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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CP-WWTR1 (FusionGDB2 ID:19244)

Fusion Gene Summary for CP-WWTR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CP-WWTR1
Fusion gene ID: 19244
HgeneTgene
Gene symbol

CP

WWTR1

Gene ID

1356

25937

Gene nameceruloplasminWW domain containing transcription regulator 1
SynonymsCP-2TAZ
Cytomap

3q24-q25.1

3q25.1

Type of geneprotein-codingprotein-coding
Descriptionceruloplasminceruloplasmin (ferroxidase)WW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264613, ENST00000462336, 
ENST00000465804, ENST00000360632, 
ENST00000467467, ENST00000474080, 
Fusion gene scores* DoF score6 X 5 X 5=15010 X 8 X 9=720
# samples 713
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CP [Title/Abstract] AND WWTR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCP(148905839)-WWTR1(149387678), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWTR1

GO:0008284

positive regulation of cell proliferation

18227151

TgeneWWTR1

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

TgeneWWTR1

GO:0017145

stem cell division

18568018

TgeneWWTR1

GO:0035329

hippo signaling

18227151|20412773

TgeneWWTR1

GO:0060390

regulation of SMAD protein signal transduction

18568018


check buttonFusion gene breakpoints across CP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWTR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0U4-01ACPchr3

148905839

-WWTR1chr3

149387678

-
ChimerDB4STADTCGA-R5-A7ZI-01ACPchr3

148905839

-WWTR1chr3

149260324

-


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Fusion Gene ORF analysis for CP-WWTR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264613ENST00000465804CPchr3

148905839

-WWTR1chr3

149387678

-
5CDS-intronENST00000264613ENST00000360632CPchr3

148905839

-WWTR1chr3

149387678

-
5CDS-intronENST00000264613ENST00000467467CPchr3

148905839

-WWTR1chr3

149387678

-
5CDS-intronENST00000264613ENST00000474080CPchr3

148905839

-WWTR1chr3

149387678

-
5CDS-intronENST00000264613ENST00000474080CPchr3

148905839

-WWTR1chr3

149260324

-
5UTR-3CDSENST00000462336ENST00000360632CPchr3

148905839

-WWTR1chr3

149260324

-
5UTR-3CDSENST00000462336ENST00000465804CPchr3

148905839

-WWTR1chr3

149260324

-
5UTR-3CDSENST00000462336ENST00000467467CPchr3

148905839

-WWTR1chr3

149260324

-
5UTR-5UTRENST00000462336ENST00000465804CPchr3

148905839

-WWTR1chr3

149387678

-
5UTR-intronENST00000462336ENST00000360632CPchr3

148905839

-WWTR1chr3

149387678

-
5UTR-intronENST00000462336ENST00000467467CPchr3

148905839

-WWTR1chr3

149387678

-
5UTR-intronENST00000462336ENST00000474080CPchr3

148905839

-WWTR1chr3

149387678

-
5UTR-intronENST00000462336ENST00000474080CPchr3

148905839

-WWTR1chr3

149260324

-
In-frameENST00000264613ENST00000360632CPchr3

148905839

-WWTR1chr3

149260324

-
In-frameENST00000264613ENST00000465804CPchr3

148905839

-WWTR1chr3

149260324

-
In-frameENST00000264613ENST00000467467CPchr3

148905839

-WWTR1chr3

149260324

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264613CPchr3148905839-ENST00000465804WWTR1chr3149260324-633221272122761849
ENST00000264613CPchr3148905839-ENST00000360632WWTR1chr3149260324-332221272122761849
ENST00000264613CPchr3148905839-ENST00000467467WWTR1chr3149260324-295721272122761849

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264613ENST00000465804CPchr3148905839-WWTR1chr3149260324-0.0002398050.9997602
ENST00000264613ENST00000360632CPchr3148905839-WWTR1chr3149260324-0.0005975170.9994025
ENST00000264613ENST00000467467CPchr3148905839-WWTR1chr3149260324-0.0008629480.9991371

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Fusion Genomic Features for CP-WWTR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CP-WWTR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:148905839/chr3:149387678)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019209_3576211066.0DomainNote=Plastocyanin-like 2
HgeneCPchr3:148905839chr3:149260324ENST00000264613-101920_2006211066.0DomainNote=Plastocyanin-like 1
HgeneCPchr3:148905839chr3:149260324ENST00000264613-101920_3576211066.0DomainNote=F5/8 type A 1
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019370_5606211066.0DomainNote=Plastocyanin-like 3
TgeneWWTR1chr3:148905839chr3:149260324ENST0000036063227225_259189401.0Coiled coilOntology_term=ECO:0000255
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046580438225_259189401.0Coiled coilOntology_term=ECO:0000255
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046746727225_259189401.0Coiled coilOntology_term=ECO:0000255
TgeneWWTR1chr3:148905839chr3:149260324ENST0000036063227194_241189401.0Compositional biasNote=Gln-rich
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046580438194_241189401.0Compositional biasNote=Gln-rich
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046746727194_241189401.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019370_7186211066.0DomainNote=F5/8 type A 2
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019570_7186211066.0DomainNote=Plastocyanin-like 4
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019730_10616211066.0DomainNote=F5/8 type A 3
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019730_9006211066.0DomainNote=Plastocyanin-like 5
HgeneCPchr3:148905839chr3:149260324ENST00000264613-1019908_10616211066.0DomainNote=Plastocyanin-like 6
TgeneWWTR1chr3:148905839chr3:149260324ENST0000036063227124_157189401.0DomainWW
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046580438124_157189401.0DomainWW
TgeneWWTR1chr3:148905839chr3:149260324ENST0000046746727124_157189401.0DomainWW


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Fusion Gene Sequence for CP-WWTR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19244_19244_1_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000360632_length(transcript)=3322nt_BP=2127nt
AGAGTTATGCACACCCTAATGCCTCCAACAATAACTGTTGACTTTTTATTTTCAGTCAGAGAAGCCTGGCAACCAAGAACTGTTTTTTTG
GTGGTTTACGAGAACTTAACTGAATTGGAAAATATTTGCTTTAATGAAACAATTTACTCTTGTGCAACACTAAATTGTGTCAATCAAGCA
AATAAGGAAGAAAGTCTTATTTATAAAATTGCCTGCTCCTGATTTTACTTCATTTCTTCTCAGGCTCCAAGAAGGGGAAAAAAATGAAGA
TTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAAGAAAAGCATTATTACATTGGAATTATTGAAACGACTT
GGGATTATGCCTCTGACCATGGGGAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCAGATAGAA
TTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTTAGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTT
TAGGCCCTATTATCAAAGCTGAAACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCATTCACATG
GAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACAGATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAG
AGCAGTATACATACATGTTGCTTGCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCATTCCCACA
TTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGTAAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATA
TTGACCGAGAATTTGTGGTGATGTTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGCTCAGAAC
CAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTATTCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGAC
TCTCCATGTGTGCTGAAGACAGAGTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCACGGGCAAG
CACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACCCTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAG
AATGGATGCTCAGCTGTCAGAATCTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCTTCATCAA
AGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAAATCATCTGGAACTATGCTCCCTCTGGTATAGACATCT
TCACTAAAGAAAACTTAACAGCACCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTATAAAAAGC
TGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGCCCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCA
TTTGGGCAGAGGTGGGAGACACCATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTGAGATTCA
ATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGAAGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAG
AAACATTCACCTATGAATGGACTGTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTATTCTGCTG
TGGAACCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGCAAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAG
ATGTAGACAAGGAATTCTATTTGTTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTTACAACTG
CACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATGCACTTGATGAATCACCAACACCAGCAGCAGATGGCCC
CCAGTACCCTGAGCCAGCAGAACCACCCCACTCAGAACCCACCCGCAGGGCTCATGAGTATGCCCAATGCGCTGACCACTCAGCAGCAGC
AGCAGCAGAAACTGCGGCTTCAGAGAATCCAGATGGAGAGAGAAAGGATTCGAATGCGCCAAGAGGAGCTCATGAGGCAGGAAGCTGCCC
TCTGTCGACAGCTCCCCATGGAAGCTGAGACTCTTGCCCCAGTTCAGGCTGCTGTCAACCCACCCACGATGACCCCAGACATGAGATCCA
TCACTAATAATAGCTCAGATCCTTTCCTCAATGGAGGGCCATATCATTCGAGGGAGCAGAGCACTGACAGTGGCCTGGGGTTAGGGTGCT
ACAGTGTCCCCACAACTCCGGAGGACTTCCTCAGCAATGTGGATGAGATGGATACAGGAGAAAACGCAGGACAAACACCCATGAACATCA
ATCCCCAACAGACCCGTTTCCCTGATTTCCTTGACTGTCTTCCAGGAACAAACGTTGACTTAGGAACTTTGGAATCTGAAGACCTGATCC
CCCTCTTCAATGATGTAGAGTCTGCTCTGAACAAAAGTGAGCCCTTTCTAACCTGGCTGTAATCACTACCATTGTAACTTGGATGTAGCC
ATGACCTTACATTTCCTGGGCCTCTTGGAAAAAGTGATGGAGCAGAGCAAGTCTGCAGGTGCACCACTTCCCGCCTCCATGACTCGTGCT
CCCTCCTTTTTATGTTGCCAGTTTAATCATTGCCTGGTTTTGATTGAGAGTAACTTAAGTTAAACATAAATAAATATTCTATTTTCATTT
TCTGCAAGCCTGCGTTCTTGTGACAGATTATACAGAATTGTGTCTGCAGGATTGATTATGCAGAATACTTTTCTCTTTCTTCTCTGCTGC
CCCATGGCTAAGCTTTATGGGTGTTAATTGAAATTTATACACCAATTGATTTTAAACCATAAAAAGCTGACCACAGGCAGTTACTTCTGA
GGGCATCTTGGTCCAGGAAATGTGCACAAAATTCGACCTGATTTACAGTTTCAAAAACTGTATTGATGACAGTAGTACCAAATGCTTTAA

>19244_19244_1_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000360632_length(amino acids)=849AA_BP=639
MLLILLHFFSGSKKGKKMKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYL
QYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATE
EQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF
QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNH
LKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASF
TNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPK
EVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED
FQESNKMHLMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAET
LAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFL

--------------------------------------------------------------
>19244_19244_2_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000465804_length(transcript)=6332nt_BP=2127nt
AGAGTTATGCACACCCTAATGCCTCCAACAATAACTGTTGACTTTTTATTTTCAGTCAGAGAAGCCTGGCAACCAAGAACTGTTTTTTTG
GTGGTTTACGAGAACTTAACTGAATTGGAAAATATTTGCTTTAATGAAACAATTTACTCTTGTGCAACACTAAATTGTGTCAATCAAGCA
AATAAGGAAGAAAGTCTTATTTATAAAATTGCCTGCTCCTGATTTTACTTCATTTCTTCTCAGGCTCCAAGAAGGGGAAAAAAATGAAGA
TTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAAGAAAAGCATTATTACATTGGAATTATTGAAACGACTT
GGGATTATGCCTCTGACCATGGGGAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCAGATAGAA
TTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTTAGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTT
TAGGCCCTATTATCAAAGCTGAAACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCATTCACATG
GAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACAGATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAG
AGCAGTATACATACATGTTGCTTGCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCATTCCCACA
TTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGTAAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATA
TTGACCGAGAATTTGTGGTGATGTTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGCTCAGAAC
CAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTATTCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGAC
TCTCCATGTGTGCTGAAGACAGAGTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCACGGGCAAG
CACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACCCTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAG
AATGGATGCTCAGCTGTCAGAATCTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCTTCATCAA
AGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAAATCATCTGGAACTATGCTCCCTCTGGTATAGACATCT
TCACTAAAGAAAACTTAACAGCACCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTATAAAAAGC
TGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGCCCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCA
TTTGGGCAGAGGTGGGAGACACCATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTGAGATTCA
ATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGAAGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAG
AAACATTCACCTATGAATGGACTGTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTATTCTGCTG
TGGAACCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGCAAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAG
ATGTAGACAAGGAATTCTATTTGTTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTTACAACTG
CACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATGCACTTGATGAATCACCAACACCAGCAGCAGATGGCCC
CCAGTACCCTGAGCCAGCAGAACCACCCCACTCAGAACCCACCCGCAGGGCTCATGAGTATGCCCAATGCGCTGACCACTCAGCAGCAGC
AGCAGCAGAAACTGCGGCTTCAGAGAATCCAGATGGAGAGAGAAAGGATTCGAATGCGCCAAGAGGAGCTCATGAGGCAGGAAGCTGCCC
TCTGTCGACAGCTCCCCATGGAAGCTGAGACTCTTGCCCCAGTTCAGGCTGCTGTCAACCCACCCACGATGACCCCAGACATGAGATCCA
TCACTAATAATAGCTCAGATCCTTTCCTCAATGGAGGGCCATATCATTCGAGGGAGCAGAGCACTGACAGTGGCCTGGGGTTAGGGTGCT
ACAGTGTCCCCACAACTCCGGAGGACTTCCTCAGCAATGTGGATGAGATGGATACAGGAGAAAACGCAGGACAAACACCCATGAACATCA
ATCCCCAACAGACCCGTTTCCCTGATTTCCTTGACTGTCTTCCAGGAACAAACGTTGACTTAGGAACTTTGGAATCTGAAGACCTGATCC
CCCTCTTCAATGATGTAGAGTCTGCTCTGAACAAAAGTGAGCCCTTTCTAACCTGGCTGTAATCACTACCATTGTAACTTGGATGTAGCC
ATGACCTTACATTTCCTGGGCCTCTTGGAAAAAGTGATGGAGCAGAGCAAGTCTGCAGGTGCACCACTTCCCGCCTCCATGACTCGTGCT
CCCTCCTTTTTATGTTGCCAGTTTAATCATTGCCTGGTTTTGATTGAGAGTAACTTAAGTTAAACATAAATAAATATTCTATTTTCATTT
TCTGCAAGCCTGCGTTCTTGTGACAGATTATACAGAATTGTGTCTGCAGGATTGATTATGCAGAATACTTTTCTCTTTCTTCTCTGCTGC
CCCATGGCTAAGCTTTATGGGTGTTAATTGAAATTTATACACCAATTGATTTTAAACCATAAAAAGCTGACCACAGGCAGTTACTTCTGA
GGGCATCTTGGTCCAGGAAATGTGCACAAAATTCGACCTGATTTACAGTTTCAAAAACTGTATTGATGACAGTAGTACCAAATGCTTTAA
AAACTATTTAACTTGAGCTTTAAAAATCATTGTATGGATAGTAAAATTCTACTGTATGGAATACAATGTAATTTTGAATCCATGCTGGCT
CTGATGGCTCTTATTAGTCTGTATTTATAAAGGCACACAGTCCTATTGTAGCTTATCTTTCGTTATTTTACTGCAGAGCATCTAGACAAC
TTAGTCCCTCCAGCGGGAAAGTAGCAGCAGCAGCATTAGTCACAGGTCTTACACTACAGATCTTGTGAAAGAGACCAGTTTGGTACTAAT
TATGAGCATTTTATTCAAACAAAAGTTTTTGAAATATTACAACTGGGGATTTAAAAAATTGCAGCTTAGAATCTGATGGTTTTTTTTTTT
CTTGATGTTGTTTGTTTGTTTTTGAGATCGAGTTTTGCTCTTGTTGTCCAGGCTGGAATGCAATGGCACAATCTCGGCTCACTGCAACCT
CTGCCTTCTGGGTTCAAGCGATTCTCCTGCCTTAGCCTCCCGAGTAGCTGGGATTACAGGCACCTGCCACCACGTCCGGCTAATTTTTTG
TATTTTGAGTAGAGACGGGGTTTCACCATAATGGTCAGGCTGTTCTCAAACTCCTGATCTCAGGTGATCCACCCATCTCGGCCTCCCAAA
GTGCTGGGATTACTGGCGTGAGCCACCGCACCCGGCCTTGATGTTTATTTTATAAAGCACTGTAATTTTGTAGCTGATGACAAAAGGCAG
CCAAATGTTTTTGATAAATCAGTGGCAACTGTATTTTTGTCTTTTGAAATAACTCTGAAAACATCAGGACAACATAGATTTCAACCTGAT
AGCACACCACACACAGTGAGCTGTTGCTTTTTAAATTCTGAAGCCTTGTCAGGTTTGCTTCCTAGATTTCAAGTGTTTAAAATAATTCTA
TCTATGAAACTGAAGGATGAAGCAGATCTCTGACTGACATGTAAAAAAAAATGCCCTTTGAGGGTGTATGGTGGAGATAAATGTTTCTGA
ATTCAGTAAAATTGATTCCTAAGTATATTATCCTAATCCTGTTTGCTACAGTTGGTATAAAAAGGCATGAAATATGTATTCAATACCTCT
TATGTAACCAAAACCATTTTTAATTAGCTTTTAAGGACTGAGAGAGCATCATGTTCAACTGGCATGCAGTCTGCCTGCATTGCCAATGAA
GTCCTCAACTGTTTAATATTTTGAACTAATATTATTTATAATCTATGAATTTAATCTTTTTTGAAAGACTTTAATAATTTGAGTCTCTGA
GAGGATACTTTCAATTTCCATGGGGGACTTATTTGTTGGGGATCTTAAATAAGATTCCTTTTGATCTACCGGAATATACATGTACAGAGT
ACATTGGATCATGTTGGAAAGAAGGCAAGTGAAAAGGTCAGAGATGAAGTAGCAAAGTTATGGAATATCGTGGAAAGGATACTAGTTGTG
AAATGGAAAGAGACAAGTTATAGTACCCCAAAAGCAAAACAAGCAGGAGATGCAAGAGATGCCCCAAAAGGACAAAGCAACAATTTTCTG
TTGCCACCTTTATACCGGAAGACTCTGTTGTAGAAGAAAAGAAGGCTTTGGTGCACCTTATGTGGGAGGAGGAGGGGCAGGGCATGCTGA
TGCTGAGCGTACAGGCAGACAAGAGCGTAGCCTGCTGTTGCCTCCATCACTATGAAATGACTTATTTTACCTGAAGGACCCATGGTTTAT
GTTCCTCTAATTCCTTTCACTCTCCCTAAGCCCTCTGAGAGAGATGAAGATAGATGATTTTATTGCTACTAAATTGAAGGGAGCACTATT
TCTTTTTGTCTTTTGTTAGCAAAAAATTGCAAAAAGAATTGTACATTCTTGCTAAAAATAAATAAATAAATAAAAAATTAAAAAAACAAG
GGACCTAACAAAACTCAGCAGTGTTACTGTATTTTTAAAAAATATTTTTATAGACTCATTTTCAGGTTATTAAATGTAAGAGAAACAGAT
ACCCCTCTTTTTTAAAGTAGGTAAATCATTGATGATTTATATTACCAATTTTTAGAAGTAATTTTCTAGTAAGCTTGTGGCATCAGAAAA
TACTAGAAGATTTTTTTAGTTAAATTAGTTAGAACATTTATGAATGAATATAATAAATATTTTTTCAGAATAAAATATGGACCCTTTGTG
TTTACTAATAGATAAAGCCAGATATAATTTTTTGTTTTTAAGGCCACAAAATATGGCCTTTGTTAAAGAACACTAAAGTTAGAAATCTAA
AGTTAGAGCAACTTTTTAATGGCTATTTCCTATTATTGTAAGTGTTAAAACCCCTGCAGAATTCTTGATAAGGTGCTATTTATACTATAT
TTCTTATTATAAGATAACTGTCTTTAGTCTTCTTAGTACTAGTCTTTTTAGTACTAAATCAATCAGTAAACATCATCATTTCACCCCAAA
ATTTTGTCACAGAAAAGGCGTATCAAATGAAAAATAATTTCAGAGATCTTTCTTTCAAGATATTTTTTCCTGATAAAATACATTGTCTTG
AAGTAAATACATTGTCAAAACCTAATTGCAATTCTGTTAAATCTAAGTAATTTTTAGACAGTGTTTCACCGTATTATTTAGGATGTGAAA
TGCCATTTCTTTCACTGATTACACCATATACAGGAAACAGGTAAAACAGTGAAAACTTTATTGTGCTGGTTGATGCCAACTTGGTTGAAA
AGCTCTCTGCAGAAGAAGTGATCTAGACTGACAGAAGTGTTGCTAATTACAAGTTGTGTTCTCATGACGTAATTAGAAAGTAACTTCTCA
AAGTACAACTTTTATGAAAAAAATAAGCTGTTAAAAAAAGGAAATCGTAGGTTAATTTAATTGGGAAAATGGGCAATTGACAGAGACCAT
TTTCCTAACACATATATGTGCTAGTACTTTAACTTTTTAAAATTTTACTTCTACGTTTTGTAATATAAAAATTTCTATTTTAAGTTTAGA
ATGTTATACGTACCGAAAGTATGCAGCCAAATCGATCAGATCAAACCATTTTACCTGGAGTTTGGTACTGGTTTTTACTTCTCTGAATCT

>19244_19244_2_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000465804_length(amino acids)=849AA_BP=639
MLLILLHFFSGSKKGKKMKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYL
QYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATE
EQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF
QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNH
LKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASF
TNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPK
EVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED
FQESNKMHLMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAET
LAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFL

--------------------------------------------------------------
>19244_19244_3_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000467467_length(transcript)=2957nt_BP=2127nt
AGAGTTATGCACACCCTAATGCCTCCAACAATAACTGTTGACTTTTTATTTTCAGTCAGAGAAGCCTGGCAACCAAGAACTGTTTTTTTG
GTGGTTTACGAGAACTTAACTGAATTGGAAAATATTTGCTTTAATGAAACAATTTACTCTTGTGCAACACTAAATTGTGTCAATCAAGCA
AATAAGGAAGAAAGTCTTATTTATAAAATTGCCTGCTCCTGATTTTACTTCATTTCTTCTCAGGCTCCAAGAAGGGGAAAAAAATGAAGA
TTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAAGAAAAGCATTATTACATTGGAATTATTGAAACGACTT
GGGATTATGCCTCTGACCATGGGGAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCAGATAGAA
TTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTTAGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTT
TAGGCCCTATTATCAAAGCTGAAACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCATTCACATG
GAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACAGATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAG
AGCAGTATACATACATGTTGCTTGCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCATTCCCACA
TTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGTAAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATA
TTGACCGAGAATTTGTGGTGATGTTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGCTCAGAAC
CAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTATTCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGAC
TCTCCATGTGTGCTGAAGACAGAGTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCACGGGCAAG
CACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACCCTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAG
AATGGATGCTCAGCTGTCAGAATCTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCTTCATCAA
AGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAAATCATCTGGAACTATGCTCCCTCTGGTATAGACATCT
TCACTAAAGAAAACTTAACAGCACCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTATAAAAAGC
TGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGCCCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCA
TTTGGGCAGAGGTGGGAGACACCATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTGAGATTCA
ATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGAAGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAG
AAACATTCACCTATGAATGGACTGTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTATTCTGCTG
TGGAACCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGCAAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAG
ATGTAGACAAGGAATTCTATTTGTTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTTACAACTG
CACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATGCACTTGATGAATCACCAACACCAGCAGCAGATGGCCC
CCAGTACCCTGAGCCAGCAGAACCACCCCACTCAGAACCCACCCGCAGGGCTCATGAGTATGCCCAATGCGCTGACCACTCAGCAGCAGC
AGCAGCAGAAACTGCGGCTTCAGAGAATCCAGATGGAGAGAGAAAGGATTCGAATGCGCCAAGAGGAGCTCATGAGGCAGGAAGCTGCCC
TCTGTCGACAGCTCCCCATGGAAGCTGAGACTCTTGCCCCAGTTCAGGCTGCTGTCAACCCACCCACGATGACCCCAGACATGAGATCCA
TCACTAATAATAGCTCAGATCCTTTCCTCAATGGAGGGCCATATCATTCGAGGGAGCAGAGCACTGACAGTGGCCTGGGGTTAGGGTGCT
ACAGTGTCCCCACAACTCCGGAGGACTTCCTCAGCAATGTGGATGAGATGGATACAGGAGAAAACGCAGGACAAACACCCATGAACATCA
ATCCCCAACAGACCCGTTTCCCTGATTTCCTTGACTGTCTTCCAGGAACAAACGTTGACTTAGGAACTTTGGAATCTGAAGACCTGATCC
CCCTCTTCAATGATGTAGAGTCTGCTCTGAACAAAAGTGAGCCCTTTCTAACCTGGCTGTAATCACTACCATTGTAACTTGGATGTAGCC
ATGACCTTACATTTCCTGGGCCTCTTGGAAAAAGTGATGGAGCAGAGCAAGTCTGCAGGTGCACCACTTCCCGCCTCCATGACTCGTGCT

>19244_19244_3_CP-WWTR1_CP_chr3_148905839_ENST00000264613_WWTR1_chr3_149260324_ENST00000467467_length(amino acids)=849AA_BP=639
MLLILLHFFSGSKKGKKMKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYL
QYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATE
EQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF
QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNH
LKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASF
TNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPK
EVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED
FQESNKMHLMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAET
LAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CP-WWTR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CP-WWTR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CP-WWTR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource