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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPSF6-ETHE1 (FusionGDB2 ID:19153)

Fusion Gene Summary for CPSF6-ETHE1

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6-ETHE1
Fusion gene ID: 19153
HgeneTgene
Gene symbol

CPSF6

ETHE1

Gene ID

11052

23474

Gene namecleavage and polyadenylation specific factor 6ETHE1 persulfide dioxygenase
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7HSCO|YF13H12
Cytomap

12q15

19q13.31

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage persulfide dioxygenase ETHE1, mitochondrialethylmalonic encephalopathy 1hepatoma subtracted clone one proteinprotein ETHE1, mitochondrialsulfur dioxygenase ETHE1
Modification date2020031320200313
UniProtAcc

Q16630

O95571

Ensembl transtripts involved in fusion geneENST00000550987, ENST00000266679, 
ENST00000435070, ENST00000456847, 
ENST00000551516, 		ENST00000292147, 
ENST00000600651, 
Fusion gene scores* DoF score69 X 12 X 19=1573211 X 2 X 7=154
# samples 7112
** MAII scorelog2(71/15732*10)=-4.46973925655087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/154*10)=-0.359895945086383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPSF6 [Title/Abstract] AND ETHE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69633486)-ETHE1(44015718), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085

TgeneETHE1

GO:0006749

glutathione metabolic process

23144459

TgeneETHE1

GO:0070813

hydrogen sulfide metabolic process

23144459


check buttonFusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETHE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-A8CXCPSF6chr12

69633486

+ETHE1chr19

44015718

-


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Fusion Gene ORF analysis for CPSF6-ETHE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000550987ENST00000292147CPSF6chr12

69633486

+ETHE1chr19

44015718

-
3UTR-3CDSENST00000550987ENST00000600651CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000266679ENST00000292147CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000266679ENST00000600651CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000435070ENST00000292147CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000435070ENST00000600651CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000456847ENST00000292147CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000456847ENST00000600651CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000551516ENST00000292147CPSF6chr12

69633486

+ETHE1chr19

44015718

-
In-frameENST00000551516ENST00000600651CPSF6chr12

69633486

+ETHE1chr19

44015718

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435070CPSF6chr1269633486+ENST00000292147ETHE1chr1944015718-691170110559149
ENST00000435070CPSF6chr1269633486+ENST00000600651ETHE1chr1944015718-823170110577155
ENST00000456847CPSF6chr1269633486+ENST00000292147ETHE1chr1944015718-62810747496149
ENST00000456847CPSF6chr1269633486+ENST00000600651ETHE1chr1944015718-76010747514155
ENST00000266679CPSF6chr1269633486+ENST00000292147ETHE1chr1944015718-6129131480149
ENST00000266679CPSF6chr1269633486+ENST00000600651ETHE1chr1944015718-7449131498155
ENST00000551516CPSF6chr1269633486+ENST00000292147ETHE1chr1944015718-586655454149
ENST00000551516CPSF6chr1269633486+ENST00000600651ETHE1chr1944015718-718655472155

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435070ENST00000292147CPSF6chr1269633486+ETHE1chr1944015718-0.0119135740.98808646
ENST00000435070ENST00000600651CPSF6chr1269633486+ETHE1chr1944015718-0.0133867780.9866132
ENST00000456847ENST00000292147CPSF6chr1269633486+ETHE1chr1944015718-0.0112824990.98871756
ENST00000456847ENST00000600651CPSF6chr1269633486+ETHE1chr1944015718-0.0146510940.9853489
ENST00000266679ENST00000292147CPSF6chr1269633486+ETHE1chr1944015718-0.0099591440.99004084
ENST00000266679ENST00000600651CPSF6chr1269633486+ETHE1chr1944015718-0.0172760580.9827239
ENST00000551516ENST00000292147CPSF6chr1269633486+ETHE1chr1944015718-0.0123364940.98766345
ENST00000551516ENST00000600651CPSF6chr1269633486+ETHE1chr1944015718-0.0265373480.97346264

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Fusion Genomic Features for CPSF6-ETHE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPSF6-ETHE1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69633486/chr19:44015718)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPSF6

Q16630

ETHE1

O95571

FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}.FUNCTION: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111208_39820701.3333333333334Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111490_55120701.3333333333334Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110208_398202111.0Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110490_551202111.0Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111202_20620701.3333333333334MotifGAR
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110202_206202111.0MotifGAR
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111358_55120701.3333333333334Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111404_55120701.3333333333334RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111405_55120701.3333333333334RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+111510_55120701.3333333333334RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr19:44015718ENST00000266679+11181_16120701.3333333333334RegionNecessary for nuclear paraspeckles localization
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110358_551202111.0Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110404_551202111.0RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110405_551202111.0RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+110510_551202111.0RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr19:44015718ENST00000435070+11081_161202111.0RegionNecessary for nuclear paraspeckles localization


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Fusion Gene Sequence for CPSF6-ETHE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19153_19153_1_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000266679_ETHE1_chr19_44015718_ENST00000292147_length(transcript)=612nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GGCGTTGGAGACCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGC
CCTGTTGATCCGTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACT
TCCAGGAGACTGTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCT
CACCCTCAGCTGTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGACTTTGCTGTTCCAGCCAACAT
GCGCTGTGGGGTGCAGACACCCACTGCCTGATCTCACTTCTGTCAGATGCTCCCATCCACTATTAATGCACTAGGTGGGAGGAGAGGGCG

>19153_19153_1_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000266679_ETHE1_chr19_44015718_ENST00000292147_length(amino acids)=149AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_2_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000266679_ETHE1_chr19_44015718_ENST00000600651_length(transcript)=744nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GGCGTTGGAGACCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGC
CCTGTTGATCCGTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACT
TCCAGGAGACTGTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCT
CACCCTCAGCTGTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGGTGAGCAGCTGGGGACCTGGAC
TTCTGGGTCTGAGAGAGGAGGGGCTGGGGTCTTGGACTCCTGGGTCTGAGAGAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGA
GGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGAGGCTGGGGGCCTGGACTCCTGGGTCTAAGGGAGGAGGGGCTGGGGGAC
TGGACTCCTGGGTCTGAGGCAGTAGGGGCTGGGGGCCTGGACTCCTGGCTCTGAGGGAGTAGGGGCTGGGCTGGGGGCCTGGGCTCCTGA

>19153_19153_2_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000266679_ETHE1_chr19_44015718_ENST00000600651_length(amino acids)=155AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_3_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000435070_ETHE1_chr19_44015718_ENST00000292147_length(transcript)=691nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGCGTTGGAGA
CCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGCCCTGTTGATCC
GTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACTTCCAGGAGACT
GTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCTCACCCTCAGCT
GTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGACTTTGCTGTTCCAGCCAACATGCGCTGTGGGG
TGCAGACACCCACTGCCTGATCTCACTTCTGTCAGATGCTCCCATCCACTATTAATGCACTAGGTGGGAGGAGAGGGCGGCAATGACACT

>19153_19153_3_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000435070_ETHE1_chr19_44015718_ENST00000292147_length(amino acids)=149AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_4_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000435070_ETHE1_chr19_44015718_ENST00000600651_length(transcript)=823nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGCGTTGGAGA
CCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGCCCTGTTGATCC
GTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACTTCCAGGAGACT
GTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCTCACCCTCAGCT
GTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGGTGAGCAGCTGGGGACCTGGACTTCTGGGTCTG
AGAGAGGAGGGGCTGGGGTCTTGGACTCCTGGGTCTGAGAGAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGG
GGGCCTGGACTCCTGGGTCTGAGGGAGGAGAGGCTGGGGGCCTGGACTCCTGGGTCTAAGGGAGGAGGGGCTGGGGGACTGGACTCCTGG
GTCTGAGGCAGTAGGGGCTGGGGGCCTGGACTCCTGGCTCTGAGGGAGTAGGGGCTGGGCTGGGGGCCTGGGCTCCTGAGTCTGAGGGAG

>19153_19153_4_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000435070_ETHE1_chr19_44015718_ENST00000600651_length(amino acids)=155AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_5_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000456847_ETHE1_chr19_44015718_ENST00000292147_length(transcript)=628nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGGCGTTGGAGACCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGG
CCTTCACTGGAGATGCCCTGTTGATCCGTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATG
AAAAGATCTTCACACTTCCAGGAGACTGTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGA
CTCTGAACCCTCGGCTCACCCTCAGCTGTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGACTTTG
CTGTTCCAGCCAACATGCGCTGTGGGGTGCAGACACCCACTGCCTGATCTCACTTCTGTCAGATGCTCCCATCCACTATTAATGCACTAG

>19153_19153_5_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000456847_ETHE1_chr19_44015718_ENST00000292147_length(amino acids)=149AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_6_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000456847_ETHE1_chr19_44015718_ENST00000600651_length(transcript)=760nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGGCGTTGGAGACCAGGGCCAGCCCTGGCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGG
CCTTCACTGGAGATGCCCTGTTGATCCGTGGGTGTGGGCGGACAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATG
AAAAGATCTTCACACTTCCAGGAGACTGTCTGATCTACCCTGCTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGA
CTCTGAACCCTCGGCTCACCCTCAGCTGTGAGGAGTTTGTCAAAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGGTGAGC
AGCTGGGGACCTGGACTTCTGGGTCTGAGAGAGGAGGGGCTGGGGTCTTGGACTCCTGGGTCTGAGAGAGGAGGGGCTGGGGGCCTGGAC
TCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGAGGCTGGGGGCCTGGACTCCTGGGTCTAAGGGA
GGAGGGGCTGGGGGACTGGACTCCTGGGTCTGAGGCAGTAGGGGCTGGGGGCCTGGACTCCTGGCTCTGAGGGAGTAGGGGCTGGGCTGG

>19153_19153_6_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000456847_ETHE1_chr19_44015718_ENST00000600651_length(amino acids)=155AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

--------------------------------------------------------------
>19153_19153_7_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000551516_ETHE1_chr19_44015718_ENST00000292147_length(transcript)=586nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGCGTTGGAGACCAGGGCCAGCCCTG
GCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGCCCTGTTGATCCGTGGGTGTGGGCGGA
CAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACTTCCAGGAGACTGTCTGATCTACCCTG
CTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCTCACCCTCAGCTGTGAGGAGTTTGTCA
AAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGACTTTGCTGTTCCAGCCAACATGCGCTGTGGGGTGCAGACACCCACTG
CCTGATCTCACTTCTGTCAGATGCTCCCATCCACTATTAATGCACTAGGTGGGAGGAGAGGGCGGCAATGACACTGCACCTCTCCTTTCC

>19153_19153_7_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000551516_ETHE1_chr19_44015718_ENST00000292147_length(amino acids)=149AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

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>19153_19153_8_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000551516_ETHE1_chr19_44015718_ENST00000600651_length(transcript)=718nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGCGTTGGAGACCAGGGCCAGCCCTG
GCCACACCCCAGGCTGTGTCACCTTCGTCCTGAATGACCACAGCATGGCCTTCACTGGAGATGCCCTGTTGATCCGTGGGTGTGGGCGGA
CAGACTTCCAGCAAGGCTGTGCCAAGACCTTGTACCACTCGGTCCATGAAAAGATCTTCACACTTCCAGGAGACTGTCTGATCTACCCTG
CTCACGATTACCATGGGTTCACAGTGTCCACCGTGGAGGAGGAGAGGACTCTGAACCCTCGGCTCACCCTCAGCTGTGAGGAGTTTGTCA
AAATCATGGGCAACCTGAACTTGCCTAAACCTCAGCAGATAGGTGAGCAGCTGGGGACCTGGACTTCTGGGTCTGAGAGAGGAGGGGCTG
GGGTCTTGGACTCCTGGGTCTGAGAGAGGAGGGGCTGGGGGCCTGGACTCCTGGGTCTGAGGGAGGAGGGGCTGGGGGCCTGGACTCCTG
GGTCTGAGGGAGGAGAGGCTGGGGGCCTGGACTCCTGGGTCTAAGGGAGGAGGGGCTGGGGGACTGGACTCCTGGGTCTGAGGCAGTAGG

>19153_19153_8_CPSF6-ETHE1_CPSF6_chr12_69633486_ENST00000551516_ETHE1_chr19_44015718_ENST00000600651_length(amino acids)=155AA_BP=19
MADGVDHIDIYADVGEEFNQALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAH

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Fusion Gene PPI Analysis for CPSF6-ETHE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPSF6-ETHE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPSF6-ETHE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource