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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTR3B-FYB (FusionGDB2 ID:1844)

Fusion Gene Summary for ACTR3B-FYB

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR3B-FYB
Fusion gene ID: 1844
HgeneTgene
Gene symbol

ACTR3B

FYB

Gene ID

57180

2533

Gene nameactin related protein 3BFYN binding protein 1
SynonymsARP11|ARP3BETAADAP|FYB|PRO0823|SLAP-130|SLAP130|THC3
Cytomap

7q36.1-q36.2

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 3BARP3 actin related protein 3 homolog BARP3-betaactin-like protein 3Bactin-related protein 3-betaactin-related protein ARP4actin-related protein Arp11FYN-binding protein 1FYB-120/130FYN-T-binding proteinFYN-binding proteinSLP-76-associated phosphoproteinadhesion and degranulation-promoting adaptor proteinp120/p130
Modification date2020031320200313
UniProtAcc

Q9P1U1

O15117

Ensembl transtripts involved in fusion geneENST00000256001, ENST00000377776, 
ENST00000397282, ENST00000488782, 
ENST00000537264, 		ENST00000351578, 
ENST00000503065, ENST00000505428, 
ENST00000512982, ENST00000515010, 
ENST00000540520, 
Fusion gene scores* DoF score6 X 4 X 4=9614 X 11 X 6=924
# samples 615
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACTR3B [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTR3B(152611569)-FYB(39267461), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACTR3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FYB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACQ203965ACTR3Bchr7

152611569

+FYBchr5

39267461

+


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Fusion Gene ORF analysis for ACTR3B-FYB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000256001ENST00000351578ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000256001ENST00000503065ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000256001ENST00000505428ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000256001ENST00000512982ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000256001ENST00000515010ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000256001ENST00000540520ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000351578ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000503065ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000505428ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000512982ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000515010ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000377776ENST00000540520ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000351578ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000503065ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000505428ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000512982ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000515010ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000397282ENST00000540520ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000351578ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000503065ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000505428ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000512982ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000515010ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000488782ENST00000540520ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000351578ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000503065ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000505428ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000512982ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000515010ACTR3Bchr7

152611569

+FYBchr5

39267461

+
intron-intronENST00000537264ENST00000540520ACTR3Bchr7

152611569

+FYBchr5

39267461

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACTR3B-FYB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACTR3B-FYB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:152611569/:39267461)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR3B

Q9P1U1

FYB

O15117

FUNCTION: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}.FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACTR3B-FYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACTR3B-FYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTR3B-FYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTR3B-FYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource