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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRAMP1L-PICK1 (FusionGDB2 ID:19268)

Fusion Gene Summary for CRAMP1L-PICK1

check button Fusion gene summary
Fusion gene informationFusion gene name: CRAMP1L-PICK1
Fusion gene ID: 19268
HgeneTgene
Gene symbol

CRAMP1L

PICK1

Gene ID

57585

9463

Gene namecramped chromatin regulator homolog 1protein interacting with PRKCA 1
SynonymsCRAMP1L|HN1L|TCE4PICK|PRKCABP
Cytomap

16p13.3

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionprotein cramped-likeCrm, cramped-likeT-complex expressed gene 4hematological and neurological expressed 1-like proteinPRKCA-binding proteinprotein interacting with C kinase 1protein kinase C-alpha-binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262317, ENST00000293925, 
ENST00000397412, ENST00000436138, 
ENST00000356976, ENST00000468288, 
ENST00000404072, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 5 X 3=60
# samples 65
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRAMP1L [Title/Abstract] AND PICK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRAMP1L(1720810)-PICK1(38470314), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePICK1

GO:0007205

protein kinase C-activating G protein-coupled receptor signaling pathway

10623590

TgenePICK1

GO:0015844

monoamine transport

11343649


check buttonFusion gene breakpoints across CRAMP1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PICK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8534-01ACRAMP1Lchr16

1720810

+PICK1chr22

38470314

+


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Fusion Gene ORF analysis for CRAMP1L-PICK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262317ENST00000356976CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000262317ENST00000468288CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000293925ENST00000356976CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000293925ENST00000468288CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000397412ENST00000356976CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000397412ENST00000468288CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000436138ENST00000356976CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
5CDS-intronENST00000436138ENST00000468288CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
In-frameENST00000262317ENST00000404072CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
In-frameENST00000293925ENST00000404072CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
In-frameENST00000397412ENST00000404072CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+
In-frameENST00000436138ENST00000404072CRAMP1Lchr16

1720810

+PICK1chr22

38470314

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397412CRAMP1Lchr161720810+ENST00000404072PICK1chr2238470314+472737449941571352
ENST00000436138CRAMP1Lchr161720810+ENST00000404072PICK1chr2238470314+46193636040491349
ENST00000293925CRAMP1Lchr161720810+ENST00000404072PICK1chr2238470314+46283645040581352
ENST00000262317CRAMP1Lchr161720810+ENST00000404072PICK1chr2238470314+2753177002183727

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397412ENST00000404072CRAMP1Lchr161720810+PICK1chr2238470314+0.0063500510.99365
ENST00000436138ENST00000404072CRAMP1Lchr161720810+PICK1chr2238470314+0.0058848950.9941151
ENST00000293925ENST00000404072CRAMP1Lchr161720810+PICK1chr2238470314+0.005795510.99420446
ENST00000262317ENST00000404072CRAMP1Lchr161720810+PICK1chr2238470314+0.0315744580.9684256

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Fusion Genomic Features for CRAMP1L-PICK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CRAMP1Lchr161720810+PICK1chr2238470313+0.00670360.99329644
CRAMP1Lchr161720810+PICK1chr2238470313+0.00670360.99329644

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CRAMP1L-PICK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:1720810/chr22:38470314)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000262317+1213161_224590645.0DomainSANT
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000293925+1920161_22412151270.0DomainSANT
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000397412+2021161_22412151270.0DomainSANT
TgenePICK1chr16:1720810chr22:38470314ENST000003569761013382_388278416.0Compositional biasNote=Poly-Glu
TgenePICK1chr16:1720810chr22:38470314ENST000004040721013382_388278416.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000262317+12131069_1246590645.0Compositional biasNote=Ser-rich
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000293925+19201069_124612151270.0Compositional biasNote=Ser-rich
HgeneCRAMP1Lchr16:1720810chr22:38470314ENST00000397412+20211069_124612151270.0Compositional biasNote=Ser-rich
TgenePICK1chr16:1720810chr22:38470314ENST000003569761013144_357278416.0DomainAH
TgenePICK1chr16:1720810chr22:38470314ENST00000356976101322_105278416.0DomainPDZ
TgenePICK1chr16:1720810chr22:38470314ENST000004040721013144_357278416.0DomainAH
TgenePICK1chr16:1720810chr22:38470314ENST00000404072101322_105278416.0DomainPDZ


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Fusion Gene Sequence for CRAMP1L-PICK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19268_19268_1_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000262317_PICK1_chr22_38470314_ENST00000404072_length(transcript)=2753nt_BP=1770nt
ATGCTCCGCACCGATGCAGGAGAAGACTTGGCAGATGCACCTGCGGAGGAGCTCCAGGAGAAGGGGAGCCCCGCGGGGCCTCCGCCGTCT
CAGGGACAGCCTGCCGCCAGGCCCCCGAAGGAGGTCCCCGCCAGCCGGCTGGCTCAGCAGCTCCGTGAGGAGGGCTGGAACCTGCAGACC
TCCGAAAGCCTCACGCTGGCCGAAGTCTACCTCATGATGGGCAAGCCCAGCAAGCTGCAGCTGGAGTACGACTGGCTGGGGCCCGGCCGC
CAGGACCCCCGCCCCGGCTCCCTACCCACCGCCCTCCACAAGCAGCGCCTCCTCAGCTGCCTCCTGAAGCTCATTTCCACCGAGGTCAAC
CCCAAGCTGGCTCTGGAAGCAAACACCATCTCTACAGCCTCAGTAAGGCCCGCCCAGGAGGAGCAGTCGATGACGCCCCCAGGGAAGGTG
GTGACCGTCAGCTCTCGCAGCCCCCGCTGCCCTCGGAACCAGGCCTCCCTCCGCAGCAGCAAGACCTTCCCGCCCAGCTCTGCACCCTGC
TCCTCAGGTTTGAGAAACCCTCCAAGACCCCTCTTGGTGCCTGGTCCCTCCAGCACAGGAAGCAATGACTCAGATGGAGGCCTTTTTGCT
GTCCCGACAACCTTGCCACCCAACAGCCGACACGGGAAGCTCTTCTCTCCCAGTAAAGAAGCAGAGCTGACTTTCCGCCAGCATCTGAAC
TCCATCAGTATGCAGTCGGATTTCTTCCTGCCAAAGCCCCGGAAGCTGCGGAACCGGCACCTGCGGAAGCCACTGGTGGTCCAGAGAACA
CTGCTCCCTAGACCATCGGAAAACCAGTCCCACAACGTTTGTTCCTTCTCCATCCTGTCTAACTCTTCCGTAACTGGGAGAGGTTCGTTC
CGGCCCATCCAGTCTTCTCTGACCAAAGCAGCTCTGTCTCGGCCGATCGTGCCCAAGGTCCTTCCACCCCAGGCCACGAGTCACCTGGCC
AGTGCTATCGACTTAGCAGCTACAAGTGCCGGCATCCTTTCCGGGAACCCCCTCCCTGCCTTGGACACCGAGGGCTTGTCTGGCATCTCT
CCACTGTCTTCAGACGAGGTGACGGGTGCCATCTCGGGGCAGGACTCTACTGGAACTCACCAGGATGGAGACACCCTCCCCACCGTGGGG
GGCTCCGACCCATTTGTCAGCATCCCTTCGAGGCCTGAGCAGGAGCCAGTGGCAGACAGTTTCCAGGGCTCATCTGTTCTCTCCTTATCT
GAGCTGCCCAAGGCCCCTCTCCAGAATGGCCTCTCCATACCGCTGTCCTCGTCAGAGAGCTCCAGCACCCGGCTGTCTCCACCAGACGTC
TCTGCTCTGCTCGACATCTCCCTGCCCGGCCCACCTGAGGATGCGCTGTCACAGGGCGAGCCTGCCACACACATTAGCGACTCCATCATT
GAGATCGCCATCAGCTCCGGTGAAGGAGTCCCTCTTTCTCCAGCAAAACTGAATGGCAGTGACAGTTCCAAGAGCCTTCCCTCCCCGTCC
AGCAGCCCCCAGCCACACTGGATCGCCTCTCCCACCCACGACCCCCAGTGGTACCCCAGTGACTCCACCGACTCCTCGCTCAGCAGCCTG
TTTGCAAGCTTCATCTCCCCAGAGAAGAGCCGGAAGATGTTGCCGACTCCCATTGGGACCAACAGTGGCACTTCCTTGCTTGGCCCCAGC
TTGTTGGATGGAAACTCGCGGGACTCATTTGTGTCCAGGTCCCTGGCTGACGTTGCAGAGGCCCTAGGCGAGCCCCTTTACCGGGTGAGC
ACCGGCAACTATGAGTACCGCCTGATCCTGCGCTGCCGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGATGTGCTGGAGAAG
ATGGAGCTGCTGGACCAGAAGCACGTCCAGGACATCGTGTTCCAGCTGCAGCGCCTCGTGTCCACCATGTCCAAGTACTACAACGACTGC
TACGCAGTGCTGCGGGATGCCGACGTCTTCCCCATCGAGGTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAGGAGGAGTTC
ACAGATGGGGAGGAGGAGGAGGAGGAGGAAGACACGGCAGCTGGGGAGCCGTCCAGGGATACACGAGGGGCTGCTGGGCCCTTGGACAAG
GGTGGAAGCTGGTGTGACTCCTGAGTGCCCCGCGGCTGTGGTGCCGGGGGCAGGGTGCGTGGGAGGACGGAGCCTGGGAGCGGGGCGGGG
CCGCCGCGCAAGGGGGCGACGCATAAAGGCCTGCTGGCTTGGGGCGCCTGCCTCCCTGCTCCTCTGTCCTCGCACAGCGAACCTGGGCTC
CTGCCCAGGACAGGCACCAGGGTCATGGCCTGGGACCTGGACACTGGCCCCTCCACCCTCCCTCCCCTCCCGGCTCCCCGGCCAGAGGGA
GAGCTTGGTCTCTGGACCTGCCTTAGGAAGGAGAGGGAGGGCAGGAAGGAAAAGAAAGGACTTGGAGGTGGCAGGAGTCCGAGCCCTGCT
CCTTGTGGGCGCTCACACTGCCCCCGGAGCCTGCTGGGAGTGGGGCCAGCCGTGGACAGCTGAGGTTGGGGTCAATGCCTCCTGGGCACC
CTTGCCTCGCCCCAGACCGGCCCGTCCAGTCCCCATCACACCTCGGCGGCCTTTATTTATTCTGTTCCCCCAGCTCGGCCACTTCTCTGA

>19268_19268_1_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000262317_PICK1_chr22_38470314_ENST00000404072_length(amino acids)=727AA_BP=590
MLRTDAGEDLADAPAEELQEKGSPAGPPPSQGQPAARPPKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGR
QDPRPGSLPTALHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSPRCPRNQASLRSSKTFPPSSAPC
SSGLRNPPRPLLVPGPSSTGSNDSDGGLFAVPTTLPPNSRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRT
LLPRPSENQSHNVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAATSAGILSGNPLPALDTEGLSGIS
PLSSDEVTGAISGQDSTGTHQDGDTLPTVGGSDPFVSIPSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDV
SALLDISLPGPPEDALSQGEPATHISDSIIEIAISSGEGVPLSPAKLNGSDSSKSLPSPSSSPQPHWIASPTHDPQWYPSDSTDSSLSSL
FASFISPEKSRKMLPTPIGTNSGTSLLGPSLLDGNSRDSFVSRSLADVAEALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEK
MELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDK

--------------------------------------------------------------
>19268_19268_2_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000293925_PICK1_chr22_38470314_ENST00000404072_length(transcript)=4628nt_BP=3645nt
ATGACAGTGAAGTTGGGCGACGGCGGCAGCGGGGAGGACGGGCTCAAGAAGCTGGGCAAGCGGGCGGCCGATGAGGAGTCCCTGGAAGGA
GAAGGGGCCGGCGGCGCAGACGCGGCCGAGGAGAGCAGCGGCACAAAGAGGGACGAGAAGACCCCCCGGGCCGGCGCCGACGGCCCCCCC
GCGCCCCCCGGCGCGCCGCAGGCGCCGTCCCCGCCGCAGGGCAGCCCCCAGGACCAGCACCACTTCCTCCGGTCCAGCGTGCGGCCGCAG
AGCAAGAGGCCCAGGAAGGATCCTCCGAGCGCTGTGGGGAGCGGCAACGCCGGTGGCTCGGGGCCCCGCGGAAAAGGAGCTGAAGGTGGT
GGATCATCGTCTGGAAATGTGTCTGGGGTTGCCCCTGCTGCCCCTGCAGGGGGCTCGCGCTCCTCCTCCCGGAACTTAGGGTCTTCTGGT
GGCGAGAAGGAAGAAGGCAAAAAGGTCCGGCGGCAGTGGGAGTCGTGGAGCACAGAGGACAAGAACACCTTCTTCGAGGGGCTGTACGAG
CATGGGAAAGACTTTGAAGCGATTCAGAACAACATTGCGCTGAAGTACAAGAAGAAAGGCAAGCCAGCAAGCATGGTGAAGAACAAGGAG
CAGGTCCGCCACTTCTACTACCGCACCTGGCACAAGATCACCAAGTACATCGACTTTGATCATGTGTTCTCTCGAGGCCTGAAGAAGTCA
TCCCAGGAACTGTATGGCCTGATCTGCTATGGCGAGCTGCGCAAGAAGATTGGGGGCTGTATGGATGACAAGAATGCAACAAAGCTGAAT
GAACTCATTCAGGTTGGGGCCACCACTGTACGTTACAAAGGGCGGAACCTGCGGATCAAAGCGCCCATGTGCCGGGCCCTGAAGAAGCTG
TGCGATCCAGATGGCTTGAGTGATGAAGAGGACCAGAAGCCAGTGCGCCTGCCTCTGAAAGTCCCTATAGAGCTACAGCCGCGGAACAAC
CACGCCTGGGCCCGTGTGCAGAGCCTTGCCCAGAACCCACGCCTCAGGATGATCGTGGAGCTACATCGAAAGGTCTCCAGCCTCATCGAA
TTCTTGAAGCAGAAGTGGGCGCTCCATGAGGTGCGAGTTCGGAAGACACTCGAGGAGCGGCAGCTGCAGGACTCATGCTCCGCACCGATG
CAGGAGAAGGTGACACTGCACTTGTTCCCAGGCGAGAACTGTACACTGACACCGCTGCCGGGCGTGGCTCGCGTGGTGCACTCCAAGGCC
TTCTGCACAGTGCACTGGCAGGAGGGCGGCCGGTGCAAGCAGAGTGCCAAGGACGCCCACGTGCTGCCCCCAGCCCAGATCCTGGGCATC
CAGAGTGGGCAGGGCACGGCCCGGGGCCAGGTGAAATGCCCGCGGAGCGGAGCTGAGGGCAAGGGTGTGGGGCGGCCCCCTCCTGCGGCT
GACGCCTTGCAGAGCTCCGGAGAGAGTTCCCCCGAAAGCGCCCCCGGGGAGGGGGCTGCCCTAAGCTTGAGCAGCCCGGACGCTCCTGAC
AGGCCTCCTCCCAGGCACCAGGACACTGGGCCATGTCTTGAGAAGACCCCTGCAGAAGGCAGGGACAGTCCCACCCGGGAGCCAGGGGCC
TTGCCGTGTGCCTGTGGCCAGCTCCCAGACCTGGAGGACGAGCTCTCGCTTCTAGACCCCTTGCCCCGCTACCTAAAGTCCTGTCAGGAC
CTCATTGTCCCCGAGCAGTGCCGCTGTGCGGACACACGGCCTGGGAGCGAGCAGCCCCCTCTGGGCGGGGCGGCCTCCCCAGAGGTGCTG
GCTCCTGTCAGCAAGGAGGCTGCTGACCTTGCTCCCACTGGCCCATCCCCGAGGCCCGGCCCCGGGCTCCTGCTGGATGTTTGCACTAAA
GACTTGGCAGATGCACCTGCGGAGGAGCTCCAGGAGAAGGGGAGCCCCGCGGGGCCTCCGCCGTCTCAGGGACAGCCTGCCGCCAGGCCC
CCGAAGGAGGTCCCCGCCAGCCGGCTGGCTCAGCAGCTCCGTGAGGAGGGCTGGAACCTGCAGACCTCCGAAAGCCTCACGCTGGCCGAA
GTCTACCTCATGATGGGCAAGCCCAGCAAGCTGCAGCTGGAGTACGACTGGCTGGGGCCCGGCCGCCAGGACCCCCGCCCCGGCTCCCTA
CCCACCGCCCTCCACAAGCAGCGCCTCCTCAGCTGCCTCCTGAAGCTCATTTCCACCGAGGTCAACCCCAAGCTGGCTCTGGAAGCAAAC
ACCATCTCTACAGCCTCAGTAAGGCCCGCCCAGGAGGAGCAGTCGATGACGCCCCCAGGGAAGGTGGTGACCGTCAGCTCTCGCAGCCCC
CGCTGCCCTCGGAACCAGGCCTCCCTCCGCAGCAGCAAGACCTTCCCGCCCAGCTCTGCACCCTGCTCCTCAGGTTTGAGAAACCCTCCA
AGACCCCTCTTGGTGCCTGGTCCCTCCAGCACAGGAAGCAATGACTCAGATGGAGGCCTTTTTGCTGTCCCGACAACCTTGCCACCCAAC
AGCCGACACGGGAAGCTCTTCTCTCCCAGTAAAGAAGCAGAGCTGACTTTCCGCCAGCATCTGAACTCCATCAGTATGCAGTCGGATTTC
TTCCTGCCAAAGCCCCGGAAGCTGCGGAACCGGCACCTGCGGAAGCCACTGGTGGTCCAGAGAACACTGCTCCCTAGACCATCGGAAAAC
CAGTCCCACAACGTTTGTTCCTTCTCCATCCTGTCTAACTCTTCCGTAACTGGGAGAGGTTCGTTCCGGCCCATCCAGTCTTCTCTGACC
AAAGCAGCTCTGTCTCGGCCGATCGTGCCCAAGGTCCTTCCACCCCAGGCCACGAGTCACCTGGCCAGTGCTATCGACTTAGCAGCTACA
AGTGCCGGCATCCTTTCCGGGAACCCCCTCCCTGCCTTGGACACCGAGGGCTTGTCTGGCATCTCTCCACTGTCTTCAGACGAGGTGACG
GGTGCCATCTCGGGGCAGGACTCTACTGGAACTCACCAGGATGGAGACACCCTCCCCACCGTGGGGGGCTCCGACCCATTTGTCAGCATC
CCTTCGAGGCCTGAGCAGGAGCCAGTGGCAGACAGTTTCCAGGGCTCATCTGTTCTCTCCTTATCTGAGCTGCCCAAGGCCCCTCTCCAG
AATGGCCTCTCCATACCGCTGTCCTCGTCAGAGAGCTCCAGCACCCGGCTGTCTCCACCAGACGTCTCTGCTCTGCTCGACATCTCCCTG
CCCGGCCCACCTGAGGATGCGCTGTCACAGGGCGAGCCTGCCACACACATTAGCGACTCCATCATTGAGATCGCCATCAGCTCCGGTCAG
TACGGTGAAGGAGTCCCTCTTTCTCCAGCAAAACTGAATGGCAGTGACAGTTCCAAGAGCCTTCCCTCCCCGTCCAGCAGCCCCCAGCCA
CACTGGATCGCCTCTCCCACCCACGACCCCCAGTGGTACCCCAGTGACTCCACCGACTCCTCGCTCAGCAGCCTGTTTGCAAGCTTCATC
TCCCCAGAGAAGAGCCGGAAGATGTTGCCGACTCCCATTGGGACCAACAGTGGCACTTCCTTGCTTGGCCCCAGCTTGTTGGATGGAAAC
TCGCGGGACTCATTTGTGTCCAGGTCCCTGGCTGACGTTGCAGAGGCCCTAGGCGAGCCCCTTTACCGGGTGAGCACCGGCAACTATGAG
TACCGCCTGATCCTGCGCTGCCGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGATGTGCTGGAGAAGATGGAGCTGCTGGAC
CAGAAGCACGTCCAGGACATCGTGTTCCAGCTGCAGCGCCTCGTGTCCACCATGTCCAAGTACTACAACGACTGCTACGCAGTGCTGCGG
GATGCCGACGTCTTCCCCATCGAGGTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAGGAGGAGTTCACAGATGGGGAGGAG
GAGGAGGAGGAGGAAGACACGGCAGCTGGGGAGCCGTCCAGGGATACACGAGGGGCTGCTGGGCCCTTGGACAAGGGTGGAAGCTGGTGT
GACTCCTGAGTGCCCCGCGGCTGTGGTGCCGGGGGCAGGGTGCGTGGGAGGACGGAGCCTGGGAGCGGGGCGGGGCCGCCGCGCAAGGGG
GCGACGCATAAAGGCCTGCTGGCTTGGGGCGCCTGCCTCCCTGCTCCTCTGTCCTCGCACAGCGAACCTGGGCTCCTGCCCAGGACAGGC
ACCAGGGTCATGGCCTGGGACCTGGACACTGGCCCCTCCACCCTCCCTCCCCTCCCGGCTCCCCGGCCAGAGGGAGAGCTTGGTCTCTGG
ACCTGCCTTAGGAAGGAGAGGGAGGGCAGGAAGGAAAAGAAAGGACTTGGAGGTGGCAGGAGTCCGAGCCCTGCTCCTTGTGGGCGCTCA
CACTGCCCCCGGAGCCTGCTGGGAGTGGGGCCAGCCGTGGACAGCTGAGGTTGGGGTCAATGCCTCCTGGGCACCCTTGCCTCGCCCCAG
ACCGGCCCGTCCAGTCCCCATCACACCTCGGCGGCCTTTATTTATTCTGTTCCCCCAGCTCGGCCACTTCTCTGAAGGAGGGCTGGGTTC

>19268_19268_2_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000293925_PICK1_chr22_38470314_ENST00000404072_length(amino acids)=1352AA_BP=1215
MTVKLGDGGSGEDGLKKLGKRAADEESLEGEGAGGADAAEESSGTKRDEKTPRAGADGPPAPPGAPQAPSPPQGSPQDQHHFLRSSVRPQ
SKRPRKDPPSAVGSGNAGGSGPRGKGAEGGGSSSGNVSGVAPAAPAGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFEGLYE
HGKDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITKYIDFDHVFSRGLKKSSQELYGLICYGELRKKIGGCMDDKNATKLN
ELIQVGATTVRYKGRNLRIKAPMCRALKKLCDPDGLSDEEDQKPVRLPLKVPIELQPRNNHAWARVQSLAQNPRLRMIVELHRKVSSLIE
FLKQKWALHEVRVRKTLEERQLQDSCSAPMQEKVTLHLFPGENCTLTPLPGVARVVHSKAFCTVHWQEGGRCKQSAKDAHVLPPAQILGI
QSGQGTARGQVKCPRSGAEGKGVGRPPPAADALQSSGESSPESAPGEGAALSLSSPDAPDRPPPRHQDTGPCLEKTPAEGRDSPTREPGA
LPCACGQLPDLEDELSLLDPLPRYLKSCQDLIVPEQCRCADTRPGSEQPPLGGAASPEVLAPVSKEAADLAPTGPSPRPGPGLLLDVCTK
DLADAPAEELQEKGSPAGPPPSQGQPAARPPKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGRQDPRPGSL
PTALHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSPRCPRNQASLRSSKTFPPSSAPCSSGLRNPP
RPLLVPGPSSTGSNDSDGGLFAVPTTLPPNSRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRTLLPRPSEN
QSHNVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAATSAGILSGNPLPALDTEGLSGISPLSSDEVT
GAISGQDSTGTHQDGDTLPTVGGSDPFVSIPSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDVSALLDISL
PGPPEDALSQGEPATHISDSIIEIAISSGQYGEGVPLSPAKLNGSDSSKSLPSPSSSPQPHWIASPTHDPQWYPSDSTDSSLSSLFASFI
SPEKSRKMLPTPIGTNSGTSLLGPSLLDGNSRDSFVSRSLADVAEALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLD
QKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWC

--------------------------------------------------------------
>19268_19268_3_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000397412_PICK1_chr22_38470314_ENST00000404072_length(transcript)=4727nt_BP=3744nt
CGCGCACCCCGGCCCCGCCCCCGCGCGCCGTCCGTGAGGTCCCCACCGGCCGCCGTAGCCGGAACTGCTGCTGAGGGCGGCGGGCCGGCT
TCGCTAGGGATGACAGTGAAGTTGGGCGACGGCGGCAGCGGGGAGGACGGGCTCAAGAAGCTGGGCAAGCGGGCGGCCGATGAGGAGTCC
CTGGAAGGAGAAGGGGCCGGCGGCGCAGACGCGGCCGAGGAGAGCAGCGGCACAAAGAGGGACGAGAAGACCCCCCGGGCCGGCGCCGAC
GGCCCCCCCGCGCCCCCCGGCGCGCCGCAGGCGCCGTCCCCGCCGCAGGGCAGCCCCCAGGACCAGCACCACTTCCTCCGGTCCAGCGTG
CGGCCGCAGAGCAAGAGGCCCAGGAAGGATCCTCCGAGCGCTGTGGGGAGCGGCAACGCCGGTGGCTCGGGGCCCCGCGGAAAAGGAGCT
GAAGGTGGTGGATCATCGTCTGGAAATGTGTCTGGGGTTGCCCCTGCTGCCCCTGCAGGGGGCTCGCGCTCCTCCTCCCGGAACTTAGGG
TCTTCTGGTGGCGAGAAGGAAGAAGGCAAAAAGGTCCGGCGGCAGTGGGAGTCGTGGAGCACAGAGGACAAGAACACCTTCTTCGAGGGG
CTGTACGAGCATGGGAAAGACTTTGAAGCGATTCAGAACAACATTGCGCTGAAGTACAAGAAGAAAGGCAAGCCAGCAAGCATGGTGAAG
AACAAGGAGCAGGTCCGCCACTTCTACTACCGCACCTGGCACAAGATCACCAAGTACATCGACTTTGATCATGTGTTCTCTCGAGGCCTG
AAGAAGTCATCCCAGGAACTGTATGGCCTGATCTGCTATGGCGAGCTGCGCAAGAAGATTGGGGGCTGTATGGATGACAAGAATGCAACA
AAGCTGAATGAACTCATTCAGGTTGGGGCCACCACTGTACGTTACAAAGGGCGGAACCTGCGGATCAAAGCGCCCATGTGCCGGGCCCTG
AAGAAGCTGTGCGATCCAGATGGCTTGAGTGATGAAGAGGACCAGAAGCCAGTGCGCCTGCCTCTGAAAGTCCCTATAGAGCTACAGCCG
CGGAACAACCACGCCTGGGCCCGTGTGCAGAGCCTTGCCCAGAACCCACGCCTCAGGATGATCGTGGAGCTACATCGAAAGGTCTCCAGC
CTCATCGAATTCTTGAAGCAGAAGTGGGCGCTCCATGAGGTGCGAGTTCGGAAGACACTCGAGGAGCGGCAGCTGCAGGACTCATGCTCC
GCACCGATGCAGGAGAAGGTGACACTGCACTTGTTCCCAGGCGAGAACTGTACACTGACACCGCTGCCGGGCGTGGCTCGCGTGGTGCAC
TCCAAGGCCTTCTGCACAGTGCACTGGCAGGAGGGCGGCCGGTGCAAGCAGAGTGCCAAGGACGCCCACGTGCTGCCCCCAGCCCAGATC
CTGGGCATCCAGAGTGGGCAGGGCACGGCCCGGGGCCAGGTGAAATGCCCGCGGAGCGGAGCTGAGGGCAAGGGTGTGGGGCGGCCCCCT
CCTGCGGCTGACGCCTTGCAGAGCTCCGGAGAGAGTTCCCCCGAAAGCGCCCCCGGGGAGGGGGCTGCCCTAAGCTTGAGCAGCCCGGAC
GCTCCTGACAGGCCTCCTCCCAGGCACCAGGACACTGGGCCATGTCTTGAGAAGACCCCTGCAGAAGGCAGGGACAGTCCCACCCGGGAG
CCAGGGGCCTTGCCGTGTGCCTGTGGCCAGCTCCCAGACCTGGAGGACGAGCTCTCGCTTCTAGACCCCTTGCCCCGCTACCTAAAGTCC
TGTCAGGACCTCATTGTCCCCGAGCAGTGCCGCTGTGCGGACACACGGCCTGGGAGCGAGCAGCCCCCTCTGGGCGGGGCGGCCTCCCCA
GAGGTGCTGGCTCCTGTCAGCAAGGAGGCTGCTGACCTTGCTCCCACTGGCCCATCCCCGAGGCCCGGCCCCGGGCTCCTGCTGGATGTT
TGCACTAAAGACTTGGCAGATGCACCTGCGGAGGAGCTCCAGGAGAAGGGGAGCCCCGCGGGGCCTCCGCCGTCTCAGGGACAGCCTGCC
GCCAGGCCCCCGAAGGAGGTCCCCGCCAGCCGGCTGGCTCAGCAGCTCCGTGAGGAGGGCTGGAACCTGCAGACCTCCGAAAGCCTCACG
CTGGCCGAAGTCTACCTCATGATGGGCAAGCCCAGCAAGCTGCAGCTGGAGTACGACTGGCTGGGGCCCGGCCGCCAGGACCCCCGCCCC
GGCTCCCTACCCACCGCCCTCCACAAGCAGCGCCTCCTCAGCTGCCTCCTGAAGCTCATTTCCACCGAGGTCAACCCCAAGCTGGCTCTG
GAAGCAAACACCATCTCTACAGCCTCAGTAAGGCCCGCCCAGGAGGAGCAGTCGATGACGCCCCCAGGGAAGGTGGTGACCGTCAGCTCT
CGCAGCCCCCGCTGCCCTCGGAACCAGGCCTCCCTCCGCAGCAGCAAGACCTTCCCGCCCAGCTCTGCACCCTGCTCCTCAGGTTTGAGA
AACCCTCCAAGACCCCTCTTGGTGCCTGGTCCCTCCAGCACAGGAAGCAATGACTCAGATGGAGGCCTTTTTGCTGTCCCGACAACCTTG
CCACCCAACAGCCGACACGGGAAGCTCTTCTCTCCCAGTAAAGAAGCAGAGCTGACTTTCCGCCAGCATCTGAACTCCATCAGTATGCAG
TCGGATTTCTTCCTGCCAAAGCCCCGGAAGCTGCGGAACCGGCACCTGCGGAAGCCACTGGTGGTCCAGAGAACACTGCTCCCTAGACCA
TCGGAAAACCAGTCCCACAACGTTTGTTCCTTCTCCATCCTGTCTAACTCTTCCGTAACTGGGAGAGGTTCGTTCCGGCCCATCCAGTCT
TCTCTGACCAAAGCAGCTCTGTCTCGGCCGATCGTGCCCAAGGTCCTTCCACCCCAGGCCACGAGTCACCTGGCCAGTGCTATCGACTTA
GCAGCTACAAGTGCCGGCATCCTTTCCGGGAACCCCCTCCCTGCCTTGGACACCGAGGGCTTGTCTGGCATCTCTCCACTGTCTTCAGAC
GAGGTGACGGGTGCCATCTCGGGGCAGGACTCTACTGGAACTCACCAGGATGGAGACACCCTCCCCACCGTGGGGGGCTCCGACCCATTT
GTCAGCATCCCTTCGAGGCCTGAGCAGGAGCCAGTGGCAGACAGTTTCCAGGGCTCATCTGTTCTCTCCTTATCTGAGCTGCCCAAGGCC
CCTCTCCAGAATGGCCTCTCCATACCGCTGTCCTCGTCAGAGAGCTCCAGCACCCGGCTGTCTCCACCAGACGTCTCTGCTCTGCTCGAC
ATCTCCCTGCCCGGCCCACCTGAGGATGCGCTGTCACAGGGCGAGCCTGCCACACACATTAGCGACTCCATCATTGAGATCGCCATCAGC
TCCGGTCAGTACGGTGAAGGAGTCCCTCTTTCTCCAGCAAAACTGAATGGCAGTGACAGTTCCAAGAGCCTTCCCTCCCCGTCCAGCAGC
CCCCAGCCACACTGGATCGCCTCTCCCACCCACGACCCCCAGTGGTACCCCAGTGACTCCACCGACTCCTCGCTCAGCAGCCTGTTTGCA
AGCTTCATCTCCCCAGAGAAGAGCCGGAAGATGTTGCCGACTCCCATTGGGACCAACAGTGGCACTTCCTTGCTTGGCCCCAGCTTGTTG
GATGGAAACTCGCGGGACTCATTTGTGTCCAGGTCCCTGGCTGACGTTGCAGAGGCCCTAGGCGAGCCCCTTTACCGGGTGAGCACCGGC
AACTATGAGTACCGCCTGATCCTGCGCTGCCGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGATGTGCTGGAGAAGATGGAG
CTGCTGGACCAGAAGCACGTCCAGGACATCGTGTTCCAGCTGCAGCGCCTCGTGTCCACCATGTCCAAGTACTACAACGACTGCTACGCA
GTGCTGCGGGATGCCGACGTCTTCCCCATCGAGGTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAGGAGGAGTTCACAGAT
GGGGAGGAGGAGGAGGAGGAGGAAGACACGGCAGCTGGGGAGCCGTCCAGGGATACACGAGGGGCTGCTGGGCCCTTGGACAAGGGTGGA
AGCTGGTGTGACTCCTGAGTGCCCCGCGGCTGTGGTGCCGGGGGCAGGGTGCGTGGGAGGACGGAGCCTGGGAGCGGGGCGGGGCCGCCG
CGCAAGGGGGCGACGCATAAAGGCCTGCTGGCTTGGGGCGCCTGCCTCCCTGCTCCTCTGTCCTCGCACAGCGAACCTGGGCTCCTGCCC
AGGACAGGCACCAGGGTCATGGCCTGGGACCTGGACACTGGCCCCTCCACCCTCCCTCCCCTCCCGGCTCCCCGGCCAGAGGGAGAGCTT
GGTCTCTGGACCTGCCTTAGGAAGGAGAGGGAGGGCAGGAAGGAAAAGAAAGGACTTGGAGGTGGCAGGAGTCCGAGCCCTGCTCCTTGT
GGGCGCTCACACTGCCCCCGGAGCCTGCTGGGAGTGGGGCCAGCCGTGGACAGCTGAGGTTGGGGTCAATGCCTCCTGGGCACCCTTGCC
TCGCCCCAGACCGGCCCGTCCAGTCCCCATCACACCTCGGCGGCCTTTATTTATTCTGTTCCCCCAGCTCGGCCACTTCTCTGAAGGAGG

>19268_19268_3_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000397412_PICK1_chr22_38470314_ENST00000404072_length(amino acids)=1352AA_BP=1215
MTVKLGDGGSGEDGLKKLGKRAADEESLEGEGAGGADAAEESSGTKRDEKTPRAGADGPPAPPGAPQAPSPPQGSPQDQHHFLRSSVRPQ
SKRPRKDPPSAVGSGNAGGSGPRGKGAEGGGSSSGNVSGVAPAAPAGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFEGLYE
HGKDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITKYIDFDHVFSRGLKKSSQELYGLICYGELRKKIGGCMDDKNATKLN
ELIQVGATTVRYKGRNLRIKAPMCRALKKLCDPDGLSDEEDQKPVRLPLKVPIELQPRNNHAWARVQSLAQNPRLRMIVELHRKVSSLIE
FLKQKWALHEVRVRKTLEERQLQDSCSAPMQEKVTLHLFPGENCTLTPLPGVARVVHSKAFCTVHWQEGGRCKQSAKDAHVLPPAQILGI
QSGQGTARGQVKCPRSGAEGKGVGRPPPAADALQSSGESSPESAPGEGAALSLSSPDAPDRPPPRHQDTGPCLEKTPAEGRDSPTREPGA
LPCACGQLPDLEDELSLLDPLPRYLKSCQDLIVPEQCRCADTRPGSEQPPLGGAASPEVLAPVSKEAADLAPTGPSPRPGPGLLLDVCTK
DLADAPAEELQEKGSPAGPPPSQGQPAARPPKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGRQDPRPGSL
PTALHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSPRCPRNQASLRSSKTFPPSSAPCSSGLRNPP
RPLLVPGPSSTGSNDSDGGLFAVPTTLPPNSRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRTLLPRPSEN
QSHNVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAATSAGILSGNPLPALDTEGLSGISPLSSDEVT
GAISGQDSTGTHQDGDTLPTVGGSDPFVSIPSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDVSALLDISL
PGPPEDALSQGEPATHISDSIIEIAISSGQYGEGVPLSPAKLNGSDSSKSLPSPSSSPQPHWIASPTHDPQWYPSDSTDSSLSSLFASFI
SPEKSRKMLPTPIGTNSGTSLLGPSLLDGNSRDSFVSRSLADVAEALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLD
QKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWC

--------------------------------------------------------------
>19268_19268_4_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000436138_PICK1_chr22_38470314_ENST00000404072_length(transcript)=4619nt_BP=3636nt
ATGACAGTGAAGTTGGGCGACGGCGGCAGCGGGGAGGACGGGCTCAAGAAGCTGGGCAAGCGGGCGGCCGATGAGGAGTCCCTGGAAGGA
GAAGGGGCCGGCGGCGCAGACGCGGCCGAGGAGAGCAGCGGCACAAAGAGGGACGAGAAGACCCCCCGGGCCGGCGCCGACGGCCCCCCC
GCGCCCCCCGGCGCGCCGCAGGCGCCGTCCCCGCCGCAGGGCAGCCCCCAGGACCAGCACCACTTCCTCCGGTCCAGCGTGCGGCCGCAG
AGCAAGAGGCCCAGGAAGGATCCTCCGAGCGCTGTGGGGAGCGGCAACGCCGGTGGCTCGGGGCCCCGCGGAAAAGACAGACATCTTCCA
AAGGCCCAGCTCTGGCTGTCTATTAGCCGCGTGCCTTTCGGGGGCTCGCGCTCCTCCTCCCGGAACTTAGGGTCTTCTGGTGGCGAGAAG
GAAGAAGGCAAAAAGGTCCGGCGGCAGTGGGAGTCGTGGAGCACAGAGGACAAGAACACCTTCTTCGAGGGGCTGTACGAGCATGGGAAA
GACTTTGAAGCGATTCAGAACAACATTGCGCTGAAGTACAAGAAGAAAGGCAAGCCAGCAAGCATGGTGAAGAACAAGGAGCAGGTCCGC
CACTTCTACTACCGCACCTGGCACAAGATCACCAAGTACATCGACTTTGATCATGTGTTCTCTCGAGGCCTGAAGAAGTCATCCCAGGAA
CTGTATGGCCTGATCTGCTATGGCGAGCTGCGCAAGAAGATTGGGGGCTGTATGGATGACAAGAATGCAACAAAGCTGAATGAACTCATT
CAGGTTGGGGCCACCACTGTACGTTACAAAGGGCGGAACCTGCGGATCAAAGCGCCCATGTGCCGGGCCCTGAAGAAGCTGTGCGATCCA
GATGGCTTGAGTGATGAAGAGGACCAGAAGCCAGTGCGCCTGCCTCTGAAAGTCCCTATAGAGCTACAGCCGCGGAACAACCACGCCTGG
GCCCGTGTGCAGAGCCTTGCCCAGAACCCACGCCTCAGGATGATCGTGGAGCTACATCGAAAGGTCTCCAGCCTCATCGAATTCTTGAAG
CAGAAGTGGGCGCTCCATGAGGTGCGAGTTCGGAAGACACTCGAGGAGCGGCAGCTGCAGGACTCATGCTCCGCACCGATGCAGGAGAAG
GTGACACTGCACTTGTTCCCAGGCGAGAACTGTACACTGACACCGCTGCCGGGCGTGGCTCGCGTGGTGCACTCCAAGGCCTTCTGCACA
GTGCACTGGCAGGAGGGCGGCCGGTGCAAGCAGAGTGCCAAGGACGCCCACGTGCTGCCCCCAGCCCAGATCCTGGGCATCCAGAGTGGG
CAGGGCACGGCCCGGGGCCAGGTGAAATGCCCGCGGAGCGGAGCTGAGGGCAAGGGTGTGGGGCGGCCCCCTCCTGCGGCTGACGCCTTG
CAGAGCTCCGGAGAGAGTTCCCCCGAAAGCGCCCCCGGGGAGGGGGCTGCCCTAAGCTTGAGCAGCCCGGACGCTCCTGACAGGCCTCCT
CCCAGGCACCAGGACACTGGGCCATGTCTTGAGAAGACCCCTGCAGAAGGCAGGGACAGTCCCACCCGGGAGCCAGGGGCCTTGCCGTGT
GCCTGTGGCCAGCTCCCAGACCTGGAGGACGAGCTCTCGCTTCTAGACCCCTTGCCCCGCTACCTAAAGTCCTGTCAGGACCTCATTGTC
CCCGAGCAGTGCCGCTGTGCGGACACACGGCCTGGGAGCGAGCAGCCCCCTCTGGGCGGGGCGGCCTCCCCAGAGGTGCTGGCTCCTGTC
AGCAAGGAGGCTGCTGACCTTGCTCCCACTGGCCCATCCCCGAGGCCCGGCCCCGGGCTCCTGCTGGATGTTTGCACTAAAGACTTGGCA
GATGCACCTGCGGAGGAGCTCCAGGAGAAGGGGAGCCCCGCGGGGCCTCCGCCGTCTCAGGGACAGCCTGCCGCCAGGCCCCCGAAGGAG
GTCCCCGCCAGCCGGCTGGCTCAGCAGCTCCGTGAGGAGGGCTGGAACCTGCAGACCTCCGAAAGCCTCACGCTGGCCGAAGTCTACCTC
ATGATGGGCAAGCCCAGCAAGCTGCAGCTGGAGTACGACTGGCTGGGGCCCGGCCGCCAGGACCCCCGCCCCGGCTCCCTACCCACCGCC
CTCCACAAGCAGCGCCTCCTCAGCTGCCTCCTGAAGCTCATTTCCACCGAGGTCAACCCCAAGCTGGCTCTGGAAGCAAACACCATCTCT
ACAGCCTCAGTAAGGCCCGCCCAGGAGGAGCAGTCGATGACGCCCCCAGGGAAGGTGGTGACCGTCAGCTCTCGCAGCCCCCGCTGCCCT
CGGAACCAGGCCTCCCTCCGCAGCAGCAAGACCTTCCCGCCCAGCTCTGCACCCTGCTCCTCAGGTTTGAGAAACCCTCCAAGACCCCTC
TTGGTGCCTGGTCCCTCCAGCACAGGAAGCAATGACTCAGATGGAGGCCTTTTTGCTGTCCCGACAACCTTGCCACCCAACAGCCGACAC
GGGAAGCTCTTCTCTCCCAGTAAAGAAGCAGAGCTGACTTTCCGCCAGCATCTGAACTCCATCAGTATGCAGTCGGATTTCTTCCTGCCA
AAGCCCCGGAAGCTGCGGAACCGGCACCTGCGGAAGCCACTGGTGGTCCAGAGAACACTGCTCCCTAGACCATCGGAAAACCAGTCCCAC
AACGTTTGTTCCTTCTCCATCCTGTCTAACTCTTCCGTAACTGGGAGAGGTTCGTTCCGGCCCATCCAGTCTTCTCTGACCAAAGCAGCT
CTGTCTCGGCCGATCGTGCCCAAGGTCCTTCCACCCCAGGCCACGAGTCACCTGGCCAGTGCTATCGACTTAGCAGCTACAAGTGCCGGC
ATCCTTTCCGGGAACCCCCTCCCTGCCTTGGACACCGAGGGCTTGTCTGGCATCTCTCCACTGTCTTCAGACGAGGTGACGGGTGCCATC
TCGGGGCAGGACTCTACTGGAACTCACCAGGATGGAGACACCCTCCCCACCGTGGGGGGCTCCGACCCATTTGTCAGCATCCCTTCGAGG
CCTGAGCAGGAGCCAGTGGCAGACAGTTTCCAGGGCTCATCTGTTCTCTCCTTATCTGAGCTGCCCAAGGCCCCTCTCCAGAATGGCCTC
TCCATACCGCTGTCCTCGTCAGAGAGCTCCAGCACCCGGCTGTCTCCACCAGACGTCTCTGCTCTGCTCGACATCTCCCTGCCCGGCCCA
CCTGAGGATGCGCTGTCACAGGGCGAGCCTGCCACACACATTAGCGACTCCATCATTGAGATCGCCATCAGCTCCGGTCAGTACGGTGAA
GGAGTCCCTCTTTCTCCAGCAAAACTGAATGGCAGTGACAGTTCCAAGAGCCTTCCCTCCCCGTCCAGCAGCCCCCAGCCACACTGGATC
GCCTCTCCCACCCACGACCCCCAGTGGTACCCCAGTGACTCCACCGACTCCTCGCTCAGCAGCCTGTTTGCAAGCTTCATCTCCCCAGAG
AAGAGCCGGAAGATGTTGCCGACTCCCATTGGGACCAACAGTGGCACTTCCTTGCTTGGCCCCAGCTTGTTGGATGGAAACTCGCGGGAC
TCATTTGTGTCCAGGTCCCTGGCTGACGTTGCAGAGGCCCTAGGCGAGCCCCTTTACCGGGTGAGCACCGGCAACTATGAGTACCGCCTG
ATCCTGCGCTGCCGCCAGGAGGCGCGCGCCCGCTTCTCCCAGATGCGCAAGGATGTGCTGGAGAAGATGGAGCTGCTGGACCAGAAGCAC
GTCCAGGACATCGTGTTCCAGCTGCAGCGCCTCGTGTCCACCATGTCCAAGTACTACAACGACTGCTACGCAGTGCTGCGGGATGCCGAC
GTCTTCCCCATCGAGGTAGACCTGGCGCACACCACATTGGCCTATGGCCTCAACCAGGAGGAGTTCACAGATGGGGAGGAGGAGGAGGAG
GAGGAAGACACGGCAGCTGGGGAGCCGTCCAGGGATACACGAGGGGCTGCTGGGCCCTTGGACAAGGGTGGAAGCTGGTGTGACTCCTGA
GTGCCCCGCGGCTGTGGTGCCGGGGGCAGGGTGCGTGGGAGGACGGAGCCTGGGAGCGGGGCGGGGCCGCCGCGCAAGGGGGCGACGCAT
AAAGGCCTGCTGGCTTGGGGCGCCTGCCTCCCTGCTCCTCTGTCCTCGCACAGCGAACCTGGGCTCCTGCCCAGGACAGGCACCAGGGTC
ATGGCCTGGGACCTGGACACTGGCCCCTCCACCCTCCCTCCCCTCCCGGCTCCCCGGCCAGAGGGAGAGCTTGGTCTCTGGACCTGCCTT
AGGAAGGAGAGGGAGGGCAGGAAGGAAAAGAAAGGACTTGGAGGTGGCAGGAGTCCGAGCCCTGCTCCTTGTGGGCGCTCACACTGCCCC
CGGAGCCTGCTGGGAGTGGGGCCAGCCGTGGACAGCTGAGGTTGGGGTCAATGCCTCCTGGGCACCCTTGCCTCGCCCCAGACCGGCCCG
TCCAGTCCCCATCACACCTCGGCGGCCTTTATTTATTCTGTTCCCCCAGCTCGGCCACTTCTCTGAAGGAGGGCTGGGTTCTGGGCCTGT

>19268_19268_4_CRAMP1L-PICK1_CRAMP1L_chr16_1720810_ENST00000436138_PICK1_chr22_38470314_ENST00000404072_length(amino acids)=1349AA_BP=1212
MTVKLGDGGSGEDGLKKLGKRAADEESLEGEGAGGADAAEESSGTKRDEKTPRAGADGPPAPPGAPQAPSPPQGSPQDQHHFLRSSVRPQ
SKRPRKDPPSAVGSGNAGGSGPRGKDRHLPKAQLWLSISRVPFGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFEGLYEHGK
DFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITKYIDFDHVFSRGLKKSSQELYGLICYGELRKKIGGCMDDKNATKLNELI
QVGATTVRYKGRNLRIKAPMCRALKKLCDPDGLSDEEDQKPVRLPLKVPIELQPRNNHAWARVQSLAQNPRLRMIVELHRKVSSLIEFLK
QKWALHEVRVRKTLEERQLQDSCSAPMQEKVTLHLFPGENCTLTPLPGVARVVHSKAFCTVHWQEGGRCKQSAKDAHVLPPAQILGIQSG
QGTARGQVKCPRSGAEGKGVGRPPPAADALQSSGESSPESAPGEGAALSLSSPDAPDRPPPRHQDTGPCLEKTPAEGRDSPTREPGALPC
ACGQLPDLEDELSLLDPLPRYLKSCQDLIVPEQCRCADTRPGSEQPPLGGAASPEVLAPVSKEAADLAPTGPSPRPGPGLLLDVCTKDLA
DAPAEELQEKGSPAGPPPSQGQPAARPPKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGRQDPRPGSLPTA
LHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSPRCPRNQASLRSSKTFPPSSAPCSSGLRNPPRPL
LVPGPSSTGSNDSDGGLFAVPTTLPPNSRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRTLLPRPSENQSH
NVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAATSAGILSGNPLPALDTEGLSGISPLSSDEVTGAI
SGQDSTGTHQDGDTLPTVGGSDPFVSIPSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDVSALLDISLPGP
PEDALSQGEPATHISDSIIEIAISSGQYGEGVPLSPAKLNGSDSSKSLPSPSSSPQPHWIASPTHDPQWYPSDSTDSSLSSLFASFISPE
KSRKMLPTPIGTNSGTSLLGPSLLDGNSRDSFVSRSLADVAEALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CRAMP1L-PICK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRAMP1L-PICK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRAMP1L-PICK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource