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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPT1A-LPXN (FusionGDB2 ID:19222)

Fusion Gene Summary for CPT1A-LPXN

check button Fusion gene summary
Fusion gene informationFusion gene name: CPT1A-LPXN
Fusion gene ID: 19222
HgeneTgene
Gene symbol

CPT1A

LPXN

Gene ID

1374

9404

Gene namecarnitine palmitoyltransferase 1Aleupaxin
SynonymsCPT1|CPT1-L|L-CPT1LDPL
Cytomap

11q13.3

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncarnitine O-palmitoyltransferase 1, liver isoformCPT ICPTI-Lcarnitine O-palmitoyltransferase I, liver isoformcarnitine palmitoyltransferase 1A (liver)carnitine palmitoyltransferase I, liverleupaxin
Modification date2020031520200313
UniProtAcc

P50416

O60711

Ensembl transtripts involved in fusion geneENST00000538994, ENST00000265641, 
ENST00000376618, ENST00000539743, 
ENST00000540367, ENST00000537756, 
ENST00000395074, ENST00000528489, 
ENST00000528954, 
Fusion gene scores* DoF score25 X 23 X 12=69007 X 6 X 5=210
# samples 326
** MAII scorelog2(32/6900*10)=-4.43045255166553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPT1A [Title/Abstract] AND LPXN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPT1A(68566686)-LPXN(58338186), # samples:3
Anticipated loss of major functional domain due to fusion event.CPT1A-LPXN seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CPT1A-LPXN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CPT1A-LPXN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPT1A

GO:0001676

long-chain fatty acid metabolic process

11350182

HgeneCPT1A

GO:0009437

carnitine metabolic process

11350182

TgeneLPXN

GO:0007162

negative regulation of cell adhesion

20543562

TgeneLPXN

GO:0050859

negative regulation of B cell receptor signaling pathway

17640867


check buttonFusion gene breakpoints across CPT1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPXN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-94-A5I6-01ACPT1Achr11

68566686

-LPXNchr11

58338186

-
ChimerDB4LUSCTCGA-94-A5I6CPT1Achr11

68566686

-LPXNchr11

58338186

-


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Fusion Gene ORF analysis for CPT1A-LPXN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000538994ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
5UTR-3CDSENST00000538994ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
5UTR-3CDSENST00000538994ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000265641ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000265641ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000265641ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000376618ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000376618ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000376618ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000539743ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000539743ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000540367ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
Frame-shiftENST00000540367ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-
In-frameENST00000539743ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
In-frameENST00000540367ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
intron-3CDSENST00000537756ENST00000395074CPT1Achr11

68566686

-LPXNchr11

58338186

-
intron-3CDSENST00000537756ENST00000528489CPT1Achr11

68566686

-LPXNchr11

58338186

-
intron-3CDSENST00000537756ENST00000528954CPT1Achr11

68566686

-LPXNchr11

58338186

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540367CPT1Achr1168566686-ENST00000528489LPXNchr1158338186-2238722231822599
ENST00000539743CPT1Achr1168566686-ENST00000528489LPXNchr1158338186-2238722231822599

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540367ENST00000528489CPT1Achr1168566686-LPXNchr1158338186-0.0155285080.9844715
ENST00000539743ENST00000528489CPT1Achr1168566686-LPXNchr1158338186-0.0155285080.9844715

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Fusion Genomic Features for CPT1A-LPXN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPT1A-LPXN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68566686/chr11:58338186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPT1A

P50416

LPXN

O60711

FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:9691089}.FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-6192_47231774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-61974_102231774.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-6192_47231757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-61974_102231757.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-5182_47231774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-51874_102231774.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-5182_47231757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-51874_102231757.0Topological domainMitochondrial intermembrane
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-619103_122231774.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-61948_73231774.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-619103_122231757.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-61948_73231757.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-518103_122231774.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-51848_73231774.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-518103_122231757.0TransmembraneHelical
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-51848_73231757.0TransmembraneHelical
TgeneLPXNchr11:68566686chr11:58338186ENST0000039507409150_2084387.0DomainLIM zinc-binding 1
TgeneLPXNchr11:68566686chr11:58338186ENST0000039507409209_2674387.0DomainLIM zinc-binding 2
TgeneLPXNchr11:68566686chr11:58338186ENST0000039507409268_3264387.0DomainLIM zinc-binding 3
TgeneLPXNchr11:68566686chr11:58338186ENST0000039507409327_3864387.0DomainLIM zinc-binding 4
TgeneLPXNchr11:68566686chr11:58338186ENST0000052895409150_2089392.0DomainLIM zinc-binding 1
TgeneLPXNchr11:68566686chr11:58338186ENST0000052895409209_2679392.0DomainLIM zinc-binding 2
TgeneLPXNchr11:68566686chr11:58338186ENST0000052895409268_3269392.0DomainLIM zinc-binding 3
TgeneLPXNchr11:68566686chr11:58338186ENST0000052895409327_3869392.0DomainLIM zinc-binding 4
TgeneLPXNchr11:68566686chr11:58338186ENST00000395074093_154387.0MotifNote=LD motif 1
TgeneLPXNchr11:68566686chr11:58338186ENST000003950740970_824387.0MotifNote=LD motif 2
TgeneLPXNchr11:68566686chr11:58338186ENST000003950740992_1034387.0MotifNote=LD motif 3
TgeneLPXNchr11:68566686chr11:58338186ENST000005289540970_829392.0MotifNote=LD motif 2
TgeneLPXNchr11:68566686chr11:58338186ENST000005289540992_1039392.0MotifNote=LD motif 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-619555_567231774.0RegionCoenzyme A binding
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-619555_567231757.0RegionCoenzyme A binding
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-518555_567231774.0RegionCoenzyme A binding
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-518555_567231757.0RegionCoenzyme A binding
HgeneCPT1Achr11:68566686chr11:58338186ENST00000265641-619123_773231774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000376618-619123_773231757.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000539743-518123_773231774.0Topological domainCytoplasmic
HgeneCPT1Achr11:68566686chr11:58338186ENST00000540367-518123_773231757.0Topological domainCytoplasmic
TgeneLPXNchr11:68566686chr11:58338186ENST00000528954093_159392.0MotifNote=LD motif 1


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Fusion Gene Sequence for CPT1A-LPXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19222_19222_1_CPT1A-LPXN_CPT1A_chr11_68566686_ENST00000539743_LPXN_chr11_58338186_ENST00000528489_length(transcript)=2238nt_BP=722nt
CTCCTTCTCCTTCCAGGTACTCTCTGAAGATGGCAGAAGCTCACCAAGCTGTGGCCTTTCAGTTCACGGTCACTCCGGACGGGATTGACC
TGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCTCTGGACTTCATTCCTGGAAAAAGAAGTTCATCAGATTCAAGAACGGCATCA
TCACTGGCGTGTACCCGGCAAGCCCCTCCAGTTGGCTTATCGTGGTGGTGGGCGTGATGACAACGATGTACGCCAAGATCGACCCCTCGT
TAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGGCCAACTGCATGTCCAGCCAGACGAAGAACGTGGTCAGCGGCGTGCTGTTTG
GCACCGGCCTGTGGGTGGCCCTCATCGTCACCATGCGCTACTCCCTGAAAGTGCTGCTCTCCTACCACGGGTGGATGTTCACTGAGCACG
GCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGGTCAAGATCTTTTCAGGCCGAAAACCCATGTTGTACAGCTTCCAGACATCGC
TGCCTCGCCTGCCGGTCCCGGCTGTCAAAGACACTGTGAACAGGTATCTACAGTCGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAAC
GGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTGGACCAAGATTACAGTGGTATTTGAAGTTAAAATCCTGGTGGGCTACAAATT
ACATGCCTTATTGGAGGAACTGGAACGCTCCACCCTTCAGGACAGTGATGAATATTCCAACCCAGCTCCTCTTCCCCTGGATCAGCATTC
CAGAAAGGAGACTAACCTTGATGAGACTTCGGAGATCCTTTCTATTCAGGATAACACAAGTCCCTTGCCGTGAAGCCCAAGAGCCAAAGG
AATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTGACTGAGATGCAGGCCAAGGTTGCAGTGA
GAGCAGATGCTGGCAAGAAGCACTTACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCAATGCTTGGGGGTCTGGAGCAGGAATTGC
AGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCTGGGAAGGTGATCCATGCTCTAGGGCAAT
CATGGCATCCTGAGCATTTTGTCTGTACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTCTTTGAGCGGAGTGGCTTGGCCTACTGCC
CCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGATAAAGTGCTGACAGCAATGAACCAGACCT
GGCACCCAGAGCACTTCTTCTGCTCTCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCATGAGAAGGACAAGAAGCCATATTGCCGAA
AGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAACTACCTTTCAGCCATGGACACTGTCTGGC
ACCCAGAGTGCTTTGTTTGTGGGGACTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAACTGGATGGACGTCCATTCTGTGAGCTCC
ATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGTATCAGTGCCATGGGGTACAAGTTCCATC
CTGAGCACTTTGTGTGTGCTTTCTGCCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAGAATGACAAGACCTATTGTCAACCTTGCT
TCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCTTATAAAATTTAAACCAAGAGAGGAGAGGAAAGGGT
AAATTTTCTGTTACTGACCTTCTGCTTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAAATAAAGGAACTTCTAGACTTTACATGAC
TAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCTTTCTCCCTCTCTTCTCCAATCAAGCACTTGGAGTT
AGATCTAGGTCCTTCTATCTCGTCCCTCTACAGATGTATTTTCCACTTGCATAATTCATGCCAACACTGGTTTTCTTAGGTTTCTCCATT

>19222_19222_1_CPT1A-LPXN_CPT1A_chr11_68566686_ENST00000539743_LPXN_chr11_58338186_ENST00000528489_length(amino acids)=599AA_BP=233
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPA
VKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYMPYWRNWNAPPFRTVMNIPTQLLFPWISIPERRLTLM
RLRRSFLFRITQVPCREAQEPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATV
PKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFC
SHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT

--------------------------------------------------------------
>19222_19222_2_CPT1A-LPXN_CPT1A_chr11_68566686_ENST00000540367_LPXN_chr11_58338186_ENST00000528489_length(transcript)=2238nt_BP=722nt
CTCCTTCTCCTTCCAGGTACTCTCTGAAGATGGCAGAAGCTCACCAAGCTGTGGCCTTTCAGTTCACGGTCACTCCGGACGGGATTGACC
TGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCTCTGGACTTCATTCCTGGAAAAAGAAGTTCATCAGATTCAAGAACGGCATCA
TCACTGGCGTGTACCCGGCAAGCCCCTCCAGTTGGCTTATCGTGGTGGTGGGCGTGATGACAACGATGTACGCCAAGATCGACCCCTCGT
TAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGGCCAACTGCATGTCCAGCCAGACGAAGAACGTGGTCAGCGGCGTGCTGTTTG
GCACCGGCCTGTGGGTGGCCCTCATCGTCACCATGCGCTACTCCCTGAAAGTGCTGCTCTCCTACCACGGGTGGATGTTCACTGAGCACG
GCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGGTCAAGATCTTTTCAGGCCGAAAACCCATGTTGTACAGCTTCCAGACATCGC
TGCCTCGCCTGCCGGTCCCGGCTGTCAAAGACACTGTGAACAGGTATCTACAGTCGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAAC
GGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTGGACCAAGATTACAGTGGTATTTGAAGTTAAAATCCTGGTGGGCTACAAATT
ACATGCCTTATTGGAGGAACTGGAACGCTCCACCCTTCAGGACAGTGATGAATATTCCAACCCAGCTCCTCTTCCCCTGGATCAGCATTC
CAGAAAGGAGACTAACCTTGATGAGACTTCGGAGATCCTTTCTATTCAGGATAACACAAGTCCCTTGCCGTGAAGCCCAAGAGCCAAAGG
AATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTGACTGAGATGCAGGCCAAGGTTGCAGTGA
GAGCAGATGCTGGCAAGAAGCACTTACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCAATGCTTGGGGGTCTGGAGCAGGAATTGC
AGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCTGGGAAGGTGATCCATGCTCTAGGGCAAT
CATGGCATCCTGAGCATTTTGTCTGTACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTCTTTGAGCGGAGTGGCTTGGCCTACTGCC
CCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGATAAAGTGCTGACAGCAATGAACCAGACCT
GGCACCCAGAGCACTTCTTCTGCTCTCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCATGAGAAGGACAAGAAGCCATATTGCCGAA
AGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAACTACCTTTCAGCCATGGACACTGTCTGGC
ACCCAGAGTGCTTTGTTTGTGGGGACTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAACTGGATGGACGTCCATTCTGTGAGCTCC
ATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGTATCAGTGCCATGGGGTACAAGTTCCATC
CTGAGCACTTTGTGTGTGCTTTCTGCCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAGAATGACAAGACCTATTGTCAACCTTGCT
TCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCTTATAAAATTTAAACCAAGAGAGGAGAGGAAAGGGT
AAATTTTCTGTTACTGACCTTCTGCTTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAAATAAAGGAACTTCTAGACTTTACATGAC
TAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCTTTCTCCCTCTCTTCTCCAATCAAGCACTTGGAGTT
AGATCTAGGTCCTTCTATCTCGTCCCTCTACAGATGTATTTTCCACTTGCATAATTCATGCCAACACTGGTTTTCTTAGGTTTCTCCATT

>19222_19222_2_CPT1A-LPXN_CPT1A_chr11_68566686_ENST00000540367_LPXN_chr11_58338186_ENST00000528489_length(amino acids)=599AA_BP=233
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPA
VKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYMPYWRNWNAPPFRTVMNIPTQLLFPWISIPERRLTLM
RLRRSFLFRITQVPCREAQEPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATV
PKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFC
SHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPT1A-LPXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPT1A-LPXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPT1A-LPXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource