FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:COPZ1-ITGA7 (FusionGDB2 ID:18674)

Fusion Gene Summary for COPZ1-ITGA7

check button Fusion gene summary
Fusion gene informationFusion gene name: COPZ1-ITGA7
Fusion gene ID: 18674
HgeneTgene
Gene symbol

COPZ1

ITGA7

Gene ID

22818

3679

Gene nameCOPI coat complex subunit zeta 1integrin subunit alpha 7
SynonymsCGI-120|COPZ|HSPC181|zeta-COP|zeta1-COP-
Cytomap

12q13.13

12q13.2

Type of geneprotein-codingprotein-coding
Descriptioncoatomer subunit zeta-1coatomer protein complex subunit zeta 1coatomer protein complex, subunit zetazeta-1 COPzeta-1-coat proteinintegrin alpha-7integrin alpha 7 chain
Modification date2020031320200328
UniProtAcc

P61923

Q13683

Ensembl transtripts involved in fusion geneENST00000262061, ENST00000455864, 
ENST00000549116, ENST00000551779, 
ENST00000552218, ENST00000552362, 
ENST00000553231, ENST00000416254, 
ENST00000549043, ENST00000548281, 
ENST00000548753, 		ENST00000257879, 
ENST00000257880, ENST00000347027, 
ENST00000394229, ENST00000394230, 
ENST00000452168, ENST00000553804, 
ENST00000555728, 
Fusion gene scores* DoF score12 X 4 X 10=4805 X 3 X 5=75
# samples 135
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COPZ1 [Title/Abstract] AND ITGA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOPZ1(54718965)-ITGA7(56105918), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPZ1

GO:0006891

intra-Golgi vesicle-mediated transport

11056392


check buttonFusion gene breakpoints across COPZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ITGA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BE-01ACOPZ1chr12

54718965

+ITGA7chr12

56105918

-
ChimerDB4SARCTCGA-WK-A8Y0-01ACOPZ1chr12

54718965

+ITGA7chr12

56105918

-


Top

Fusion Gene ORF analysis for COPZ1-ITGA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262061ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000262061ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000455864ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000549116ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000551779ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552218ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000552362ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5CDS-intronENST00000553231ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000416254ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
5UTR-intronENST00000549043ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548281ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000257879COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000257880COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000347027COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000394229COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000394230COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000452168COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000553804COPZ1chr12

54718965

+ITGA7chr12

56105918

-
intron-intronENST00000548753ENST00000555728COPZ1chr12

54718965

+ITGA7chr12

56105918

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for COPZ1-ITGA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for COPZ1-ITGA7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54718965/:56105918)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPZ1

P61923

ITGA7

Q13683

FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). {ECO:0000250|UniProtKB:P53600}.FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for COPZ1-ITGA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for COPZ1-ITGA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for COPZ1-ITGA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for COPZ1-ITGA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource