FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:COPZ1-HOXC4 (FusionGDB2 ID:18671)

Fusion Gene Summary for COPZ1-HOXC4

check button Fusion gene summary
Fusion gene informationFusion gene name: COPZ1-HOXC4
Fusion gene ID: 18671
HgeneTgene
Gene symbol

COPZ1

HOXC4

Gene ID

22818

3221

Gene nameCOPI coat complex subunit zeta 1homeobox C4
SynonymsCGI-120|COPZ|HSPC181|zeta-COP|zeta1-COPHOX3|HOX3E|cp19
Cytomap

12q13.13

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioncoatomer subunit zeta-1coatomer protein complex subunit zeta 1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat proteinhomeobox protein Hox-C4homeo box 3Ehomeobox protein CP19homeobox protein Hox-3E
Modification date2020031320200313
UniProtAcc

P61923

P09017

Ensembl transtripts involved in fusion geneENST00000262061, ENST00000455864, 
ENST00000549116, ENST00000551779, 
ENST00000552218, ENST00000552362, 
ENST00000553231, ENST00000416254, 
ENST00000549043, ENST00000548281, 
ENST00000548753, 		ENST00000430889, 
ENST00000507650, ENST00000609810, 
ENST00000303406, 
Fusion gene scores* DoF score12 X 4 X 10=4803 X 3 X 2=18
# samples 133
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COPZ1 [Title/Abstract] AND HOXC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOPZ1(54718965)-HOXC4(54448044), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPZ1

GO:0006891

intra-Golgi vesicle-mediated transport

11056392

TgeneHOXC4

GO:0045944

positive regulation of transcription by RNA polymerase II

15252056


check buttonFusion gene breakpoints across COPZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HOXC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0I6-01ACOPZ1chr12

54718965

+HOXC4chr12

54448044

+


Top

Fusion Gene ORF analysis for COPZ1-HOXC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262061ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000262061ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000262061ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000455864ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000455864ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000455864ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000549116ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000549116ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000549116ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000551779ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000551779ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000551779ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552218ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552218ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552218ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552362ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552362ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000552362ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000553231ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000553231ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5CDS-intronENST00000553231ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-3CDSENST00000416254ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-3CDSENST00000549043ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000416254ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000416254ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000416254ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000549043ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000549043ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
5UTR-intronENST00000549043ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000262061ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000455864ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000549116ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000551779ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000552218ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000552362ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
In-frameENST00000553231ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-3CDSENST00000548281ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-3CDSENST00000548753ENST00000303406COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548281ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548281ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548281ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548753ENST00000430889COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548753ENST00000507650COPZ1chr12

54718965

+HOXC4chr12

54448044

+
intron-intronENST00000548753ENST00000609810COPZ1chr12

54718965

+HOXC4chr12

54448044

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262061COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+63455131511126
ENST00000552218COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+63051127507126
ENST00000553231COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+62243119499126
ENST00000552362COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+62243119499126
ENST00000455864COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+62243119499126
ENST00000549116COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+61738114494126
ENST00000551779COPZ1chr1254718965+ENST00000303406HOXC4chr1254448044+61031107487126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262061ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.427451340.5725487
ENST00000552218ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.44534010.5546599
ENST00000553231ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.43659790.5634021
ENST00000552362ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.43659790.5634021
ENST00000455864ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.43659790.5634021
ENST00000549116ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.490323630.5096764
ENST00000551779ENST00000303406COPZ1chr1254718965+HOXC4chr1254448044+0.520137970.47986203

Top

Fusion Genomic Features for COPZ1-HOXC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for COPZ1-HOXC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:54718965/chr12:54448044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPZ1

P61923

HOXC4

P09017

FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250|UniProtKB:P53600}.FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOXC4chr12:54718965chr12:54448044ENST0000030340604183_1860265.0Compositional biasNote=Poly-Arg
TgeneHOXC4chr12:54718965chr12:54448044ENST000003034060454_600265.0Compositional biasNote=Poly-Pro
TgeneHOXC4chr12:54718965chr12:54448044ENST0000043088902183_1860265.0Compositional biasNote=Poly-Arg
TgeneHOXC4chr12:54718965chr12:54448044ENST000004308890254_600265.0Compositional biasNote=Poly-Pro
TgeneHOXC4chr12:54718965chr12:54448044ENST0000030340604156_2150265.0DNA bindingHomeobox
TgeneHOXC4chr12:54718965chr12:54448044ENST0000043088902156_2150265.0DNA bindingHomeobox
TgeneHOXC4chr12:54718965chr12:54448044ENST0000030340604135_1400265.0MotifNote=Antp-type hexapeptide
TgeneHOXC4chr12:54718965chr12:54448044ENST0000043088902135_1400265.0MotifNote=Antp-type hexapeptide

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for COPZ1-HOXC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18671_18671_1_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000262061_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=634nt_BP=55nt
TTTTGCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATC
CCTCCAGCGCCGCCAGCAAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGG
AACCCAAGCGCTCGAGGACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGA
GAAGGATCGAGATCGCCCACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACC
ACCGACTCCCCAACACCAAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAG
ACCACTCCCAGAGCGCCACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCC
CATGCCCCCACCCTCCCCTCACACACAAATTGACTCTTATTTATAGAATTTAATATATATATATATATATATATATATAGGTTCTTTTCT

>18671_18671_1_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000262061_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_2_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000455864_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=622nt_BP=43nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTCCAGCGCCG
CCAGCAAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACCCAAGCGCT
CGAGGACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAGGATCGAGA
TCGCCCACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCGACTCCCCA
ACACCAAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCACTCCCAGA
GCGCCACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATGCCCCCACC

>18671_18671_2_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000455864_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_3_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000549116_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=617nt_BP=38nt
GGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTCCAGCGCCGCCAGC
AAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACCCAAGCGCTCGAGG
ACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAGGATCGAGATCGCC
CACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCGACTCCCCAACACC
AAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCACTCCCAGAGCGCC
ACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATGCCCCCACCCTCCC

>18671_18671_3_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000549116_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_4_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000551779_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=610nt_BP=31nt
GCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTCCAGCGCCGCCAGCAAGCAAC
CCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACCCAAGCGCTCGAGGACAGCCT
ATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAGGATCGAGATCGCCCACTCGC
TGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCGACTCCCCAACACCAAAGTCA
GGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCACTCCCAGAGCGCCACGCCGC
CGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATGCCCCCACCCTCCCCTCACAC

>18671_18671_4_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000551779_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_5_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000552218_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=630nt_BP=51nt
GCGGCTCCACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTC
CAGCGCCGCCAGCAAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACC
CAAGCGCTCGAGGACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAG
GATCGAGATCGCCCACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCG
ACTCCCCAACACCAAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCA
CTCCCAGAGCGCCACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATG
CCCCCACCCTCCCCTCACACACAAATTGACTCTTATTTATAGAATTTAATATATATATATATATATATATATATAGGTTCTTTTCTCTCT

>18671_18671_5_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000552218_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_6_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000552362_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=622nt_BP=43nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTCCAGCGCCG
CCAGCAAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACCCAAGCGCT
CGAGGACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAGGATCGAGA
TCGCCCACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCGACTCCCCA
ACACCAAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCACTCCCAGA
GCGCCACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATGCCCCCACC

>18671_18671_6_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000552362_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------
>18671_18671_7_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000553231_HOXC4_chr12_54448044_ENST00000303406_length(transcript)=622nt_BP=43nt
ACGTCGGCACCAGCTGCGGGGCAAGATGGAGGCGCTGATTTTGCCCGCCAGCCTGCAGCCAGCCAGCCCCCGACCATCCCTCCAGCGCCG
CCAGCAAGCAACCCATAGTCTACCCATGGATGAAAAAAATTCACGTTAGCACGGTGAACCCCAATTATAACGGAGGGGAACCCAAGCGCT
CGAGGACAGCCTATACCCGGCAGCAAGTCCTGGAATTAGAGAAAGAGTTTCATTACAACCGCTACCTGACCCGAAGGAGAAGGATCGAGA
TCGCCCACTCGCTGTGCCTCTCTGAGAGGCAGATCAAAATCTGGTTCCAAAACCGTCGCATGAAATGGAAGAAGGACCACCGACTCCCCA
ACACCAAAGTCAGGTCAGCACCCCCGGCCGGCGCTGCGCCCAGCACCCTTTCGGCAGCTACCCCGGGTACTTCTGAAGACCACTCCCAGA
GCGCCACGCCGCCGGAGCAGCAACGGGCAGAGGACATTACCAGGTTATAAAACATAACTCACACCCCTGCCCCCACCCCATGCCCCCACC

>18671_18671_7_COPZ1-HOXC4_COPZ1_chr12_54718965_ENST00000553231_HOXC4_chr12_54448044_ENST00000303406_length(amino acids)=126AA_BP=
MKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for COPZ1-HOXC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for COPZ1-HOXC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for COPZ1-HOXC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource