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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPSF6-DCN (FusionGDB2 ID:19150)

Fusion Gene Summary for CPSF6-DCN

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6-DCN
Fusion gene ID: 19150
HgeneTgene
Gene symbol

CPSF6

DCN

Gene ID

11052

1634

Gene namecleavage and polyadenylation specific factor 6decorin
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
Cytomap

12q15

12q21.33

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
Modification date2020031320200313
UniProtAcc

Q16630

P07585

Ensembl transtripts involved in fusion geneENST00000266679, ENST00000435070, 
ENST00000456847, ENST00000551516, 
ENST00000550987, 		ENST00000052754, 
ENST00000228329, ENST00000303320, 
ENST00000393155, ENST00000420120, 
ENST00000425043, ENST00000441303, 
ENST00000456569, ENST00000547568, 
ENST00000552962, ENST00000546370, 
ENST00000546745, ENST00000548768, 
ENST00000550099, ENST00000551354, 
Fusion gene scores* DoF score69 X 12 X 19=1573212 X 9 X 6=648
# samples 7112
** MAII scorelog2(71/15732*10)=-4.46973925655087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPSF6 [Title/Abstract] AND DCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69656342)-DCN(91540029), # samples:1
Anticipated loss of major functional domain due to fusion event.CPSF6-DCN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CPSF6-DCN seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CPSF6-DCN seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085

TgeneDCN

GO:0010508

positive regulation of autophagy

23798385

TgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

TgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

TgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

TgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

TgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-FB-A7DR-01ACPSF6chr12

69656342

+DCNchr12

91540029

-


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Fusion Gene ORF analysis for CPSF6-DCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000266679ENST00000052754CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000228329CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000303320CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000393155CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000420120CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000425043CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000441303CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000456569CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000547568CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000266679ENST00000552962CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000052754CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000228329CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000303320CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000393155CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000420120CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000425043CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000441303CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000456569CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000547568CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000435070ENST00000552962CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000052754CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000228329CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000303320CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000393155CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000420120CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000425043CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000441303CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000456569CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000547568CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-3CDSENST00000456847ENST00000552962CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000266679ENST00000546370CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000266679ENST00000546745CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000266679ENST00000548768CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000266679ENST00000550099CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000266679ENST00000551354CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000435070ENST00000546370CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000435070ENST00000546745CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000435070ENST00000548768CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000435070ENST00000550099CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000435070ENST00000551354CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000456847ENST00000546370CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000456847ENST00000546745CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000456847ENST00000548768CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000456847ENST00000550099CPSF6chr12

69656342

+DCNchr12

91540029

-
3UTR-intronENST00000456847ENST00000551354CPSF6chr12

69656342

+DCNchr12

91540029

-
5CDS-intronENST00000551516ENST00000546370CPSF6chr12

69656342

+DCNchr12

91540029

-
5CDS-intronENST00000551516ENST00000546745CPSF6chr12

69656342

+DCNchr12

91540029

-
5CDS-intronENST00000551516ENST00000548768CPSF6chr12

69656342

+DCNchr12

91540029

-
5CDS-intronENST00000551516ENST00000550099CPSF6chr12

69656342

+DCNchr12

91540029

-
5CDS-intronENST00000551516ENST00000551354CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000228329CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000303320CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000393155CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000420120CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000425043CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000441303CPSF6chr12

69656342

+DCNchr12

91540029

-
Frame-shiftENST00000551516ENST00000552962CPSF6chr12

69656342

+DCNchr12

91540029

-
In-frameENST00000551516ENST00000052754CPSF6chr12

69656342

+DCNchr12

91540029

-
In-frameENST00000551516ENST00000456569CPSF6chr12

69656342

+DCNchr12

91540029

-
In-frameENST00000551516ENST00000547568CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000052754CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000228329CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000303320CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000393155CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000420120CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000425043CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000441303CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000456569CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000547568CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-3CDSENST00000550987ENST00000552962CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-intronENST00000550987ENST00000546370CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-intronENST00000550987ENST00000546745CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-intronENST00000550987ENST00000548768CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-intronENST00000550987ENST00000550099CPSF6chr12

69656342

+DCNchr12

91540029

-
intron-intronENST00000550987ENST00000551354CPSF6chr12

69656342

+DCNchr12

91540029

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000551516CPSF6chr1269656342+ENST00000052754DCNchr1291540029-1177172520566
ENST00000551516CPSF6chr1269656342+ENST00000547568DCNchr1291540029-367172520566
ENST00000551516CPSF6chr1269656342+ENST00000456569DCNchr1291540029-189172519062

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000551516ENST00000052754CPSF6chr1269656342+DCNchr1291540029-0.315639560.68436044
ENST00000551516ENST00000547568CPSF6chr1269656342+DCNchr1291540029-0.666167860.33383214
ENST00000551516ENST00000456569CPSF6chr1269656342+DCNchr1291540029-0.99365110.006348989

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Fusion Genomic Features for CPSF6-DCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPSF6-DCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69656342/chr12:91540029)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPSF6

Q16630

DCN

P07585

FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}.FUNCTION: May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011208_398590701.3333333333334Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011490_551590701.3333333333334Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910208_3985532111.0Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910490_5515532111.0Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011202_206590701.3333333333334MotifGAR
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910202_2065532111.0MotifGAR
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011358_551590701.3333333333334Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011404_551590701.3333333333334RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011405_551590701.3333333333334RegionNecessary for RNA-binding
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+1011510_551590701.3333333333334RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69656342chr12:91540029ENST00000266679+101181_161590701.3333333333334RegionNecessary for nuclear paraspeckles localization
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910358_5515532111.0Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910404_5515532111.0RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910405_5515532111.0RegionNecessary for RNA-binding
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+910510_5515532111.0RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69656342chr12:91540029ENST00000435070+91081_1615532111.0RegionNecessary for nuclear paraspeckles localization
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468305_334295360.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468335_359295360.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946187_212186251.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946213_233186251.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946234_257186251.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946258_281186251.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946282_304186251.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946305_334186251.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946335_359186251.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024118_141108173.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024142_162108173.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024163_186108173.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024187_212108173.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024213_233108173.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024234_257108173.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024258_281108173.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024282_304108173.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024305_334108173.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000030332024335_359108173.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568305_334295360.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568335_359295360.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035187_212186251.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035213_233186251.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035234_257186251.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035258_281186251.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035282_304186251.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035305_334186251.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035335_359186251.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324163_186148213.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324187_212148213.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324213_233148213.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324234_257148213.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324258_281148213.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324282_304148213.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324305_334148213.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324335_359148213.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313118_141108173.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313142_162108173.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313163_186108173.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313187_212108173.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313213_233108173.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313234_257108173.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313258_281108173.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313282_304108173.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313305_334108173.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000044130313335_359108173.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902118_1417076.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902142_1627076.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902163_1867076.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902187_2127076.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902213_2337076.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902234_2577076.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902258_2817076.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902282_3047076.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902305_3347076.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000045656902335_3597076.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST000004565690273_937076.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000004565690294_1177076.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835163_186148213.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835187_212148213.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835213_233148213.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835234_257148213.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835258_281148213.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835282_304148213.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835305_334148213.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835335_359148213.0RepeatNote=LRR 12
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279305_334295360.0RepeatNote=LRR 11
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279335_359295360.0RepeatNote=LRR 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDCNchr12:69656342chr12:91540029ENST000000527546854_67295360.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000002283294654_67186251.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000003033202454_67108173.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000003931556854_67295360.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000004201203554_67186251.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000004250432454_67148213.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000004413031354_67108173.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000004565690254_677076.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000005475683554_67148213.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST000005529627954_67295360.0Compositional biasNote=Cys-rich
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468118_141295360.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468142_162295360.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468163_186295360.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468187_212295360.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468213_233295360.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468234_257295360.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468258_281295360.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000005275468282_304295360.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST000000527546873_93295360.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000000527546894_117295360.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946118_141186251.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946142_162186251.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000022832946163_186186251.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST000002283294673_93186251.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000002283294694_117186251.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST000003033202473_93108173.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000003033202494_117108173.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568118_141295360.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568142_162295360.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568163_186295360.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568187_212295360.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568213_233295360.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568234_257295360.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568258_281295360.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000039315568282_304295360.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST000003931556873_93295360.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000003931556894_117295360.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035118_141186251.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035142_162186251.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000042012035163_186186251.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST000004201203573_93186251.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000004201203594_117186251.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324118_141148213.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000042504324142_162148213.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST000004250432473_93148213.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000004250432494_117148213.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST000004413031373_93108173.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000004413031394_117108173.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835118_141148213.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000054756835142_162148213.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST000005475683573_93148213.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000005475683594_117148213.0RepeatNote=LRR 2
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279118_141295360.0RepeatNote=LRR 3
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279142_162295360.0RepeatNote=LRR 4
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279163_186295360.0RepeatNote=LRR 5
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279187_212295360.0RepeatNote=LRR 6
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279213_233295360.0RepeatNote=LRR 7
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279234_257295360.0RepeatNote=LRR 8
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279258_281295360.0RepeatNote=LRR 9
TgeneDCNchr12:69656342chr12:91540029ENST0000055296279282_304295360.0RepeatNote=LRR 10
TgeneDCNchr12:69656342chr12:91540029ENST000005529627973_93295360.0RepeatNote=LRR 1
TgeneDCNchr12:69656342chr12:91540029ENST000005529627994_117295360.0RepeatNote=LRR 2


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Fusion Gene Sequence for CPSF6-DCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19150_19150_1_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000052754_length(transcript)=1177nt_BP=172nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGAAGCTGAATATGAGAGAGAAGCAG
AGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGGTTGTCTA
CCTTCATAACAACAATATCTCTGTAGTTGGATCAAGTGACTTCTGCCCACCTGGACACAACACCAAAAAGGCTTCTTATTCGGGTGTGAG
TCTTTTCAGCAACCCGGTCCAGTACTGGGAGATACAGCCATCCACCTTCAGATGTGTCTACGTGCGCTCTGCCATTCAACTCGGAAACTA
TAAGTAATTCTCAAGAAAGCCCTCATTTTTATAACCTGGCAAAATCTTGTTAATGTCATTGCTAAAAAATAAATAAAAGCTAGATACTGG
AAACCTAACTGCAATGTGGATGTTTTACCCACATGACTTATTATGCATAAAGCCAAATTTCCAGTTTAAGTAATTGCCTACAATAAAAAG
AAATTTTGCCTGCCATTTTCAGAATCATCTTTTGAAGCTTTCTGTTGATGTTAACTGAGCTACTAGAGATATTCTTATTTCACTAAATGT
AAAATTTGGAGTAAATATATATGTCAATATTTAGTAAAGCTTTTCTTTTTTAATTTCCAGGAAAAAATAAAAAGAGTATGAGTCTTCTGT
AATTCATTGAGCAGTTAGCTCATTTGAGATAAAGTCAAATGCCAAACACTAGCTCTGTATTAATCCCCATCATTACTGGTAAAGCCTCAT
TTGAATGTGTGAATTCAATACAGGCTATGTAAAATTTTTACTAATGTCATTATTTTGAAAAAATAAATTTAAAAATACATTCAAAATTAC
TATTGTATACAAGCTTAATTGTTAATATTCCCTAAACACAATTTTATGAAGGGAGAAGACATTGGTTTGTTGACAATAACAGTACATCTT
TTCAAGTTCTCAGCTATTTCTTCTACCTCTCCCTATCTTACATTTGAGTATGGTAACTTATGTCATCTATGTTGAATGTAAGCTTATAAA
GCACAAAGCATACATTTCCTGACTGGTCTAGAGAACTGATGTTTCAATTTACCCCTCTGCTAAATAAATATTAAAACTATCATGTGACTT

>19150_19150_1_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000052754_length(amino acids)=66AA_BP=

--------------------------------------------------------------
>19150_19150_2_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000456569_length(transcript)=189nt_BP=172nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGAAGCTGAATATGAGAGAGAAGCAG
AGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGGTTGTCTA

>19150_19150_2_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000456569_length(amino acids)=62AA_BP=

--------------------------------------------------------------
>19150_19150_3_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000547568_length(transcript)=367nt_BP=172nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGAAGCTGAATATGAGAGAGAAGCAG
AGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAGGTTGTCTA
CCTTCATAACAACAATATCTCTGTAGTTGGATCAAGTGACTTCTGCCCACCTGGACACAACACCAAAAAGGCTTCTTATTCGGGTGTGAG
TCTTTTCAGCAACCCGGTCCAGTACTGGGAGATACAGCCATCCACCTTCAGATGTGTCTACGTGCGCTCTGCCATTCAACTCGGAAACTA

>19150_19150_3_CPSF6-DCN_CPSF6_chr12_69656342_ENST00000551516_DCN_chr12_91540029_ENST00000547568_length(amino acids)=66AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPSF6-DCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPSF6-DCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPSF6-DCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource