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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREB3-TLN1 (FusionGDB2 ID:19340)

Fusion Gene Summary for CREB3-TLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CREB3-TLN1
Fusion gene ID: 19340
HgeneTgene
Gene symbol

CREB3

TLN1

Gene ID

148327

7094

Gene namecAMP responsive element binding protein 3 like 4talin 1
SynonymsAIBZIP|ATCE1|CREB3|CREB4|JAL|hJALILWEQ|TLN|talin-1
Cytomap

1q21.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-responsive element-binding protein 3-like protein 4CREB-4androgen-induced basic leucine zipper proteinattaching to CRE-like 1cAMP responsive element binding protein 1cAMP-responsive element-binding protein 3-like protein 4cAMP-responsive talin-1
Modification date2020031320200313
UniProtAcc

O43889

.
Ensembl transtripts involved in fusion geneENST00000486056, ENST00000353704, 
ENST00000314888, ENST00000540444, 
ENST00000464379, 
Fusion gene scores* DoF score4 X 4 X 3=4812 X 13 X 7=1092
# samples 615
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREB3 [Title/Abstract] AND TLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREB3(35733482)-TLN1(35711789), # samples:3
TLN1(35732071)-CREB3(35732992), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREB3

GO:0045944

positive regulation of transcription by RNA polymerase II

16236796


check buttonFusion gene breakpoints across CREB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-6488CREB3chr9

35733279

+TLN1chr9

35725724

-
ChimerDB4HNSCTCGA-QK-A64ZCREB3chr9

35733279

+TLN1chr9

35711789

-
ChimerDB4HNSCTCGA-QK-A64ZCREB3chr9

35733482

+TLN1chr9

35711789

-


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Fusion Gene ORF analysis for CREB3-TLN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486056ENST00000314888CREB3chr9

35733279

+TLN1chr9

35711789

-
3UTR-3CDSENST00000486056ENST00000314888CREB3chr9

35733482

+TLN1chr9

35711789

-
3UTR-3CDSENST00000486056ENST00000540444CREB3chr9

35733279

+TLN1chr9

35711789

-
3UTR-3CDSENST00000486056ENST00000540444CREB3chr9

35733482

+TLN1chr9

35711789

-
3UTR-5UTRENST00000486056ENST00000314888CREB3chr9

35733279

+TLN1chr9

35725724

-
3UTR-5UTRENST00000486056ENST00000540444CREB3chr9

35733279

+TLN1chr9

35725724

-
3UTR-intronENST00000486056ENST00000464379CREB3chr9

35733279

+TLN1chr9

35725724

-
3UTR-intronENST00000486056ENST00000464379CREB3chr9

35733279

+TLN1chr9

35711789

-
3UTR-intronENST00000486056ENST00000464379CREB3chr9

35733482

+TLN1chr9

35711789

-
5CDS-5UTRENST00000353704ENST00000314888CREB3chr9

35733279

+TLN1chr9

35725724

-
5CDS-5UTRENST00000353704ENST00000540444CREB3chr9

35733279

+TLN1chr9

35725724

-
5CDS-intronENST00000353704ENST00000464379CREB3chr9

35733279

+TLN1chr9

35725724

-
5CDS-intronENST00000353704ENST00000464379CREB3chr9

35733279

+TLN1chr9

35711789

-
5CDS-intronENST00000353704ENST00000464379CREB3chr9

35733482

+TLN1chr9

35711789

-
In-frameENST00000353704ENST00000314888CREB3chr9

35733279

+TLN1chr9

35711789

-
In-frameENST00000353704ENST00000314888CREB3chr9

35733482

+TLN1chr9

35711789

-
In-frameENST00000353704ENST00000540444CREB3chr9

35733279

+TLN1chr9

35711789

-
In-frameENST00000353704ENST00000540444CREB3chr9

35733482

+TLN1chr9

35711789

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CREB3-TLN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CREB3-TLN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:35733482/chr9:35711789)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREB3

O43889

.
FUNCTION: Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613). {ECO:0000269|PubMed:10984507, ECO:0000269|PubMed:15001559, ECO:0000269|PubMed:15845366, ECO:0000269|PubMed:16940180, ECO:0000269|PubMed:17296613, ECO:0000269|PubMed:18587271, ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:9271389}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many promoters to activate transcription of the genes. Binds to the unfolded protein response element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). {ECO:0000269|PubMed:16940180}.; FUNCTION: [Isoform 2]: Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. {ECO:0000269|PubMed:19779205}.; FUNCTION: (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression. {ECO:0000269|PubMed:17054986}.; FUNCTION: [Isoform 1]: (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. {ECO:0000269|PubMed:10623756, ECO:0000269|PubMed:15705566}.; FUNCTION: [Isoform 1]: (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein. {ECO:0000269|PubMed:10675342}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral promoters. {ECO:0000269|PubMed:10623756}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3]: (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein. {ECO:0000269|PubMed:10675342}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+3913_17115372.0MotifNote=LXXLL motif 1
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+3954_58115372.0MotifNote=LXXLL motif 2
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+4913_17145372.0MotifNote=LXXLL motif 1
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+4954_58145372.0MotifNote=LXXLL motif 2
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+391_92115372.0RegionTranscription activation (acidic)
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+491_92145372.0RegionTranscription activation (acidic)
TgeneTLN1chr9:35733279chr9:35711789ENST0000031488827572293_253312272542.0DomainI/LWEQ
TgeneTLN1chr9:35733482chr9:35711789ENST0000031488827572293_253312272542.0DomainI/LWEQ

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39316_361115372.0Compositional biasNote=Pro-rich
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49316_361145372.0Compositional biasNote=Pro-rich
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39150_213115372.0DomainbZIP
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49150_213145372.0DomainbZIP
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39152_184115372.0RegionBasic motif
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39192_213115372.0RegionLeucine-zipper
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49152_184145372.0RegionBasic motif
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49192_213145372.0RegionLeucine-zipper
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+391_230115372.0Topological domainCytoplasmic
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39248_371115372.0Topological domainLumenal
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+491_230145372.0Topological domainCytoplasmic
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49248_371145372.0Topological domainLumenal
HgeneCREB3chr9:35733279chr9:35711789ENST00000353704+39231_247115372.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCREB3chr9:35733482chr9:35711789ENST00000353704+49231_247145372.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTLN1chr9:35733279chr9:35711789ENST00000314888275786_40312272542.0DomainFERM
TgeneTLN1chr9:35733482chr9:35711789ENST00000314888275786_40312272542.0DomainFERM


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Fusion Gene Sequence for CREB3-TLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CREB3-TLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTLN1chr9:35733279chr9:35711789ENST0000031488827571327_19481227.02542.0SYNM
TgeneTLN1chr9:35733482chr9:35711789ENST0000031488827571327_19481227.02542.0SYNM
TgeneTLN1chr9:35733279chr9:35711789ENST0000031488827571359_16591227.02542.0VCL and F-actin
TgeneTLN1chr9:35733482chr9:35711789ENST0000031488827571359_16591227.02542.0VCL and F-actin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTLN1chr9:35733279chr9:35711789ENST000003148882757280_4351227.02542.0LAYN
TgeneTLN1chr9:35733482chr9:35711789ENST000003148882757280_4351227.02542.0LAYN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREB3-TLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREB3-TLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource