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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COPS7A-CLSTN3 (FusionGDB2 ID:18644)

Fusion Gene Summary for COPS7A-CLSTN3

check button Fusion gene summary
Fusion gene informationFusion gene name: COPS7A-CLSTN3
Fusion gene ID: 18644
HgeneTgene
Gene symbol

COPS7A

CLSTN3

Gene ID

50813

9746

Gene nameCOP9 signalosome subunit 7Acalsyntenin 3
SynonymsCSN7|CSN7A|SGN7aCDHR14|CSTN3|alcbeta
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 7aCOP9 complex subunit 7aCOP9 constitutive photomorphogenic homolog subunit 7AJAB1-containing signalosome subunit 7adermal papilla-derived protein 10calsyntenin-3alc-betaalcadein betacadherin-related family member 14
Modification date2020031320200320
UniProtAcc

Q9UBW8

Q9BQT9

Ensembl transtripts involved in fusion geneENST00000229251, ENST00000534877, 
ENST00000534947, ENST00000539735, 
ENST00000542150, ENST00000543155, 
ENST00000538410, 		ENST00000331148, 
ENST00000266546, ENST00000537408, 
Fusion gene scores* DoF score8 X 5 X 6=2402 X 1 X 2=4
# samples 72
** MAII scorelog2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: COPS7A [Title/Abstract] AND CLSTN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOPS7A(6839986)-CLSTN3(7310085), # samples:1
Anticipated loss of major functional domain due to fusion event.COPS7A-CLSTN3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
COPS7A-CLSTN3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPS7A

GO:0000338

protein deneddylation

19141280


check buttonFusion gene breakpoints across COPS7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLSTN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XK-AAJA-01ACOPS7Achr12

6839986

+CLSTN3chr12

7310085

+


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Fusion Gene ORF analysis for COPS7A-CLSTN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000229251ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
5CDS-3UTRENST00000534877ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
5CDS-3UTRENST00000534947ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
5CDS-3UTRENST00000539735ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
5CDS-3UTRENST00000542150ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
5CDS-3UTRENST00000543155ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000229251ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000229251ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000534877ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000534877ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000534947ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000534947ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000539735ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000539735ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000543155ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
Frame-shiftENST00000543155ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
In-frameENST00000542150ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
In-frameENST00000542150ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
intron-3CDSENST00000538410ENST00000266546COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
intron-3CDSENST00000538410ENST00000537408COPS7Achr12

6839986

+CLSTN3chr12

7310085

+
intron-3UTRENST00000538410ENST00000331148COPS7Achr12

6839986

+CLSTN3chr12

7310085

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000542150COPS7Achr126839986+ENST00000266546CLSTN3chr127310085+186665840660206
ENST00000542150COPS7Achr126839986+ENST00000537408CLSTN3chr127310085+185365840660206

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000542150ENST00000266546COPS7Achr126839986+CLSTN3chr127310085+0.863057550.13694242
ENST00000542150ENST00000537408COPS7Achr126839986+CLSTN3chr127310085+0.86326370.13673626

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Fusion Genomic Features for COPS7A-CLSTN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
COPS7Achr126839987+CLSTN3chr127310084+0.0009514660.99904853
COPS7Achr126839987+CLSTN3chr127310084+0.0009514660.99904853

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for COPS7A-CLSTN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6839986/chr12:7310085)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPS7A

Q9UBW8

CLSTN3

Q9BQT9

FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.FUNCTION: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000229251+78185_233262276.0Coiled coilOntology_term=ECO:0000255
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000534877+78185_233262276.0Coiled coilOntology_term=ECO:0000255
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000534947+67185_233262276.0Coiled coilOntology_term=ECO:0000255
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000539735+78185_233262276.0Coiled coilOntology_term=ECO:0000255
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000543155+78185_233262276.0Coiled coilOntology_term=ECO:0000255
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000229251+782_159262276.0DomainPCI
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000534877+782_159262276.0DomainPCI
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000534947+672_159262276.0DomainPCI
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000539735+782_159262276.0DomainPCI
HgeneCOPS7Achr12:6839986chr12:7310085ENST00000543155+782_159262276.0DomainPCI
TgeneCLSTN3chr12:6839986chr12:7310085ENST000002665461518869_956842957.0Topological domainCytoplasmic
TgeneCLSTN3chr12:6839986chr12:7310085ENST000005374081417869_956854969.0Topological domainCytoplasmic
TgeneCLSTN3chr12:6839986chr12:7310085ENST000002665461518848_868842957.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLSTN3chr12:6839986chr12:7310085ENST000002665461518146_246842957.0DomainCadherin 2
TgeneCLSTN3chr12:6839986chr12:7310085ENST00000266546151829_145842957.0DomainCadherin 1
TgeneCLSTN3chr12:6839986chr12:7310085ENST000005374081417146_246854969.0DomainCadherin 2
TgeneCLSTN3chr12:6839986chr12:7310085ENST00000537408141729_145854969.0DomainCadherin 1
TgeneCLSTN3chr12:6839986chr12:7310085ENST00000266546151820_847842957.0Topological domainExtracellular
TgeneCLSTN3chr12:6839986chr12:7310085ENST00000537408141720_847854969.0Topological domainExtracellular
TgeneCLSTN3chr12:6839986chr12:7310085ENST000005374081417848_868854969.0TransmembraneHelical


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Fusion Gene Sequence for COPS7A-CLSTN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18644_18644_1_COPS7A-CLSTN3_COPS7A_chr12_6839986_ENST00000542150_CLSTN3_chr12_7310085_ENST00000266546_length(transcript)=1866nt_BP=658nt
AGTGGCCAGAGCGACTCTTCAGGGAGGTGGCAGGAAAGGCTTGGAACAGCTGCCGGAGGTGACGGAGCGGCGGCCCCGCCCGGTGCGCTG
GAGGTCGAAGCTTCCAGCTGAAGCCCGGAATCTTCCTCCACTAACAGAGGCTCAGAAGAATAAGCTTCGACACCTCTCAGTTGTCACCCT
GGCTGCTAAAGTAAAGTGTATCCCATATGCAGTGTTGCTGGAGGCTCTTGCCCTGCGTAATGTGCGGCAGCTGGAAGACCTTGTGATTGA
GGCTGTGTATGCTGACGTGCTTCGTGGCTCCCTGGACCAGCGCAACCAGCGGCTCGAGGTTGACTACAGCATCGGGCGGGACATCCAGCG
CCAGGACCTCAGTGCCATTGCCCGAACCCTGCAGGAATGGTGTGTGGGCTGTGAGGTCGTGCTGTCAGGCATTGAGGAGCAGGTGAGCCG
TGCCAACCAACACAAGGAGCAGCAGCTGGGCCTGAAGCAGCAGATTGAGAGTGAGGTTGCCAACCTTAAAAAAACCATTAAAGTTACGAC
GGCAGCAGCAGCCGCAGCCACATCTCAGGACCCTGAGCAACACCTGACTGAGCTGAGGGAACCAGCTCCTGGCACCAACCAGCGCCAGCC
CAGCAAGAAAGCCTCAAAGGGCAAGGGGTGATACCCAGCGCCGCAACCCTCATCATTGTGGTGTGCGTGGGCTTCCTGGTGCTCATGGTC
GTCCTGGGCCTGGTGCGCATCCATTCCCTTCACCGCCGCGTCTCAGGGGCCGGCGGGCCTCCAGGGGCCTCCAGTGACCCCAAGGACCCA
GACCTCTTCTGGGATGACTCAGCTCTCACCATCATTGTGAACCCCATGGAGTCCTACCAGAATCGGCAGTCCTGTGTGACGGGGGCTGTT
GGGGGCCAGCAGGAGGATGAGGACAGCAGTGACTCGGAGGTGGCCGATTCCCCCAGCAGCGACGAGAGACGCATCATCGAGACCCCCCCA
CACCGCTACTAAGGCCTACACCTCTCCCCACGCAGAGGGGGAATTCTGCCCTGGTGAAACAGACACTCCAGACATGGGAGAAGGACTTTC
TGGGAACACAGAGACCAAGAGGGAGAGAGGCTTCAGAACCAGTCCTCCTTTCATTTCAAAACCCCAGCGGGCCCTCTGGAGTCCGCCCTG
CCCCTCCCCCGGCCCCCCATCCCTCACTTCTGGGCTGTCATGCTCCTGGTGTGCCCCTTGCACTGGGGCTGGCTGGGTTGGAAAGTGGGC
TGGACTTCAGCTGCCTTTCTACCCCCAATGGCAGCTGCCCCCTTAGCACTCACTGTGTTGGGGAGAGGGTGACGATTGCAATGGCTGGGG
CTGGGGCTGGGGGTGGGATTGAAGGAAACCCTCTCCTCTCCCCTTCCCTTCTCTCTCCTGTCCATGGGAAGCTTTTCCCCCTCTGCAGGG
CTCCCTCAGCTGGACCATCGTCCCTGCTTCTCTTATGATCGCCCCACCTCATTTCCATTTCAGTCTGGGGACCCCATTTCTCCCTCCTTT
CCAACTTCCTTCCTTTCTTGTCCTGTTTCCCTTCCTGCCCTTGCAGTCCTGAGGTCCTGCAGCCCCGGCCCCTCCTCCGTGACCTGGTGT
GGCCAGGCTGCGGGGACGGGAGGGGACGTGGGGGCCCCGGGTGTACATATATAATGTATATTTTTTCAATGTTGTCGTGAGTGCAGCCCA
TGTTCCTGCGTGCAGCTCACGGCCTTGTGTGTATGTGTGTGTGTGTGTGTGTGTGAGGCATCGTCATGTCCTGGGGCAGGGGCGGGGGGT

>18644_18644_1_COPS7A-CLSTN3_COPS7A_chr12_6839986_ENST00000542150_CLSTN3_chr12_7310085_ENST00000266546_length(amino acids)=206AA_BP=
MEQLPEVTERRPRPVRWRSKLPAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQ
RNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQ

--------------------------------------------------------------
>18644_18644_2_COPS7A-CLSTN3_COPS7A_chr12_6839986_ENST00000542150_CLSTN3_chr12_7310085_ENST00000537408_length(transcript)=1853nt_BP=658nt
AGTGGCCAGAGCGACTCTTCAGGGAGGTGGCAGGAAAGGCTTGGAACAGCTGCCGGAGGTGACGGAGCGGCGGCCCCGCCCGGTGCGCTG
GAGGTCGAAGCTTCCAGCTGAAGCCCGGAATCTTCCTCCACTAACAGAGGCTCAGAAGAATAAGCTTCGACACCTCTCAGTTGTCACCCT
GGCTGCTAAAGTAAAGTGTATCCCATATGCAGTGTTGCTGGAGGCTCTTGCCCTGCGTAATGTGCGGCAGCTGGAAGACCTTGTGATTGA
GGCTGTGTATGCTGACGTGCTTCGTGGCTCCCTGGACCAGCGCAACCAGCGGCTCGAGGTTGACTACAGCATCGGGCGGGACATCCAGCG
CCAGGACCTCAGTGCCATTGCCCGAACCCTGCAGGAATGGTGTGTGGGCTGTGAGGTCGTGCTGTCAGGCATTGAGGAGCAGGTGAGCCG
TGCCAACCAACACAAGGAGCAGCAGCTGGGCCTGAAGCAGCAGATTGAGAGTGAGGTTGCCAACCTTAAAAAAACCATTAAAGTTACGAC
GGCAGCAGCAGCCGCAGCCACATCTCAGGACCCTGAGCAACACCTGACTGAGCTGAGGGAACCAGCTCCTGGCACCAACCAGCGCCAGCC
CAGCAAGAAAGCCTCAAAGGGCAAGGGGTGATACCCAGCGCCGCAACCCTCATCATTGTGGTGTGCGTGGGCTTCCTGGTGCTCATGGTC
GTCCTGGGCCTGGTGCGCATCCATTCCCTTCACCGCCGCGTCTCAGGGGCCGGCGGGCCTCCAGGGGCCTCCAGTGACCCCAAGGACCCA
GACCTCTTCTGGGATGACTCAGCTCTCACCATCATTGTGAACCCCATGGAGTCCTACCAGAATCGGCAGTCCTGTGTGACGGGGGCTGTT
GGGGGCCAGCAGGAGGATGAGGACAGCAGTGACTCGGAGGTGGCCGATTCCCCCAGCAGCGACGAGAGACGCATCATCGAGACCCCCCCA
CACCGCTACTAAGGCCTACACCTCTCCCCACGCAGAGGGGGAATTCTGCCCTGGTGAAACAGACACTCCAGACATGGGAGAAGGACTTTC
TGGGAACACAGAGACCAAGAGGGAGAGAGGCTTCAGAACCAGTCCTCCTTTCATTTCAAAACCCCAGCGGGCCCTCTGGAGTCCGCCCTG
CCCCTCCCCCGGCCCCCCATCCCTCACTTCTGGGCTGTCATGCTCCTGGTGTGCCCCTTGCACTGGGGCTGGCTGGGTTGGAAAGTGGGC
TGGACTTCAGCTGCCTTTCTACCCCCAATGGCAGCTGCCCCCTTAGCACTCACTGTGTTGGGGAGAGGGTGACGATTGCAATGGCTGGGG
CTGGGGCTGGGGGTGGGATTGAAGGAAACCCTCTCCTCTCCCCTTCCCTTCTCTCTCCTGTCCATGGGAAGCTTTTCCCCCTCTGCAGGG
CTCCCTCAGCTGGACCATCGTCCCTGCTTCTCTTATGATCGCCCCACCTCATTTCCATTTCAGTCTGGGGACCCCATTTCTCCCTCCTTT
CCAACTTCCTTCCTTTCTTGTCCTGTTTCCCTTCCTGCCCTTGCAGTCCTGAGGTCCTGCAGCCCCGGCCCCTCCTCCGTGACCTGGTGT
GGCCAGGCTGCGGGGACGGGAGGGGACGTGGGGGCCCCGGGTGTACATATATAATGTATATTTTTTCAATGTTGTCGTGAGTGCAGCCCA
TGTTCCTGCGTGCAGCTCACGGCCTTGTGTGTATGTGTGTGTGTGTGTGTGTGTGAGGCATCGTCATGTCCTGGGGCAGGGGCGGGGGGT

>18644_18644_2_COPS7A-CLSTN3_COPS7A_chr12_6839986_ENST00000542150_CLSTN3_chr12_7310085_ENST00000537408_length(amino acids)=206AA_BP=
MEQLPEVTERRPRPVRWRSKLPAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQ
RNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COPS7A-CLSTN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COPS7A-CLSTN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COPS7A-CLSTN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource