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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:COMMD7-MMP24 (FusionGDB2 ID:18542) |
Fusion Gene Summary for COMMD7-MMP24 |
Fusion gene summary |
Fusion gene information | Fusion gene name: COMMD7-MMP24 | Fusion gene ID: 18542 | Hgene | Tgene | Gene symbol | COMMD7 | MMP24 | Gene ID | 149951 | 10893 |
Gene name | COMM domain containing 7 | matrix metallopeptidase 24 | |
Synonyms | C20orf92|dJ1085F17.3 | MMP-24|MMP25|MT-MMP 5|MT-MMP5|MT5-MMP|MT5MMP|MTMMP5 | |
Cytomap | 20q11.21 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | COMM domain-containing protein 7 | matrix metalloproteinase-24matrix metallopeptidase 24 (membrane-inserted)matrix metalloproteinase 24 (membrane-inserted)membrane-type 5 matrix metalloproteinasemembrane-type matrix metalloproteinase 5 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q86VX2 | Q9Y5R2 | |
Ensembl transtripts involved in fusion gene | ENST00000278980, ENST00000446419, | ENST00000246186, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 6 X 7 X 5=210 |
# samples | 7 | 6 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/210*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COMMD7 [Title/Abstract] AND MMP24 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | COMMD7(31315700)-MMP24(33851594), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COMMD7 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 15799966 |
Hgene | COMMD7 | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 15799966 |
Hgene | COMMD7 | GO:0045892 | negative regulation of transcription, DNA-templated | 15799966 |
Fusion gene breakpoints across COMMD7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MMP24 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-7723-01A | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
ChimerDB4 | STAD | TCGA-BR-7723-01A | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33855008 | + |
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Fusion Gene ORF analysis for COMMD7-MMP24 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000278980 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
In-frame | ENST00000278980 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33855008 | + |
In-frame | ENST00000446419 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + |
In-frame | ENST00000446419 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33855008 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000278980 | COMMD7 | chr20 | 31315700 | - | ENST00000246186 | MMP24 | chr20 | 33851594 | + | 4357 | 847 | 342 | 1967 | 541 |
ENST00000446419 | COMMD7 | chr20 | 31315700 | - | ENST00000246186 | MMP24 | chr20 | 33851594 | + | 3812 | 302 | 64 | 1422 | 452 |
ENST00000278980 | COMMD7 | chr20 | 31315700 | - | ENST00000246186 | MMP24 | chr20 | 33855008 | + | 4195 | 847 | 342 | 1805 | 487 |
ENST00000446419 | COMMD7 | chr20 | 31315700 | - | ENST00000246186 | MMP24 | chr20 | 33855008 | + | 3650 | 302 | 64 | 1260 | 398 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000278980 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + | 0.00802624 | 0.99197376 |
ENST00000446419 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33851594 | + | 0.007887525 | 0.9921125 |
ENST00000278980 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33855008 | + | 0.009776044 | 0.99022394 |
ENST00000446419 | ENST00000246186 | COMMD7 | chr20 | 31315700 | - | MMP24 | chr20 | 33855008 | + | 0.010394406 | 0.98960567 |
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Fusion Genomic Features for COMMD7-MMP24 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
COMMD7 | chr20 | 31315699 | - | MMP24 | chr20 | 33851593 | + | 5.51E-12 | 1 |
COMMD7 | chr20 | 31315699 | - | MMP24 | chr20 | 33855007 | + | 7.03E-09 | 1 |
COMMD7 | chr20 | 31315699 | - | MMP24 | chr20 | 33851593 | + | 5.51E-12 | 1 |
COMMD7 | chr20 | 31315699 | - | MMP24 | chr20 | 33855007 | + | 7.03E-09 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for COMMD7-MMP24 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31315700/chr20:33851594) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
COMMD7 | MMP24 |
FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}. | FUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 643_645 | 272 | 646.0 | Motif | Note=PDZ-binding | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 643_645 | 326 | 646.0 | Motif | Note=PDZ-binding | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 377_425 | 272 | 646.0 | Repeat | Note=Hemopexin 1 | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 426_471 | 272 | 646.0 | Repeat | Note=Hemopexin 2 | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 473_521 | 272 | 646.0 | Repeat | Note=Hemopexin 3 | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 522_569 | 272 | 646.0 | Repeat | Note=Hemopexin 4 | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 377_425 | 326 | 646.0 | Repeat | Note=Hemopexin 1 | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 426_471 | 326 | 646.0 | Repeat | Note=Hemopexin 2 | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 473_521 | 326 | 646.0 | Repeat | Note=Hemopexin 3 | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 522_569 | 326 | 646.0 | Repeat | Note=Hemopexin 4 | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 624_645 | 272 | 646.0 | Topological domain | Cytoplasmic | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 624_645 | 326 | 646.0 | Topological domain | Cytoplasmic | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 603_623 | 272 | 646.0 | Transmembrane | Helical | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 603_623 | 326 | 646.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | COMMD7 | chr20:31315700 | chr20:33851594 | ENST00000278980 | - | 3 | 9 | 133_200 | 80 | 201.0 | Domain | COMM |
Hgene | COMMD7 | chr20:31315700 | chr20:33851594 | ENST00000446419 | - | 3 | 9 | 133_200 | 79 | 200.0 | Domain | COMM |
Hgene | COMMD7 | chr20:31315700 | chr20:33855008 | ENST00000278980 | - | 3 | 9 | 133_200 | 80 | 201.0 | Domain | COMM |
Hgene | COMMD7 | chr20:31315700 | chr20:33855008 | ENST00000446419 | - | 3 | 9 | 133_200 | 79 | 200.0 | Domain | COMM |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 149_152 | 272 | 646.0 | Compositional bias | Note=Poly-Arg | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 149_152 | 326 | 646.0 | Compositional bias | Note=Poly-Arg | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 137_144 | 272 | 646.0 | Motif | Cysteine switch | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 137_144 | 326 | 646.0 | Motif | Cysteine switch | |
Tgene | MMP24 | chr20:31315700 | chr20:33851594 | ENST00000246186 | 3 | 9 | 53_602 | 272 | 646.0 | Topological domain | Extracellular | |
Tgene | MMP24 | chr20:31315700 | chr20:33855008 | ENST00000246186 | 4 | 9 | 53_602 | 326 | 646.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for COMMD7-MMP24 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>18542_18542_1_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000278980_MMP24_chr20_33851594_ENST00000246186_length(transcript)=4357nt_BP=847nt GTGATGCTGGGGTGATGCTGATGCCCTTCCAAGGTTGAGACCTAGTCTCTACTCTGATGTCAGCTCTCCGAGAGACACTCTGGCCTGCTT TGTTCCCTTCCCTGTCCCCAGTGTCTGGCATCGAGTAGGCTGCCATAAATATCTCTGGAGTGCATAGTAACAGTGATGATGATAATAGCA GCTAGCCATTGATTGAAGACCTCTTGTGTGCCGGTCTCTGCGTTAAACATTTCTGGAGGCTTAACTCATTTAAGGAGCTACCCCAGCCAT CATTTTCTCAGATGGTGAAACTGAGGTTCAGAGAGGCCAAGCGCCGTACCCAAAGGTCACTCAGCGGGAGAGCTGGCAGGAAACCTCGCG TCTGCCGGTGCCGGCGCCGCCCCTGCCCCTCCCCGGAGCCCGGCGGCCGCGCGTGTCCGCGGCCCTGCGAGGGCTCCCCGGCTCCGGACA GCCCAGGGCGGCCGGGGGAGGAGTGCGCTGCGACGGCCGTGGCGAAAGTGCGGTTGTGGATGCGCGGAGAGGCCGGCAGCGGTGGCAGCG GCAGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAG GACCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTC CACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTC AGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCATGAGCTGGGCCACGCGCTGGGACTG GAGCACTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAG GGCATCCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTCCGCAGGATCCACTCACCA TCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGT GACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGTCTGCGCAATAACCGAGTG CAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTT GTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTGGGGGAGCTGGGCAGCTGT TTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGC GAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCCCAAGGAGCCTTCATCAGC AAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGC AACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGACGTGGACATCATG GTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTAC ACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGC CCTCTCTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGG CCCTAGGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGT GGGTGTCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGA CCATGCCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCT GTGGGAAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCC CCTACCCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGG CAGATCCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCA GCTGGGTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTT TAGGTGAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACT CTAGCGCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGA GTTTGTGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAG TTAGGTGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGC CCCCACTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCT GACCTCGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTG ACCTTCACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCT TGTCACTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAG CGTGCTGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGC TTACCCTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCT GTGTCCCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGCGGAGATATTAGTG ATTCATAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCGTGTTAGGCCCTGG GAGGCCGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTG TGTCCCCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTC CTGGTCCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTG GCAGGCCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCC TAGAGGCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGG GGCCCCAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAGCCTTTGTATAATG >18542_18542_1_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000278980_MMP24_chr20_33851594_ENST00000246186_length(amino acids)=541AA_BP=168 MAGNLASAGAGAAPAPPRSPAAARVRGPARAPRLRTAQGGRGRSALRRPWRKCGCGCAERPAAVAAAAEEEAEQGGGGGGTCGAGARAMG RLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGNDLFLVAVHEL GHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPG TKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSL GELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSV EPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEW -------------------------------------------------------------- >18542_18542_2_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000278980_MMP24_chr20_33855008_ENST00000246186_length(transcript)=4195nt_BP=847nt GTGATGCTGGGGTGATGCTGATGCCCTTCCAAGGTTGAGACCTAGTCTCTACTCTGATGTCAGCTCTCCGAGAGACACTCTGGCCTGCTT TGTTCCCTTCCCTGTCCCCAGTGTCTGGCATCGAGTAGGCTGCCATAAATATCTCTGGAGTGCATAGTAACAGTGATGATGATAATAGCA GCTAGCCATTGATTGAAGACCTCTTGTGTGCCGGTCTCTGCGTTAAACATTTCTGGAGGCTTAACTCATTTAAGGAGCTACCCCAGCCAT CATTTTCTCAGATGGTGAAACTGAGGTTCAGAGAGGCCAAGCGCCGTACCCAAAGGTCACTCAGCGGGAGAGCTGGCAGGAAACCTCGCG TCTGCCGGTGCCGGCGCCGCCCCTGCCCCTCCCCGGAGCCCGGCGGCCGCGCGTGTCCGCGGCCCTGCGAGGGCTCCCCGGCTCCGGACA GCCCAGGGCGGCCGGGGGAGGAGTGCGCTGCGACGGCCGTGGCGAAAGTGCGGTTGTGGATGCGCGGAGAGGCCGGCAGCGGTGGCAGCG GCAGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAG GACCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTC CACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTC AGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTC CGCAGGATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGC ACCAAACCCAACATCTGTGACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGT CTGCGCAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAA AGGGCCGATGGGAGATTTGTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTG GGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAG CGGTACTGGCGCTACAGCGAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCC CAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTG GAGCCAGGCTACCCGCGCAACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAG GACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGC ATCCTGGTGCTGGTCTACACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGG GTGTGAGCAGCCCAGAGCCCTCTCTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGC TCACCAGGGCCAGCAGGGCCCTAGGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATG GGGGCTGTGCCCCAGGGTGGGTGTCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGC TCCATCCGGAGGCAGGGACCATGCCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGC TGGAACCCAGCACCCTCTGTGGGAAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACAC CTGCTGGTCAGATGTCCCCCTACCCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGT TTCCCTGCTGGCAGACGGCAGATCCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGC AGGCAGGGCTGTGGCCCAGCTGGGTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGC AAAGGCTGCTTGAGGCTTTAGGTGAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAA GGTGCTGCTAAGGCCACTCTAGCGCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCAT TTCTGGAGGAAGATCCGAGTTTGTGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCT GGAGCTCAGCCTCACCAGTTAGGTGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGC GTCTGAAGTGCTCAGTGCCCCCACTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCC CAGAGCTTGGCCCTTGCTGACCTCGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCT GAGGGGGCTCCCTTTTTGACCTTCACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTAC GGCGGAGGCAGCCCTGCTTGTCACTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAG GTGTCAGGCAGTCTCCAGCGTGCTGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTC TCTGGGATTGGGGTCGGCTTACCCTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGG TGCCCATGTGGGTCCGCTGTGTCCCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACA ACTGCGGAGATATTAGTGATTCATAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAA ACTCGTGTTAGGCCCTGGGAGGCCGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAG TGGGCTGGCTGGGTCTTGTGTCCCCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGG CCTCCCTTCCCCCACTTCCTGGTCCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAG GCTCCCCATTGGCTCCTGGCAGGCCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCA GGCCCAGAGGGCTCAGCCTAGAGGCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACA GAGGGGCAAAGCACTGGGGGCCCCAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTG >18542_18542_2_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000278980_MMP24_chr20_33855008_ENST00000246186_length(amino acids)=487AA_BP=168 MAGNLASAGAGAAPAPPRSPAAARVRGPARAPRLRTAQGGRGRSALRRPWRKCGCGCAERPAAVAAAAEEEAEQGGGGGGTCGAGARAMG RLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGPPAEPLEPTRP LPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPAR IDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWK GIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIP -------------------------------------------------------------- >18542_18542_3_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000446419_MMP24_chr20_33851594_ENST00000246186_length(transcript)=3812nt_BP=302nt AGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAGGA CCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTT CCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAG CATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGGAACGACCTCTTCCTGGTGGCTGTGCATGAGCTGGGCCACGCGCTGGGACTGGAGCA CTCCAGCGACCCCAGCGCCATCATGGCGCCCTTCTACCAGTACATGGAGACGCACAACTTCAAGCTGCCCCAGGACGATCTCCAGGGCAT CCAGAAGATCTATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTCCGCAGGATCCACTCACCATCGGA GAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAAACCCAACATCTGTGACGG CAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGTCTGCGCAATAACCGAGTGCAGGA GGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGCCGATGGGAGATTTGTCTT CTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCC CCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGCGAGGA GCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGA AGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGCAACAT CCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGACGTGGACATCATGGTGAC CATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTACACCAT CTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGCCCTCT CTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGGCCCTA GGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGTGGGTG TCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGACCATG CCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCTGTGGG AAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCCCCTAC CCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGGCAGAT CCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCAGCTGG GTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTTTAGGT GAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACTCTAGC GCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGAGTTTG TGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAGTTAGG TGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGCCCCCA CTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCTGACCT CGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTGACCTT CACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCTTGTCA CTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAGCGTGC TGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGCTTACC CTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCTGTGTC CCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGCGGAGATATTAGTGATTCA TAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCGTGTTAGGCCCTGGGAGGC CGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTGTGTCC CCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTCCTGGT CCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTGGCAGG CCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCCTAGAG GCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGGGGCCC CAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAGCCTTTGTATAATGTTTTT >18542_18542_3_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000446419_MMP24_chr20_33851594_ENST00000246186_length(amino acids)=452AA_BP=79 MGRLHCTEDPVPEAVGGDMQQLNQLGAQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGNDLFLVAVHE LGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTP GTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHS LGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLS VEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQE -------------------------------------------------------------- >18542_18542_4_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000446419_MMP24_chr20_33855008_ENST00000246186_length(transcript)=3650nt_BP=302nt AGCGGAGGAGGAAGCTGAGCAGGGCGGCGGCGGCGGTGGAACCTGCGGGGCTGGGGCGCGCGCCATGGGCCGCCTGCACTGCACTGAGGA CCCGGTGCCGGAGGCCGTGGGCGGCGACATGCAGCAGCTGAACCAGCTGGGCGCGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTT CCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAG CATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGACCCCCAGCCGAGCCTCTGGAGCCCACAAGGCCACTCCCTACACTCCCCGTCCGCAG GATCCACTCACCATCGGAGAGGAAACACGAGCGCCAGCCCAGGCCCCCTCGGCCGCCCCTCGGGGACCGGCCATCCACACCAGGCACCAA ACCCAACATCTGTGACGGCAACTTCAACACAGTGGCCCTCTTCCGGGGCGAGATGTTTGTCTTTAAGGATCGCTGGTTCTGGCGTCTGCG CAATAACCGAGTGCAGGAGGGCTACCCCATGCAGATCGAGCAGTTCTGGAAGGGCCTGCCTGCCCGCATCGACGCAGCCTATGAAAGGGC CGATGGGAGATTTGTCTTCTTCAAAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTGGGTACCCCCACAGCCTGGGGGA GCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCTACTTTTTCAAAGGCGAGCGGTA CTGGCGCTACAGCGAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGGGCATCCCACAGGCTCCCCAAGG AGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCC AGGCTACCCGCGCAACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGA CGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCT GGTGCTGGTCTACACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTG AGCAGCCCAGAGCCCTCTCTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACC AGGGCCAGCAGGGCCCTAGGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGC TGTGCCCCAGGGTGGGTGTCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCAT CCGGAGGCAGGGACCATGCCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAA CCCAGCACCCTCTGTGGGAAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCT GGTCAGATGTCCCCCTACCCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCC TGCTGGCAGACGGCAGATCCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCA GGGCTGTGGCCCAGCTGGGTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGG CTGCTTGAGGCTTTAGGTGAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGC TGCTAAGGCCACTCTAGCGCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTG GAGGAAGATCCGAGTTTGTGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGC TCAGCCTCACCAGTTAGGTGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTG AAGTGCTCAGTGCCCCCACTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAG CTTGGCCCTTGCTGACCTCGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGG GGCTCCCTTTTTGACCTTCACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGG AGGCAGCCCTGCTTGTCACTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTC AGGCAGTCTCCAGCGTGCTGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGG GATTGGGGTCGGCTTACCCTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCC ATGTGGGTCCGCTGTGTCCCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGC GGAGATATTAGTGATTCATAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCG TGTTAGGCCCTGGGAGGCCGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGC TGGCTGGGTCTTGTGTCCCCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCC CTTCCCCCACTTCCTGGTCCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCC CCATTGGCTCCTGGCAGGCCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCC AGAGGGCTCAGCCTAGAGGCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGG GCAAAGCACTGGGGGCCCCAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAG >18542_18542_4_COMMD7-MMP24_COMMD7_chr20_31315700_ENST00000446419_MMP24_chr20_33855008_ENST00000246186_length(amino acids)=398AA_BP=79 MGRLHCTEDPVPEAVGGDMQQLNQLGAQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGPPAEPLEPTR PLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPA RIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVW KGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for COMMD7-MMP24 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COMMD7-MMP24 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COMMD7-MMP24 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |