Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CRB3-RTP1 (FusionGDB2 ID:19285)

Fusion Gene Summary for CRB3-RTP1

Fusion gene summary

Fusion gene information	Fusion gene name: CRB3-RTP1
	Fusion gene ID: 19285
		Hgene	Tgene
	Gene symbol	CRB3	RTP1
	Gene ID	92359	132112
	Gene name	crumbs cell polarity complex component 3	receptor transporter protein 1
	Synonyms	-	Z3CXXC1
	Cytomap	19p13.3	3q27.3
	Type of gene	protein-coding	protein-coding
	Description	protein crumbs homolog 3crumbs 3, cell polarity complex componentcrumbs family member 3	receptor-transporting protein 13CxxC-type zinc finger protein 1receptor (chemosensory) transporter protein 1zinc finger, 3CxxC-type 1
	Modification date	20200313	20200313
	UniProtAcc	Q9BUF7	.
	Ensembl transtripts involved in fusion gene	ENST00000308243, ENST00000356762, ENST00000598494, ENST00000600229,	ENST00000312295,
Fusion gene scores	* DoF score	3 X 3 X 3=27	2 X 1 X 1=2
	# samples	3	2
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/2*10)=3.32192809488736
Context	PubMed: CRB3 [Title/Abstract] AND RTP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CRB3(6466620)-RTP1(186915378), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CRB3	GO:0072659	protein localization to plasma membrane	17332497
Tgene	RTP1	GO:0051205	protein insertion into membrane	15550249

Fusion gene breakpoints across CRB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RTP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A124-01A	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+

Top

Fusion Gene ORF analysis for CRB3-RTP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000308243	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+
In-frame	ENST00000356762	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+
In-frame	ENST00000598494	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+
In-frame	ENST00000600229	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000598494

CRB3

chr19

6466620

ENST00000312295

RTP1

chr3

186915378

3411

1299

1305

2015

236

ENST00000600229

CRB3

chr19

6466620

ENST00000312295

RTP1

chr3

186915378

3046

934

940

1650

236

ENST00000356762

CRB3

chr19

6466620

ENST00000312295

RTP1

chr3

186915378

2574

462

162

1178

338

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000598494	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+	0.3038787	0.6961213
ENST00000600229	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+	0.28635097	0.71364903
ENST00000356762	ENST00000312295	CRB3	chr19	6466620	+	RTP1	chr3	186915378	+	0.10511525	0.8948847

Top

Fusion Genomic Features for CRB3-RTP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CRB3-RTP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:6466620/chr3:186915378)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CRB3 Q9BUF7	.
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250\|UniProtKB:Q8QZT4, ECO:0000269\|PubMed:12771187, ECO:0000269\|PubMed:14718572}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000356762

27_59

100

124.0

Topological domain

Extracellular

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000356762

60_80

100

124.0

Transmembrane

Helical

Tgene

RTP1

chr19:6466620

chr3:186915378

ENST00000312295

1_238

264.0

Topological domain

Cytoplasmic

Tgene

RTP1

chr19:6466620

chr3:186915378

ENST00000312295

260_263

264.0

Topological domain

Extracellular

Tgene

RTP1

chr19:6466620

chr3:186915378

ENST00000312295

239_259

264.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000308243

27_59

121.0

Topological domain

Extracellular

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000308243

81_120

121.0

Topological domain

Cytoplasmic

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000356762

81_120

100

124.0

Topological domain

Cytoplasmic

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000598494

27_59

121.0

Topological domain

Extracellular

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000598494

81_120

121.0

Topological domain

Cytoplasmic

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000600229

27_59

121.0

Topological domain

Extracellular

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000600229

81_120

121.0

Topological domain

Cytoplasmic

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000308243

60_80

121.0

Transmembrane

Helical

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000598494

60_80

121.0

Transmembrane

Helical

Hgene

CRB3

chr19:6466620

chr3:186915378

ENST00000600229

60_80

121.0

Transmembrane

Helical

Top

Fusion Gene Sequence for CRB3-RTP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19285_19285_1_CRB3-RTP1_CRB3_chr19_6466620_ENST00000356762_RTP1_chr3_186915378_ENST00000312295_length(transcript)=2574nt_BP=462nt
ACGGACCGAGGGTTCGAGGGAGGGACACGGACCAGGAACCTGAGCTAGGTCAAAGACGCCCGGGCCAGGTGCCCCGTCGCAGGTGCCCCT
GGCCGGAGATGCGGTAGGAGGGGCGAGCGCGAGAAGCCCCTTCCTCGGCGCTGCCAACCCGCCACCCAGCCCATGGCGAACCCCGGGCTG
GGGCTGCTTCTGGCGCTGGGCCTGCCGTTCCTGCTGGCCCGCTGGGGCCGAGCCTGGGGGCAAATACAGACCACTTCTGCAAATGAGAAT
AGCACTGTTTTGCCTTCATCCACCAGCTCCAGCTCCGATGGCAACCTGCGTCCAGAAGCCATCACTGCTATCATCGTGGTCTTCTCCCTC
TTGGCTGCCTTGCTCCTGGCTGTGGGGCTGGCACTGTTGGTGCGGAAGCTTCGGGAGAAGCGGCAGACGGAGGGCACCTACCGGCCCAGT
AGCGAGGAGCAGTGGAAATTGCCTTCCCTCACTACTGACGAGACCATGTGTAAAAGCGTGACCACAGATGAGTGGAAGAAAGTCTTCTAT
GAGAAGATGGAGGAGGCAAAGCCGGCTGACAGCTGGGACCTCATCATAGACCCCAACCTCAAGCACAATGTGCTGAGCCCTGGTTGGAAG
CAGTACCTGGAATTGCATGCTTCAGGCAGGTTCCACTGCTCCTGGTGCTGGCACACCTGGCAGTCGCCCTACGTGGTCATCCTCTTCCAC
ATGTTCCTGGACCGCGCCCAGCGGGCGGGCTCGGTGCGCATGCGCGTCTTCAAGCAGCTGTGCTATGAGTGCGGCACGGCGCGGCTGGAC
GAGTCCAGCATGCTGGAGGAGAACATCGAGGGCCTGGTGGACAACCTCATCACCAGCCTGCGCGAGCAGTGCTACGGCGAGCGTGGCGGC
CAGTACCGCATCCACGTGGCCAGCCGCCAGGACAACCGGCGGCACCGCGGAGAGTTCTGCGAGGCCTGCCAGGAGGGCATCGTGCACTGG
AAGCCCAGCGAGAAGCTGCTGGAGGAGGAGGCGACCACCTACACCTTCTCCCGGGCGCCCAGCCCCACCAAGTCGCAGGACCAGACGGGC
TCAGGCTGGAACTTCTGCTCTATCCCCTGGTGCTTGTTTTGGGCCACGGTCCTGCTGCTGATCATCTACCTGCAGTTCTCTTTCCGTAGC
TCCGTATAAGATTCCGTGGTTGGGCCCAGAGCCTGTCGAGGGTGCCAGTTAGCTGATGCGAGGGTAGAGGAGAGACGTGGGTTGAGAATA
GTGTAAACTTCTAGCGCTGGTGATGTCACTGACTCAGTGGGGATCTTGGACAAATTATACAGTTTTTCCATCTATAAAACTCAGGGTTTG
GGCAAGATCATTGGTTTATCATAGTGAAACCCAGGACCCCAAAGTTCTGCGTAGGTGCCTCAGGGACTTTTGGATTTGGAAAGTAGGCTA
AGCTAGTGGGTGTCTCCAACTCCTGATCTAAACACCCATCCTCCAACTCCTACCTCCTCCTCTTGCTTCGATCAGAACAGCTTTACTTTA
GATAGGGTTCCATTTAAGATTTTTGTACCAAAAAAAAAAAAAAAAAAAGTTTAACTACTTTTAAAAAGTTTGAAAATTAGAGGACTGGGT
GATCTCAAAAGGGCTTTCCACAGTAATGAGCTCGACCTTGCTCTTATTAGTCCCTCACCCCTGCCCCTCATGATCTCCCACTTTCTCTAG
CTGCAGCCTTAAATTAGCTTCTTTGCCCACCCTGTGAGCCTCATCCGTGATTCTGCCTTCACACACGCAGCAGAGGTTTCCCTTGAAGTG
CAAGAGGTGGGAGATCAGGCTGTTCCTTTGCTGCCAGGTACACAGGGTCTCTTTTTTTTGTTTCTCAGATTCCAGCTTCTTTCCACTCAG
GGCAGATTCTGGGGTCTGCCTGCCTGAAAGATGGTGGTTGGGGTGGGGTCTCATAGAGTTAGGCTTCTCACCCACTGCGTATTAACTGGC
AGAGAATTTAGGGGAGGTTCAGAAGACAGAGTTTTAGAAGCAAAGCACAAAATCTCTGGGAGGCATTATAATGGAGGGTCTTCAGAGTTC
GGGGACCAAGTCTAGCAGATTCTCAGCAGTGCTGATGGCCAGAATTCAGGAGCAGGGGCCTGGCCTCCTGGGTTCTTTGCTGAAATTATA
GTTGAATGGCTTTCTCACATTGGCCAAGCATGAGGCCTCTTGCCAAAGATCAGCTGTCCCCCTAAAGCCACAGGGATGGGGTATCTTCAG
CAAGAGAGAGGGCGTTAAAGATGTAAAATGCTTTGTCCATGGGGAAGTGCACAGATATGTGGGAGAACCTTACAAGGCTCTAAAATGAGA
TGTGATATGGCTTGAAATGGGAGGAGACACTTTCTGACAGTGGGGGGTCTGGAATGGAATTGGTGGGGACAGGCAGCAAGCTGCACTTTT
GAGGGGCCTCATTTACCCCACCTCTGTTAAAAACTTGACTACTCTCCTCTTTAATAGAAAGTCACCATCATCTGTAGTGATGGAGGAAGG

>19285_19285_1_CRB3-RTP1_CRB3_chr19_6466620_ENST00000356762_RTP1_chr3_186915378_ENST00000312295_length(amino acids)=338AA_BP=100
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTE
GTYRPSSEEQWKLPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPY
VVILFHMFLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQ

--------------------------------------------------------------
>19285_19285_2_CRB3-RTP1_CRB3_chr19_6466620_ENST00000598494_RTP1_chr3_186915378_ENST00000312295_length(transcript)=3411nt_BP=1299nt
TTATTTATTTATTTATTTTTTGTAGAGAATGAGGCCTCGCTGTGTTGCCCAGGCTGGTCTCGGACTCCTGGCCTCAAGCAATCCTCTTGC
CTCGGCCTCTCAAAGTGTTGGGATTACAGGCGTGAGCCATTGCGCCTGGGCAGGTATTTTTTCTCATTAAGCGCTCCCCATCCAAGTCTG
CCCTAGGCAGGAGTGCCTAGTGCACGGGTACATACATACCCCGTGCGTCTCCACACCTGTGCGCTCCCACAGATATGCTCGCAATGCAGG
TGTAAGGTCCCCCTCACACCTGCGCGCTTCCGCGGTCTCCCTCCCCGCATCCCCATTAAGGGACTGGGGTCCCGTTACAGGTGCGCCCAC
AGCGCGGCCCCGCCCCCTTCTTGACTCCGCCCTCTCAGCGAGGCTCAGGTGCACAAGCCGGAAGTGCGCTCTCCCAGGTGCCCCGTCGCA
GGTGCCCCTGGCCGGAGATGCGGTAGGAGGGGCGAGCGCGAGAAGCCCCTTCCTCGGCGCTGCCAACCCGCCACCCAGCCCATGGCGAAC
CCCGGGCTGGGGCTGCTTCTGGCGCTGGGCCTGCCGTTCCTGCTGGCCCGCTGGGGCCGAGCCTGGGGGCAAATACAGACCACTTCTGCA
AATGAGAATAGCACTGTTTTGCCTTCATCCACCAGCTCCAGCTCCGATGGCAACCTGGTGGGTGCCCGCGTGCCACCGACCCCCAACCTC
AAGTTGCCGCCGGAAGAGCGGCTCATCTGAACGCTGGGGCCTGCTGCAGCCACCAACACTGCCCAGGACTGCGGGTTGCTGGCTTGTACA
CCGCAGCTGCCACCGAGACACCAGCCTCTGATGGCTCAGGAGGACTTGTGGGGAGAGGCTGGGGGCACCCATGTGGTGGGCTCTGTGCAG
CATGTTGCCTCTGCTTGGCTGTGCCTGCAGCTCAGGGTGCTGGGGCTCGGGACCCACCCCCCTGCTTGCGGAACCAACTTTTCTCTGTGT
GTCCAGCAGGCCCCACAACCCCCTCTCCTTTCTTTCAGTTCTCCCATGCAGCCGAGGCCCGGGCCCCTCAGGACTCCAAGGAGACGGTGC
AGGGCTGCCTGCCCATCTAGGTCCCCTCTCCTGCATCTGTCTCCCTTCATTGCTGTGTGACCTTGGGGAAAGGCAGTGCCCTCTCTGGGC
AGTCAGATCCACCCAGTGCTTAATAGCAGGGAAGAAGGTACTTCAAAGACTCTGCCCCTGAGGTCAAGAGAGGATGGGGCTATTCACTTT
TATATATTTATATAAAATTAGTAGTGAGATGTAACAAAATGGAAATTGCCTTCCCTCACTACTGACGAGACCATGTGTAAAAGCGTGACC
ACAGATGAGTGGAAGAAAGTCTTCTATGAGAAGATGGAGGAGGCAAAGCCGGCTGACAGCTGGGACCTCATCATAGACCCCAACCTCAAG
CACAATGTGCTGAGCCCTGGTTGGAAGCAGTACCTGGAATTGCATGCTTCAGGCAGGTTCCACTGCTCCTGGTGCTGGCACACCTGGCAG
TCGCCCTACGTGGTCATCCTCTTCCACATGTTCCTGGACCGCGCCCAGCGGGCGGGCTCGGTGCGCATGCGCGTCTTCAAGCAGCTGTGC
TATGAGTGCGGCACGGCGCGGCTGGACGAGTCCAGCATGCTGGAGGAGAACATCGAGGGCCTGGTGGACAACCTCATCACCAGCCTGCGC
GAGCAGTGCTACGGCGAGCGTGGCGGCCAGTACCGCATCCACGTGGCCAGCCGCCAGGACAACCGGCGGCACCGCGGAGAGTTCTGCGAG
GCCTGCCAGGAGGGCATCGTGCACTGGAAGCCCAGCGAGAAGCTGCTGGAGGAGGAGGCGACCACCTACACCTTCTCCCGGGCGCCCAGC
CCCACCAAGTCGCAGGACCAGACGGGCTCAGGCTGGAACTTCTGCTCTATCCCCTGGTGCTTGTTTTGGGCCACGGTCCTGCTGCTGATC
ATCTACCTGCAGTTCTCTTTCCGTAGCTCCGTATAAGATTCCGTGGTTGGGCCCAGAGCCTGTCGAGGGTGCCAGTTAGCTGATGCGAGG
GTAGAGGAGAGACGTGGGTTGAGAATAGTGTAAACTTCTAGCGCTGGTGATGTCACTGACTCAGTGGGGATCTTGGACAAATTATACAGT
TTTTCCATCTATAAAACTCAGGGTTTGGGCAAGATCATTGGTTTATCATAGTGAAACCCAGGACCCCAAAGTTCTGCGTAGGTGCCTCAG
GGACTTTTGGATTTGGAAAGTAGGCTAAGCTAGTGGGTGTCTCCAACTCCTGATCTAAACACCCATCCTCCAACTCCTACCTCCTCCTCT
TGCTTCGATCAGAACAGCTTTACTTTAGATAGGGTTCCATTTAAGATTTTTGTACCAAAAAAAAAAAAAAAAAAAGTTTAACTACTTTTA
AAAAGTTTGAAAATTAGAGGACTGGGTGATCTCAAAAGGGCTTTCCACAGTAATGAGCTCGACCTTGCTCTTATTAGTCCCTCACCCCTG
CCCCTCATGATCTCCCACTTTCTCTAGCTGCAGCCTTAAATTAGCTTCTTTGCCCACCCTGTGAGCCTCATCCGTGATTCTGCCTTCACA
CACGCAGCAGAGGTTTCCCTTGAAGTGCAAGAGGTGGGAGATCAGGCTGTTCCTTTGCTGCCAGGTACACAGGGTCTCTTTTTTTTGTTT
CTCAGATTCCAGCTTCTTTCCACTCAGGGCAGATTCTGGGGTCTGCCTGCCTGAAAGATGGTGGTTGGGGTGGGGTCTCATAGAGTTAGG
CTTCTCACCCACTGCGTATTAACTGGCAGAGAATTTAGGGGAGGTTCAGAAGACAGAGTTTTAGAAGCAAAGCACAAAATCTCTGGGAGG
CATTATAATGGAGGGTCTTCAGAGTTCGGGGACCAAGTCTAGCAGATTCTCAGCAGTGCTGATGGCCAGAATTCAGGAGCAGGGGCCTGG
CCTCCTGGGTTCTTTGCTGAAATTATAGTTGAATGGCTTTCTCACATTGGCCAAGCATGAGGCCTCTTGCCAAAGATCAGCTGTCCCCCT
AAAGCCACAGGGATGGGGTATCTTCAGCAAGAGAGAGGGCGTTAAAGATGTAAAATGCTTTGTCCATGGGGAAGTGCACAGATATGTGGG
AGAACCTTACAAGGCTCTAAAATGAGATGTGATATGGCTTGAAATGGGAGGAGACACTTTCTGACAGTGGGGGGTCTGGAATGGAATTGG
TGGGGACAGGCAGCAAGCTGCACTTTTGAGGGGCCTCATTTACCCCACCTCTGTTAAAAACTTGACTACTCTCCTCTTTAATAGAAAGTC

>19285_19285_2_CRB3-RTP1_CRB3_chr19_6466620_ENST00000598494_RTP1_chr3_186915378_ENST00000312295_length(amino acids)=236AA_BP=
MPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPYVVILFHMFLDRA
QRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKL

--------------------------------------------------------------
>19285_19285_3_CRB3-RTP1_CRB3_chr19_6466620_ENST00000600229_RTP1_chr3_186915378_ENST00000312295_length(transcript)=3046nt_BP=934nt
ACCGACGGACCGAGGGTTCGAGGGAGGGACACGGACCAGGAACCTGAGCTAGGTCAAAGACGCCCGGGCCAGGTGCCCCGTCGCAGGTGC
CCCTGGCCGGAGATGCGGTAGGAGGGGCGAGCGCGAGAAGCCCCTTCCTCGGCGCTGCCAACCCGCCACCCAGCCCATGGCGAACCCCGG
GCTGGGGCTGCTTCTGGCGCTGGGCCTGCCGTTCCTGCTGGCCCGCTGGGGCCGAGCCTGGGGGCAAATACAGACCACTTCTGCAAATGA
GAATAGCACTGTTTTGCCTTCATCCACCAGCTCCAGCTCCGATGGCAACCTGGTGGGTGCCCGCGTGCCACCGACCCCCAACCTCAAGTT
GCCGCCGGAAGAGCGGCTCATCTGAACGCTGGGGCCTGCTGCAGCCACCAACACTGCCCAGGACTGCGGGTTGCTGGCTTGTACACCGCA
GCTGCCACCGAGACACCAGCCTCTGATGGCTCAGGAGGACTTGTGGGGAGAGGCTGGGGGCACCCATGTGGTGGGCTCTGTGCAGCATGT
TGCCTCTGCTTGGCTGTGCCTGCAGCTCAGGGTGCTGGGGCTCGGGACCCACCCCCCTGCTTGCGGAACCAACTTTTCTCTGTGTGTCCA
GCAGGCCCCACAACCCCCTCTCCTTTCTTTCAGTTCTCCCATGCAGCCGAGGCCCGGGCCCCTCAGGACTCCAAGGAGACGGTGCAGGGC
TGCCTGCCCATCTAGGTCCCCTCTCCTGCATCTGTCTCCCTTCATTGCTGTGTGACCTTGGGGAAAGGCAGTGCCCTCTCTGGGCAGTCA
GATCCACCCAGTGCTTAATAGCAGGGAAGAAGGTACTTCAAAGACTCTGCCCCTGAGGTCAAGAGAGGATGGGGCTATTCACTTTTATAT
ATTTATATAAAATTAGTAGTGAGATGTAACAAAATGGAAATTGCCTTCCCTCACTACTGACGAGACCATGTGTAAAAGCGTGACCACAGA
TGAGTGGAAGAAAGTCTTCTATGAGAAGATGGAGGAGGCAAAGCCGGCTGACAGCTGGGACCTCATCATAGACCCCAACCTCAAGCACAA
TGTGCTGAGCCCTGGTTGGAAGCAGTACCTGGAATTGCATGCTTCAGGCAGGTTCCACTGCTCCTGGTGCTGGCACACCTGGCAGTCGCC
CTACGTGGTCATCCTCTTCCACATGTTCCTGGACCGCGCCCAGCGGGCGGGCTCGGTGCGCATGCGCGTCTTCAAGCAGCTGTGCTATGA
GTGCGGCACGGCGCGGCTGGACGAGTCCAGCATGCTGGAGGAGAACATCGAGGGCCTGGTGGACAACCTCATCACCAGCCTGCGCGAGCA
GTGCTACGGCGAGCGTGGCGGCCAGTACCGCATCCACGTGGCCAGCCGCCAGGACAACCGGCGGCACCGCGGAGAGTTCTGCGAGGCCTG
CCAGGAGGGCATCGTGCACTGGAAGCCCAGCGAGAAGCTGCTGGAGGAGGAGGCGACCACCTACACCTTCTCCCGGGCGCCCAGCCCCAC
CAAGTCGCAGGACCAGACGGGCTCAGGCTGGAACTTCTGCTCTATCCCCTGGTGCTTGTTTTGGGCCACGGTCCTGCTGCTGATCATCTA
CCTGCAGTTCTCTTTCCGTAGCTCCGTATAAGATTCCGTGGTTGGGCCCAGAGCCTGTCGAGGGTGCCAGTTAGCTGATGCGAGGGTAGA
GGAGAGACGTGGGTTGAGAATAGTGTAAACTTCTAGCGCTGGTGATGTCACTGACTCAGTGGGGATCTTGGACAAATTATACAGTTTTTC
CATCTATAAAACTCAGGGTTTGGGCAAGATCATTGGTTTATCATAGTGAAACCCAGGACCCCAAAGTTCTGCGTAGGTGCCTCAGGGACT
TTTGGATTTGGAAAGTAGGCTAAGCTAGTGGGTGTCTCCAACTCCTGATCTAAACACCCATCCTCCAACTCCTACCTCCTCCTCTTGCTT
CGATCAGAACAGCTTTACTTTAGATAGGGTTCCATTTAAGATTTTTGTACCAAAAAAAAAAAAAAAAAAAGTTTAACTACTTTTAAAAAG
TTTGAAAATTAGAGGACTGGGTGATCTCAAAAGGGCTTTCCACAGTAATGAGCTCGACCTTGCTCTTATTAGTCCCTCACCCCTGCCCCT
CATGATCTCCCACTTTCTCTAGCTGCAGCCTTAAATTAGCTTCTTTGCCCACCCTGTGAGCCTCATCCGTGATTCTGCCTTCACACACGC
AGCAGAGGTTTCCCTTGAAGTGCAAGAGGTGGGAGATCAGGCTGTTCCTTTGCTGCCAGGTACACAGGGTCTCTTTTTTTTGTTTCTCAG
ATTCCAGCTTCTTTCCACTCAGGGCAGATTCTGGGGTCTGCCTGCCTGAAAGATGGTGGTTGGGGTGGGGTCTCATAGAGTTAGGCTTCT
CACCCACTGCGTATTAACTGGCAGAGAATTTAGGGGAGGTTCAGAAGACAGAGTTTTAGAAGCAAAGCACAAAATCTCTGGGAGGCATTA
TAATGGAGGGTCTTCAGAGTTCGGGGACCAAGTCTAGCAGATTCTCAGCAGTGCTGATGGCCAGAATTCAGGAGCAGGGGCCTGGCCTCC
TGGGTTCTTTGCTGAAATTATAGTTGAATGGCTTTCTCACATTGGCCAAGCATGAGGCCTCTTGCCAAAGATCAGCTGTCCCCCTAAAGC
CACAGGGATGGGGTATCTTCAGCAAGAGAGAGGGCGTTAAAGATGTAAAATGCTTTGTCCATGGGGAAGTGCACAGATATGTGGGAGAAC
CTTACAAGGCTCTAAAATGAGATGTGATATGGCTTGAAATGGGAGGAGACACTTTCTGACAGTGGGGGGTCTGGAATGGAATTGGTGGGG
ACAGGCAGCAAGCTGCACTTTTGAGGGGCCTCATTTACCCCACCTCTGTTAAAAACTTGACTACTCTCCTCTTTAATAGAAAGTCACCAT

>19285_19285_3_CRB3-RTP1_CRB3_chr19_6466620_ENST00000600229_RTP1_chr3_186915378_ENST00000312295_length(amino acids)=236AA_BP=
MPSLTTDETMCKSVTTDEWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQSPYVVILFHMFLDRA
QRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITSLREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CRB3-RTP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CRB3	chr19:6466620	chr3:186915378	ENST00000308243	+	1	3	84_120	0	121.0	EPB41L5
Hgene	CRB3	chr19:6466620	chr3:186915378	ENST00000356762	+	4	5	84_120	100.0	124.0	EPB41L5
Hgene	CRB3	chr19:6466620	chr3:186915378	ENST00000598494	+	1	4	84_120	0	121.0	EPB41L5
Hgene	CRB3	chr19:6466620	chr3:186915378	ENST00000600229	+	1	4	84_120	0	121.0	EPB41L5

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CRB3-RTP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CRB3-RTP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source