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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CORO1C-PACRG (FusionGDB2 ID:18718)

Fusion Gene Summary for CORO1C-PACRG

check button Fusion gene summary
Fusion gene informationFusion gene name: CORO1C-PACRG
Fusion gene ID: 18718
HgeneTgene
Gene symbol

CORO1C

PACRG

Gene ID

23603

135138

Gene namecoronin 1Cparkin coregulated
SynonymsHCRNN4GLUP|HAK005771|PACRG2.1|PARK2CRG
Cytomap

12q24.11

6q26

Type of geneprotein-codingprotein-coding
Descriptioncoronin-1Ccoronin, actin binding protein, 1Ccoronin-3parkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene protein
Modification date2020032220200313
UniProtAcc

Q9ULV4

PACRGL

Ensembl transtripts involved in fusion geneENST00000261401, ENST00000549384, 
ENST00000420959, ENST00000421578, 
ENST00000541050, ENST00000549772, 
ENST00000337019, ENST00000366888, 
ENST00000366889, ENST00000542669, 
Fusion gene scores* DoF score12 X 6 X 8=57613 X 11 X 13=1859
# samples 1319
** MAII scorelog2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1859*10)=-3.29045544658853
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORO1C [Title/Abstract] AND PACRG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCORO1C(109125205)-PACRG(163735859), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCORO1C

GO:0016197

endosomal transport

30220460

HgeneCORO1C

GO:0090148

membrane fission

30220460

HgeneCORO1C

GO:0097750

endosome membrane tubulation

30220460


check buttonFusion gene breakpoints across CORO1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PACRG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-XR-A8TG-01ACORO1Cchr12

109125205

-PACRGchr6

163735859

+


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Fusion Gene ORF analysis for CORO1C-PACRG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261401ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000261401ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000261401ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-intronENST00000261401ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-intronENST00000549384ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000420959ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000421578ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000541050ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000549772ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CORO1C-PACRG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CORO1Cchr12109125204-PACRGchr6163735858+1.46E-111
CORO1Cchr12109125204-PACRGchr6163735858+1.46E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CORO1C-PACRG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:109125205/:163735859)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CORO1C

Q9ULV4

PACRG

PACRGL

FUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.248

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CORO1C-PACRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CORO1C-PACRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CORO1C-PACRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CORO1C-PACRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource