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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACTR3-FAM104B (FusionGDB2 ID:1861)

Fusion Gene Summary for ACTR3-FAM104B

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTR3-FAM104B
Fusion gene ID: 1861
HgeneTgene
Gene symbol

ACTR3

FAM104B

Gene ID

10096

90736

Gene nameactin related protein 3family with sequence similarity 104 member B
SynonymsARP3CXorf44
Cytomap

2q14.1

Xp11.21

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 3ARP3 actin related protein 3 homologactin-like protein 3protein FAM104B
Modification date2020032720200313
UniProtAcc

P61158

Q5XKR9

Ensembl transtripts involved in fusion geneENST00000263238, ENST00000535589, 
ENST00000536059, 		ENST00000478918, 
ENST00000425133, ENST00000472571, 
ENST00000489298, ENST00000332132, 
ENST00000358460, ENST00000477847, 
Fusion gene scores* DoF score12 X 10 X 6=7201 X 1 X 1=1
# samples 131
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ACTR3 [Title/Abstract] AND FAM104B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACTR3(114699936)-FAM104B(55172744), # samples:1
Anticipated loss of major functional domain due to fusion event.ACTR3-FAM104B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTR3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539|17220302

HgeneACTR3

GO:0045944

positive regulation of transcription by RNA polymerase II

17220302


check buttonFusion gene breakpoints across ACTR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM104B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315358ACTR3chr2

114699936

+FAM104BchrX

55172744

-


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Fusion Gene ORF analysis for ACTR3-FAM104B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263238ENST00000478918ACTR3chr2

114699936

+FAM104BchrX

55172744

-
5CDS-5UTRENST00000535589ENST00000478918ACTR3chr2

114699936

+FAM104BchrX

55172744

-
5CDS-5UTRENST00000536059ENST00000478918ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000263238ENST00000425133ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000263238ENST00000472571ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000263238ENST00000489298ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000535589ENST00000425133ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000535589ENST00000472571ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000535589ENST00000489298ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000536059ENST00000425133ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000536059ENST00000472571ACTR3chr2

114699936

+FAM104BchrX

55172744

-
Frame-shiftENST00000536059ENST00000489298ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000263238ENST00000332132ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000263238ENST00000358460ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000263238ENST00000477847ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000535589ENST00000332132ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000535589ENST00000358460ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000535589ENST00000477847ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000536059ENST00000332132ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000536059ENST00000358460ACTR3chr2

114699936

+FAM104BchrX

55172744

-
In-frameENST00000536059ENST00000477847ACTR3chr2

114699936

+FAM104BchrX

55172744

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263238ACTR3chr2114699936+ENST00000332132FAM104BchrX55172744-208311782421405387
ENST00000263238ACTR3chr2114699936+ENST00000358460FAM104BchrX55172744-208311782421405387
ENST00000263238ACTR3chr2114699936+ENST00000477847FAM104BchrX55172744-210311782421405387
ENST00000536059ACTR3chr2114699936+ENST00000332132FAM104BchrX55172744-18089032311130299
ENST00000536059ACTR3chr2114699936+ENST00000358460FAM104BchrX55172744-18089032311130299
ENST00000536059ACTR3chr2114699936+ENST00000477847FAM104BchrX55172744-18289032311130299
ENST00000535589ACTR3chr2114699936+ENST00000332132FAM104BchrX55172744-19009952901222310
ENST00000535589ACTR3chr2114699936+ENST00000358460FAM104BchrX55172744-19009952901222310
ENST00000535589ACTR3chr2114699936+ENST00000477847FAM104BchrX55172744-19209952901222310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263238ENST00000332132ACTR3chr2114699936+FAM104BchrX55172744-0.0007075210.9992925
ENST00000263238ENST00000358460ACTR3chr2114699936+FAM104BchrX55172744-0.0007075210.9992925
ENST00000263238ENST00000477847ACTR3chr2114699936+FAM104BchrX55172744-0.0007400960.9992599
ENST00000536059ENST00000332132ACTR3chr2114699936+FAM104BchrX55172744-0.0008277080.99917233
ENST00000536059ENST00000358460ACTR3chr2114699936+FAM104BchrX55172744-0.0008277080.99917233
ENST00000536059ENST00000477847ACTR3chr2114699936+FAM104BchrX55172744-0.0008797960.9991202
ENST00000535589ENST00000332132ACTR3chr2114699936+FAM104BchrX55172744-0.00038770.9996123
ENST00000535589ENST00000358460ACTR3chr2114699936+FAM104BchrX55172744-0.00038770.9996123
ENST00000535589ENST00000477847ACTR3chr2114699936+FAM104BchrX55172744-0.000269040.999731

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Fusion Genomic Features for ACTR3-FAM104B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACTR3-FAM104B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:114699936/chrX:55172744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTR3

P61158

FAM104B

Q5XKR9

FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACTR3-FAM104B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1861_1861_1_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000332132_length(transcript)=2083nt_BP=1178nt
ATCTTGGCTTCCCGGGGAAAGGCGGCGTGAGGGGAAGAAGTTGTAGGGTGGGGGCAGGAGTGAGGAGGAGGGAAGAGAGAGGGGGAGGAG
GCCGCGGCGGGGCAGGGCGGGGACTGCCTGCCTGCCTGGGTTGCGGAAGTGATAGCCGCCGACCGAGCCTGCTGCTTTCTTGCTACTGCT
TCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGCCCTTGTCTCCCGCCGCCAATCTCTGGCCCC
TAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGACGGCTGCCGGCCTGTGTGGTGGACTGTGGCA
CGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGG
GTGATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAA
CAAAGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAG
AACCTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCT
TCAATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGA
CCGGTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTC
CAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTG
CTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTA
AACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTC
ATCCAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACC
AGATTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCT
TTGGTCCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTT
TCAAGGAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCA
CTCATTTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCC
TGTGTTTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCC
CTGAAACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATT
TGTAAAATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCA
AGATCTGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTG
ATAAAAAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAG

>1861_1861_1_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000332132_length(amino acids)=387AA_BP=312
MSPAANLWPLAARSRRRQQQQQARRKMAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGD
EAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWT
SRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNK
YDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGLSKP

--------------------------------------------------------------
>1861_1861_2_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000358460_length(transcript)=2083nt_BP=1178nt
ATCTTGGCTTCCCGGGGAAAGGCGGCGTGAGGGGAAGAAGTTGTAGGGTGGGGGCAGGAGTGAGGAGGAGGGAAGAGAGAGGGGGAGGAG
GCCGCGGCGGGGCAGGGCGGGGACTGCCTGCCTGCCTGGGTTGCGGAAGTGATAGCCGCCGACCGAGCCTGCTGCTTTCTTGCTACTGCT
TCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGCCCTTGTCTCCCGCCGCCAATCTCTGGCCCC
TAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGACGGCTGCCGGCCTGTGTGGTGGACTGTGGCA
CGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGG
GTGATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAA
CAAAGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAG
AACCTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCT
TCAATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGA
CCGGTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTC
CAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTG
CTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTA
AACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTC
ATCCAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACC
AGATTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCT
TTGGTCCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTT
TCAAGGAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCA
CTCATTTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCC
TGTGTTTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCC
CTGAAACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATT
TGTAAAATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCA
AGATCTGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTG
ATAAAAAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAG

>1861_1861_2_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000358460_length(amino acids)=387AA_BP=312
MSPAANLWPLAARSRRRQQQQQARRKMAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGD
EAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWT
SRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNK
YDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGLSKP

--------------------------------------------------------------
>1861_1861_3_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000477847_length(transcript)=2103nt_BP=1178nt
ATCTTGGCTTCCCGGGGAAAGGCGGCGTGAGGGGAAGAAGTTGTAGGGTGGGGGCAGGAGTGAGGAGGAGGGAAGAGAGAGGGGGAGGAG
GCCGCGGCGGGGCAGGGCGGGGACTGCCTGCCTGCCTGGGTTGCGGAAGTGATAGCCGCCGACCGAGCCTGCTGCTTTCTTGCTACTGCT
TCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGCCCTTGTCTCCCGCCGCCAATCTCTGGCCCC
TAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGACGGCTGCCGGCCTGTGTGGTGGACTGTGGCA
CGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGG
GTGATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAA
CAAAGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAG
AACCTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCT
TCAATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGA
CCGGTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTC
CAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTG
CTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTA
AACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTC
ATCCAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACC
AGATTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGGTATGTACCATGCCAAGGTCTTTACTCCCATATCAACCAGA
CCTTGAAGGAGGCTCACTTCAACAGCCTGCAGCAGCGAGGGCAAGCTCCAACATGATGAATTAGGACTTCCTTATTCCAACCTAAACTGT
GTTTATAAAAGCAATTGCATACACACCAAAAAAAGTCTATTGGTTTTTAAGTCTACATTTTAAGTAACAAGTTAATGGGCAGTTGTTTAA
TTGGGGTTTTACTTCACTGTTGTACTTTTAAAGGGGCTGTGAATAAATGTTTATGAAATTTTTATTTTTATTTTTATTTTACTCTTTCTA
CATAGAGTTTTCAAGTTGAGTGTCAATTTCATGTTAAGGTAGCAATATGAGGAAACTTCTCCTGTGCATTGAAGCCATATGTCCAATTCA
GATTGATTTCCAGATCTGTCAGTTAGAAACTCTATGTTAAACATCTTTTTAAAATACAAGTAAGTCTTCATTTTTAAAAATACAGTAGCC
TAGTAAAGAGGTATGTAGCTTTCATTTAAAAAACAAACAAAAAATCCACACTCAAAAAACCATAAGTTAGTATTCCCAAATATGCAAAGC
CAGATTCAGTCTTGCACTGAAATGAACTGCCATACTCCCCTCAGAAGGTAGATGTTCTGTTGAAATTGCTCTCTAGTTGTAATGGCAACA
ATCAGACCCAGTTTAGACTATGAACATGAAAATCTCTCTCTAATAACTGTCTCTACACTTTGTATTTCCAGGGAGAATGTTTCTAAGGCT

>1861_1861_3_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000263238_FAM104B_chrX_55172744_ENST00000477847_length(amino acids)=387AA_BP=312
MSPAANLWPLAARSRRRQQQQQARRKMAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGD
EAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWT
SRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNK
YDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGYVPC

--------------------------------------------------------------
>1861_1861_4_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000332132_length(transcript)=1900nt_BP=995nt
ACTACGGTGGGCAGCGCCGCCCAAAGGGCGCTGGGGACGGTCGTCTTGGGGGTGGTCCCCGGGCCCGACCCATCCGGCTTTCCTTTCCCT
CCGCGCCCGTTTTTGCCAGTCGGTTTGGGGACCCAGGGGCCGAGCTCGGGGACTGGCCTGGCAGGGGAGCTAGAAAAGAGAAGCGCTCCT
GGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGGGTG
ATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAACAA
AGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAAC
CTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCA
ATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCG
GTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAA
TCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTA
AGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAAC
AGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATC
CAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGA
TTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCTTTG
GTCCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTTTCA
AGGAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCACTC
ATTTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCCTGT
GTTTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCCCTG
AAACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATTTGT
AAAATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCAAGA
TCTGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTGATA
AAAAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAGCTT

>1861_1861_4_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000332132_length(amino acids)=310AA_BP=235
MKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYI
AVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERY
SYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDA

--------------------------------------------------------------
>1861_1861_5_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000358460_length(transcript)=1900nt_BP=995nt
ACTACGGTGGGCAGCGCCGCCCAAAGGGCGCTGGGGACGGTCGTCTTGGGGGTGGTCCCCGGGCCCGACCCATCCGGCTTTCCTTTCCCT
CCGCGCCCGTTTTTGCCAGTCGGTTTGGGGACCCAGGGGCCGAGCTCGGGGACTGGCCTGGCAGGGGAGCTAGAAAAGAGAAGCGCTCCT
GGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGGGTG
ATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAACAA
AGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAAC
CTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCA
ATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCG
GTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAA
TCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTA
AGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAAC
AGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATC
CAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGA
TTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCTTTG
GTCCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTTTCA
AGGAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCACTC
ATTTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCCTGT
GTTTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCCCTG
AAACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATTTGT
AAAATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCAAGA
TCTGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTGATA
AAAAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAGCTT

>1861_1861_5_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000358460_length(amino acids)=310AA_BP=235
MKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYI
AVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERY
SYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDA

--------------------------------------------------------------
>1861_1861_6_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000477847_length(transcript)=1920nt_BP=995nt
ACTACGGTGGGCAGCGCCGCCCAAAGGGCGCTGGGGACGGTCGTCTTGGGGGTGGTCCCCGGGCCCGACCCATCCGGCTTTCCTTTCCCT
CCGCGCCCGTTTTTGCCAGTCGGTTTGGGGACCCAGGGGCCGAGCTCGGGGACTGGCCTGGCAGGGGAGCTAGAAAAGAGAAGCGCTCCT
GGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCTGTATTGCTATTAAGGAGTCAGCAAAAGTGGGTG
ATCAAGCTCAAAGGAGGGTGATGAAAGGTGTTGATGACCTAGACTTCTTCATTGGTGATGAAGCAATAGAAAAACCTACATATGCAACAA
AGTGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAAC
CTGAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCA
ATGTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCG
GTACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAA
TCGCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTA
AGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAAC
AGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATC
CAGAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGA
TTGTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGGTATGTACCATGCCAAGGTCTTTACTCCCATATCAACCAGACCT
TGAAGGAGGCTCACTTCAACAGCCTGCAGCAGCGAGGGCAAGCTCCAACATGATGAATTAGGACTTCCTTATTCCAACCTAAACTGTGTT
TATAAAAGCAATTGCATACACACCAAAAAAAGTCTATTGGTTTTTAAGTCTACATTTTAAGTAACAAGTTAATGGGCAGTTGTTTAATTG
GGGTTTTACTTCACTGTTGTACTTTTAAAGGGGCTGTGAATAAATGTTTATGAAATTTTTATTTTTATTTTTATTTTACTCTTTCTACAT
AGAGTTTTCAAGTTGAGTGTCAATTTCATGTTAAGGTAGCAATATGAGGAAACTTCTCCTGTGCATTGAAGCCATATGTCCAATTCAGAT
TGATTTCCAGATCTGTCAGTTAGAAACTCTATGTTAAACATCTTTTTAAAATACAAGTAAGTCTTCATTTTTAAAAATACAGTAGCCTAG
TAAAGAGGTATGTAGCTTTCATTTAAAAAACAAACAAAAAATCCACACTCAAAAAACCATAAGTTAGTATTCCCAAATATGCAAAGCCAG
ATTCAGTCTTGCACTGAAATGAACTGCCATACTCCCCTCAGAAGGTAGATGTTCTGTTGAAATTGCTCTCTAGTTGTAATGGCAACAATC
AGACCCAGTTTAGACTATGAACATGAAAATCTCTCTCTAATAACTGTCTCTACACTTTGTATTTCCAGGGAGAATGTTTCTAAGGCTCTT

>1861_1861_6_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000535589_FAM104B_chrX_55172744_ENST00000477847_length(amino acids)=310AA_BP=235
MKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYI
AVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERY
SYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDA

--------------------------------------------------------------
>1861_1861_7_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000332132_length(transcript)=1808nt_BP=903nt
GACCGAGCCTGCTGCTTTCTTGCTACTGCTTCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGC
CCTTGTCTCCCGCCGCCAATCTCTGGCCCCTAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGAC
GGCTGCCGGCCTGTGTGGTGGACTGTGGCACGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCT
TGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAACCT
GAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCAAT
GTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCGGT
ACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATC
GCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAG
GCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAG
TATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCA
GAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGATT
GTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCTTTGGT
CCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTTTCAAG
GAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCACTCAT
TTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCCTGTGT
TTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCCCTGAA
ACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATTTGTAA
AATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCAAGATC
TGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTGATAAA
AAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAGCTTTT

>1861_1861_7_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000332132_length(amino acids)=299AA_BP=224
MLEIQNHSLSSLPWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAAS
WTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEF
NKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGLS

--------------------------------------------------------------
>1861_1861_8_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000358460_length(transcript)=1808nt_BP=903nt
GACCGAGCCTGCTGCTTTCTTGCTACTGCTTCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGC
CCTTGTCTCCCGCCGCCAATCTCTGGCCCCTAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGAC
GGCTGCCGGCCTGTGTGGTGGACTGTGGCACGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCT
TGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAACCT
GAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCAAT
GTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCGGT
ACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATC
GCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAG
GCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAG
TATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCA
GAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGATT
GTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGATTGTCTAAACCTGTTTATGTCATAAACTGGTTTATGTCCTTTGGT
CCTGAAATAAAACTCAATACTTCACAGCAGGGAAGGAACCAAGCTGTTTAAAACTACTTATCTCCGCTATGAAGGAGAAGTATTTTCAAG
GAATATCAGAAGAAAGTAGAAAGTGAGAGGAGGTTCCAGCTGGGCTTCCTGGGTCAAGTAGGGGCTCAGAAAGCTGTGAAACTCACTCAT
TTCCTGCATGCGGACTTACTTTGGTCCTGGATGAATAATATTGAAGATATGTGCTTAAAACATTCCTAACATCAGAATTTGCGCCTGTGT
TTTCTTCCCCAAGAAAGCTATAAACAGCGAAAATTTTGTTGTAAGCTTCCCTGTGTCCTCTCTCCCTCTCTCCCTTCCCCCTCCCCTGAA
ACTAAAAGGAATGTTAAAAGCCCACTTTTCTGTGACCAGCAGACCTTATCTATGGTCCCAATTCCAATTCCTTGTAAACACAATTTGTAA
AATCCCGTGAGATCCTGTCTCCTTTGCCATCCCGCTGCAAGGTTATAAGTAGAGAAAACTTAAGTTACAATTCCAGTTTTCCTCAAGATC
TGAGACATGTTAATTGTCTTTGTTTCTCCCTCTGGTAACATCTTCCCACCACACATATTTCCTGCCTTAGAGAGTTTAAAAGGTGATAAA
AAAATCTAACACTGGCTACCCCGCTCGGGACCCCTTCCACGCTGTGAAAGCTTTGTACTGTCACTCTGCTTAATAAAGCCTACAGCTTTT

>1861_1861_8_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000358460_length(amino acids)=299AA_BP=224
MLEIQNHSLSSLPWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAAS
WTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEF
NKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGLS

--------------------------------------------------------------
>1861_1861_9_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000477847_length(transcript)=1828nt_BP=903nt
GACCGAGCCTGCTGCTTTCTTGCTACTGCTTCGGCTTCCCGGCTACCCCCCGGACGGTGAAGGCGGCCCAGCTGTGGATGGTCAGATAGC
CCTTGTCTCCCGCCGCCAATCTCTGGCCCCTAGCAGCACGGAGCAGACGGCGGCAGCAGCAGCAGCAGGCGAGGAGGAAGATGGCGGGAC
GGCTGCCGGCCTGTGTGGTGGACTGTGGCACGGGGTATACAAAACTAGGATATGCTGGAAATACAGAACCACAGTTTATCATCCCTTCCT
TGGCCAATCCGCCATGGTATAGTTGAAGATTGGGACTTAATGGAAAGGTTTATGGAGCAAGTGATCTTTAAATATTTAAGGGCAGAACCT
GAAGACCATTATTTTCTTTTGACTGAACCTCCATTGAATACTCCAGAAAACAGGGAATATACTGCTGAAATAATGTTTGAGTCCTTCAAT
GTTCCAGGCTTGTACATTGCTGTGCAGGCTGTTCTTGCCTTAGCTGCATCTTGGACCTCAAGACAAGTAGGAGAACGGACGTTGACCGGT
ACGGTAATAGACAGTGGAGATGGTGTCACTCATGTCATTCCTGTGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATC
GCAGGACGAGATATAACATATTTTATTCAGCAACTGCTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAG
GCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGATTTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAG
TATACTGGAATCAATGCTATCTCAAAGAAAGAGTTTTCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCA
GAGTTTTCATGGAGTGATAATGAAAGGAGCAGCAGCCGCATTAATATCCCAGAGAGAGCAAGTGGACCAGAAGGCAACTTAAACCAGATT
GTTACTGAACCCGATGCAAACTTTCCCCAGTTCTTGCATGAGGGGTATGTACCATGCCAAGGTCTTTACTCCCATATCAACCAGACCTTG
AAGGAGGCTCACTTCAACAGCCTGCAGCAGCGAGGGCAAGCTCCAACATGATGAATTAGGACTTCCTTATTCCAACCTAAACTGTGTTTA
TAAAAGCAATTGCATACACACCAAAAAAAGTCTATTGGTTTTTAAGTCTACATTTTAAGTAACAAGTTAATGGGCAGTTGTTTAATTGGG
GTTTTACTTCACTGTTGTACTTTTAAAGGGGCTGTGAATAAATGTTTATGAAATTTTTATTTTTATTTTTATTTTACTCTTTCTACATAG
AGTTTTCAAGTTGAGTGTCAATTTCATGTTAAGGTAGCAATATGAGGAAACTTCTCCTGTGCATTGAAGCCATATGTCCAATTCAGATTG
ATTTCCAGATCTGTCAGTTAGAAACTCTATGTTAAACATCTTTTTAAAATACAAGTAAGTCTTCATTTTTAAAAATACAGTAGCCTAGTA
AAGAGGTATGTAGCTTTCATTTAAAAAACAAACAAAAAATCCACACTCAAAAAACCATAAGTTAGTATTCCCAAATATGCAAAGCCAGAT
TCAGTCTTGCACTGAAATGAACTGCCATACTCCCCTCAGAAGGTAGATGTTCTGTTGAAATTGCTCTCTAGTTGTAATGGCAACAATCAG
ACCCAGTTTAGACTATGAACATGAAAATCTCTCTCTAATAACTGTCTCTACACTTTGTATTTCCAGGGAGAATGTTTCTAAGGCTCTTGT

>1861_1861_9_ACTR3-FAM104B_ACTR3_chr2_114699936_ENST00000536059_FAM104B_chrX_55172744_ENST00000477847_length(amino acids)=299AA_BP=224
MLEIQNHSLSSLPWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAAS
WTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEF
NKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFSWSDNERSSSRINIPERASGPEGNLNQIVTEPDANFPQFLHEGYV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACTR3-FAM104B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACTR3-FAM104B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACTR3-FAM104B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource