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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CORO2B-SLC22A23 (FusionGDB2 ID:18734)

Fusion Gene Summary for CORO2B-SLC22A23

check button Fusion gene summary
Fusion gene informationFusion gene name: CORO2B-SLC22A23
Fusion gene ID: 18734
HgeneTgene
Gene symbol

CORO2B

SLC22A23

Gene ID

10391

63027

Gene namecoronin 2Bsolute carrier family 22 member 23
SynonymsCLIPINCC6orf85
Cytomap

15q23

6p25.2

Type of geneprotein-codingprotein-coding
Descriptioncoronin-2Bclipin Ccoronin, actin binding protein, 2Bcoronin-like protein Csolute carrier family 22 member 23ion transporter protein
Modification date2020031320200313
UniProtAcc

Q9UQ03

.
Ensembl transtripts involved in fusion geneENST00000566799, ENST00000261861, 
ENST00000540068, ENST00000543950, 
ENST00000380298, ENST00000380302, 
ENST00000490273, ENST00000433689, 
ENST00000406686, ENST00000436008, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 6=216
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORO2B [Title/Abstract] AND SLC22A23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCORO2B(68871616)-SLC22A23(3416089), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCORO2B

GO:0010812

negative regulation of cell-substrate adhesion

29162887

HgeneCORO2B

GO:0032956

regulation of actin cytoskeleton organization

29162887

HgeneCORO2B

GO:0080135

regulation of cellular response to stress

29162887

HgeneCORO2B

GO:1904950

negative regulation of establishment of protein localization

29162887

HgeneCORO2B

GO:1904951

positive regulation of establishment of protein localization

29162887


check buttonFusion gene breakpoints across CORO2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC22A23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-YD-A89C-06ACORO2Bchr15

68871616

-SLC22A23chr6

3416089

-
ChimerDB4SKCMTCGA-YD-A89C-06ACORO2Bchr15

68871616

+SLC22A23chr6

3416089

-


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Fusion Gene ORF analysis for CORO2B-SLC22A23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000566799ENST00000380298CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5CDS-5UTRENST00000566799ENST00000380302CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5CDS-5UTRENST00000566799ENST00000490273CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5CDS-intronENST00000566799ENST00000433689CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-3CDSENST00000261861ENST00000406686CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-3CDSENST00000261861ENST00000436008CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-5UTRENST00000261861ENST00000380298CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-5UTRENST00000261861ENST00000380302CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-5UTRENST00000261861ENST00000490273CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
5UTR-intronENST00000261861ENST00000433689CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
In-frameENST00000566799ENST00000406686CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
In-frameENST00000566799ENST00000436008CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-3CDSENST00000540068ENST00000406686CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-3CDSENST00000540068ENST00000436008CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-3CDSENST00000543950ENST00000406686CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-3CDSENST00000543950ENST00000436008CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000540068ENST00000380298CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000540068ENST00000380302CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000540068ENST00000490273CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000543950ENST00000380298CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000543950ENST00000380302CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-5UTRENST00000543950ENST00000490273CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-intronENST00000540068ENST00000433689CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-
intron-intronENST00000543950ENST00000433689CORO2Bchr15

68871616

+SLC22A23chr6

3416089

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566799CORO2Bchr1568871616+ENST00000436008SLC22A23chr63416089-556844291474481
ENST00000566799CORO2Bchr1568871616+ENST00000406686SLC22A23chr63416089-504844291450473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566799ENST00000436008CORO2Bchr1568871616+SLC22A23chr63416089-0.0055737960.99442625
ENST00000566799ENST00000406686CORO2Bchr1568871616+SLC22A23chr63416089-0.0064061550.9935939

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Fusion Genomic Features for CORO2B-SLC22A23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CORO2B-SLC22A23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:68871616/chr6:3416089)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CORO2B

Q9UQ03

.
FUNCTION: May play a role in the reorganization of neuronal actin structure.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804234_254218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804258_278218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804288_308218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804315_335218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804344_364218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804467_487218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804494_514218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804538_558218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804569_589218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST0000038029804598_618218362.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010234_2540406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010258_2780406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010288_3080406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010315_3350406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010344_3640406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010467_4870406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010494_5140406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010538_5580406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010569_5890406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000380302010598_6180406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010234_254218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010258_278218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010288_308218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010315_335218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010344_364218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010467_487218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010494_514218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010538_558218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010569_589218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000406686010598_618218687.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111234_2540406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111258_2780406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111288_3080406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111315_3350406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111344_3640406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111467_4870406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111494_5140406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111538_5580406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111569_5890406.0TransmembraneHelical
TgeneSLC22A23chr15:68871616chr6:3416089ENST00000490273111598_6180406.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112436_4790476.0Coiled coilOntology_term=ECO:0000255
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112436_4790476.0Coiled coilOntology_term=ECO:0000255
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112436_4790476.0Coiled coilOntology_term=ECO:0000255
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112436_4795481.0Coiled coilOntology_term=ECO:0000255
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112128_1700476.0RepeatNote=WD 3
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112171_2120476.0RepeatNote=WD 4
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112213_2590476.0RepeatNote=WD 5
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112260_3050476.0RepeatNote=WD 6
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+11229_770476.0RepeatNote=WD 1
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+112306_3450476.0RepeatNote=WD 7
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000261861+11278_1270476.0RepeatNote=WD 2
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112128_1700476.0RepeatNote=WD 3
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112171_2120476.0RepeatNote=WD 4
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112213_2590476.0RepeatNote=WD 5
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112260_3050476.0RepeatNote=WD 6
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+11229_770476.0RepeatNote=WD 1
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+112306_3450476.0RepeatNote=WD 7
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000540068+11278_1270476.0RepeatNote=WD 2
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112128_1700476.0RepeatNote=WD 3
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112171_2120476.0RepeatNote=WD 4
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112213_2590476.0RepeatNote=WD 5
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112260_3050476.0RepeatNote=WD 6
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+11229_770476.0RepeatNote=WD 1
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+112306_3450476.0RepeatNote=WD 7
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000543950+11278_1270476.0RepeatNote=WD 2
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112128_1705481.0RepeatNote=WD 3
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112171_2125481.0RepeatNote=WD 4
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112213_2595481.0RepeatNote=WD 5
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112260_3055481.0RepeatNote=WD 6
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+11229_775481.0RepeatNote=WD 1
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+112306_3455481.0RepeatNote=WD 7
HgeneCORO2Bchr15:68871616chr6:3416089ENST00000566799+11278_1275481.0RepeatNote=WD 2


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Fusion Gene Sequence for CORO2B-SLC22A23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18734_18734_1_CORO2B-SLC22A23_CORO2B_chr15_68871616_ENST00000566799_SLC22A23_chr6_3416089_ENST00000406686_length(transcript)=5048nt_BP=44nt
GCGCCCCCGCTCCGCCGCGGAGTTTCTGCATGACTGTCACAAAGTGGGATCTTGTGTGTGATAATGCCTGGAAGGTCCATATCGCTAAGT
TCTCCTTACTGGTTGGATTAATCTTTGGCTACCTAATAACTGGATGCATTGCTGACTGGGTCGGCCGGCGGCCTGTGCTGCTGTTTTCCA
TCATCTTCATTCTGATCTTTGGACTGACTGTGGCACTGTCAGTGAATGTGACAATGTTCAGCACACTCAGGTTCTTTGAAGGATTTTGCC
TGGCTGGAATCATTCTCACCTTGTATGCTTTACGAATAGAGCTGTGCCCCCCTGGAAAACGGTTCATGATTACGATGGTGGCGAGCTTCG
TGGCCATGGCGGGCCAGTTCCTCATGCCTGGGCTAGCCGCCCTGTGCCGGGATTGGCAGGTGCTGCAGGCCCTCATCATCTGCCCCTTCC
TGCTCATGCTGCTCTACTGGTCGATATTCCCCGAGTCCCTCCGGTGGCTAATGGCCACCCAGCAGTTTGAGTCTGCAAAGAGGCTGATCC
TCCACTTCACACAGAAGAATCGCATGAACCCTGAGGGCGACATCAAGGGTGTGATACCAGAGCTGGAGAAAGAGCTTTCCCGGAGGCCCA
AGAAGGTCTGCATCGTGAAGGTGGTGGGGACACGGAACCTGTGGAAGAACATTGTGGTCCTGTGTGTGAACTCGCTGACGGGGTACGGGA
TCCACCACTGCTTTGCCAGGAGCATGATGGGCCACGAGGTGAAGGTGCCGCTCCTGGAGAACTTCTATGCTGACTACTATACCACGGCCA
GCATCGCGCTGGTGTCCTGCCTGGCCATGTGCGTGGTGGTCCGATTCCTCGGGCGCAGGGGAGGGCTGCTGCTCTTCATGATCCTCACCG
CCCTGGCCTCACTCCTGCAGCTCGGCCTCCTCAACCTGATTGGAAAGTACAGCCAGCACCCAGACTCAGGGATGAGTGACAGCGTCAAGG
ACAAATTTTCCATCGCGTTTTCCATCGTGGGCATGTTTGCCTCCCATGCGGTGGGGAGCCTCAGCGTGTTCTTCTGTGCGGAGATCACCC
CGACGGTGATAAGGTGTGGCGGGCTGGGGCTGGTGCTGGCCAGCGCGGGCTTCGGCATGCTGACGGCACCCATCATCGAGCTGCACAACC
AGAAAGGCTACTTCCTGCACCACATCATCTTTGCCTGCTGCACGCTCATCTGCATCATCTGCATCCTCCTGCTGCCCGAGAGCAGGGACC
AGAACCTGCCTGAGAACATTTCTAACGGGGAGCACTACACGCGCCAGCCGCTGCTGCCGCACAAGAAGGGGGAGCAGCCACTGCTGCTCA
CCAACGCCGAGCTCAAGGACTACTCGGGCCTCCACGATGCCGCAGCCGCGGGTGACACACTGCCCGAGGGTGCCACGGCCAACGGCATGA
AGGCCATGTAGCCCGGCCTGCGGAACCCGGGGCTCCAGGGTCTGGGGCAGCTTGGGCACAGGTTTACAGACCAGGGACCGAACACGCAGC
CAGGGGTGGGAAAGCTGCCTCAGCCAAGCTGAGCCTCTCAACTGGTGTGGGGAAATCCTGTCTTTCCAAAAGTCCAAGGAGCGCGGGTCG
GAGGAGACAAACTCTTTGGAAATAACCCTTTCAAGACTTTCTTTTCTGCCGTTAAATGTGTGTATTTATTTTGGTCATTTTTACGAGAAG
CACTTTATTCCCTCTCCCTCTCACTGATCACAAATGGAATCACCTCCCTGGGCAGCGAGACGCAGTTGCTCTGGGAAGATGCCACAGTGA
CCAGGGCCATGGCCGGTCCCTCTGGGGAGATGGGACACGGCTCCTGGCAGCACCCAGGAGCCCCCCAGGCTGCCTGCCTGCGTGCAGAGG
CAGGAGAGGACCGTGGAGCGTTTCCGGGACTGCATTTTAGACGGAGTGAAATGTACATGAATTTGGCTTTTGCTAGAGTCTGTGTATGGT
TTTTTAAGGTCCTTTTTCCCTTTCTGTTTGTAAGGTAAGAGCTTCTGTTCGTGTGCAGGGAAAGCAGCTCACAGACGCCGTTAAAACCAG
CTTCATCTTTCCTTCAGGATCATCCTTTTGTACTTGATGCTGGAAGCTCTTGGAGAAAAAGCTTAAACATTTCACCAGAAATCTTAATTG
AGCAGCAGTCATATCGCCACAGCTTTGTGAGTACACAGCTAACAGATGCGTCGAGACCTGAGATGTGCTCGTTTTTATTCCTCCTCTCCC
AGATTGGCTCCAGCAGAAAAGTCCCTCGTGCACAGGCAGCTCTTGTGCCGGCACTACTTGAAAACATGGCTACTTTCTAAGCTACAAACC
ATTAGAAAATAACTCAAAAAGATGGCAGAGGCAAATCCACAGAAGGGGGGCTGCCCTCCACACACACACGCCCGTCACCCACACCTTGAG
CACACACCATGAAGATCACCAGCTTGGATGGCCGTCACCTCAGACATCACTCCAGGGAGCACCCGCAGGAGCTGGGCCCCCTCACGCCTG
CCTTCCTGGGCCAGCTTCCTGCTTGCAGTCACTCGCATAGCACAGAGGTGGGGCTTCGGGCAGGGAGCGGAGATTCCTCATAGGTGAGTC
CAAATGACCTCCAGCCTCTCGAAGGCATCAAGACAAATTGAAAGAAAGCAATAACTCACCAAAGCTCAACGCTGCCCCTGCCTCGACCTC
CATGGGTCTCTTCGTGTTCCTCGTTTCACCCCAGAAAGTGGAGGTTTCCTCTTGGCATTTTCGGAGGAAACTTGTAGGACACCCAAGGCG
ACTAAGAGACAGCCTCCTTGGCAAGGGCAGGCACCACTTTGTAGCAACTTGGGCACCAGCTTTTCTGGACAGCCTGGCTTCTTACTGGCA
TTGTCCAACTCATCCCTTCTCGAAGCATGTCTTTGCCATGGGCTGTGTCCTTCCAGGGAAATTGTGGTCTCGGGCCTGGGTGAGACAATG
AAGTGACTTCCAACCGACAGTTGCTAGAATTCACAGGGCAGAAAAGGGGTTGACCTTCTCCCCTTCTGGCTTTCCACCCGGCCTGCTGCT
TGCTGTCGCCACTCATGTCTCCTCCACATGCGGTCCACACATCAGTAAGGGCCTGGAGATGTGTAAAGACACAGCAAGGGGCAAGCAGAC
TCTTGGCCACGTGTTTCCAGTGGCTGGACCACGCCGACACCTGGGATCTTGAGATACCCAGGAAGGGAGGCTGTCTGGCCAGCCTCTCCC
TGCCTCCACTTGCTCCACGTCCAGCTCCTCACCTTCCCTCTTTTTTAAAGTCACATTTCCATGTTTCAACATTAGTTTGCATTCACCTTT
ACAAAGGCCTTTCTTTAGATCTGTGCAGCCTTTGCGTGCCAAACTTGTGAAATTCCTTTTACCTTTTTTGGAGTACTTGCTATAAAGCCA
CCTGTCAACAAACCCCCATTATGTACAGAATAGGACCTATCCAGTAGCCAGGCCAGTAGGCAGTTGGGGAAGGTGGGAAGGATCCAGCGA
GGCCCCTGAGCCTGCACCTGGACAGGTGTACGTCTGCACCCATCACCCTCAGCACCAGGCCACCCTGCAGTCCACTTACTGTACTGTGTT
GTGGAAGGATATGCTAAGTGATGAAAGTTGCGAGCAGTCTCACTGGTCGTGTAAACTTTTTTTTTTTTTTGGAAATTGAAGCTGTAGAGT
GCTGCCCGAAATCTCTAGGAAGTTGGTGGCAAGGGACAGCACTCACACTCTTCTGGTCATGATCTCTGATCTCCACCTCAAATGACAATA
AAAAACTGGTCCAACGAAGACACTGCTCAGCACTTCAGCCATCAGGACTAATCCATCGATGACTGGAAAAGAGGCTAGCTTTGAGGAAAA
CAGCCTGGGCTCTTGGGAGCAGAGTCCAGTGGGTGTGAGGCTGACTTGCCGACGGTCGGCAGGTAATGGCTCTCAGCCGGCGAGGCGGTC
CCACAGCTCTCCTCCCAGGGCAGCCTGAGGAGGAGGAGGCCGGGTGCCTGTTTGGTGGCAGCTTCAGCCTAGGGATACCTGAAGCTGTTG
AGCAACACCTTTATGAAATGTTGCCAGAGCAGCAACACTTCCCTGTGGGCACAGCCCCGGGAAATCCGGTACCAAGTGAGCAAGGTGGCA
GGACCCACCCAAGCCTGATACGCATCTGGGCCCGCCGGGCTCAGCAGGGGAGGCTGCTACGGCTGCCCACTTCCCAGCACCGTCTGTCAC
GCTTGAACCCCTCTGTGCTGTTCCCTTCCTGGCTAATAGGGAGACCCTTCGCAGGCACCCACTGTTTCAACTTGACCCTCCCACCCCCTG
CTACTCTCCTCCACACACCCCTCCGTTCCGCTAGCCTACCCTGTCAGCCTTTCAATAAAAGTTATGCACAAATGTGAACACCTGAGATGG
AGCTGAACATTTCTTCACTTTGTTCTTTTTCTGAAGTCAAACTCTTATCAAATGCCCTAAAATTATTACCACCCAAGAGAAACAGGAAAA
AGGTTACATGTTTTTGTTTACTGAGAGTAAGATCACCTGCATCTGGAAGACGGGCTGGTAAATTGGTTTGGCTACAGAACAGAAAGAAAA
CAAAAACAAACCTCGTAAGGGAAGTATCACACTCAGACACCACCGCTTCCTAGAGCCAAATGAGCAATCCCAAACTGCAAGTGCCATAAG
TGGGCCTGTGAGGTCACACCGCCCGGCCCGAGGTATCGCATGTGCGGGGGAGGTCCACACTACAGCTGTCCTCTCGTCTAGAAGGCACCA
CCTCGCTTTCATGTCCCGTGTGTTTTGGAAAAGCAGTATGGTGTGTCATGTCTAGCGGCGAACACTTCCCTCCCTGTCCTTGAGGTTGTA
ATATAAAAACTGTGTTTCTGTACGTGTGGGTGGGAATTCTCTGACGGTGCTCGTTCATAGCACAAGCTTACGCTGAGTTCTGAACTGTCG
TTCACAGCTGCGTGTCTGCATGGTGTCGCATCTGTTGTACCTTTGGGGAAAATTTGTATGTAAATGTACAGAAATAAAAACGTTGCCCCA

>18734_18734_1_CORO2B-SLC22A23_CORO2B_chr15_68871616_ENST00000566799_SLC22A23_chr6_3416089_ENST00000406686_length(amino acids)=473AA_BP=5
MTVTKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA
LRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMN
PEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAM
CVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG
LVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLLTNAELKDYSG

--------------------------------------------------------------
>18734_18734_2_CORO2B-SLC22A23_CORO2B_chr15_68871616_ENST00000566799_SLC22A23_chr6_3416089_ENST00000436008_length(transcript)=5568nt_BP=44nt
GCGCCCCCGCTCCGCCGCGGAGTTTCTGCATGACTGTCACAAAGTGGGATCTTGTGTGTGATAATGCCTGGAAGGTCCATATCGCTAAGT
TCTCCTTACTGGTTGGATTAATCTTTGGCTACCTAATAACTGGATGCATTGCTGACTGGGTCGGCCGGCGGCCTGTGCTGCTGTTTTCCA
TCATCTTCATTCTGATCTTTGGACTGACTGTGGCACTGTCAGTGAATGTGACAATGTTCAGCACACTCAGGTTCTTTGAAGGATTTTGCC
TGGCTGGAATCATTCTCACCTTGTATGCTTTACGAATAGAGCTGTGCCCCCCTGGAAAACGGTTCATGATTACGATGGTGGCGAGCTTCG
TGGCCATGGCGGGCCAGTTCCTCATGCCTGGGCTAGCCGCCCTGTGCCGGGATTGGCAGGTGCTGCAGGCCCTCATCATCTGCCCCTTCC
TGCTCATGCTGCTCTACTGGTCGATATTCCCCGAGTCCCTCCGGTGGCTAATGGCCACCCAGCAGTTTGAGTCTGCAAAGAGGCTGATCC
TCCACTTCACACAGAAGAATCGCATGAACCCTGAGGGCGACATCAAGGGTGTGATACCAGAGCTGGAGAAAGAGCTTTCCCGGAGGCCCA
AGAAGGTCTGCATCGTGAAGGTGGTGGGGACACGGAACCTGTGGAAGAACATTGTGGTCCTGTGTGTGAACTCGCTGACGGGGTACGGGA
TCCACCACTGCTTTGCCAGGAGCATGATGGGCCACGAGGTGAAGGTGCCGCTCCTGGAGAACTTCTATGCTGACTACTATACCACGGCCA
GCATCGCGCTGGTGTCCTGCCTGGCCATGTGCGTGGTGGTCCGATTCCTCGGGCGCAGGGGAGGGCTGCTGCTCTTCATGATCCTCACCG
CCCTGGCCTCACTCCTGCAGCTCGGCCTCCTCAACCTGATTGGAAAGTACAGCCAGCACCCAGACTCAGAACTGCAGCTGAAGTTGGCCG
TAGGGATGAGTGACAGCGTCAAGGACAAATTTTCCATCGCGTTTTCCATCGTGGGCATGTTTGCCTCCCATGCGGTGGGGAGCCTCAGCG
TGTTCTTCTGTGCGGAGATCACCCCGACGGTGATAAGGTGTGGCGGGCTGGGGCTGGTGCTGGCCAGCGCGGGCTTCGGCATGCTGACGG
CACCCATCATCGAGCTGCACAACCAGAAAGGCTACTTCCTGCACCACATCATCTTTGCCTGCTGCACGCTCATCTGCATCATCTGCATCC
TCCTGCTGCCCGAGAGCAGGGACCAGAACCTGCCTGAGAACATTTCTAACGGGGAGCACTACACGCGCCAGCCGCTGCTGCCGCACAAGA
AGGGGGAGCAGCCACTGCTGCTCACCAACGCCGAGCTCAAGGACTACTCGGGCCTCCACGATGCCGCAGCCGCGGGTGACACACTGCCCG
AGGGTGCCACGGCCAACGGCATGAAGGCCATGTAGCCCGGCCTGCGGAACCCGGGGCTCCAGGGTCTGGGGCAGCTTGGGCACAGGTTTA
CAGACCAGGGACCGAACACGCAGCCAGGGGTGGGAAAGCTGCCTCAGCCAAGCTGAGCCTCTCAACTGGTGTGGGGAAATCCTGTCTTTC
CAAAAGTCCAAGGAGCGCGGGTCGGAGGAGACAAACTCTTTGGAAATAACCCTTTCAAGACTTTCTTTTCTGCCGTTAAATGTGTGTATT
TATTTTGGTCATTTTTACGAGAAGCACTTTATTCCCTCTCCCTCTCACTGATCACAAATGGAATCACCTCCCTGGGCAGCGAGACGCAGT
TGCTCTGGGAAGATGCCACAGTGACCAGGGCCATGGCCGGTCCCTCTGGGGAGATGGGACACGGCTCCTGGCAGCACCCAGGAGCCCCCC
AGGCTGCCTGCCTGCGTGCAGAGGCAGGAGAGGACCGTGGAGCGTTTCCGGGACTGCATTTTAGACGGAGTGAAATGTACATGAATTTGG
CTTTTGCTAGAGTCTGTGTATGGTTTTTTAAGGTCCTTTTTCCCTTTCTGTTTGTAAGGTAAGAGCTTCTGTTCGTGTGCAGGGAAAGCA
GCTCACAGACGCCGTTAAAACCAGCTTCATCTTTCCTTCAGGATCATCCTTTTGTACTTGATGCTGGAAGCTCTTGGAGAAAAAGCTTAA
ACATTTCACCAGAAATCTTAATTGAGCAGCAGTCATATCGCCACAGCTTTGTGAGTACACAGCTAACAGATGCGTCGAGACCTGAGATGT
GCTCGTTTTTATTCCTCCTCTCCCAGATTGGCTCCAGCAGAAAAGTCCCTCGTGCACAGGCAGCTCTTGTGCCGGCACTACTTGAAAACA
TGGCTACTTTCTAAGCTACAAACCATTAGAAAATAACTCAAAAAGATGGCAGAGGCAAATCCACAGAAGGGGGGCTGCCCTCCACACACA
CACGCCCGTCACCCACACCTTGAGCACACACCATGAAGATCACCAGCTTGGATGGCCGTCACCTCAGACATCACTCCAGGGAGCACCCGC
AGGAGCTGGGCCCCCTCACGCCTGCCTTCCTGGGCCAGCTTCCTGCTTGCAGTCACTCGCATAGCACAGAGGTGGGGCTTCGGGCAGGGA
GCGGAGATTCCTCATAGGTGAGTCCAAATGACCTCCAGCCTCTCGAAGGCATCAAGACAAATTGAAAGAAAGCAATAACTCACCAAAGCT
CAACGCTGCCCCTGCCTCGACCTCCATGGGTCTCTTCGTGTTCCTCGTTTCACCCCAGAAAGTGGAGGTTTCCTCTTGGCATTTTCGGAG
GAAACTTGTAGGACACCCAAGGCGACTAAGAGACAGCCTCCTTGGCAAGGGCAGGCACCACTTTGTAGCAACTTGGGCACCAGCTTTTCT
GGACAGCCTGGCTTCTTACTGGCATTGTCCAACTCATCCCTTCTCGAAGCATGTCTTTGCCATGGGCTGTGTCCTTCCAGGGAAATTGTG
GTCTCGGGCCTGGGTGAGACAATGAAGTGACTTCCAACCGACAGTTGCTAGAATTCACAGGGCAGAAAAGGGGTTGACCTTCTCCCCTTC
TGGCTTTCCACCCGGCCTGCTGCTTGCTGTCGCCACTCATGTCTCCTCCACATGCGGTCCACACATCAGTAAGGGCCTGGAGATGTGTAA
AGACACAGCAAGGGGCAAGCAGACTCTTGGCCACGTGTTTCCAGTGGCTGGACCACGCCGACACCTGGGATCTTGAGATACCCAGGAAGG
GAGGCTGTCTGGCCAGCCTCTCCCTGCCTCCACTTGCTCCACGTCCAGCTCCTCACCTTCCCTCTTTTTTAAAGTCACATTTCCATGTTT
CAACATTAGTTTGCATTCACCTTTACAAAGGCCTTTCTTTAGATCTGTGCAGCCTTTGCGTGCCAAACTTGTGAAATTCCTTTTACCTTT
TTTGGAGTACTTGCTATAAAGCCACCTGTCAACAAACCCCCATTATGTACAGAATAGGACCTATCCAGTAGCCAGGCCAGTAGGCAGTTG
GGGAAGGTGGGAAGGATCCAGCGAGGCCCCTGAGCCTGCACCTGGACAGGTGTACGTCTGCACCCATCACCCTCAGCACCAGGCCACCCT
GCAGTCCACTTACTGTACTGTGTTGTGGAAGGATATGCTAAGTGATGAAAGTTGCGAGCAGTCTCACTGGTCGTGTAAACTTTTTTTTTT
TTTTGGAAATTGAAGCTGTAGAGTGCTGCCCGAAATCTCTAGGAAGTTGGTGGCAAGGGACAGCACTCACACTCTTCTGGTCATGATCTC
TGATCTCCACCTCAAATGACAATAAAAAACTGGTCCAACGAAGACACTGCTCAGCACTTCAGCCATCAGGACTAATCCATCGATGACTGG
AAAAGAGGCTAGCTTTGAGGAAAACAGCCTGGGCTCTTGGGAGCAGAGTCCAGTGGGTGTGAGGCTGACTTGCCGACGGTCGGCAGGTAA
TGGCTCTCAGCCGGCGAGGCGGTCCCACAGCTCTCCTCCCAGGGCAGCCTGAGGAGGAGGAGGCCGGGTGCCTGTTTGGTGGCAGCTTCA
GCCTAGGGATACCTGAAGCTGTTGAGCAACACCTTTATGAAATGTTGCCAGAGCAGCAACACTTCCCTGTGGGCACAGCCCCGGGAAATC
CGGTACCAAGTGAGCAAGGTGGCAGGACCCACCCAAGCCTGATACGCATCTGGGCCCGCCGGGCTCAGCAGGGGAGGCTGCTACGGCTGC
CCACTTCCCAGCACCGTCTGTCACGCTTGAACCCCTCTGTGCTGTTCCCTTCCTGGCTAATAGGGAGACCCTTCGCAGGCACCCACTGTT
TCAACTTGACCCTCCCACCCCCTGCTACTCTCCTCCACACACCCCTCCGTTCCGCTAGCCTACCCTGTCAGCCTTTCAATAAAAGTTATG
CACAAATGTGAACACCTGAGATGGAGCTGAACATTTCTTCACTTTGTTCTTTTTCTGAAGTCAAACTCTTATCAAATGCCCTAAAATTAT
TACCACCCAAGAGAAACAGGAAAAAGGTTACATGTTTTTGTTTACTGAGAGTAAGATCACCTGCATCTGGAAGACGGGCTGGTAAATTGG
TTTGGCTACAGAACAGAAAGAAAACAAAAACAAACCTCGTAAGGGAAGTATCACACTCAGACACCACCGCTTCCTAGAGCCAAATGAGCA
ATCCCAAACTGCAAGTGCCATAAGTGGGCCTGTGAGGTCACACCGCCCGGCCCGAGGTATCGCATGTGCGGGGGAGGTCCACACTACAGC
TGTCCTCTCGTCTAGAAGGCACCACCTCGCTTTCATGTCCCGTGTGTTTTGGAAAAGCAGTATGGTGTGTCATGTCTAGCGGCGAACACT
TCCCTCCCTGTCCTTGAGGTTGTAATATAAAAACTGTGTTTCTGTACGTGTGGGTGGGAATTCTCTGACGGTGCTCGTTCATAGCACAAG
CTTACGCTGAGTTCTGAACTGTCGTTCACAGCTGCGTGTCTGCATGGTGTCGCATCTGTTGTACCTTTGGGGAAAATTTGTATGTAAATG
TACAGAAATAAAAACGTTGCCCCATTAACAGATTTCCTCTGGAATGTCTTCCCTACCTCACCTGATGGTATCCACCGAAGGGCATTTCAC
TACCATTAATGGTGAGTAATAAAATCCTCCGTGTTCATTCAGACCTCACTGCGTCACTACTTTGAACGCCTCTGTAAGCTGTGTCTTCAC
TCGCCCCGAGGTGGGTGGAGGGAGGCCTCTCACTCTGCTTCGAGTCCTGGTCTTAAAGGTAGTCAGAGGCAGAGGCTGGATTAAACACAC
ACTGTTTACCAAGTGCCACTCTCAGACCACCTGAGAGACGGGGGCCATCAGTAAAATTAAGAGGAATTTTTTTCCCTTGTTCGTGTATGT
TCTGCTGATCCGTGGCCTGAAGGTTCCTAGAGACGTCAAGAAATGAATATCTTACACTGTGATTCTGTGAGGAAAGACTGGTAACCCAAA

>18734_18734_2_CORO2B-SLC22A23_CORO2B_chr15_68871616_ENST00000566799_SLC22A23_chr6_3416089_ENST00000436008_length(amino acids)=481AA_BP=5
MTVTKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYA
LRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMN
PEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAM
CVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPT
VIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLLTN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CORO2B-SLC22A23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CORO2B-SLC22A23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CORO2B-SLC22A23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource