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCGGTGTCA
TGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAAAATTAC
TTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAATAACAAA
TAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGAAGGAAT
CATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGCTTTAGT
ATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCATTGTTGC
ATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACTTATTGG
AATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATGCTGAAG

>1835_1835_5_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000260641_SMC4_chr3_160129708_ENST00000469762_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

--------------------------------------------------------------
>1835_1835_6_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000344722_length(transcript)=4556nt_BP=232nt
GGAAGAAGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAG
GAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGT
TGGAAGACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGG
CCAGACTGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCG
GAGAGTTGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAA
AAACATAGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAA
ACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAAT
GAAAGCTAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACA
GCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAA
AGAAAAGGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGA
AAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGA
GAAAGAACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCG
TCATAATACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAG
AGATATAGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTT
TAAAAGTTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGC
AATAATTCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGC
TATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAA
TATTGGAGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCG
TTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGA
TCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGAC
TGGTGGTGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACA
GTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACG
AGAAATGAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACT
TGAAGCTAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGC
TGTGGCTGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCA
ACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAG
AAACCTTCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCT
GAAAAGTCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAA
TCTGCTTCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGA
TGGTCACATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTAT
TGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCG
GTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAA
AATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAAT
AACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGA
AGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGC
TTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCAT
TGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACT
TATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATG
CTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAAC
TAGATCATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTACAAAAAT
ATGACAATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAG
GCAAAGTCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAAT
CTTGGATAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGT
AAACCAGTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGA
GAGCCAGTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAG
TAAGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGAT
AGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAA
GTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAA
GTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGA
ATTAATTAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGT

>1835_1835_6_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000344722_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

--------------------------------------------------------------
>1835_1835_7_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000357388_length(transcript)=4565nt_BP=232nt
GGAAGAAGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAG
GAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGT
TGGAAGACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGG
CCAGACTGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCG
GAGAGTTGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAA
AAACATAGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAA
ACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAAT
GAAAGCTAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACA
GCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAA
AGAAAAGGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGA
AAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGA
GAAAGAACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCG
TCATAATACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAG
AGATATAGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTT
TAAAAGTTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGC
AATAATTCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGC
TATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAA
TATTGGAGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCG
TTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGA
TCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGAC
TGGTGGTGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACA
GTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACG
AGAAATGAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACT
TGAAGCTAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGC
TGTGGCTGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCA
ACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAG
AAACCTTCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCT
GAAAAGTCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAA
TCTGCTTCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGA
TGGTCACATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTAT
TGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCG
GTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAA
AATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAAT
AACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGA
AGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGC
TTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCAT
TGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACT
TATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATG
CTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAAC
TAGATCATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTACAAAAAT
ATGACAATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAG
GCAAAGTCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAAT
CTTGGATAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGT
AAACCAGTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGA
GAGCCAGTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAG
TAAGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAACTTGAT
AGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAGTGGAAA
GTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGGACATAA
GTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGA
ATTAATTAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGT

>1835_1835_7_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000357388_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

--------------------------------------------------------------
>1835_1835_8_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000360111_length(transcript)=4380nt_BP=232nt
GGAAGAAGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAG
GAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGT
TGGAAGACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGG
CCAGACTGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCG
GAGAGTTGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAA
AAACATAGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAA
ACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAAT
GAAAGCTAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACA
GCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAA
AGAAAAGGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGA
AAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGA
GAAAGAACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCG
TCATAATACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAG
AGATATAGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTT
TAAAAGTTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGC
AATAATTCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGC
TATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAA
TATTGGAGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCG
TTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGA
TCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGAC
TGGTGGTGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACA
GTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACG
AGAAATGAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACT
TGAAGCTAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGC
TGTGGCTGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCA
ACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAG
AAACCTTCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCT
GAAAAGTCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAA
TCCTATTGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGA
AGCCCGGTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATT
GGACAAAATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTA
TATAATAACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTT
CTCTGAAGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTC
ATTGGCTTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGT
GTCCATTGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGA
TAGACTTATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAAC
TTTATGCTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCC
CTAAACTAGATCATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTCTCTATAATTGCTTCTAGATTAC
AAAAATATGACAATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGGTCAGGTAACTTGCCAAACTAAAAAGTATGTTA
GTTGAGGCAAAGTCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATACCTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCA
ACTAATCTTGGATAGATTCTTTAAGGCATTCCACTTAGCTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATAT
TTTTGTAAACCAGTCATTCTGAATTATAGTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATT
ACCAGAGAGCCAGTAAATTAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGT
ATGAAGTAAGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTCAA
CTTGATAGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTACTTTAGTAATAAG
TGGAAAGTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTCAAGAATGTTATAATGCTAAGGG
ACATAAGTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCTGCCCTAGCTGTTAAATTTCTGGGTATTTATCC
TAAGGAATTAATTAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATTGTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGT

>1835_1835_8_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000360111_length(amino acids)=1063AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYE
DLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPL

--------------------------------------------------------------
>1835_1835_9_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000462787_length(transcript)=3419nt_BP=232nt
GGAAGAAGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAG
GAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGT
TGGAAGACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGG
CCAGACTGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCG
GAGAGTTGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAA
AAACATAGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAA
ACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAAT
GAAAGCTAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACA
GCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAA
AGAAAAGGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGA
AAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGA
GAAAGAACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCG
TCATAATACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAG
AGATATAGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTT
TAAAAGTTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGC
AATAATTCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGC
TATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAA
TATTGGAGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCG
TTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGA
TCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGAC
TGGTGGTGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACA
GTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACG
AGAAATGAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACT
TGAAGCTAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGC
TGTGGCTGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCA
ACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAG
AAACCTTCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCT
GAAAAGTCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAA
TCCTATTGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGA
AGCCCGGTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATT
GGACAAAATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTA
TATAATAACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTT
CTCTGAAGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTC
ATTGGCTTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGT
GTCCATTGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGA
TAGACTTATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAAC
TTTATGCTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCC

>1835_1835_9_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000462787_length(amino acids)=1063AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYE
DLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPL

--------------------------------------------------------------
>1835_1835_10_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000469762_length(transcript)=3513nt_BP=232nt
GGAAGAAGAGAAAACGGCCGGGCGGCGGTGGCTGTAGGTTGTGCGGCTGCAGCGGCTCTTCCCTGGGCGGACGATGGACAGCCAGGGCAG
GAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGTGGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGT
TGGAAGACCTATTATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGGGTGAAGTTGAACAAATTGCTATGATGAAACCAAAAGG
CCAGACTGAACACGATGAGGGTATGCTTGAATATTTAGAAGATATAATTGGTTGTGGACGGCTAAATGAACCTATTAAAGTCTTGTGTCG
GAGAGTTGAAATATTAAATGAACACAGAGGAGAGAAGTTAAACAGGGTAAAGATGGTGGAAAAGGAAAAGGATGCCTTAGAAGGAGAGAA
AAACATAGCTATCGAATTTCTTACCTTGGAAAATGAAATATTTAGAAAAAAGAATCATGTTTGTCAATATTATATTTATGAGTTGCAGAA
ACGAATTGCTGAAATGGAAACTCAAAAGGAAAAAATTCATGAAGATACCAAAGAAATTAATGAGAAGAGCAATATACTATCAAATGAAAT
GAAAGCTAAGAATAAAGATGTAAAAGATACAGAAAAGAAACTGAATAAAATTACAAAATTTATTGAGGAGAATAAAGAAAAATTTACACA
GCTAGATTTGGAAGATGTTCAAGTTAGAGAAAAGTTAAAACATGCCACGAGTAAAGCCAAAAAACTGGAGAAACAACTTCAAAAAGATAA
AGAAAAGGTTGAAGAATTTAAAAGTATACCTGCCAAGAGTAACAATATCATTAATGAAACAACAACCAGAAACAATGCCCTCGAGAAGGA
AAAAGAGAAAGAAGAAAAAAAATTAAAGGAAGTTATGGATAGCCTTAAACAGGAAACACAAGGGCTTCAGAAAGAAAAAGAAAGTCGAGA
GAAAGAACTTATGGGTTTCAGCAAATCGGTAAATGAAGCACGTTCAAAGATGGATGTAGCCCAGTCAGAACTTGATATCTATCTCAGTCG
TCATAATACTGCAGTGTCTCAATTAACTAAGGCTAAGGAAGCTCTAATTGCAGCTTCTGAGACTCTCAAAGAAAGGAAAGCTGCAATCAG
AGATATAGAAGGAAAACTCCCTCAAACTGAACAAGAATTAAAGGAGAAAGAAAAAGAACTTCAAAAACTTACACAAGAAGAAACAAACTT
TAAAAGTTTGGTTCATGATCTCTTTCAAAAAGTTGAAGAAGCAAAGAGCTCATTAGCAATGAATCGAAGTAGGGGGAAAGTCCTTGATGC
AATAATTCAAGAAAAAAAATCTGGCAGGATTCCAGGAATATATGGAAGATTGGGGGACTTAGGAGCCATTGATGAAAAATACGACGTGGC
TATATCATCCTGTTGTCATGCACTGGACTACATTGTTGTTGATTCTATTGATATAGCCCAAGAATGTGTAAACTTCCTTAAAAGACAAAA
TATTGGAGTTGCAACCTTTATAGGTTTAGATAAGATGGCTGTATGGGCGAAAAAGATGACCGAAATTCAAACTCCTGAAAATACTCCTCG
TTTATTTGATTTAGTAAAAGTAAAAGATGAGAAAATTCGCCAAGCTTTTTATTTTGCTTTACGAGATACCTTAGTAGCTGACAACTTGGA
TCAAGCCACAAGAGTAGCATATCAAAAAGATAGAAGATGGAGAGTGGTAACTTTACAGGGACAAATCATAGAACAGTCAGGTACAATGAC
TGGTGGTGGAAGCAAAGTAATGAAAGGAAGAATGGGTTCCTCACTTGTTATTGAAATCTCTGAAGAAGAGGTAAACAAAATGGAATCACA
GTTGCAAAACGACTCTAAAAAAGCAATGCAAATCCAAGAACAGAAAGTACAACTTGAAGAAAGAGTAGTTAAGTTACGGCATAGTGAACG
AGAAATGAGGAACACACTAGAAAAATTTACTGCAAGCATCCAGCGTTTAATAGAGCAAGAAGAATATTTGAATGTCCAAGTTAAGGAACT
TGAAGCTAATGTACTTGCTACAGCCCCTGACAAAAAAAAGCAGAAATTGCTAGAAGAAAACGTTAGTGCTTTCAAAACAGAATATGATGC
TGTGGCTGAGAAAGCTGGTAAAGTAGAAGCTGAGGTTAAACGCTTACACAATACCATCGTAGAAATCAATAATCATAAACTCAAGGCCCA
ACAAGACAAACTTGATAAAATAAATAAGCAATTAGATGAATGTGCTTCTGCTATTACTAAAGCCCAAGTAGCAATCAAGACTGCTGACAG
AAACCTTCAAAAGGCACAAGACTCTGTCTTGCGTACAGAGAAAGAAATAAAAGATACTGAGAAAGAGGTGGATGACCTAACAGCAGAGCT
GAAAAGTCTTGAGGACAAAGCAGCAGAGGTCGTAAAGAATACAAATGCTGCAGAGGAATCCTTACCAGAGATCCAGAAAGAACATCGCAA
TCTGCTTCAAGAATTAAAAGTTATTCAAGAAAATGAACATGCTCTTCAAAAAGATGCACTTAGTATTAAGTTGAAACTTGAACAAATAGA
TGGTCACATTGCTGAACATAATTCTAAAATAAAATATTGGCACAAAGAGATTTCAAAAATATCACTGCATCCTATAGAAGATAATCCTAT
TGAAGAGATTTCGGTTCTAAGCCCAGAGGATCTTGAAGCGATCAAGAATCCAGATTCTATAACAAATCAAATTGCACTTTTGGAAGCCCG
GTGTCATGAAATGAAACCAAACCTCGGTGCCATCGCAGAGTATAAAAAGAAGGAAGAATTGTATTTGCAACGGGTAGCAGAATTGGACAA
AATTACTTATGAAAGAGACAGTTTTAGACAGGCATATGAAGATCTTCGGAAACAAAGGCTTAATGAATTTATGGCAGGTTTTTATATAAT
AACAAATAAATTAAAGGAAAATTACCAAATGCTTACTTTGGGAGGGGACGCCGAACTCGAGCTTGTAGACAGCTTGGATCCTTTCTCTGA
AGGAATCATGTTCAGTGTTCGACCACCTAAGAAAAGTTGGAAAAAGATCTTCAACCTTTCGGGAGGAGAGAAAACACTTAGTTCATTGGC
TTTAGTATTTGCTCTTCACCACTACAAGCCCACTCCCCTTTACTTCATGGATGAGATTGATGCAGCCCTTGATTTTAAAAATGTGTCCAT
TGTTGCATTTTATATATATGAACAAACAAAAAATGCACAGTTCATAATAATTTCTCTTCGAAATAATATGTTTGAGATTTCGGATAGACT
TATTGGAATTTACAAGACATACAACATAACAAAAAGTGTTGCTGTAAATCCAAAAGAAATTGCATCTAAGGGACTTTGTTGAACTTTATG
CTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAAAATACATACTCCCTAAAC

>1835_1835_10_ACTR2-SMC4_ACTR2_chr2_65467096_ENST00000377982_SMC4_chr3_160129708_ENST00000469762_length(amino acids)=1121AA_BP=61
MQRLFPGRTMDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKGEVEQIAMMKPKGQTEHDEGMLEYLEDI
IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED
TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN
IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL
IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYG
RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA
FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK
VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL
HNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN
AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK
NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGG
DAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFI

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Fusion Gene PPI Analysis for ACTR2-SMC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTR2-SMC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTR2-SMC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource