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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPT1A-LPCAT2 (FusionGDB2 ID:19221)

Fusion Gene Summary for CPT1A-LPCAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: CPT1A-LPCAT2
Fusion gene ID: 19221
HgeneTgene
Gene symbol

CPT1A

LPCAT2

Gene ID

1374

54947

Gene namecarnitine palmitoyltransferase 1Alysophosphatidylcholine acyltransferase 2
SynonymsCPT1|CPT1-L|L-CPT1AGPAT11|AYTL1|LysoPAFAT
Cytomap

11q13.3

16q12.2

Type of geneprotein-codingprotein-coding
Descriptioncarnitine O-palmitoyltransferase 1, liver isoformCPT ICPTI-Lcarnitine O-palmitoyltransferase I, liver isoformcarnitine palmitoyltransferase 1A (liver)carnitine palmitoyltransferase I, liverlysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2
Modification date2020031520200313
UniProtAcc

P50416

Q7L5N7

Ensembl transtripts involved in fusion geneENST00000265641, ENST00000376618, 
ENST00000539743, ENST00000540367, 
ENST00000537756, ENST00000538994, 
ENST00000565056, ENST00000262134, 
Fusion gene scores* DoF score25 X 23 X 12=69006 X 9 X 4=216
# samples 329
** MAII scorelog2(32/6900*10)=-4.43045255166553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPT1A [Title/Abstract] AND LPCAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPT1A(68529003)-LPCAT2(55583189), # samples:2
Anticipated loss of major functional domain due to fusion event.CPT1A-LPCAT2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CPT1A-LPCAT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CPT1A-LPCAT2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPT1A

GO:0001676

long-chain fatty acid metabolic process

11350182

HgeneCPT1A

GO:0009437

carnitine metabolic process

11350182

TgeneLPCAT2

GO:0036151

phosphatidylcholine acyl-chain remodeling

21498505


check buttonFusion gene breakpoints across CPT1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPCAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A150-01ACPT1Achr11

68529003

-LPCAT2chr16

55583189

+


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Fusion Gene ORF analysis for CPT1A-LPCAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265641ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
5CDS-intronENST00000376618ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
5CDS-intronENST00000539743ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
5CDS-intronENST00000540367ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
Frame-shiftENST00000539743ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
Frame-shiftENST00000540367ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
In-frameENST00000265641ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
In-frameENST00000376618ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
intron-3CDSENST00000537756ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
intron-3CDSENST00000538994ENST00000262134CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
intron-intronENST00000537756ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+
intron-intronENST00000538994ENST00000565056CPT1Achr11

68529003

-LPCAT2chr16

55583189

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376618CPT1Achr1168529003-ENST00000262134LPCAT2chr1655583189+647021981492233694
ENST00000265641CPT1Achr1168529003-ENST00000262134LPCAT2chr1655583189+645521831342218694

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376618ENST00000262134CPT1Achr1168529003-LPCAT2chr1655583189+0.0002425060.99975747
ENST00000265641ENST00000262134CPT1Achr1168529003-LPCAT2chr1655583189+0.0002398550.9997601

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Fusion Genomic Features for CPT1A-LPCAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPT1Achr1168529002-LPCAT2chr1655583188+0.0062417850.9937582
CPT1Achr1168529002-LPCAT2chr1655583188+0.0062417850.9937582

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CPT1A-LPCAT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68529003/chr16:55583189)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPT1A

P50416

LPCAT2

Q7L5N7

FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:9691089}.FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q8BYI6, ECO:0000269|PubMed:17182612, ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-1619555_567676774.0RegionCoenzyme A binding
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-1619555_567676757.0RegionCoenzyme A binding
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-1518555_567676774.0RegionCoenzyme A binding
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-1518555_567676757.0RegionCoenzyme A binding
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-16192_47676774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-161974_102676774.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-16192_47676757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-161974_102676757.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-15182_47676774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-151874_102676774.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-15182_47676757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-151874_102676757.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-1619103_122676774.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-161948_73676774.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-1619103_122676757.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-161948_73676757.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-1518103_122676774.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-151848_73676774.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-1518103_122676757.0TransmembraneHelical
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-151848_73676757.0TransmembraneHelical
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814404_415311545.0Calcium binding1
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814441_452311545.0Calcium binding2
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814391_426311545.0DomainEF-hand 1
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814428_463311545.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPT1Achr11:68529003chr16:55583189ENST00000265641-1619123_773676774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000376618-1619123_773676757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000539743-1518123_773676774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68529003chr16:55583189ENST00000540367-1518123_773676757.0Topological domainCytoplasmic
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814146_151311545.0MotifHXXXXD motif
TgeneLPCAT2chr11:68529003chr16:55583189ENST00000262134814220_223311545.0MotifNote=EGTC motif
TgeneLPCAT2chr11:68529003chr16:55583189ENST000002621348141_57311545.0Topological domainCytoplasmic
TgeneLPCAT2chr11:68529003chr16:55583189ENST0000026213481479_544311545.0Topological domainLumenal
TgeneLPCAT2chr11:68529003chr16:55583189ENST0000026213481458_78311545.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CPT1A-LPCAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19221_19221_1_CPT1A-LPCAT2_CPT1A_chr11_68529003_ENST00000265641_LPCAT2_chr16_55583189_ENST00000262134_length(transcript)=6455nt_BP=2183nt
AATCCGCTGCTGCCGGCGTCGGGTGCGCTCGGCCTCGCCCGCGGCCCTCCTTCCCCGGCTCCCGCTCGCCGCTCGTTCACTCCACCGCCG
CCGCCGCCGCCGCCGCTGCCGCTGCCGCTGCCGCACCTCCGTAGCTGACTCGGTACTCTCTGAAGATGGCAGAAGCTCACCAAGCTGTGG
CCTTTCAGTTCACGGTCACTCCGGACGGGATTGACCTGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCTCTGGACTTCATTCCT
GGAAAAAGAAGTTCATCAGATTCAAGAACGGCATCATCACTGGCGTGTACCCGGCAAGCCCCTCCAGTTGGCTTATCGTGGTGGTGGGCG
TGATGACAACGATGTACGCCAAGATCGACCCCTCGTTAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGGCCAACTGCATGTCCA
GCCAGACGAAGAACGTGGTCAGCGGCGTGCTGTTTGGCACCGGCCTGTGGGTGGCCCTCATCGTCACCATGCGCTACTCCCTGAAAGTGC
TGCTCTCCTACCACGGGTGGATGTTCACTGAGCACGGCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGGTCAAGATCTTTTCAG
GCCGAAAACCCATGTTGTACAGCTTCCAGACATCGCTGCCTCGCCTGCCGGTCCCGGCTGTCAAAGACACTGTGAACAGGTATCTACAGT
CGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAACGGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTGGACCAAGATTACAGT
GGTATTTGAAGTTAAAATCCTGGTGGGCTACAAATTACGTGAGCGACTGGTGGGAGGAGTACATCTACCTCCGAGGACGAGGGCCGCTCA
TGGTGAACAGCAACTATTATGCCATGGATCTGCTGTATATCCTTCCAACTCACATTCAGGCAGCAAGAGCCGGCAACGCCATCCATGCCA
TCCTGCTTTACAGGCGCAAACTGGACCGGGAGGAAATCAAACCAATTCGTCTTTTGGGATCCACGATTCCACTCTGCTCCGCTCAGTGGG
AGCGGATGTTTAATACTTCCCGGATCCCAGGAGAGGAGACAGACACCATCCAGCACATGAGAGACAGCAAGCACATCGTCGTGTACCATC
GAGGACGCTACTTCAAGGTCTGGCTCTACCATGATGGGCGGCTGCTGAAGCCCCGGGAGATGGAGCAGCAGATGCAGAGGATCCTGGACA
ATACCTCGGAGCCTCAGCCCGGGGAGGCCAGGCTGGCAGCCCTCACCGCAGGAGACAGAGTTCCCTGGGCCAGGTGTCGTCAGGCCTATT
TTGGACGTGGGAAAAATAAGCAGTCTCTTGATGCTGTGGAGAAAGCAGCGTTCTTTGTGACGTTAGATGAAACTGAAGAAGGATACAGAA
GTGAAGACCCGGATACGTCAATGGACAGCTACGCCAAATCTCTACTACACGGCCGATGTTACGACAGGTGGTTTGACAAGTCGTTCACGT
TTGTTGTCTTCAAAAACGGGAAGATGGGCCTCAACGCTGAACACTCCTGGGCAGATGCGCCGATCGTGGCCCACCTTTGGGAGTACGTCA
TGTCCATTGACAGCCTCCAGCTGGGCTATGCGGAGGATGGGCACTGCAAAGGCGACATCAATCCGAACATTCCGTACCCCACCAGGCTGC
AGTGGGACATCCCGGGGGAATGTCAAGAGGTTATAGAGACCTCCCTGAACACCGCAAATCTTCTGGCAAACGACGTGGATTTCCATTCCT
TCCCATTCGTAGCCTTTGGTAAAGGAATCATCAAGAAATGTCGCACGAGCCCAGACGCCTTTGTGCAGCTGGCCCTCCAGCTGGCGCACT
ACAAGGACATGGGCAAGTTTTGCCTCACATACGAGGCCTCCATGACCCGGCTCTTCCGAGAGGGGAGGACGGAGACCGTGCGCTCCTGCA
CCACTGAGTCATGCGACTTCGTGCGGGCCATGGTGGACCCGGCCCAGACGGTGGAACAGAGGCTGAAGTTGTTCAAGTTGGCGTCTGAGA
AGCATCAGCATATGTATCGCCTCGCCATGACCGGCTCTGGGATCGATCGTCACCTCTTCTGCCTTTACGTGGTGTCTAAATATCTCGCTG
TGGAGTCCCCTTTCCTTAAGGAAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGACTGCAGATTGATGATTTCAGCAGGACAG
CTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTAGATTGGGATGGTGTTCGTAAGCATTTG
GATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCCAAGTATTTAAAGTTGCCTGTTTCAGAT
GTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAGTATGTGATTGGCCTGGCTGTCTTGTGC
AACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGATGGCTACATAACGGAGGAAGAGTTCTCC
ACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATAGCCCAAGGGGACTCAATTTCCTATGAG
GAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGACCTCCAGACGTGCCATGTGTTTTCATTA
CCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAAGAGAGTACCTCAGACAAAAAAGATGAC
TGAAAGCAGTATTTCCAATAAGGAAAACACAGTAGCTTTTGCTTGAAATTGTAAAGGCACTTATTGATAATACTTTTAATGTGTTGGTAA
TGATGTTTAAAATTGAAAGATTTTTAAAACAAAAATGATAGATTTTCTTACTAAAAATGTTTTTATTAACCTTGCTTTTATTGGAAAAAA
TCAAGCAATATTTCGTTTTCTTTTGTGTTATATTGTACTTTACTGATTCATTTACTGGTGATACATATGTTTTTATGGATTTTCCAGTTT
AATTTGCATATACAAATGAATGCAATGGTCTATTGGTGAGCATTGAGCAACACTGTATAAAGTTTTAAAAATGTAAACACTTTTTAATCT
ACTTTCCTCTAAAAATCAATAATATTCTATTATTTCTAATCCTTTTCCACTTGGGAAATAACAATGAAGAATCTGAGAATTTGACATCTA
TAACTTTACAGATTCATTTTTCCATTTAAATTTCAGTTTCTTGGATCACTGAATATGGGAAGGGAGAGCTTCACTAATTAGACGCAGCTT
CTTAAGAACTTATATTCTCTTTGACATACATCTCTATTGTAGTTTTTTGTTTTGTTTTGTTTTTTGAGATGGAGTCTTGCTCTGTCACCC
AGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCGTACCTCAGACTCCCGAGTAGTT
GGGATTACAGGTGCCCACCACCACACCCGACTAATTTTTGTATTTTTAGTAGCCATGTGGTTTTGCCATGTTGGCCAGGCTGGTTTCGAA
CTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTTCCCGGCCTATTGTAGATTTT
CTTAACTACTTGCTAAGGAAATCATATCCTTTTACATGAACTACAGGTTTAGAACTTGGTTTTAAGACAACTGCTATGGCCAGAAGGTAA
ATGGGAATTGCCTTATTGAAGGTAACATTGATTGCCTAATAAGAAAATGAATTGTTTGCCACAGAGTTGAATTTAATTTGAGTTAGATAG
TTCAGAATGTAGCACTTGCCCTATAAATGAATCAGATTTGTTCTATTTATATAATATTAGAATTAATATATTATCATGTAAGTGGGAATT
TTATTTTGTTAAGTGGACTCTCAAATTTTAGAACTTGTGTGAAATATCTCCCAGAAAACACAAAAGGTTTCAAGGTATCACCCAAAGCTA
GGGAATCAACAAACGTACTTTATTAATGCAAGACCACAATTTAAGCCCCAGGCAGGAATCCAACAGTAACATTTTTCCTTTAGGTTAAGC
AGTAATTTTTTTGAATTGTCATTTTTAATGGGTCTCACACATGCATATTGCTAATATCATTCATGTTTGAGGTTTTCAACAAAGAACCAA
TTTATTAATATAATGTACAAAAATAGTTGGTTCATTTTCTGAATTCAGTCTTTGAAATAAAACTCCTTGTTTTGGCCGTGTTTCTGAATG
TATTGGTGATTCACCCCCAAGCTAATTTTTTAAAGTCATTTTTGAAGTTGGGAAGTCTCATGAGAGATGTTGAAGTATGTATTTAATCAA
GAGTCATGATTTCAAACTAGTTTTACATATTAAGCAGTTAGTGTTCTAATTTAATGGGTAAATGTGTGTTTGGATAAATATCTGAAAATT
TTATCCTTAAGTATATATAATTATTTGCCTCTTATATGTCTTAAAGCTATTTAAACAAGGTGTTAAATGAGCCAAAACAATTAAGTAATT
AGAACAGTACATTTTTATCAGAGTGTCTGTCATATGCAATGAATGTATGTAATACTAAAAAATCATGACTACTTTTATCAAAGAAAAACC
ACACATTAATCCTATTAATCATGAAAGCGTAGCATTGTAAATTAAAGGTTTTCTTTGAGGCTCTTGAAAGTGATCCCATTGCTTTCCTGT
TTTAAAAATATTTTATGCTCTTTATTTCCACTTCTGTGAATGTGATATTTCTATTTTGTGATTATGTTACTGAATAAACAAACTTGCTAC
ATAAAATTCTTAGCAATTAAAAAAATTCTGATTCTGCCATTTTGTCTCAAATGTAATATACCCTTTTAATATCATATGTTTACATATTTA
TGAATGATTAATCATTTTTGTTTGCATTAAACTTTATGAAATGTCAGAAATGATTTTACTCTAATGAAACTCAAATTTTGCCCAAAGTAG
CAATATTCTTAAAGATGTTGAATTTTGACTGGTTGAATTTTATATAGTAACACACAAGTCGTGATCATCAATATTATTGCAGACCAGGAC
TCTGCTTATATGCCTTGCTAACAAAGATTTCTTTCACAGAGGCTTTTCTCCTCTCAAGACTTAAAGTAAGAATTACATTTTATTAAGTCA
GTTAAATGCACCATGGCTTCATATAGTAATATAAAAAAACTCTTTGAAGTGAGAAATATTATATCCTAAAACCTCTAAACCACAAACATT
CAATTGAAAGAGTTCTGTTGAAGGATAATGACATACTGACTGCTTACAGACCAAGTTGCTTGCATTTTGTATGTTTAGCCCTCCTTTGCC
ACTGCTTTTAGAGCCTTGGAAGGCTAAGTGTGATAGTAATGCTAGCTCTAATGCATATTTAAAGGAGACTGCCTCGCTTTTAGAAGACAT
CTGGTCTGCTCTCTGCATGAGGCACAGCAGTAAAGCTCTTTGATTCCCAGAATCAAGAACTCTCCCCTTCAGACTATTACCGAATGCAAG
GTGGTTAATTGAAGGCCACTAATTGATGCTCAAATAGAAGGATATTGACTATATTGGAACAGATGGAGTCTCTACTACAAAAGTCTTTGG
GTATTTGTTTCTTACATAGAAAATGCTAACATGAATAGAAAGATACTGGTGCAAGACCATTCCCGGGAAAGTAGACATACTTACATTTTT
TTCCTTTTCTGCTCATTTGAATGAACTCAATTTTATGTTAAATTGTTATATCAGAGTGACAAATAAGTGCTATGGCTTGATAGAAGTGAA
GCTCTTCACATATATTCAAAATACATATCACAAACTTTGGTAAATAGGATAGTAATCTGAAGAACTTTTGCCCTTTTTACCCCATTTACT
GTAACTCTTGTTTCTAGGTAATCGTTCTCTCTCAACAAACTTCTCAAGCGTCTGTGTAACAAGCCACATGTTCTAACAAATTGTCTCCAT
CGCACTTCAACAGCCAGGTCCCTATTTTTTATAACGTATTAACCTTATTATTTTCTTATTATTTTAAAAGAATCTATGCACATTAGCAAA
ATTTAAAAGATAGAGAAAAATATAAACAGAAAAAATTATGTTTACTTCTACCACCCTAAATCAACTATTATCAATTTTATACATATTTTA
CTCCATCTTTTTTCAAAGTTTCTTACATTTTCCAATGTCATTAAAATTCTCTGTGAATGTAAATTTTAAAAACTGTACCTACTGTTTTTT

>19221_19221_1_CPT1A-LPCAT2_CPT1A_chr11_68529003_ENST00000265641_LPCAT2_chr16_55583189_ENST00000262134_length(amino acids)=694AA_BP=
MTRYSLKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGI
IAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPR
LPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYIL
PTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRL
LKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSL
LHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETS
LNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPA

--------------------------------------------------------------
>19221_19221_2_CPT1A-LPCAT2_CPT1A_chr11_68529003_ENST00000376618_LPCAT2_chr16_55583189_ENST00000262134_length(transcript)=6470nt_BP=2198nt
GGACCCGCCTCAGCCAATCCGCTGCTGCCGGCGTCGGGTGCGCTCGGCCTCGCCCGCGGCCCTCCTTCCCCGGCTCCCGCTCGCCGCTCG
TTCACTCCACCGCCGCCGCCGCCGCCGCCGCTGCCGCTGCCGCTGCCGCACCTCCGTAGCTGACTCGGTACTCTCTGAAGATGGCAGAAG
CTCACCAAGCTGTGGCCTTTCAGTTCACGGTCACTCCGGACGGGATTGACCTGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCT
CTGGACTTCATTCCTGGAAAAAGAAGTTCATCAGATTCAAGAACGGCATCATCACTGGCGTGTACCCGGCAAGCCCCTCCAGTTGGCTTA
TCGTGGTGGTGGGCGTGATGACAACGATGTACGCCAAGATCGACCCCTCGTTAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGG
CCAACTGCATGTCCAGCCAGACGAAGAACGTGGTCAGCGGCGTGCTGTTTGGCACCGGCCTGTGGGTGGCCCTCATCGTCACCATGCGCT
ACTCCCTGAAAGTGCTGCTCTCCTACCACGGGTGGATGTTCACTGAGCACGGCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGG
TCAAGATCTTTTCAGGCCGAAAACCCATGTTGTACAGCTTCCAGACATCGCTGCCTCGCCTGCCGGTCCCGGCTGTCAAAGACACTGTGA
ACAGGTATCTACAGTCGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAACGGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTG
GACCAAGATTACAGTGGTATTTGAAGTTAAAATCCTGGTGGGCTACAAATTACGTGAGCGACTGGTGGGAGGAGTACATCTACCTCCGAG
GACGAGGGCCGCTCATGGTGAACAGCAACTATTATGCCATGGATCTGCTGTATATCCTTCCAACTCACATTCAGGCAGCAAGAGCCGGCA
ACGCCATCCATGCCATCCTGCTTTACAGGCGCAAACTGGACCGGGAGGAAATCAAACCAATTCGTCTTTTGGGATCCACGATTCCACTCT
GCTCCGCTCAGTGGGAGCGGATGTTTAATACTTCCCGGATCCCAGGAGAGGAGACAGACACCATCCAGCACATGAGAGACAGCAAGCACA
TCGTCGTGTACCATCGAGGACGCTACTTCAAGGTCTGGCTCTACCATGATGGGCGGCTGCTGAAGCCCCGGGAGATGGAGCAGCAGATGC
AGAGGATCCTGGACAATACCTCGGAGCCTCAGCCCGGGGAGGCCAGGCTGGCAGCCCTCACCGCAGGAGACAGAGTTCCCTGGGCCAGGT
GTCGTCAGGCCTATTTTGGACGTGGGAAAAATAAGCAGTCTCTTGATGCTGTGGAGAAAGCAGCGTTCTTTGTGACGTTAGATGAAACTG
AAGAAGGATACAGAAGTGAAGACCCGGATACGTCAATGGACAGCTACGCCAAATCTCTACTACACGGCCGATGTTACGACAGGTGGTTTG
ACAAGTCGTTCACGTTTGTTGTCTTCAAAAACGGGAAGATGGGCCTCAACGCTGAACACTCCTGGGCAGATGCGCCGATCGTGGCCCACC
TTTGGGAGTACGTCATGTCCATTGACAGCCTCCAGCTGGGCTATGCGGAGGATGGGCACTGCAAAGGCGACATCAATCCGAACATTCCGT
ACCCCACCAGGCTGCAGTGGGACATCCCGGGGGAATGTCAAGAGGTTATAGAGACCTCCCTGAACACCGCAAATCTTCTGGCAAACGACG
TGGATTTCCATTCCTTCCCATTCGTAGCCTTTGGTAAAGGAATCATCAAGAAATGTCGCACGAGCCCAGACGCCTTTGTGCAGCTGGCCC
TCCAGCTGGCGCACTACAAGGACATGGGCAAGTTTTGCCTCACATACGAGGCCTCCATGACCCGGCTCTTCCGAGAGGGGAGGACGGAGA
CCGTGCGCTCCTGCACCACTGAGTCATGCGACTTCGTGCGGGCCATGGTGGACCCGGCCCAGACGGTGGAACAGAGGCTGAAGTTGTTCA
AGTTGGCGTCTGAGAAGCATCAGCATATGTATCGCCTCGCCATGACCGGCTCTGGGATCGATCGTCACCTCTTCTGCCTTTACGTGGTGT
CTAAATATCTCGCTGTGGAGTCCCCTTTCCTTAAGGAAAGCTCTGGGAATACCAGTAACAGATCATACCTATGAAGACTGCAGATTGATG
ATTTCAGCAGGACAGCTAACATTGCCTATGGAAGCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTAGATTGGGATGGT
GTTCGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGAATTGAAGAATTCGCCAAGTATTTAAAG
TTGCCTGTTTCAGATGTCTTGAGACAACTTTTTGCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAGTATGTGATTGGC
CTGGCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTTGACGTTGATGAGGATGGCTACATAACG
GAGGAAGAGTTCTCCACCATTCTACAGGCTTCCCTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATAGCCCAAGGGGAC
TCAATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTTACAACATACCTAGACCTCCAGACGTGC
CATGTGTTTTCATTACCAAAAGAAGTCCAGACAACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAAGAGAGTACCTCA
GACAAAAAAGATGACTGAAAGCAGTATTTCCAATAAGGAAAACACAGTAGCTTTTGCTTGAAATTGTAAAGGCACTTATTGATAATACTT
TTAATGTGTTGGTAATGATGTTTAAAATTGAAAGATTTTTAAAACAAAAATGATAGATTTTCTTACTAAAAATGTTTTTATTAACCTTGC
TTTTATTGGAAAAAATCAAGCAATATTTCGTTTTCTTTTGTGTTATATTGTACTTTACTGATTCATTTACTGGTGATACATATGTTTTTA
TGGATTTTCCAGTTTAATTTGCATATACAAATGAATGCAATGGTCTATTGGTGAGCATTGAGCAACACTGTATAAAGTTTTAAAAATGTA
AACACTTTTTAATCTACTTTCCTCTAAAAATCAATAATATTCTATTATTTCTAATCCTTTTCCACTTGGGAAATAACAATGAAGAATCTG
AGAATTTGACATCTATAACTTTACAGATTCATTTTTCCATTTAAATTTCAGTTTCTTGGATCACTGAATATGGGAAGGGAGAGCTTCACT
AATTAGACGCAGCTTCTTAAGAACTTATATTCTCTTTGACATACATCTCTATTGTAGTTTTTTGTTTTGTTTTGTTTTTTGAGATGGAGT
CTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCGTACCTCA
GACTCCCGAGTAGTTGGGATTACAGGTGCCCACCACCACACCCGACTAATTTTTGTATTTTTAGTAGCCATGTGGTTTTGCCATGTTGGC
CAGGCTGGTTTCGAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTTCCCGG
CCTATTGTAGATTTTCTTAACTACTTGCTAAGGAAATCATATCCTTTTACATGAACTACAGGTTTAGAACTTGGTTTTAAGACAACTGCT
ATGGCCAGAAGGTAAATGGGAATTGCCTTATTGAAGGTAACATTGATTGCCTAATAAGAAAATGAATTGTTTGCCACAGAGTTGAATTTA
ATTTGAGTTAGATAGTTCAGAATGTAGCACTTGCCCTATAAATGAATCAGATTTGTTCTATTTATATAATATTAGAATTAATATATTATC
ATGTAAGTGGGAATTTTATTTTGTTAAGTGGACTCTCAAATTTTAGAACTTGTGTGAAATATCTCCCAGAAAACACAAAAGGTTTCAAGG
TATCACCCAAAGCTAGGGAATCAACAAACGTACTTTATTAATGCAAGACCACAATTTAAGCCCCAGGCAGGAATCCAACAGTAACATTTT
TCCTTTAGGTTAAGCAGTAATTTTTTTGAATTGTCATTTTTAATGGGTCTCACACATGCATATTGCTAATATCATTCATGTTTGAGGTTT
TCAACAAAGAACCAATTTATTAATATAATGTACAAAAATAGTTGGTTCATTTTCTGAATTCAGTCTTTGAAATAAAACTCCTTGTTTTGG
CCGTGTTTCTGAATGTATTGGTGATTCACCCCCAAGCTAATTTTTTAAAGTCATTTTTGAAGTTGGGAAGTCTCATGAGAGATGTTGAAG
TATGTATTTAATCAAGAGTCATGATTTCAAACTAGTTTTACATATTAAGCAGTTAGTGTTCTAATTTAATGGGTAAATGTGTGTTTGGAT
AAATATCTGAAAATTTTATCCTTAAGTATATATAATTATTTGCCTCTTATATGTCTTAAAGCTATTTAAACAAGGTGTTAAATGAGCCAA
AACAATTAAGTAATTAGAACAGTACATTTTTATCAGAGTGTCTGTCATATGCAATGAATGTATGTAATACTAAAAAATCATGACTACTTT
TATCAAAGAAAAACCACACATTAATCCTATTAATCATGAAAGCGTAGCATTGTAAATTAAAGGTTTTCTTTGAGGCTCTTGAAAGTGATC
CCATTGCTTTCCTGTTTTAAAAATATTTTATGCTCTTTATTTCCACTTCTGTGAATGTGATATTTCTATTTTGTGATTATGTTACTGAAT
AAACAAACTTGCTACATAAAATTCTTAGCAATTAAAAAAATTCTGATTCTGCCATTTTGTCTCAAATGTAATATACCCTTTTAATATCAT
ATGTTTACATATTTATGAATGATTAATCATTTTTGTTTGCATTAAACTTTATGAAATGTCAGAAATGATTTTACTCTAATGAAACTCAAA
TTTTGCCCAAAGTAGCAATATTCTTAAAGATGTTGAATTTTGACTGGTTGAATTTTATATAGTAACACACAAGTCGTGATCATCAATATT
ATTGCAGACCAGGACTCTGCTTATATGCCTTGCTAACAAAGATTTCTTTCACAGAGGCTTTTCTCCTCTCAAGACTTAAAGTAAGAATTA
CATTTTATTAAGTCAGTTAAATGCACCATGGCTTCATATAGTAATATAAAAAAACTCTTTGAAGTGAGAAATATTATATCCTAAAACCTC
TAAACCACAAACATTCAATTGAAAGAGTTCTGTTGAAGGATAATGACATACTGACTGCTTACAGACCAAGTTGCTTGCATTTTGTATGTT
TAGCCCTCCTTTGCCACTGCTTTTAGAGCCTTGGAAGGCTAAGTGTGATAGTAATGCTAGCTCTAATGCATATTTAAAGGAGACTGCCTC
GCTTTTAGAAGACATCTGGTCTGCTCTCTGCATGAGGCACAGCAGTAAAGCTCTTTGATTCCCAGAATCAAGAACTCTCCCCTTCAGACT
ATTACCGAATGCAAGGTGGTTAATTGAAGGCCACTAATTGATGCTCAAATAGAAGGATATTGACTATATTGGAACAGATGGAGTCTCTAC
TACAAAAGTCTTTGGGTATTTGTTTCTTACATAGAAAATGCTAACATGAATAGAAAGATACTGGTGCAAGACCATTCCCGGGAAAGTAGA
CATACTTACATTTTTTTCCTTTTCTGCTCATTTGAATGAACTCAATTTTATGTTAAATTGTTATATCAGAGTGACAAATAAGTGCTATGG
CTTGATAGAAGTGAAGCTCTTCACATATATTCAAAATACATATCACAAACTTTGGTAAATAGGATAGTAATCTGAAGAACTTTTGCCCTT
TTTACCCCATTTACTGTAACTCTTGTTTCTAGGTAATCGTTCTCTCTCAACAAACTTCTCAAGCGTCTGTGTAACAAGCCACATGTTCTA
ACAAATTGTCTCCATCGCACTTCAACAGCCAGGTCCCTATTTTTTATAACGTATTAACCTTATTATTTTCTTATTATTTTAAAAGAATCT
ATGCACATTAGCAAAATTTAAAAGATAGAGAAAAATATAAACAGAAAAAATTATGTTTACTTCTACCACCCTAAATCAACTATTATCAAT
TTTATACATATTTTACTCCATCTTTTTTCAAAGTTTCTTACATTTTCCAATGTCATTAAAATTCTCTGTGAATGTAAATTTTAAAAACTG

>19221_19221_2_CPT1A-LPCAT2_CPT1A_chr11_68529003_ENST00000376618_LPCAT2_chr16_55583189_ENST00000262134_length(amino acids)=694AA_BP=
MTRYSLKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGI
IAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPR
LPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYIL
PTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRL
LKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSL
LHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETS
LNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPT1A-LPCAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPT1A-LPCAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPT1A-LPCAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource