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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPSF6-TMTC2 (FusionGDB2 ID:19195)

Fusion Gene Summary for CPSF6-TMTC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6-TMTC2
Fusion gene ID: 19195
HgeneTgene
Gene symbol

CPSF6

TMTC2

Gene ID

11052

160335

Gene namecleavage and polyadenylation specific factor 6transmembrane O-mannosyltransferase targeting cadherins 2
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7IBDBP1
Cytomap

12q15

12q21.31

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage protein O-mannosyl-transferase TMTC2transmembrane and TPR repeat-containing protein 2transmembrane and tetratricopeptide repeat containing 2
Modification date2020031320200329
UniProtAcc

Q16630

.
Ensembl transtripts involved in fusion geneENST00000550987, ENST00000266679, 
ENST00000435070, ENST00000456847, 
ENST00000551516, 		ENST00000321196, 
ENST00000548305, ENST00000549919, 
Fusion gene scores* DoF score69 X 12 X 19=1573220 X 21 X 5=2100
# samples 7124
** MAII scorelog2(71/15732*10)=-4.46973925655087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2100*10)=-3.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPSF6 [Title/Abstract] AND TMTC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69633486)-TMTC2(83250789), # samples:3
TMTC2(83251359)-CPSF6(69644909), # samples:1
Anticipated loss of major functional domain due to fusion event.CPSF6-TMTC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085


check buttonFusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMTC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3NK-01ACPSF6chr12

69633486

-TMTC2chr12

83250789

+
ChimerDB4SARCTCGA-FX-A3NK-01ACPSF6chr12

69633486

+TMTC2chr12

83250789

+
ChimerDB4SARCTCGA-QC-AA9N-01ACPSF6chr12

69633486

+TMTC2chr12

83250789

+
ChimerDB4SARCTCGA-QC-AA9N-01ACPSF6chr12

69633486

+TMTC2chr12

83289597

+


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Fusion Gene ORF analysis for CPSF6-TMTC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000550987ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83250789

+
3UTR-3CDSENST00000550987ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83289597

+
3UTR-3CDSENST00000550987ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83250789

+
3UTR-3CDSENST00000550987ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83289597

+
3UTR-3CDSENST00000550987ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83250789

+
3UTR-3CDSENST00000550987ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83289597

+
Frame-shiftENST00000266679ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000266679ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000266679ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000435070ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000435070ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000435070ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000456847ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000456847ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000456847ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000551516ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000551516ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83250789

+
Frame-shiftENST00000551516ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83250789

+
In-frameENST00000266679ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000266679ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000266679ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000435070ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000435070ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000435070ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000456847ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000456847ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000456847ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000551516ENST00000321196CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000551516ENST00000548305CPSF6chr12

69633486

+TMTC2chr12

83289597

+
In-frameENST00000551516ENST00000549919CPSF6chr12

69633486

+TMTC2chr12

83289597

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435070CPSF6chr1269633486+ENST00000321196TMTC2chr1283289597+44901701102026638
ENST00000435070CPSF6chr1269633486+ENST00000548305TMTC2chr1283289597+16081701101429439
ENST00000435070CPSF6chr1269633486+ENST00000549919TMTC2chr1283289597+39401701102026638
ENST00000456847CPSF6chr1269633486+ENST00000321196TMTC2chr1283289597+4427107471963638
ENST00000456847CPSF6chr1269633486+ENST00000548305TMTC2chr1283289597+1545107471366439
ENST00000456847CPSF6chr1269633486+ENST00000549919TMTC2chr1283289597+3877107471963638
ENST00000266679CPSF6chr1269633486+ENST00000321196TMTC2chr1283289597+441191311947638
ENST00000266679CPSF6chr1269633486+ENST00000548305TMTC2chr1283289597+152991311350439
ENST00000266679CPSF6chr1269633486+ENST00000549919TMTC2chr1283289597+386191311947638
ENST00000551516CPSF6chr1269633486+ENST00000321196TMTC2chr1283289597+43856551921638
ENST00000551516CPSF6chr1269633486+ENST00000548305TMTC2chr1283289597+15036551324439
ENST00000551516CPSF6chr1269633486+ENST00000549919TMTC2chr1283289597+38356551921638

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435070ENST00000321196CPSF6chr1269633486+TMTC2chr1283289597+0.0009628070.99903727
ENST00000435070ENST00000548305CPSF6chr1269633486+TMTC2chr1283289597+0.0015898990.9984101
ENST00000435070ENST00000549919CPSF6chr1269633486+TMTC2chr1283289597+0.001576710.99842334
ENST00000456847ENST00000321196CPSF6chr1269633486+TMTC2chr1283289597+0.0009152920.9990847
ENST00000456847ENST00000548305CPSF6chr1269633486+TMTC2chr1283289597+0.0013399730.99865997
ENST00000456847ENST00000549919CPSF6chr1269633486+TMTC2chr1283289597+0.0014824750.9985176
ENST00000266679ENST00000321196CPSF6chr1269633486+TMTC2chr1283289597+0.00087350.9991265
ENST00000266679ENST00000548305CPSF6chr1269633486+TMTC2chr1283289597+0.0012818180.99871826
ENST00000266679ENST00000549919CPSF6chr1269633486+TMTC2chr1283289597+0.0014291360.9985708
ENST00000551516ENST00000321196CPSF6chr1269633486+TMTC2chr1283289597+0.0008345950.9991654
ENST00000551516ENST00000548305CPSF6chr1269633486+TMTC2chr1283289597+0.0011983640.9988016
ENST00000551516ENST00000549919CPSF6chr1269633486+TMTC2chr1283289597+0.0013712210.99862885

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Fusion Genomic Features for CPSF6-TMTC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPSF6chr1269633486+TMTC2chr1283250788+0.0003458440.9996542
CPSF6chr1269633486+TMTC2chr1283250788+0.0003458440.9996542
CPSF6chr1269633486+TMTC2chr1283289596+5.74E-081
CPSF6chr1269633486+TMTC2chr1283250788+0.0003458440.9996542
CPSF6chr1269633486+TMTC2chr1283250788+0.0003458440.9996542
CPSF6chr1269633486+TMTC2chr1283289596+5.74E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CPSF6-TMTC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69633486/chr12:83250789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPSF6

Q16630

.
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269|PubMed:14690600, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:21295486, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397, ECO:0000269|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269|PubMed:24130490}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112462_492218837.0RepeatNote=TPR 1
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112493_526218837.0RepeatNote=TPR 2
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112527_560218837.0RepeatNote=TPR 3
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112562_594218837.0RepeatNote=TPR 4
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112606_639218837.0RepeatNote=TPR 5
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112643_676218837.0RepeatNote=TPR 6
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112677_710218837.0RepeatNote=TPR 7
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112712_744218837.0RepeatNote=TPR 8
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112746_778218837.0RepeatNote=TPR 9
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112779_812218837.0RepeatNote=TPR 10
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112222_241218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112313_333218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112400_420218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112423_443218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112450_470218837.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111208_39820701.3333333333334Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111490_55120701.3333333333334Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110208_398202111.0Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110490_551202111.0Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111202_20620701.3333333333334MotifGAR
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110202_206202111.0MotifGAR
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111358_55120701.3333333333334Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111404_55120701.3333333333334RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111405_55120701.3333333333334RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+111510_55120701.3333333333334RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr12:83289597ENST00000266679+11181_16120701.3333333333334RegionNecessary for nuclear paraspeckles localization
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110358_551202111.0Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110404_551202111.0RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110405_551202111.0RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+110510_551202111.0RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr12:83289597ENST00000435070+11081_161202111.0RegionNecessary for nuclear paraspeckles localization
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112108_128218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112133_153218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112163_183218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST00000321196112184_204218837.0TransmembraneHelical
TgeneTMTC2chr12:69633486chr12:83289597ENST0000032119611285_105218837.0TransmembraneHelical


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Fusion Gene Sequence for CPSF6-TMTC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19195_19195_1_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000321196_length(transcript)=4411nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAA
CAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAAC
CAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTG
GAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAA
TGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAG
CTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTT
ATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAG
TATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGC
TACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGAT
AAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAA
TGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACA
TTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGA
AGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTG
TTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAG
GCAGTTTGCCCCACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGA
ATCACTGAGATCCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAA
GCTCTTCTTGAAGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCAT
AGAAGCAGCTGAGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGC
TAGCCTCAATGAAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCAT
TCTGCACCTCAATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAA
TCTCCGCAAACTGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTT
TTAAAAGCTGGCTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATT
GAGGTCACTACCGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGAT
GTCATTGTTACCCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACA
GATTTTGTTCATTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGC
AAACAATTAGGGTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCC
CTGTTTGGGACAGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCT
TGACCAGTGCACATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATG
GAGAGTAGAGCTAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAA
TATCGTCAATATTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAA
TGTGCAAGCTTACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGG
GAAGGTGTTTTGTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATC
GAATGTTAATCACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAA
GGCATCAAAAACAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTG
AAAACTATTTTTCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAA
ATTAAGTAGAGAACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGT
TATCAACTTCTTCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGAT
GCATTAAGCCAGTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAA
GAAGCTGGACATGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAA
GTAGTGTTCCTATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGT
AATATATATATTATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAA
CAAACCCGTGGTCAAACCAAAATAGTGGGTTGAAGTGTATTATTCATCTTTTAGTGCATTGGCAATTGCAAAAAAAAAAAAGGAATTTAA
TATAAGGCTATAGAGATTAATTCAGTGTCTAACATTTGTATTTATTTAAATAGTTATTGACCTATGATGACTTTCTAGTCTTAACATTTT
ATCTTTTTATTGTTGTTGTTCTTCCTTTCAAAGATGTGGTTCTTAATAGGTTCACTGAATGCACAGTTGAGGCACTTCTTGTGACACCAG
TTCCCAAGTAGCGTTAATAATTGGGCCTGTGTCATAAAATGCACGGATCATTAATAACTAAATGTCCCTGACACTTTTCACTACAGGGCT
GGACTTAGTAACTGACCAACTTCGGGGGGAGGGTTGGGGCAAGGGGGGGTGGGCGTTAGAACATGATCAAAAAATGTCTCCGCTCAGGGA
TTTATGGTGGATTATTGCAGACAGTGCTAAAAATATAGAGCACAAGACAAGTTTACTAAATTAAAATTTTATTTTTTGAGAAACTGTTAT
TTGTATAAATTATCAAGATTTGTAGGCTTTCCTTTTGTAGAAATAATTGTTTTATGTGCCAGAGAATTTCAATTTTGTTTTCAACAATAA

>19195_19195_1_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000321196_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_2_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000548305_length(transcript)=1529nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAA
CAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAAC
CAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTG
GAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAA
TGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAG
CTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTT
ATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAG
TATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGC
TACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGAT
AAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAA
TGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACA
TTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGA
AGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTG
TTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGTCTGGCCAATGCCTCTCTGTCCTTTTCCCTCCCCCTTGTTCTG
ATCCAGTCTCAGTGGTTTGTAACCTACAGCCTCCTTTGAGCCTATGTCCTTTGAACAACTAATATGTATACACGTTAAACTATTGTCCTT

>19195_19195_2_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000548305_length(amino acids)=439AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP

--------------------------------------------------------------
>19195_19195_3_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000549919_length(transcript)=3861nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAA
CAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAAC
CAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTG
GAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAA
TGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAG
CTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTT
ATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAG
TATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGC
TACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGAT
AAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAA
TGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACA
TTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGA
AGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTG
TTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAG
GCAGTTTGCCCCACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGA
ATCACTGAGATCCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAA
GCTCTTCTTGAAGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCAT
AGAAGCAGCTGAGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGC
TAGCCTCAATGAAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCAT
TCTGCACCTCAATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAA
TCTCCGCAAACTGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTT
TTAAAAGCTGGCTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATT
GAGGTCACTACCGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGAT
GTCATTGTTACCCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACA
GATTTTGTTCATTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGC
AAACAATTAGGGTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCC
CTGTTTGGGACAGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCT
TGACCAGTGCACATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATG
GAGAGTAGAGCTAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAA
TATCGTCAATATTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAA
TGTGCAAGCTTACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGG
GAAGGTGTTTTGTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATC
GAATGTTAATCACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAA
GGCATCAAAAACAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTG
AAAACTATTTTTCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAA
ATTAAGTAGAGAACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGT
TATCAACTTCTTCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGAT
GCATTAAGCCAGTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAA
GAAGCTGGACATGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAA
GTAGTGTTCCTATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGT
AATATATATATTATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAA

>19195_19195_3_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000266679_TMTC2_chr12_83289597_ENST00000549919_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_4_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000321196_length(transcript)=4490nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACT
TGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAA
GCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCT
GGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTAC
ACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTG
TAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCA
AAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAA
TCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCT
GCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACAC
TAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACC
CAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACT
ACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAAT
TGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGAC
GGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACC
TAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAGGCAGTTTGCCC
CACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGAATCACTGAGAT
CCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAAGCTCTTCTTGA
AGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCATAGAAGCAGCTG
AGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGCTAGCCTCAATG
AAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCATTCTGCACCTCA
ATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAATCTCCGCAAAC
TGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTTTTAAAAGCTGG
CTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATTGAGGTCACTAC
CGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGATGTCATTGTTAC
CCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACAGATTTTGTTCA
TTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGCAAACAATTAGG
GTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCCCTGTTTGGGAC
AGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCTTGACCAGTGCA
CATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATGGAGAGTAGAGC
TAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAATATCGTCAATA
TTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAATGTGCAAGCTT
ACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGGGAAGGTGTTTT
GTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATCGAATGTTAATC
ACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAAGGCATCAAAAA
CAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTGAAAACTATTTT
TCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAAATTAAGTAGAG
AACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGTTATCAACTTCT
TCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGATGCATTAAGCCA
GTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAAGAAGCTGGACA
TGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAAGTAGTGTTCCT
ATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGTAATATATATAT
TATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAACAAACCCGTGG
TCAAACCAAAATAGTGGGTTGAAGTGTATTATTCATCTTTTAGTGCATTGGCAATTGCAAAAAAAAAAAAGGAATTTAATATAAGGCTAT
AGAGATTAATTCAGTGTCTAACATTTGTATTTATTTAAATAGTTATTGACCTATGATGACTTTCTAGTCTTAACATTTTATCTTTTTATT
GTTGTTGTTCTTCCTTTCAAAGATGTGGTTCTTAATAGGTTCACTGAATGCACAGTTGAGGCACTTCTTGTGACACCAGTTCCCAAGTAG
CGTTAATAATTGGGCCTGTGTCATAAAATGCACGGATCATTAATAACTAAATGTCCCTGACACTTTTCACTACAGGGCTGGACTTAGTAA
CTGACCAACTTCGGGGGGAGGGTTGGGGCAAGGGGGGGTGGGCGTTAGAACATGATCAAAAAATGTCTCCGCTCAGGGATTTATGGTGGA
TTATTGCAGACAGTGCTAAAAATATAGAGCACAAGACAAGTTTACTAAATTAAAATTTTATTTTTTGAGAAACTGTTATTTGTATAAATT

>19195_19195_4_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000321196_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_5_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000548305_length(transcript)=1608nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACT
TGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAA
GCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCT
GGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTAC
ACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTG
TAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCA
AAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAA
TCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCT
GCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACAC
TAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACC
CAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACT
ACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAAT
TGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGAC
GGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACC
TAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGTCTGGCCAATGCCTCTCTGTCCTTTTCCCTCCCCCTTGTTCTGATCCAGTCTCA
GTGGTTTGTAACCTACAGCCTCCTTTGAGCCTATGTCCTTTGAACAACTAATATGTATACACGTTAAACTATTGTCCTTTGAGAAACTAA

>19195_19195_5_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000548305_length(amino acids)=439AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP

--------------------------------------------------------------
>19195_19195_6_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000549919_length(transcript)=3940nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACT
TGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAA
GCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCT
GGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTAC
ACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTG
TAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCA
AAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAA
TCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCT
GCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACAC
TAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACC
CAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACT
ACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAAT
TGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGAC
GGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACC
TAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAGGCAGTTTGCCC
CACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGAATCACTGAGAT
CCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAAGCTCTTCTTGA
AGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCATAGAAGCAGCTG
AGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGCTAGCCTCAATG
AAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCATTCTGCACCTCA
ATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAATCTCCGCAAAC
TGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTTTTAAAAGCTGG
CTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATTGAGGTCACTAC
CGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGATGTCATTGTTAC
CCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACAGATTTTGTTCA
TTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGCAAACAATTAGG
GTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCCCTGTTTGGGAC
AGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCTTGACCAGTGCA
CATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATGGAGAGTAGAGC
TAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAATATCGTCAATA
TTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAATGTGCAAGCTT
ACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGGGAAGGTGTTTT
GTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATCGAATGTTAATC
ACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAAGGCATCAAAAA
CAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTGAAAACTATTTT
TCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAAATTAAGTAGAG
AACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGTTATCAACTTCT
TCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGATGCATTAAGCCA
GTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAAGAAGCTGGACA
TGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAAGTAGTGTTCCT
ATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGTAATATATATAT
TATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAACAAACCCGTGG

>19195_19195_6_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000435070_TMTC2_chr12_83289597_ENST00000549919_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_7_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000321196_length(transcript)=4427nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGT
TATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCT
TCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCA
AAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCG
TAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACT
CAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACA
TTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAG
TATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGA
GCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGC
TTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTG
AAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGT
TTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGA
ACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGA
GCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAA
TTCAGAAAATGCCAAGGCAGTTTGCCCCACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAG
AGCATTGGTATATGGAATCACTGAGATCCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTA
AGAGTGAGGCTGAAAAGCTCTTCTTGAAGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGG
AAGAAGCTCGTCTCATAGAAGCAGCTGAGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCC
ACATGCTCAGACAGGCTAGCCTCAATGAAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGA
TGAACCTGGGAGCCATTCTGCACCTCAATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATG
TCATCACACAGTCCAATCTCCGCAAACTGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGC
CCATCCTCCTCCATTTTTAAAAGCTGGCTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGAC
CAGGGCAGAGGTCATTGAGGTCACTACCGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGG
AAACCTCCTGGAGGATGTCATTGTTACCCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGT
GGGTGTGTAAGTCACAGATTTTGTTCATTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTG
TCCATTCAGGCATGGCAAACAATTAGGGTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCT
AACGCTGCTGTCTTCCCTGTTTGGGACAGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAG
AATCTGCTATGTTTCTTGACCAGTGCACATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATG
TTCTGAAAAGGATATGGAGAGTAGAGCTAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGC
ATTTTTTAAATTTTAATATCGTCAATATTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAAT
AGCTATTCCTGGAGAATGTGCAAGCTTACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAG
GTTATTAGACAAAAGGGAAGGTGTTTTGTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTT
GGAAAGGGTAGGTATCGAATGTTAATCACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAG
TTTGTTCTTCTCAAAAGGCATCAAAAACAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAA
GTGCTTTTCTCAGTTGAAAACTATTTTTCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCAC
AAGAAAAAGACTATAAATTAAGTAGAGAACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCA
TAAAACACTAGTCCGTTATCAACTTCTTCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAG
AATAACAAAACTTGATGCATTAAGCCAGTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCA
GCCTCTCCATTAAAAAGAAGCTGGACATGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTG
GGATAAATAATTGAAAGTAGTGTTCCTATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAAT
AAGAAAGCCCTTCTGTAATATATATATTATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCA
GAATGATATTTAACAACAAACCCGTGGTCAAACCAAAATAGTGGGTTGAAGTGTATTATTCATCTTTTAGTGCATTGGCAATTGCAAAAA
AAAAAAAGGAATTTAATATAAGGCTATAGAGATTAATTCAGTGTCTAACATTTGTATTTATTTAAATAGTTATTGACCTATGATGACTTT
CTAGTCTTAACATTTTATCTTTTTATTGTTGTTGTTCTTCCTTTCAAAGATGTGGTTCTTAATAGGTTCACTGAATGCACAGTTGAGGCA
CTTCTTGTGACACCAGTTCCCAAGTAGCGTTAATAATTGGGCCTGTGTCATAAAATGCACGGATCATTAATAACTAAATGTCCCTGACAC
TTTTCACTACAGGGCTGGACTTAGTAACTGACCAACTTCGGGGGGAGGGTTGGGGCAAGGGGGGGTGGGCGTTAGAACATGATCAAAAAA
TGTCTCCGCTCAGGGATTTATGGTGGATTATTGCAGACAGTGCTAAAAATATAGAGCACAAGACAAGTTTACTAAATTAAAATTTTATTT
TTTGAGAAACTGTTATTTGTATAAATTATCAAGATTTGTAGGCTTTCCTTTTGTAGAAATAATTGTTTTATGTGCCAGAGAATTTCAATT

>19195_19195_7_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000321196_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_8_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000548305_length(transcript)=1545nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGT
TATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCT
TCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCA
AAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCG
TAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACT
CAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACA
TTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAG
TATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGA
GCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGC
TTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTG
AAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGT
TTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGA
ACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGA
GCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGTCTGGCCAATGCCTCTCTGTCCTTTTC
CCTCCCCCTTGTTCTGATCCAGTCTCAGTGGTTTGTAACCTACAGCCTCCTTTGAGCCTATGTCCTTTGAACAACTAATATGTATACACG
TTAAACTATTGTCCTTTGAGAAACTAATACATGATGACATTGGAATGGTTTTTTGATCAAATTTGTTTAGAAAAAGCTTCTGCTAAATAA

>19195_19195_8_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000548305_length(amino acids)=439AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP

--------------------------------------------------------------
>19195_19195_9_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000549919_length(transcript)=3877nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAAGCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGT
TATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGGACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCT
TCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTCCAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCA
AAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCTATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCG
TAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGCAGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACT
CAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCATTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACA
TTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTCCTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAG
TATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAGTGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGA
GCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATGGACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGC
TTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGGGTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTG
AAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGGCTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGT
TTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCAGGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGA
ACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGTGTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGA
GCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATCATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAA
TTCAGAAAATGCCAAGGCAGTTTGCCCCACAGAGCTTGTACAACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAG
AGCATTGGTATATGGAATCACTGAGATCCAAGACTGACCACATCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTA
AGAGTGAGGCTGAAAAGCTCTTCTTGAAGGCTATTGAGCTGGATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGG
AAGAAGCTCGTCTCATAGAAGCAGCTGAGATGGCAAAAAAAGCAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCC
ACATGCTCAGACAGGCTAGCCTCAATGAAGCAGCTGAGAAGTATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGA
TGAACCTGGGAGCCATTCTGCACCTCAATGGCAGACTCCAGAAGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATG
TCATCACACAGTCCAATCTCCGCAAACTGTGGAACATCATGGAAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGC
CCATCCTCCTCCATTTTTAAAAGCTGGCTTCCTTAGCAGACAGAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGAC
CAGGGCAGAGGTCATTGAGGTCACTACCGCTTCTGGAAGAATCCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGG
AAACCTCCTGGAGGATGTCATTGTTACCCATAGACTGTAAACCAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGT
GGGTGTGTAAGTCACAGATTTTGTTCATTTTCTGAAAGCTAATTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTG
TCCATTCAGGCATGGCAAACAATTAGGGTTAAGTGTTACGAGGGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCT
AACGCTGCTGTCTTCCCTGTTTGGGACAGCCTGCTTATCAATTTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAG
AATCTGCTATGTTTCTTGACCAGTGCACATAATGTTTTATGATTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATG
TTCTGAAAAGGATATGGAGAGTAGAGCTAACCATACTTCACACTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGC
ATTTTTTAAATTTTAATATCGTCAATATTTTCCCCCAAACTGCCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAAT
AGCTATTCCTGGAGAATGTGCAAGCTTACATAAGGATAAAGGACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAG
GTTATTAGACAAAAGGGAAGGTGTTTTGTGCTTCTCAGATGTTGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTT
GGAAAGGGTAGGTATCGAATGTTAATCACTTTCTAATGGGTACCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAG
TTTGTTCTTCTCAAAAGGCATCAAAAACAACTTATTTGAAGCTGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAA
GTGCTTTTCTCAGTTGAAAACTATTTTTCACTAGCAAAATTGGTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCAC
AAGAAAAAGACTATAAATTAAGTAGAGAACAACATTTTTATTGAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCA
TAAAACACTAGTCCGTTATCAACTTCTTCACAGAGAAAGTAGCTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAG
AATAACAAAACTTGATGCATTAAGCCAGTTCTTTGCAACTGAAAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCA
GCCTCTCCATTAAAAAGAAGCTGGACATGCAAATACATCATATTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTG
GGATAAATAATTGAAAGTAGTGTTCCTATGGCATTAGTGTTTTTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAAT
AAGAAAGCCCTTCTGTAATATATATATTATTTTGTAAACATTTCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCA
GAATGATATTTAACAACAAACCCGTGGTCAAACCAAAATAGTGGGTTGAAGTGTATTATTCATCTTTTAGTGCATTGGCAATTGCAAAAA

>19195_19195_9_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000456847_TMTC2_chr12_83289597_ENST00000549919_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_10_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000321196_length(transcript)=4385nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAA
GCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGG
ACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTC
CAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCT
ATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGC
AGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCA
TTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTC
CTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAG
TGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATG
GACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGG
GTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGG
CTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCA
GGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGT
GTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATC
ATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAGGCAGTTTGCCCCACAGAGCTTGTACA
ACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGAATCACTGAGATCCAAGACTGACCACA
TCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAAGCTCTTCTTGAAGGCTATTGAGCTGG
ATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCATAGAAGCAGCTGAGATGGCAAAAAAAG
CAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGCTAGCCTCAATGAAGCAGCTGAGAAGT
ATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCATTCTGCACCTCAATGGCAGACTCCAGA
AGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAATCTCCGCAAACTGTGGAACATCATGG
AAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTTTTAAAAGCTGGCTTCCTTAGCAGACA
GAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATTGAGGTCACTACCGCTTCTGGAAGAAT
CCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGATGTCATTGTTACCCATAGACTGTAAAC
CAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACAGATTTTGTTCATTTTCTGAAAGCTAA
TTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGCAAACAATTAGGGTTAAGTGTTACGAG
GGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCCCTGTTTGGGACAGCCTGCTTATCAAT
TTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCTTGACCAGTGCACATAATGTTTTATGA
TTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATGGAGAGTAGAGCTAACCATACTTCACA
CTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAATATCGTCAATATTTTCCCCCAAACTG
CCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAATGTGCAAGCTTACATAAGGATAAAGG
ACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGGGAAGGTGTTTTGTGCTTCTCAGATGT
TGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATCGAATGTTAATCACTTTCTAATGGGTA
CCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAAGGCATCAAAAACAACTTATTTGAAGC
TGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTGAAAACTATTTTTCACTAGCAAAATTG
GTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAAATTAAGTAGAGAACAACATTTTTATT
GAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGTTATCAACTTCTTCACAGAGAAAGTAG
CTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGATGCATTAAGCCAGTTCTTTGCAACTGA
AAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAAGAAGCTGGACATGCAAATACATCATA
TTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAAGTAGTGTTCCTATGGCATTAGTGTTT
TTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGTAATATATATATTATTTTGTAAACATT
TCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAACAAACCCGTGGTCAAACCAAAATAGT
GGGTTGAAGTGTATTATTCATCTTTTAGTGCATTGGCAATTGCAAAAAAAAAAAAGGAATTTAATATAAGGCTATAGAGATTAATTCAGT
GTCTAACATTTGTATTTATTTAAATAGTTATTGACCTATGATGACTTTCTAGTCTTAACATTTTATCTTTTTATTGTTGTTGTTCTTCCT
TTCAAAGATGTGGTTCTTAATAGGTTCACTGAATGCACAGTTGAGGCACTTCTTGTGACACCAGTTCCCAAGTAGCGTTAATAATTGGGC
CTGTGTCATAAAATGCACGGATCATTAATAACTAAATGTCCCTGACACTTTTCACTACAGGGCTGGACTTAGTAACTGACCAACTTCGGG
GGGAGGGTTGGGGCAAGGGGGGGTGGGCGTTAGAACATGATCAAAAAATGTCTCCGCTCAGGGATTTATGGTGGATTATTGCAGACAGTG
CTAAAAATATAGAGCACAAGACAAGTTTACTAAATTAAAATTTTATTTTTTGAGAAACTGTTATTTGTATAAATTATCAAGATTTGTAGG

>19195_19195_10_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000321196_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------
>19195_19195_11_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000548305_length(transcript)=1503nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAA
GCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGG
ACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTC
CAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCT
ATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGC
AGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCA
TTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTC
CTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAG
TGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATG
GACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGG
GTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGG
CTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCA
GGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGT
GTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATC
ATGAGCAGGGACACTATGAGGTCTGGCCAATGCCTCTCTGTCCTTTTCCCTCCCCCTTGTTCTGATCCAGTCTCAGTGGTTTGTAACCTA
CAGCCTCCTTTGAGCCTATGTCCTTTGAACAACTAATATGTATACACGTTAAACTATTGTCCTTTGAGAAACTAATACATGATGACATTG

>19195_19195_11_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000548305_length(amino acids)=439AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP

--------------------------------------------------------------
>19195_19195_12_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000549919_length(transcript)=3835nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGAGGAAGAACTTGTCGCTTTTCCTAA
GCATTAGTTTGTTAATTTTCTGGGGTTCCTCCCTTTTGGGTGCCCGGTTATACTGGATGGGAAACAAACCACCAAGCTTTTCCAACTCGG
ACAACCCCGCTGCTGATTCGGACAGCCTCCTCACCCGCACTCTCACCTTCTTCTACTTGCCAACCAAGAACCTCTGGCTGTTGCTATGTC
CAGATACCCTCAGTTTTGATTGGTCAATGGATGCTGTGCCTCTGCTCAAAACAGTTTGTGACTGGAGAAACCTACACACTGTGGCCTTCT
ATACTGGACTCCTTCTCCTTGCCTACTATGGTTTGAAGAGCCCGAGCGTAGACAGAGAATGCAATGGGAAAACTGTAACAAATGGCAAGC
AGAATGCAAATGGACATAGCTGCCTTTCAGATGTGGAGTACCAGAACTCAGAGACTAAGTCCAGCTTTGCATCCAAAGTAGAAAATGGCA
TTAAAAACGATGTATCACAGAGAACCCAGCTTCCTTCTACGGAGAACATTGTTGTTCTGTCTTTATCTTTGTTAATCATACCCTTTGTTC
CTGCCACGAACCTGTTTTTCTATGTCGGCTTTGTAATTGCAGAGCGAGTATTATATATTCCTAGTATGGGCTTCTGCCTACTGATTACAG
TGGGTGCTAGAGCCCTTTATGTCAAAGTCCAAAAGCGGTTCCTCAAGAGCTTGATTTTTTATGCTACAGCTACACTAATTGTTTTTTATG
GACTCAAGACTGCGATCAGGAATGGAGACTGGCAGAATGAGGAAATGCTTTATAGATCAGGGATAAAAGTAAACCCAGCTAAAGCATGGG
GTAACCTTGGAAATGTTCTGAAGAGTCAGAGCAAAATTTCTGAAGCTGAAAGCGCCTATAGAAATGCTTTGTACTACCGCAGCAACATGG
CTGACATGCTTTATAATTTAGGGCTACTTCTCCAGGAGAACAGCAGGTTTGCAGAAGCACTACATTATTATAAATTGGCCATTGGGAGCA
GGCCTACCCTGGCTTCTGCATATTTAAATACCGGTATTATTCTAATGAACCAAGGAAGGACGGAAGAAGCCCGACGGACATTCTTAAAGT
GTTCGGAGATCCCAGATGAAAACCTAAAGGACCCTCATGCACACAAGAGCTCTGTTACCAGTTGTTTGTACAACCTAGGAAAGCTGTATC
ATGAGCAGGGACACTATGAGGAAGCCCTTAGTGTATACAAGGAAGCAATTCAGAAAATGCCAAGGCAGTTTGCCCCACAGAGCTTGTACA
ACATGATGGGTGAAGCATATATGCGTTTAAGCAAACTCCCCGAAGCAGAGCATTGGTATATGGAATCACTGAGATCCAAGACTGACCACA
TCCCTGCTCATCTCACCTATGGGAAGCTGCTAGCTCTAACAGGTCGTAAGAGTGAGGCTGAAAAGCTCTTCTTGAAGGCTATTGAGCTGG
ATCCCACCAAAGGAAACTGTTACATGCATTATGGTCAGTTTCTTCTGGAAGAAGCTCGTCTCATAGAAGCAGCTGAGATGGCAAAAAAAG
CAGCTGAACTAGACAGCACAGAGTTTGATGTTGTCTTCAATGCTGCCCACATGCTCAGACAGGCTAGCCTCAATGAAGCAGCTGAGAAGT
ATTATGATCTGGCAGCCAGGCTGAGGCCTAATTATCCGGCTGCTTTGATGAACCTGGGAGCCATTCTGCACCTCAATGGCAGACTCCAGA
AGGCCGAGGCCAACTACCTGCGGGCCCTGCAGCTCAAGCCAGACGATGTCATCACACAGTCCAATCTCCGCAAACTGTGGAACATCATGG
AAAAACAAGGCTTAAAGACTTCTAAGACCTGACACAGGAGGCAGAAGCCCATCCTCCTCCATTTTTAAAAGCTGGCTTCCTTAGCAGACA
GAACTTCCCAGCAGTGCTATGACAAGAGCTGGTGTTAGACTTCAAGACCAGGGCAGAGGTCATTGAGGTCACTACCGCTTCTGGAAGAAT
CCACTTTGCTGTAGGCACAGCTGTTAACACCAAAAAGGGGAAAGCCGGAAACCTCCTGGAGGATGTCATTGTTACCCATAGACTGTAAAC
CAGAGCACTTAAAACAGAACCTTTTGGCATTCTTAAAAAGGGAGGGGTGGGTGTGTAAGTCACAGATTTTGTTCATTTTCTGAAAGCTAA
TTTCAAAATTATGTTGTTCCTTAAACACTGTGAGAGGAAGTCAGAGTGTCCATTCAGGCATGGCAAACAATTAGGGTTAAGTGTTACGAG
GGAGTGATAAACACGTAGTGTGAGTCCCAGTGAGCCGCCGGTTGTCCTAACGCTGCTGTCTTCCCTGTTTGGGACAGCCTGCTTATCAAT
TTCTGAAGCTTAGAACACTTTTTTTAATACTGTGTCAAGATCTGTCAGAATCTGCTATGTTTCTTGACCAGTGCACATAATGTTTTATGA
TTTGGATGTCAGAGGCTTCATTCTTTTGGACATCATTTGCTTTTTATGTTCTGAAAAGGATATGGAGAGTAGAGCTAACCATACTTCACA
CTCGAGTTGTATGAGGGACTGGGGAGGCCTTATATGTGTCAGGCAGGCATTTTTTAAATTTTAATATCGTCAATATTTTCCCCCAAACTG
CCCAGTAGAATTCATTGTATTAATTCTTTTGAAATTACCTTTGAAAATAGCTATTCCTGGAGAATGTGCAAGCTTACATAAGGATAAAGG
ACAGGGGAGGAGTTTGTAAGCCTTGCAGTTCCAATAACTAACCAACAGGTTATTAGACAAAAGGGAAGGTGTTTTGTGCTTCTCAGATGT
TGCTGGTTTAGGAGTGTGTGATGATGCTTGCCAGTGATTTTGTGTTTTGGAAAGGGTAGGTATCGAATGTTAATCACTTTCTAATGGGTA
CCTAAACAGCAATGCTGATAAATGTTCAAGGAATTATTTTCATCTTAGTTTGTTCTTCTCAAAAGGCATCAAAAACAACTTATTTGAAGC
TGCAATAGAGTGTAGCATTAGCCTGCATGTTTCTAGGTCTTCTGCCAAGTGCTTTTCTCAGTTGAAAACTATTTTTCACTAGCAAAATTG
GTATTTTATTTCATTACCTGTTAGTAACTACTTCAATGATCATTTCACAAGAAAAAGACTATAAATTAAGTAGAGAACAACATTTTTATT
GAACATTTTTGGCTTGCAATCAAACTTTGCCACTAAAAATTAACTTCATAAAACACTAGTCCGTTATCAACTTCTTCACAGAGAAAGTAG
CTATACTATACCCTACATATTTATTTATTTATTATTCTACTATAGCAGAATAACAAAACTTGATGCATTAAGCCAGTTCTTTGCAACTGA
AAATTACCTGTTTCTCCTTCCCTTTCACACTCCATGTATATATGATCAGCCTCTCCATTAAAAAGAAGCTGGACATGCAAATACATCATA
TTATGTTTTCTCCATATTTTATGTTTTTCTATGTATCTGAATACAGTGGGATAAATAATTGAAAGTAGTGTTCCTATGGCATTAGTGTTT
TTGTGAGAAGGGTAAATGTAGTGAGAAAGGTTTTTTCATGGCATTAATAAGAAAGCCCTTCTGTAATATATATATTATTTTGTAAACATT
TCACTGAAGGGCCAAAAGTTAAATTATAACTAAATCACTGTGTTTTCAGAATGATATTTAACAACAAACCCGTGGTCAAACCAAAATAGT

>19195_19195_12_CPSF6-TMTC2_CPSF6_chr12_69633486_ENST00000551516_TMTC2_chr12_83289597_ENST00000549919_length(amino acids)=638AA_BP=19
MADGVDHIDIYADVGEEFNQRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPD
TLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIK
NDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGL
KTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP
TLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM
MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAA
ELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPSF6-TMTC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPSF6-TMTC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPSF6-TMTC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource