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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREB3L3-PKN3 (FusionGDB2 ID:19332)

Fusion Gene Summary for CREB3L3-PKN3

check button Fusion gene summary
Fusion gene informationFusion gene name: CREB3L3-PKN3
Fusion gene ID: 19332
HgeneTgene
Gene symbol

CREB3L3

PKN3

Gene ID

84699

29941

Gene namecAMP responsive element binding protein 3 like 3protein kinase N3
SynonymsCREB-H|CREBH|HYST1481UTDP4-1
Cytomap

19p13.3

9q34.11

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factorcAMP-responsive element-binding protein, hepatic-specificserine/threonine-protein kinase N3protein kinase PKN-betaprotein-kinase C-related kinase 3
Modification date2020031320200313
UniProtAcc

Q68CJ9

.
Ensembl transtripts involved in fusion geneENST00000078445, ENST00000595923, 
ENST00000602147, ENST00000602257, 
ENST00000252587, 		ENST00000485301, 
ENST00000291906, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CREB3L3 [Title/Abstract] AND PKN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREB3L3(4171172)-PKN3(131467582), # samples:3
Anticipated loss of major functional domain due to fusion event.CREB3L3-PKN3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CREB3L3-PKN3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CREB3L3-PKN3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREB3L3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

16469704

TgenePKN3

GO:0010631

epithelial cell migration

21754995


check buttonFusion gene breakpoints across CREB3L3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PKN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-G3-A7M7-01ACREB3L3chr19

4171172

-PKN3chr9

131467582

+
ChimerDB4LIHCTCGA-G3-A7M7-01ACREB3L3chr19

4171172

+PKN3chr9

131467582

+


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Fusion Gene ORF analysis for CREB3L3-PKN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000078445ENST00000485301CREB3L3chr19

4171172

+PKN3chr9

131467582

+
5CDS-intronENST00000595923ENST00000485301CREB3L3chr19

4171172

+PKN3chr9

131467582

+
5CDS-intronENST00000602147ENST00000485301CREB3L3chr19

4171172

+PKN3chr9

131467582

+
5CDS-intronENST00000602257ENST00000485301CREB3L3chr19

4171172

+PKN3chr9

131467582

+
Frame-shiftENST00000602147ENST00000291906CREB3L3chr19

4171172

+PKN3chr9

131467582

+
In-frameENST00000078445ENST00000291906CREB3L3chr19

4171172

+PKN3chr9

131467582

+
In-frameENST00000595923ENST00000291906CREB3L3chr19

4171172

+PKN3chr9

131467582

+
In-frameENST00000602257ENST00000291906CREB3L3chr19

4171172

+PKN3chr9

131467582

+
intron-3CDSENST00000252587ENST00000291906CREB3L3chr19

4171172

+PKN3chr9

131467582

+
intron-intronENST00000252587ENST00000485301CREB3L3chr19

4171172

+PKN3chr9

131467582

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000078445CREB3L3chr194171172+ENST00000291906PKN3chr9131467582+408011227537671230
ENST00000595923CREB3L3chr194171172+ENST00000291906PKN3chr9131467582+403810803637251229
ENST00000602257CREB3L3chr194171172+ENST00000291906PKN3chr9131467582+40071049836941228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000078445ENST00000291906CREB3L3chr194171172+PKN3chr9131467582+0.0044517580.99554825
ENST00000595923ENST00000291906CREB3L3chr194171172+PKN3chr9131467582+0.004350120.9956499
ENST00000602257ENST00000291906CREB3L3chr194171172+PKN3chr9131467582+0.004396110.9956039

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Fusion Genomic Features for CREB3L3-PKN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CREB3L3chr194171172+PKN3chr9131467581+1.48E-070.9999999
CREB3L3chr194171172+PKN3chr9131467581+1.48E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CREB3L3-PKN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4171172/chr9:131467582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREB3L3

Q68CJ9

.
FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+810243_306325462.0DomainbZIP
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+810243_306324461.0DomainbZIP
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+810245_274325462.0RegionBasic motif
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+810285_306325462.0RegionLeucine-zipper
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+810245_274324461.0RegionBasic motif
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+810285_306324461.0RegionLeucine-zipper
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+8101_322325462.0Topological domainCytoplasmic
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+8101_322324461.0Topological domainCytoplasmic
TgenePKN3chr19:4171172chr9:131467582ENST00000291906022463_5548890.0Compositional biasNote=Pro-rich
TgenePKN3chr19:4171172chr9:131467582ENST00000291906022165_2458890.0DomainREM-1 3
TgenePKN3chr19:4171172chr9:131467582ENST00000291906022559_8188890.0DomainProtein kinase
TgenePKN3chr19:4171172chr9:131467582ENST000002919060225_808890.0DomainREM-1 1
TgenePKN3chr19:4171172chr9:131467582ENST00000291906022819_8898890.0DomainAGC-kinase C-terminal
TgenePKN3chr19:4171172chr9:131467582ENST0000029190602293_1638890.0DomainREM-1 2
TgenePKN3chr19:4171172chr9:131467582ENST00000291906022565_5738890.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+810344_461325462.0Topological domainLumenal
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+810344_461324461.0Topological domainLumenal
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000078445+810323_343325462.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCREB3L3chr19:4171172chr9:131467582ENST00000595923+810323_343324461.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CREB3L3-PKN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19332_19332_1_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000078445_PKN3_chr9_131467582_ENST00000291906_length(transcript)=4080nt_BP=1122nt
GTGACCGCTTCAGCATCTTTTGGGAGTGGTGACAGAGCCACAGAGGGCTGTGAGCTTGCCCGGCCCCAGGTAACGCTGGCGGTGGGTGGG
CCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAGACAGAACTGGATGGACCCATGAATACGGATTTAGCTGCTGGAAAGATGGCT
TCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTTGACCGGCAGGACGGCATCCTGAGACACGTGGAG
CTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCTGACGACTTCCTCAGCTCCATCCTGGGCTCTGGA
GACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCCGAAGACCTCCCCTCCGACCCCCAGGACACCCCT
CCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAGGGGCCCTGCCTCTCCTATCATCCTGGCAACTCT
TGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATAGACCTGGAAATGTGGAGCCCAGGAGGAAGGATC
TGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTGAAAGACCTCCTCCTTTCGGGCAGCAGTGGGGAC
CTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGATGAGAAGAAG
CTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGCCGGAAAATC
CGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGCACTGCTCAG
AATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTG
CAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGGCCCCCAGAGGATGAGAAGGAGGTGATCCGC
CGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCCACAGACCGCCGCCACTTGGGCCATGTGCAG
CAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTGCACGCCCGAATCCTGCTGCCCGGCCCTGGG
CCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCTCGGCACCTAGAGGCTCTCCGGAGGCAGCTG
CATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGCACCCCCAAGGAGAGGAAGCTCCTGGCAGCT
GCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGCAGCCTGGAGGCCAGTGGGTCCCCGGAGCCA
GGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCTGAGGGCGCCAAGAACGTGGTGAAACTGCTT
AGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAGTCCTCTCAGAAACTGGACCTCCTGCGCCTG
GCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACCCGAGAGTTGCGGGCTGCGGTGCCTGGATAC
CCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGCCTCCTGGGCTGTGAACAGTTGCTGACAGCC
GTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGGACCAAGGCCAAGCACCAGCGTGGCCGAGGC
GAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACGGGCTGGGGGCAGGTGGCCGAACAGTCCTGG
GACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGGCGGGACTGGCGGCAGCTATGTGGCGTGGCC
TTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTACCGCAGGGACTGCTTTTTGCCCAGGTGACC
TTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCTAAACGCAGAGGCCAGGACTTCCTGAGGGCT
TCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCCTGCAGCTCCCCGAGCACAATCAGCCCCCCT
AAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGTAATTTCCTGCCCAAGAAGACCCCCTTGGGT
GAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCCGAGGAGACTCCGCGCACCAAACGTCCCCAT
ATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCTCGGCTTCAGGACTTCCGCTGCTTAGCTGTG
CTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATACTACGCCATCAAAGCACTGAAGAAGCAGGAG
GTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTGGGCTGCACAGGGCACCCTTTCCTGCTCTCC
CTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGTGGTGACCTCATGATGCAGATCCACGAGGAT
GTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTCTTACACGAGAAGAAGATCATTTACAGGGAC
CTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGACTCTGCAAGGAAGGGATCGGCTTCGGGGAC
CGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAGGCATACACACGGGCTGTGGACTGGTGGGGG
CTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAGGAAGAGGTGTTTGACTGCATCGTCAACATG
GACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTCCAGAAGTGCCCGGAGAAGCGCCTCGGGGCA
GGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAAGCCCTGCTCGCCCGCACCATCCAGCCCCCC
TTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGGCTGCCGCCTGCCCTGACCCCACCTGCACCC
CACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAGCGATTCCTGGAACCCTGAGGGCATCTCCTG
GCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGCTCGTTCACCCGTGCGCCCTGCCTGGAGGTCCAGGCCTTGCTGGGTACT
TCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTGTTGTGGGCTTTGCTCAGTGTCACTGGGCAAAGTGTGTCCCTTCCCCCT
CCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGAAAGGGTGCCGCAGCAAGGAGTGATATGGTTTGTCTTTTTAAGACTGGA

>19332_19332_1_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000078445_PKN3_chr9_131467582_ENST00000291906_length(amino acids)=1230AA_BP=349
MAVGGPPAWSRDPPRHLQTELDGPMNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDSDDFLSS
ILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWS
PGGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKK
IRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDE
KEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEA
LRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKN
VVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCE
QLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQ
LCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPS
TISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDF
RCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMM
QIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRA
VDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLAR

--------------------------------------------------------------
>19332_19332_2_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000595923_PKN3_chr9_131467582_ENST00000291906_length(transcript)=4038nt_BP=1080nt
ACAGAGGGCTGTGAGCTTGCCCGGCCCCAGGTAACGCTGGCGGTGGGTGGGCCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAG
ACAGAACTGGATGGACCCATGAATACGGATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAG
CTCCTGGATCTCCTGTTTGACCGGCAGGACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGGTCCTG
CCAAACCCCGACTCTGACGACTTCCTCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGT
GATAGTGGCATCTCCGAAGACCTCCCCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCT
GCCCAGCCTGGCAAGGGGCCCTGCCTCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAA
GCCTCTGTGACCATAGACCTGGAAATGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGA
TGCAATCTCACCGTGAAAGACCTCCTCCTTTCGGGCAGCAGTGGGGACCTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCT
GGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCC
CTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAG
GAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAA
AACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCA
CCTGGGCCGAGCCAGTGGCCCCCAGAGGATGAGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAG
AACCTGCGGCGCGTGGCCACAGACCGCCGCCACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCAT
GGCGAGCTGCGGGAGCTGCACGCCCGAATCCTGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGG
GCAGAGCAGCTCAGGGCTCGGCACCTAGAGGCTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACC
CACACGTGCGCCAGTGGCACCCCCAAGGAGAGGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTG
CTGCGGATGAAGATCAGCAGCCTGGAGGCCAGTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCAC
GTTGAGGCAGCTGTGGCTGAGGGCGCCAAGAACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCC
CAGGCCCAGCTACAGGAGTCCTCTCAGAAACTGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCT
TTGCGCAGCAGAGTGACCCGAGAGTTGCGGGCTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACA
GGGACACTGCAGGTCCGCCTCCTGGGCTGTGAACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCC
TCCGAGGGCTGGCTTCGGACCAAGGCCAAGCACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAAC
CGTGTTGTGGGGCAGACGGGCTGGGGGCAGGTGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTG
GAGATTGGGGTACACTGGCGGGACTGGCGGCAGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAA
CTGTCCCTCAGCCTGGTACCGCAGGGACTGCTTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGG
CAGGAACGCATCTTCTCTAAACGCAGAGGCCAGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTC
ATGAACCTGCTGCCCCCCTGCAGCTCCCCGAGCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCT
GACCCTGCCACTCCCAGTAATTTCCTGCCCAAGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTC
CCCCAGGAGCCAACATCCGAGGAGACTCCGCGCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCC
CCCACCAGGAAACCCCCTCGGCTTCAGGACTTCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTC
AAGGGGACAGGGAAATACTACGCCATCAAAGCACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAG
CGGATCCTGGAGGCTGTGGGCTGCACAGGGCACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTG
ACTGAGTTTGTGCCTGGTGGTGACCTCATGATGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTT
GTCCTGGGGCTGCAGTTCTTACACGAGAAGAAGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTG
AAGATCGCAGACTTTGGACTCTGCAAGGAAGGGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCC
GAGGTGCTGACCCAGGAGGCATACACACGGGCTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCG
TTCCCAGGGGACACAGAGGAAGAGGTGTTTGACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAG
TTCATTCAGAAGCTCCTCCAGAAGTGCCCGGAGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTC
AGGACCACCAACTGGCAAGCCCTGCTCGCCCGCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTT
GAGGGCGAGTTCACAGGGCTGCCGCCTGCCCTGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGAC
TTCGACTTTGTGTCAGAGCGATTCCTGGAACCCTGAGGGCATCTCCTGGCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGC
TCGTTCACCCGTGCGCCCTGCCTGGAGGTCCAGGCCTTGCTGGGTACTTCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTG
TTGTGGGCTTTGCTCAGTGTCACTGGGCAAAGTGTGTCCCTTCCCCCTCCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGA

>19332_19332_2_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000595923_PKN3_chr9_131467582_ENST00000291906_length(amino acids)=1229AA_BP=348
MAVGGPPAWSRDPPRHLQTELDGPMNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQVLPNPDSDDFLSSI
LGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSP
GGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKI
RRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDEK
EVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEAL
RRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNV
VKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQ
LLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQL
CGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPST
ISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFR
CLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQ
IHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAV
DWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLART

--------------------------------------------------------------
>19332_19332_3_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000602257_PKN3_chr9_131467582_ENST00000291906_length(transcript)=4007nt_BP=1049nt
AGGTAACGCTGGCGGTGGGTGGGCCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAGACAGAACTGGATGGACCCATGAATACGG
ATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTTGACCGGCAGG
ACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCTGACGACTTCC
TCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCCGAAGACCTCC
CCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAGGGGCCCTGCC
TCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATAGACCTGGAAA
TGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTGAAAGACCTCC
TCCTTTCGGGCAGCAGTGGGGACCTGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCA
CCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAA
AAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGT
CAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAAC
TCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGGCCCCCAGAGGATG
AGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCCACAGACCGCCGCC
ACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTGCACGCCCGAATCC
TGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCTCGGCACCTAGAGG
CTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGCACCCCCAAGGAGA
GGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGCAGCCTGGAGGCCA
GTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCTGAGGGCGCCAAGA
ACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAGTCCTCTCAGAAAC
TGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACCCGAGAGTTGCGGG
CTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGCCTCCTGGGCTGTG
AACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGGACCAAGGCCAAGC
ACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACGGGCTGGGGGCAGG
TGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGGCGGGACTGGCGGC
AGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTACCGCAGGGACTGC
TTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCTAAACGCAGAGGCC
AGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCCTGCAGCTCCCCGA
GCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGTAATTTCCTGCCCA
AGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCCGAGGAGACTCCGC
GCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCTCGGCTTCAGGACT
TCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATACTACGCCATCAAAG
CACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTGGGCTGCACAGGGC
ACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGTGGTGACCTCATGA
TGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTCTTACACGAGAAGA
AGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGACTCTGCAAGGAAG
GGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAGGCATACACACGGG
CTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAGGAAGAGGTGTTTG
ACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTCCAGAAGTGCCCGG
AGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAAGCCCTGCTCGCCC
GCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGGCTGCCGCCTGCCC
TGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAGCGATTCCTGGAAC
CCTGAGGGCATCTCCTGGCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGCTCGTTCACCCGTGCGCCCTGCCTGGAGGTCC
AGGCCTTGCTGGGTACTTCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTGTTGTGGGCTTTGCTCAGTGTCACTGGGCAAA
GTGTGTCCCTTCCCCCTCCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGAAAGGGTGCCGCAGCAAGGAGTGATATGGTTT

>19332_19332_3_CREB3L3-PKN3_CREB3L3_chr19_4171172_ENST00000602257_PKN3_chr9_131467582_ENST00000291906_length(amino acids)=1228AA_BP=347
MAVGGPPAWSRDPPRHLQTELDGPMNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDSDDFLSS
ILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWS
PGGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIR
RKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDEKE
VIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALR
RQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVV
KLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQL
LTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLC
GVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTI
SPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRC
LAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI
HEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVD
WWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CREB3L3-PKN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREB3L3-PKN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREB3L3-PKN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource