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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COMT-COMT (FusionGDB2 ID:18557)

Fusion Gene Summary for COMT-COMT

check button Fusion gene summary
Fusion gene informationFusion gene name: COMT-COMT
Fusion gene ID: 18557
HgeneTgene
Gene symbol

COMT

COMT

Gene ID

1312

1312

Gene namecatechol-O-methyltransferasecatechol-O-methyltransferase
SynonymsHEL-S-98nHEL-S-98n
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptioncatechol O-methyltransferasecatechol-O-methyltransferase isoformepididymis secretory sperm binding protein Li 98ntesticular tissue protein Li 42catechol O-methyltransferasecatechol-O-methyltransferase isoformepididymis secretory sperm binding protein Li 98ntesticular tissue protein Li 42
Modification date2020032920200329
UniProtAcc.

Q86VU5

Ensembl transtripts involved in fusion geneENST00000493893, ENST00000361682, 
ENST00000403184, ENST00000403710, 
ENST00000406520, ENST00000407537, 
ENST00000449653, 		ENST00000361682, 
ENST00000403184, ENST00000403710, 
ENST00000406520, ENST00000407537, 
ENST00000449653, ENST00000493893, 
Fusion gene scores* DoF score13 X 12 X 5=7806 X 12 X 4=288
# samples 1514
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/288*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COMT [Title/Abstract] AND COMT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOMT(19951222)-COMT(19951702), # samples:1
COMT(19532758)-COMT(19938877), # samples:1
Anticipated loss of major functional domain due to fusion event.COMT-COMT seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
COMT-COMT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
COMT-COMT seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
COMT-COMT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
COMT-COMT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
COMT-COMT seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOMT

GO:0042424

catecholamine catabolic process

15645182|21846718

TgeneCOMT

GO:0042424

catecholamine catabolic process

15645182|21846718


check buttonFusion gene breakpoints across COMT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI298713COMTchr22

19951222

-COMTchr22

19951702

+
ChiTaRS5.0N/AEI708414COMTchr22

19532758

-COMTchr22

19938877

-


Top

Fusion Gene ORF analysis for COMT-COMT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493893ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3CDSENST00000493893ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3CDSENST00000493893ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3CDSENST00000493893ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3CDSENST00000493893ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3CDSENST00000493893ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
3UTR-3UTRENST00000493893ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000361682ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000403184ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000403710ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000406520ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000407537ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
5CDS-3UTRENST00000449653ENST00000493893COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000361682ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000403184ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000403710ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000406520ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000407537ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
Frame-shiftENST00000449653ENST00000403184COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000361682ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000361682ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000361682ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000361682ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000361682ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403184ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403184ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403184ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403184ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403184ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403710ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403710ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403710ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403710ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000403710ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000406520ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000406520ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000406520ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000406520ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000406520ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000407537ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000407537ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000407537ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000407537ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000407537ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000449653ENST00000361682COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000449653ENST00000403710COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000449653ENST00000406520COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000449653ENST00000407537COMTchr22

19951222

-COMTchr22

19951702

+
In-frameENST00000449653ENST00000449653COMTchr22

19951222

-COMTchr22

19951702

+
intron-intronENST00000361682ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000361682ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403184ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000403710ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000406520ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000407537ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000449653ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000361682COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000403184COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000403710COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000406520COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000407537COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000449653COMTchr22

19532758

-COMTchr22

19938877

-
intron-intronENST00000493893ENST00000493893COMTchr22

19532758

-COMTchr22

19938877

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for COMT-COMT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for COMT-COMT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19951222/chr22:19951702)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COMT

Q86VU5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative O-methyltransferase. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMTchr22:19951222chr22:19951702ENST0000036168206167_1700272.0RegionNote=S-adenosyl-L-methionine binding
TgeneCOMTchr22:19951222chr22:19951702ENST0000040371006167_1700272.0RegionNote=S-adenosyl-L-methionine binding
TgeneCOMTchr22:19951222chr22:19951702ENST0000040652006167_1700272.0RegionNote=S-adenosyl-L-methionine binding
TgeneCOMTchr22:19951222chr22:19951702ENST0000040753707167_1700222.0RegionNote=S-adenosyl-L-methionine binding
TgeneCOMTchr22:19951222chr22:19951702ENST0000044965304167_1700222.0RegionNote=S-adenosyl-L-methionine binding
TgeneCOMTchr22:19951222chr22:19951702ENST00000361682061_60272.0Topological domainCytoplasmic
TgeneCOMTchr22:19951222chr22:19951702ENST000003616820627_2710272.0Topological domainExtracellular
TgeneCOMTchr22:19951222chr22:19951702ENST00000403710061_60272.0Topological domainCytoplasmic
TgeneCOMTchr22:19951222chr22:19951702ENST000004037100627_2710272.0Topological domainExtracellular
TgeneCOMTchr22:19951222chr22:19951702ENST00000406520061_60272.0Topological domainCytoplasmic
TgeneCOMTchr22:19951222chr22:19951702ENST000004065200627_2710272.0Topological domainExtracellular
TgeneCOMTchr22:19951222chr22:19951702ENST00000407537071_60222.0Topological domainCytoplasmic
TgeneCOMTchr22:19951222chr22:19951702ENST000004075370727_2710222.0Topological domainExtracellular
TgeneCOMTchr22:19951222chr22:19951702ENST00000449653041_60222.0Topological domainCytoplasmic
TgeneCOMTchr22:19951222chr22:19951702ENST000004496530427_2710222.0Topological domainExtracellular
TgeneCOMTchr22:19951222chr22:19951702ENST00000361682067_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCOMTchr22:19951222chr22:19951702ENST00000403710067_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCOMTchr22:19951222chr22:19951702ENST00000406520067_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCOMTchr22:19951222chr22:19951702ENST00000407537077_260222.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCOMTchr22:19951222chr22:19951702ENST00000449653047_260222.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOMTchr22:19951222chr22:19951702ENST00000361682-16167_1700272.0RegionNote=S-adenosyl-L-methionine binding
HgeneCOMTchr22:19951222chr22:19951702ENST00000403710-16167_1700272.0RegionNote=S-adenosyl-L-methionine binding
HgeneCOMTchr22:19951222chr22:19951702ENST00000406520-16167_1700272.0RegionNote=S-adenosyl-L-methionine binding
HgeneCOMTchr22:19951222chr22:19951702ENST00000407537-17167_1700222.0RegionNote=S-adenosyl-L-methionine binding
HgeneCOMTchr22:19951222chr22:19951702ENST00000449653-14167_1700222.0RegionNote=S-adenosyl-L-methionine binding
HgeneCOMTchr22:19951222chr22:19951702ENST00000361682-161_60272.0Topological domainCytoplasmic
HgeneCOMTchr22:19951222chr22:19951702ENST00000361682-1627_2710272.0Topological domainExtracellular
HgeneCOMTchr22:19951222chr22:19951702ENST00000403710-161_60272.0Topological domainCytoplasmic
HgeneCOMTchr22:19951222chr22:19951702ENST00000403710-1627_2710272.0Topological domainExtracellular
HgeneCOMTchr22:19951222chr22:19951702ENST00000406520-161_60272.0Topological domainCytoplasmic
HgeneCOMTchr22:19951222chr22:19951702ENST00000406520-1627_2710272.0Topological domainExtracellular
HgeneCOMTchr22:19951222chr22:19951702ENST00000407537-171_60222.0Topological domainCytoplasmic
HgeneCOMTchr22:19951222chr22:19951702ENST00000407537-1727_2710222.0Topological domainExtracellular
HgeneCOMTchr22:19951222chr22:19951702ENST00000449653-141_60222.0Topological domainCytoplasmic
HgeneCOMTchr22:19951222chr22:19951702ENST00000449653-1427_2710222.0Topological domainExtracellular
HgeneCOMTchr22:19951222chr22:19951702ENST00000361682-167_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCOMTchr22:19951222chr22:19951702ENST00000403710-167_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCOMTchr22:19951222chr22:19951702ENST00000406520-167_260272.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCOMTchr22:19951222chr22:19951702ENST00000407537-177_260222.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCOMTchr22:19951222chr22:19951702ENST00000449653-147_260222.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for COMT-COMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for COMT-COMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COMT-COMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COMT-COMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource