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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREBBP-CASKIN1 (FusionGDB2 ID:19353)

Fusion Gene Summary for CREBBP-CASKIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP-CASKIN1
Fusion gene ID: 19353
HgeneTgene
Gene symbol

CREBBP

CASKIN1

Gene ID

1387

57524

Gene nameCREB binding proteinCASK interacting protein 1
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1ANKS5A
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPcaskin-1
Modification date2020032920200313
UniProtAcc

Q92793

Q8WXD9

Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000564289, ENST00000343516, 
Fusion gene scores* DoF score43 X 38 X 17=277783 X 3 X 2=18
# samples 614
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CREBBP [Title/Abstract] AND CASKIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREBBP(3794895)-CASKIN1(2240359), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASKIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GU-A42R-01ACREBBPchr16

3794895

-CASKIN1chr16

2240359

-
ChimerDB4BLCATCGA-GU-A42RCREBBPchr16

3794894

-CASKIN1chr16

2240359

-


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Fusion Gene ORF analysis for CREBBP-CASKIN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262367ENST00000564289CREBBPchr16

3794895

-CASKIN1chr16

2240359

-
5CDS-intronENST00000262367ENST00000564289CREBBPchr16

3794894

-CASKIN1chr16

2240359

-
5CDS-intronENST00000382070ENST00000564289CREBBPchr16

3794895

-CASKIN1chr16

2240359

-
5CDS-intronENST00000382070ENST00000564289CREBBPchr16

3794894

-CASKIN1chr16

2240359

-
In-frameENST00000262367ENST00000343516CREBBPchr16

3794895

-CASKIN1chr16

2240359

-
In-frameENST00000262367ENST00000343516CREBBPchr16

3794894

-CASKIN1chr16

2240359

-
In-frameENST00000382070ENST00000343516CREBBPchr16

3794895

-CASKIN1chr16

2240359

-
In-frameENST00000382070ENST00000343516CREBBPchr16

3794894

-CASKIN1chr16

2240359

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163794895-ENST00000343516CASKIN1chr162240359-10361479260689932795
ENST00000382070CREBBPchr163794895-ENST00000343516CASKIN1chr162240359-96414072082732757
ENST00000262367CREBBPchr163794894-ENST00000343516CASKIN1chr162240359-10361479260689932795
ENST00000382070CREBBPchr163794894-ENST00000343516CASKIN1chr162240359-96414072082732757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000343516CREBBPchr163794895-CASKIN1chr162240359-0.0075499170.9924501
ENST00000382070ENST00000343516CREBBPchr163794895-CASKIN1chr162240359-0.0046009910.99539906
ENST00000262367ENST00000343516CREBBPchr163794894-CASKIN1chr162240359-0.0075499170.9924501
ENST00000382070ENST00000343516CREBBPchr163794894-CASKIN1chr162240359-0.0046009910.99539906

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Fusion Genomic Features for CREBBP-CASKIN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CREBBP-CASKIN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3794895/chr16:2240359)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

CASKIN1

Q8WXD9

FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.FUNCTION: May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311061_106413272443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301061_106412892405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311061_106413272443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301061_106412892405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311103_117513272443.0DomainBromo
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-2331587_66613272443.0DomainKIX
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301103_117512892405.0DomainBromo
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-2230587_66612892405.0DomainKIX
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311103_117513272443.0DomainBromo
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-2331587_66613272443.0DomainKIX
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301103_117512892405.0DomainBromo
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-2230587_66612892405.0DomainKIX
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-2331347_43313272443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-2230347_43312892405.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-2331347_43313272443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-2230347_43312892405.0Zinc fingerTAZ-type 1
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020714_1365311432.0Compositional biasNote=Pro-rich
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020714_1365311432.0Compositional biasNote=Pro-rich
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020281_347311432.0DomainSH3
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020472_535311432.0DomainSAM 1
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020541_605311432.0DomainSAM 2
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020281_347311432.0DomainSH3
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020472_535311432.0DomainSAM 1
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020541_605311432.0DomainSAM 2
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020375_469311432.0RegionCASK-binding
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020375_469311432.0RegionCASK-binding
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020114_143311432.0RepeatNote=ANK 3
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020147_176311432.0RepeatNote=ANK 4
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020188_217311432.0RepeatNote=ANK 5
TgeneCASKIN1chr16:3794894chr16:2240359ENST00000343516020220_249311432.0RepeatNote=ANK 6
TgeneCASKIN1chr16:3794894chr16:2240359ENST0000034351602048_77311432.0RepeatNote=ANK 1
TgeneCASKIN1chr16:3794894chr16:2240359ENST0000034351602081_110311432.0RepeatNote=ANK 2
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020114_143311432.0RepeatNote=ANK 3
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020147_176311432.0RepeatNote=ANK 4
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020188_217311432.0RepeatNote=ANK 5
TgeneCASKIN1chr16:3794895chr16:2240359ENST00000343516020220_249311432.0RepeatNote=ANK 6
TgeneCASKIN1chr16:3794895chr16:2240359ENST0000034351602048_77311432.0RepeatNote=ANK 1
TgeneCASKIN1chr16:3794895chr16:2240359ENST0000034351602081_110311432.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311199_148713272443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311555_156213272443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311943_194813272443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311967_197013272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23312081_208513272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23312199_221613272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23312245_224813272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23312297_230013272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301199_148712892405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301555_156212892405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301943_194812892405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301967_197012892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22302081_208512892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22302199_221612892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22302245_224812892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22302297_230012892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311199_148713272443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311555_156213272443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311943_194813272443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311967_197013272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23312081_208513272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23312199_221613272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23312245_224813272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23312297_230013272443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301199_148712892405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301555_156212892405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301943_194812892405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301967_197012892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22302081_208512892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22302199_221612892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22302245_224812892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22302297_230012892405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311323_170013272443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301323_170012892405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311323_170013272443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301323_170012892405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311434_143613272443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311446_144713272443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301434_143612892405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301446_144712892405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311434_143613272443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311446_144713272443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301434_143612892405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301446_144712892405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311701_174413272443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311765_184613272443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301701_174412892405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301765_184612892405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311701_174413272443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311765_184613272443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301701_174412892405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301765_184612892405.0Zinc fingerTAZ-type 2


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Fusion Gene Sequence for CREBBP-CASKIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19353_19353_1_CREBBP-CASKIN1_CREBBP_chr16_3794894_ENST00000262367_CASKIN1_chr16_2240359_ENST00000343516_length(transcript)=10361nt_BP=4792nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGATTTT
GGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTT
CCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGC
GCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAG
AGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCA
CTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAAC
TTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAAT
GGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCT
GAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACT
GGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAA
CAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACA
TCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTA
CTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAAC
GTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAG
AACTGCACACGACATGACTGTCCTGTTTGCCTCCCTTTGAAAAATGCCAGTGACAAGCGAAACCAACAAACCATCCTGGGGTCTCCAGCT
AGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCC
ATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCA
CAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAG
CAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAAC
ATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTG
CGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTA
GCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAG
ATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCT
CAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGG
ATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCT
GTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACC
AACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATG
GGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCC
AGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAG
CACACGACACCACCTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACC
CCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCT
CAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCG
CTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCT
GACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAG
ATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAA
AAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCG
CGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCT
TTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGG
AAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAG
ACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGT
GGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTAT
CAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACG
ACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATG
CATCAGATTTGCGTTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAA
GAAAACAAATTCAGTGCTAAGAAGCTCCTGGGTTCCACCAAGAAGATCAATGTCAACTTCCAGGACCCGGATGGCTTCTCGGCTCTGCAC
CATGCGGCCCTGAACGGCAACACGGAATTGATCAGCCTGCTGCTGGAGGCCCAGGCCGCTGTGGACATCAAGGACAACAAAGGCATGCGG
CCGCTGCACTATGCGGCCTGGCAGGGCCGGAAGGAGCCCATGAAGCTGGTGCTGAAGGCGGGCTCGGCCGTGAACATCCCGTCTGATGAG
GGCCACATCCCCCTGCACCTGGCGGCCCAGCATGGTCACTATGATGTGTCTGAGATGCTGCTACAGCACCAGTCTAACCCGTGCATGGTG
GACAACTCGGGGAAGACGCCCCTGGACCTGGCCTGCGAGTTCGGCCGCGTTGGGGTGGTCCAGCTGCTCCTCAGCAGCAATATGTGTGCG
GCGCTGCTGGAGCCCCGGCCGGGAGACGCCACCGACCCCAACGGCACCAGCCCTTTGCACCTCGCAGCTAAAAACGGCCACATCGACATC
ATCAGGCTCCTCCTCCAAGCCGGCATCGACATTAACCGCCAGACCAAGTCCGGCACGGCCCTGCACGAGGCTGCGCTCTGCGGAAAGACA
GAGGTGGTGCGGCTGCTGCTGGATAGCGGGATCAATGCCCACGTGAGGAACACCTACAGCCAGACAGCCCTGGACATCGTGCACCAGTTC
ACCACGTCCCAGGCCAGCAGGGAGATCAAGCAGCTGTTGCGAGAGGCCTCAGCGGCCCTGCAGGTCCGGGCGACCAAGGATTATTGCAAC
AATTACGACCTGACCAGCCTCAACGTGAAGGCAGGGGACATCATCACAGTCCTCGAGCAGCATCCGGATGGCCGGTGGAAGGGCTGCATC
CATGACAACCGGACGGGCAATGACCGGGTGGGCTACTTCCCGTCCTCCCTGGGCGAGGCCATTGTCAAGCGAGCAGGTTCCCGAGCAGGC
ACTGAACCAAGCCTGCCCCAGGGAAGCAGCTCATCGGGACCCTCTGCACCCCCAGAGGAGATCTGGGTGCTGAGGAAGCCTTTTGCAGGT
GGGGACCGAAGCGGCAGCATTAGCGGCATGGCTGGCGGCCGGGGCAGCGGGGGTCACGCCCTACACGCGGGCTCTGAAGGCGTCAAGCTC
CTGGCAACGGTGCTTTCCCAGAAGTCCGTCTCTGAGTCCGGCCCGGGGGACAGCCCCGCCAAGCCTCCGGAAGGCTCTGCAGGTGTGGCC
CGGTCCCAGCCTCCAGTGGCCCACGCCGGGCAGGTCTATGGGGAGCAGCCGCCCAAGAAGCTGGAGCCAGCATCGGAGGGCAAGAGCTCT
GAGGCCGTGAGCCAGTGGCTCACCGCGTTCCAGCTGCAGCTCTACGCCCCCAACTTCATCAGCGCCGGCTACGACCTGCCCACCATCAGC
CGCATGACTCCCGAGGACCTCACGGCCATTGGTGTCACCAAGCCGGGCCACCGGAAGAAGATCGCGGCAGAGATCAGCGGCCTAAGCATC
CCTGACTGGCTGCCTGAGCACAAACCCGCTAACCTGGCCGTGTGGCTGTCCATGATCGGCCTGGCCCAGTACTACAAGGTGTTGGTGGAC
AATGGCTACGAGAACATTGATTTCATCACCGACATCACCTGGGAGGACCTGCAGGAGATCGGCATCACCAAGCTGGGGCACCAGAAGAAG
CTGATGCTCGCTGTGAGGAAGCTGGCAGAGCTGCAGAAGGCTGAATACGCCAAGTATGAGGGGGGCCCCCTGCGCCGGAAGGCGCCCCAG
TCTCTTGAAGTGATGGCCATCGAGTCGCCGCCCCCGCCTGAGCCCACACCGGCCGACTGCCAGTCCCCTAAAATGACCACCTTCCAGGAC
AGCGAGCTCAGTGACGAGCTGCAGGCTGCCATGACTGGCCCGGCTGAGGTGGGGCCCACCACTGAGAAGCCCTCCAGCCACCTGCCACCC
ACCCCGAGGGCCACCACGCGGCAGGACTCCAGCCTGGGTGGTCGGGCACGGCACATGAGCAGCTCGCAGGAGCTGCTGGGAGATGGGCCC
CCTGGGCCCAGCAGCCCCATGTCTCGAAGCCAGGAGTACCTCCTGGATGAGGGCCCCGCCCCCGGCACCCCGCCCAGGGAGGCCCGGCCC
GGCCGCCACGGCCACAGCATCAAGAGGGCCAGCGTGCCCCCCGTGCCTGGCAAGCCACGGCAGGTCCTCCCACCAGGCACTAGCCACTTC
ACGCCCCCCCAGACGCCCACCAAAACCCGACCAGGCTCTCCCCAGGCCCTTGGGGGACCTCATGGTCCAGCCCCAGCTACGGCCAAGGTG
AAGCCCACCCCGCAGCTGCTGCCGCCGACAGAGCGCCCCATGTCACCCCGCTCCCTGCCTCAGTCACCGACGCACCGCGGCTTTGCCTAC
GTGCTGCCCCAGCCCGTGGAGGGCGAGGTGGGGCCGGCTGCCCCGGGGCCTGCGCCCCCACCCGTGCCGACGGCTGTGCCCACACTGTGC
CTGCCCCCTGAGGCCGACGCGGAGCCGGGGCGGCCCAAGAAGCGGGCCCACAGCCTGAATCGCTATGCGGCGTCCGACAGCGAGCCGGAG
CGGGACGAGCTGCTGGTGCCTGCGGCTGCCGGCCCCTATGCCACGGTCCAGCGGCGCGTGGGCCGCAGCCACTCAGTGAGGGCGCCCGCA
GGTGCCGACAAGAACGTCAACCGCAGCCAGTCCTTTGCCGTGCGGCCCCGAAAGAAGGGGCCCCCGCCGCCCCCACCCAAGCGCTCCAGC
TCGGCCCTGGCTAGTGCCAACCTGGCGGATGAGCCGGTGCCTGACGCCGAGCCTGAGGATGGCCTGCTGGGGGTCCGGGCACAGTGCCGG
CGGGCCAGTGACCTGGCCGGCAGCGTGGACACGGGTAGTGCCGGCAGTGTGAAGAGCATCGCGGCCATGCTGGAGCTGTCCTCCATTGGG
GGTGGGGGCCGGGCTGCCCGCAGGCCTCCTGAGGGCCACCCCACTCCCCGCCCTGCCAGCCCAGAGCCGGGCCGGGTGGCCACCGTGCTG
GCCTCAGTGAAACACAAAGAGGCCATCGGGCCTGGCGGGGAGGTGGTGAACCGGCGCCGCACGCTCAGCGGGCCAGTCACCGGACTTCTG
GCCACTGCCCGCCGGGGGCCTGGGGAGTCGGCAGACCCAGGCCCCTTTGTGGAGGATGGCACTGGCCGGCAGCGGCCTCGGGGTCCCTCC
AAGGGCGAGGCGGGTGTCGAAGGCCCGCCCTTGGCCAAGGTGGAAGCCAGCGCCACACTCAAGAGGCGCATCCGGGCCAAGCAGAACCAG
CAGGAGAACGTCAAGTTCATCCTGACCGAGTCTGACACGGTCAAGCGCAGGCCCAAGGCCAAGGAGCGGGAGGCCGGGCCTGAGCCACCA
CCGCCACTGTCCGTGTACCATAATGGCACTGGCACCGTGCGCCGCCGACCGGCCTCGGAGCAGGCTGGGCCTCCGGAGCTGCCTCCACCG
CCCCCGCCTGCCGAACCCCCGCCCACCGACCTGGCGCACCTACCCCCATTGCCCCCGCCCGAGGGCGAAGCCCGGAAGCCGGCCAAGCCG
CCTGTCTCTCCCAAGCCCGTCCTGACGCAGCCTGTGCCCAAGCTCCAGGGCTCGCCCACACCCACCTCCAAGAAGGTGCCGCTGCCAGGC
CCTGGCAGCCCAGAGGTGAAGCGCGCCCACGGCACGCCACCGCCCGTGTCTCCCAAGCCGCCGCCGCCGCCCACAGCGCCCAAGCCCGTC
AAGGCGGTCGCGGGGCTGCCTTCGGGCAGCGCCGGCCCTTCACCCGCACCCTCGCCCGCGCGACAGCCGCCCGCCGCCCTCGCCAAGCCG
CCCGGTACGCCGCCCTCGCTGGGCGCCAGCCCCGCCAAGCCCCCGTCCCCCGGCGCGCCCGCGCTGCACGTGCCCGCCAAGCCCCCGCGA
GCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGCCCCCCGCCCCGCCCGAAGGCGCCTCGCCAGGGGACAGCGCCCGGCAGAAACTGGAG
GAGACAAGCGCGTGCCTGGCCGCGGCGCTGCAGGCGGTGGAGGAGAAGATCCGGCAGGAGGACGCGCAGGGCCCGCGCGACTCGGCGGCG
GAAAAGAGCACTGGCAGCATCCTGGACGACATCGGCAGCATGTTCGACGACCTGGCCGACCAGCTGGATGCCATGCTGGAGTGAACGCCG
CCTGGCCGGGCCCTCCCGCGCCGCCCGGGCCCTCCCCGCACACTGACCTATACCTCAGGATGGGCGCGTCTGGGCGCGGCGCGAGCGGCC
GGGCAGGGCCCTGCAGAAGCACAACTCCGGCCCCTGGACCCGGGCCGGGGCGCCCACCGGGGACCGCCTGGCCGGGGGCTCCAAGGGCTC
TAGGCAGACCCTGCGCCCGCGGGTCCTCCCCACCTGCTGCTCCCCGTGCAATACCTGCTGGGCCTCCTGCCCGCGCGGGAGGGGAGGGCG
CCCCGGGACCAGGGATGGGGCAGCGCACAGGCCCGGGCCCAGCACAGAACTGCCCATCGGGACGCCCGGCCAGCCGCTCGGGCGCAGCAC
AAGGGACAGGGGACCAAGGTCAGGGCCCCCCTGCCCCACCGCACCCCCAGAATATAAGCTATCAAGAGTATTAATTTATTGGGAATGAGC
TGAGGCGGATTTCCCCAGAGAAACAAAAAGGTATAACTTTAACAAATATATATTTAAAGAAAGAAATATTATTGATTCTATAGAAAACCA
TTTACCAACTGAAAGGACACGAAGTCTAGCTCCGGACAAAAGCTGTTAGAGGCCCAGGCTGTCTGCCTGCGGTCCTTCCTCCGGCCAGAG
TGGAGGCCCCAGGCTGCTAGCACAGGTGGAAGGCTGGGGCCCGGGGGCGGGTGCTCTGCCGGGGGCTCCTCCGTGCTTCTCTCCTAAGTT
CTCTGCGCCCCAAGAACTCGAGGTTGTGCCTTGCTCTCGGCGGCCGTGTCCTCCTCCTGGCGTGGCTGCGTCCCAGGGCGCGGGTGGGTT
TGGTGAATGTGGGTGTGTCAGCGTGGCAGCCACGTGGAAGCAGGGCATGTAGCAGGCCAGGCCACGGGCTTGCAGCTCCTCTGAGGGTGT
GCCTGGCCCCCTCTCCAGGGGCTGTGCAGGCAGCCCATCCACCCCAGTGGAGTTCCCACGGACGCTTCTGCTCATGGTCCAAGGCTGTGT
TGTGTGGTCATTCTCGCCCTCCCTTTTCCTCTCTCCTCCTGCCCCCTCCAAGAAGTACTGACTGGTCTCCTCTATCGTGTTTGCTGATCC
ACAGTGTTGGGCACAACTTTGACGTTTCTTAAAAAAAAAATTTAAAAAATGCCGAAAACCAGCGATTGTGGTGTGGGGCGGGTGGAGGCG
GCTGGCGGAGGTGGCGTCCCGGCGTGCAGGGCCCCTTCCTGCTGTCTCACCCCGTGTTTCCCTGCGAGTGGACGTGCCCAGCTGTCCCCC
CAGGCCTCTCCTCAGAGGGCGGCACAGGCTGGGCTCCAGCAGGTGGGCAGGGGAGGTCTGGGCAAGGCGCTGCCGTCGGCTGTCAATAAA

>19353_19353_1_CREBBP-CASKIN1_CREBBP_chr16_3794894_ENST00000262367_CASKIN1_chr16_2240359_ENST00000343516_length(amino acids)=2795AA_BP=1396
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSN
PNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLM
NDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYH
LLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPR
AASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNP
LNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAA
QAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGE
SKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALY
RQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPV
MQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVD
CKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVD
IKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQL
LLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQT
ALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIV
KRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKP
PEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIA
AEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGG
PLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSS
QELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHG
PAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRY
AASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGL
LGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTL
SGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKE
REAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPT
SKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPAL
HVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQL

--------------------------------------------------------------
>19353_19353_2_CREBBP-CASKIN1_CREBBP_chr16_3794894_ENST00000382070_CASKIN1_chr16_2240359_ENST00000343516_length(transcript)=9641nt_BP=4072nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGATTTTGGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGC
CTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATC
AACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATG
GCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGG
CCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGA
CCTGGTATCTGCATGAATGCTAACTTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCA
CAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAG
GGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGA
GGCATGGCCAAGATGGGAATAACTGGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGA
GTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTG
CCAAATATGTCTCAGATGCAAACATCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAA
CTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTC
CCGCATTGTCGAACCATGAAAAACGTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGCCATCCTGGGGTCTCCAGCT
AGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCC
ATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCA
CAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAG
CAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAAC
ATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTG
CGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTA
GCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAG
ATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCT
CAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGG
ATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCT
GTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACC
AACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATG
GGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCC
AGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAG
CACACGACACCACCTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACC
CCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCT
CAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCG
CTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCT
GACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAG
ATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAA
AAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCG
CGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCT
TTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGG
AAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAG
ACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGT
GGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTAT
CAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACG
ACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATG
CATCAGATTTGCGTTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAA
GAAAACAAATTCAGTGCTAAGAAGCTCCTGGGTTCCACCAAGAAGATCAATGTCAACTTCCAGGACCCGGATGGCTTCTCGGCTCTGCAC
CATGCGGCCCTGAACGGCAACACGGAATTGATCAGCCTGCTGCTGGAGGCCCAGGCCGCTGTGGACATCAAGGACAACAAAGGCATGCGG
CCGCTGCACTATGCGGCCTGGCAGGGCCGGAAGGAGCCCATGAAGCTGGTGCTGAAGGCGGGCTCGGCCGTGAACATCCCGTCTGATGAG
GGCCACATCCCCCTGCACCTGGCGGCCCAGCATGGTCACTATGATGTGTCTGAGATGCTGCTACAGCACCAGTCTAACCCGTGCATGGTG
GACAACTCGGGGAAGACGCCCCTGGACCTGGCCTGCGAGTTCGGCCGCGTTGGGGTGGTCCAGCTGCTCCTCAGCAGCAATATGTGTGCG
GCGCTGCTGGAGCCCCGGCCGGGAGACGCCACCGACCCCAACGGCACCAGCCCTTTGCACCTCGCAGCTAAAAACGGCCACATCGACATC
ATCAGGCTCCTCCTCCAAGCCGGCATCGACATTAACCGCCAGACCAAGTCCGGCACGGCCCTGCACGAGGCTGCGCTCTGCGGAAAGACA
GAGGTGGTGCGGCTGCTGCTGGATAGCGGGATCAATGCCCACGTGAGGAACACCTACAGCCAGACAGCCCTGGACATCGTGCACCAGTTC
ACCACGTCCCAGGCCAGCAGGGAGATCAAGCAGCTGTTGCGAGAGGCCTCAGCGGCCCTGCAGGTCCGGGCGACCAAGGATTATTGCAAC
AATTACGACCTGACCAGCCTCAACGTGAAGGCAGGGGACATCATCACAGTCCTCGAGCAGCATCCGGATGGCCGGTGGAAGGGCTGCATC
CATGACAACCGGACGGGCAATGACCGGGTGGGCTACTTCCCGTCCTCCCTGGGCGAGGCCATTGTCAAGCGAGCAGGTTCCCGAGCAGGC
ACTGAACCAAGCCTGCCCCAGGGAAGCAGCTCATCGGGACCCTCTGCACCCCCAGAGGAGATCTGGGTGCTGAGGAAGCCTTTTGCAGGT
GGGGACCGAAGCGGCAGCATTAGCGGCATGGCTGGCGGCCGGGGCAGCGGGGGTCACGCCCTACACGCGGGCTCTGAAGGCGTCAAGCTC
CTGGCAACGGTGCTTTCCCAGAAGTCCGTCTCTGAGTCCGGCCCGGGGGACAGCCCCGCCAAGCCTCCGGAAGGCTCTGCAGGTGTGGCC
CGGTCCCAGCCTCCAGTGGCCCACGCCGGGCAGGTCTATGGGGAGCAGCCGCCCAAGAAGCTGGAGCCAGCATCGGAGGGCAAGAGCTCT
GAGGCCGTGAGCCAGTGGCTCACCGCGTTCCAGCTGCAGCTCTACGCCCCCAACTTCATCAGCGCCGGCTACGACCTGCCCACCATCAGC
CGCATGACTCCCGAGGACCTCACGGCCATTGGTGTCACCAAGCCGGGCCACCGGAAGAAGATCGCGGCAGAGATCAGCGGCCTAAGCATC
CCTGACTGGCTGCCTGAGCACAAACCCGCTAACCTGGCCGTGTGGCTGTCCATGATCGGCCTGGCCCAGTACTACAAGGTGTTGGTGGAC
AATGGCTACGAGAACATTGATTTCATCACCGACATCACCTGGGAGGACCTGCAGGAGATCGGCATCACCAAGCTGGGGCACCAGAAGAAG
CTGATGCTCGCTGTGAGGAAGCTGGCAGAGCTGCAGAAGGCTGAATACGCCAAGTATGAGGGGGGCCCCCTGCGCCGGAAGGCGCCCCAG
TCTCTTGAAGTGATGGCCATCGAGTCGCCGCCCCCGCCTGAGCCCACACCGGCCGACTGCCAGTCCCCTAAAATGACCACCTTCCAGGAC
AGCGAGCTCAGTGACGAGCTGCAGGCTGCCATGACTGGCCCGGCTGAGGTGGGGCCCACCACTGAGAAGCCCTCCAGCCACCTGCCACCC
ACCCCGAGGGCCACCACGCGGCAGGACTCCAGCCTGGGTGGTCGGGCACGGCACATGAGCAGCTCGCAGGAGCTGCTGGGAGATGGGCCC
CCTGGGCCCAGCAGCCCCATGTCTCGAAGCCAGGAGTACCTCCTGGATGAGGGCCCCGCCCCCGGCACCCCGCCCAGGGAGGCCCGGCCC
GGCCGCCACGGCCACAGCATCAAGAGGGCCAGCGTGCCCCCCGTGCCTGGCAAGCCACGGCAGGTCCTCCCACCAGGCACTAGCCACTTC
ACGCCCCCCCAGACGCCCACCAAAACCCGACCAGGCTCTCCCCAGGCCCTTGGGGGACCTCATGGTCCAGCCCCAGCTACGGCCAAGGTG
AAGCCCACCCCGCAGCTGCTGCCGCCGACAGAGCGCCCCATGTCACCCCGCTCCCTGCCTCAGTCACCGACGCACCGCGGCTTTGCCTAC
GTGCTGCCCCAGCCCGTGGAGGGCGAGGTGGGGCCGGCTGCCCCGGGGCCTGCGCCCCCACCCGTGCCGACGGCTGTGCCCACACTGTGC
CTGCCCCCTGAGGCCGACGCGGAGCCGGGGCGGCCCAAGAAGCGGGCCCACAGCCTGAATCGCTATGCGGCGTCCGACAGCGAGCCGGAG
CGGGACGAGCTGCTGGTGCCTGCGGCTGCCGGCCCCTATGCCACGGTCCAGCGGCGCGTGGGCCGCAGCCACTCAGTGAGGGCGCCCGCA
GGTGCCGACAAGAACGTCAACCGCAGCCAGTCCTTTGCCGTGCGGCCCCGAAAGAAGGGGCCCCCGCCGCCCCCACCCAAGCGCTCCAGC
TCGGCCCTGGCTAGTGCCAACCTGGCGGATGAGCCGGTGCCTGACGCCGAGCCTGAGGATGGCCTGCTGGGGGTCCGGGCACAGTGCCGG
CGGGCCAGTGACCTGGCCGGCAGCGTGGACACGGGTAGTGCCGGCAGTGTGAAGAGCATCGCGGCCATGCTGGAGCTGTCCTCCATTGGG
GGTGGGGGCCGGGCTGCCCGCAGGCCTCCTGAGGGCCACCCCACTCCCCGCCCTGCCAGCCCAGAGCCGGGCCGGGTGGCCACCGTGCTG
GCCTCAGTGAAACACAAAGAGGCCATCGGGCCTGGCGGGGAGGTGGTGAACCGGCGCCGCACGCTCAGCGGGCCAGTCACCGGACTTCTG
GCCACTGCCCGCCGGGGGCCTGGGGAGTCGGCAGACCCAGGCCCCTTTGTGGAGGATGGCACTGGCCGGCAGCGGCCTCGGGGTCCCTCC
AAGGGCGAGGCGGGTGTCGAAGGCCCGCCCTTGGCCAAGGTGGAAGCCAGCGCCACACTCAAGAGGCGCATCCGGGCCAAGCAGAACCAG
CAGGAGAACGTCAAGTTCATCCTGACCGAGTCTGACACGGTCAAGCGCAGGCCCAAGGCCAAGGAGCGGGAGGCCGGGCCTGAGCCACCA
CCGCCACTGTCCGTGTACCATAATGGCACTGGCACCGTGCGCCGCCGACCGGCCTCGGAGCAGGCTGGGCCTCCGGAGCTGCCTCCACCG
CCCCCGCCTGCCGAACCCCCGCCCACCGACCTGGCGCACCTACCCCCATTGCCCCCGCCCGAGGGCGAAGCCCGGAAGCCGGCCAAGCCG
CCTGTCTCTCCCAAGCCCGTCCTGACGCAGCCTGTGCCCAAGCTCCAGGGCTCGCCCACACCCACCTCCAAGAAGGTGCCGCTGCCAGGC
CCTGGCAGCCCAGAGGTGAAGCGCGCCCACGGCACGCCACCGCCCGTGTCTCCCAAGCCGCCGCCGCCGCCCACAGCGCCCAAGCCCGTC
AAGGCGGTCGCGGGGCTGCCTTCGGGCAGCGCCGGCCCTTCACCCGCACCCTCGCCCGCGCGACAGCCGCCCGCCGCCCTCGCCAAGCCG
CCCGGTACGCCGCCCTCGCTGGGCGCCAGCCCCGCCAAGCCCCCGTCCCCCGGCGCGCCCGCGCTGCACGTGCCCGCCAAGCCCCCGCGA
GCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGCCCCCCGCCCCGCCCGAAGGCGCCTCGCCAGGGGACAGCGCCCGGCAGAAACTGGAG
GAGACAAGCGCGTGCCTGGCCGCGGCGCTGCAGGCGGTGGAGGAGAAGATCCGGCAGGAGGACGCGCAGGGCCCGCGCGACTCGGCGGCG
GAAAAGAGCACTGGCAGCATCCTGGACGACATCGGCAGCATGTTCGACGACCTGGCCGACCAGCTGGATGCCATGCTGGAGTGAACGCCG
CCTGGCCGGGCCCTCCCGCGCCGCCCGGGCCCTCCCCGCACACTGACCTATACCTCAGGATGGGCGCGTCTGGGCGCGGCGCGAGCGGCC
GGGCAGGGCCCTGCAGAAGCACAACTCCGGCCCCTGGACCCGGGCCGGGGCGCCCACCGGGGACCGCCTGGCCGGGGGCTCCAAGGGCTC
TAGGCAGACCCTGCGCCCGCGGGTCCTCCCCACCTGCTGCTCCCCGTGCAATACCTGCTGGGCCTCCTGCCCGCGCGGGAGGGGAGGGCG
CCCCGGGACCAGGGATGGGGCAGCGCACAGGCCCGGGCCCAGCACAGAACTGCCCATCGGGACGCCCGGCCAGCCGCTCGGGCGCAGCAC
AAGGGACAGGGGACCAAGGTCAGGGCCCCCCTGCCCCACCGCACCCCCAGAATATAAGCTATCAAGAGTATTAATTTATTGGGAATGAGC
TGAGGCGGATTTCCCCAGAGAAACAAAAAGGTATAACTTTAACAAATATATATTTAAAGAAAGAAATATTATTGATTCTATAGAAAACCA
TTTACCAACTGAAAGGACACGAAGTCTAGCTCCGGACAAAAGCTGTTAGAGGCCCAGGCTGTCTGCCTGCGGTCCTTCCTCCGGCCAGAG
TGGAGGCCCCAGGCTGCTAGCACAGGTGGAAGGCTGGGGCCCGGGGGCGGGTGCTCTGCCGGGGGCTCCTCCGTGCTTCTCTCCTAAGTT
CTCTGCGCCCCAAGAACTCGAGGTTGTGCCTTGCTCTCGGCGGCCGTGTCCTCCTCCTGGCGTGGCTGCGTCCCAGGGCGCGGGTGGGTT
TGGTGAATGTGGGTGTGTCAGCGTGGCAGCCACGTGGAAGCAGGGCATGTAGCAGGCCAGGCCACGGGCTTGCAGCTCCTCTGAGGGTGT
GCCTGGCCCCCTCTCCAGGGGCTGTGCAGGCAGCCCATCCACCCCAGTGGAGTTCCCACGGACGCTTCTGCTCATGGTCCAAGGCTGTGT
TGTGTGGTCATTCTCGCCCTCCCTTTTCCTCTCTCCTCCTGCCCCCTCCAAGAAGTACTGACTGGTCTCCTCTATCGTGTTTGCTGATCC
ACAGTGTTGGGCACAACTTTGACGTTTCTTAAAAAAAAAATTTAAAAAATGCCGAAAACCAGCGATTGTGGTGTGGGGCGGGTGGAGGCG
GCTGGCGGAGGTGGCGTCCCGGCGTGCAGGGCCCCTTCCTGCTGTCTCACCCCGTGTTTCCCTGCGAGTGGACGTGCCCAGCTGTCCCCC
CAGGCCTCTCCTCAGAGGGCGGCACAGGCTGGGCTCCAGCAGGTGGGCAGGGGAGGTCTGGGCAAGGCGCTGCCGTCGGCTGTCAATAAA

>19353_19353_2_CREBBP-CASKIN1_CREBBP_chr16_3794894_ENST00000382070_CASKIN1_chr16_2240359_ENST00000343516_length(amino acids)=2757AA_BP=1358
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA
QPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDL
RSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGA
QPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHT
NNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQ
HTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTP
LSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDE
KKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKR
KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSY
QNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK
ENKFSAKKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDE
GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI
IRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCN
NYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAG
GDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSS
EAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVD
NGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQD
SELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARP
GRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAY
VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPA
GADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIG
GGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPS
KGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPP
PPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPV
KAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLE

--------------------------------------------------------------
>19353_19353_3_CREBBP-CASKIN1_CREBBP_chr16_3794895_ENST00000262367_CASKIN1_chr16_2240359_ENST00000343516_length(transcript)=10361nt_BP=4792nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGATTTT
GGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTT
CCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGC
GCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAG
AGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCA
CTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAAC
TTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAAT
GGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCT
GAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACT
GGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAA
CAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACA
TCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTA
CTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAAC
GTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAG
AACTGCACACGACATGACTGTCCTGTTTGCCTCCCTTTGAAAAATGCCAGTGACAAGCGAAACCAACAAACCATCCTGGGGTCTCCAGCT
AGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCC
ATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCA
CAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAG
CAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAAC
ATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTG
CGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTA
GCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAG
ATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCT
CAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGG
ATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCT
GTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACC
AACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATG
GGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCC
AGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAG
CACACGACACCACCTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACC
CCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCT
CAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCG
CTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCT
GACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAG
ATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAA
AAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCG
CGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCT
TTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGG
AAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAG
ACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGT
GGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTAT
CAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACG
ACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATG
CATCAGATTTGCGTTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAA
GAAAACAAATTCAGTGCTAAGAAGCTCCTGGGTTCCACCAAGAAGATCAATGTCAACTTCCAGGACCCGGATGGCTTCTCGGCTCTGCAC
CATGCGGCCCTGAACGGCAACACGGAATTGATCAGCCTGCTGCTGGAGGCCCAGGCCGCTGTGGACATCAAGGACAACAAAGGCATGCGG
CCGCTGCACTATGCGGCCTGGCAGGGCCGGAAGGAGCCCATGAAGCTGGTGCTGAAGGCGGGCTCGGCCGTGAACATCCCGTCTGATGAG
GGCCACATCCCCCTGCACCTGGCGGCCCAGCATGGTCACTATGATGTGTCTGAGATGCTGCTACAGCACCAGTCTAACCCGTGCATGGTG
GACAACTCGGGGAAGACGCCCCTGGACCTGGCCTGCGAGTTCGGCCGCGTTGGGGTGGTCCAGCTGCTCCTCAGCAGCAATATGTGTGCG
GCGCTGCTGGAGCCCCGGCCGGGAGACGCCACCGACCCCAACGGCACCAGCCCTTTGCACCTCGCAGCTAAAAACGGCCACATCGACATC
ATCAGGCTCCTCCTCCAAGCCGGCATCGACATTAACCGCCAGACCAAGTCCGGCACGGCCCTGCACGAGGCTGCGCTCTGCGGAAAGACA
GAGGTGGTGCGGCTGCTGCTGGATAGCGGGATCAATGCCCACGTGAGGAACACCTACAGCCAGACAGCCCTGGACATCGTGCACCAGTTC
ACCACGTCCCAGGCCAGCAGGGAGATCAAGCAGCTGTTGCGAGAGGCCTCAGCGGCCCTGCAGGTCCGGGCGACCAAGGATTATTGCAAC
AATTACGACCTGACCAGCCTCAACGTGAAGGCAGGGGACATCATCACAGTCCTCGAGCAGCATCCGGATGGCCGGTGGAAGGGCTGCATC
CATGACAACCGGACGGGCAATGACCGGGTGGGCTACTTCCCGTCCTCCCTGGGCGAGGCCATTGTCAAGCGAGCAGGTTCCCGAGCAGGC
ACTGAACCAAGCCTGCCCCAGGGAAGCAGCTCATCGGGACCCTCTGCACCCCCAGAGGAGATCTGGGTGCTGAGGAAGCCTTTTGCAGGT
GGGGACCGAAGCGGCAGCATTAGCGGCATGGCTGGCGGCCGGGGCAGCGGGGGTCACGCCCTACACGCGGGCTCTGAAGGCGTCAAGCTC
CTGGCAACGGTGCTTTCCCAGAAGTCCGTCTCTGAGTCCGGCCCGGGGGACAGCCCCGCCAAGCCTCCGGAAGGCTCTGCAGGTGTGGCC
CGGTCCCAGCCTCCAGTGGCCCACGCCGGGCAGGTCTATGGGGAGCAGCCGCCCAAGAAGCTGGAGCCAGCATCGGAGGGCAAGAGCTCT
GAGGCCGTGAGCCAGTGGCTCACCGCGTTCCAGCTGCAGCTCTACGCCCCCAACTTCATCAGCGCCGGCTACGACCTGCCCACCATCAGC
CGCATGACTCCCGAGGACCTCACGGCCATTGGTGTCACCAAGCCGGGCCACCGGAAGAAGATCGCGGCAGAGATCAGCGGCCTAAGCATC
CCTGACTGGCTGCCTGAGCACAAACCCGCTAACCTGGCCGTGTGGCTGTCCATGATCGGCCTGGCCCAGTACTACAAGGTGTTGGTGGAC
AATGGCTACGAGAACATTGATTTCATCACCGACATCACCTGGGAGGACCTGCAGGAGATCGGCATCACCAAGCTGGGGCACCAGAAGAAG
CTGATGCTCGCTGTGAGGAAGCTGGCAGAGCTGCAGAAGGCTGAATACGCCAAGTATGAGGGGGGCCCCCTGCGCCGGAAGGCGCCCCAG
TCTCTTGAAGTGATGGCCATCGAGTCGCCGCCCCCGCCTGAGCCCACACCGGCCGACTGCCAGTCCCCTAAAATGACCACCTTCCAGGAC
AGCGAGCTCAGTGACGAGCTGCAGGCTGCCATGACTGGCCCGGCTGAGGTGGGGCCCACCACTGAGAAGCCCTCCAGCCACCTGCCACCC
ACCCCGAGGGCCACCACGCGGCAGGACTCCAGCCTGGGTGGTCGGGCACGGCACATGAGCAGCTCGCAGGAGCTGCTGGGAGATGGGCCC
CCTGGGCCCAGCAGCCCCATGTCTCGAAGCCAGGAGTACCTCCTGGATGAGGGCCCCGCCCCCGGCACCCCGCCCAGGGAGGCCCGGCCC
GGCCGCCACGGCCACAGCATCAAGAGGGCCAGCGTGCCCCCCGTGCCTGGCAAGCCACGGCAGGTCCTCCCACCAGGCACTAGCCACTTC
ACGCCCCCCCAGACGCCCACCAAAACCCGACCAGGCTCTCCCCAGGCCCTTGGGGGACCTCATGGTCCAGCCCCAGCTACGGCCAAGGTG
AAGCCCACCCCGCAGCTGCTGCCGCCGACAGAGCGCCCCATGTCACCCCGCTCCCTGCCTCAGTCACCGACGCACCGCGGCTTTGCCTAC
GTGCTGCCCCAGCCCGTGGAGGGCGAGGTGGGGCCGGCTGCCCCGGGGCCTGCGCCCCCACCCGTGCCGACGGCTGTGCCCACACTGTGC
CTGCCCCCTGAGGCCGACGCGGAGCCGGGGCGGCCCAAGAAGCGGGCCCACAGCCTGAATCGCTATGCGGCGTCCGACAGCGAGCCGGAG
CGGGACGAGCTGCTGGTGCCTGCGGCTGCCGGCCCCTATGCCACGGTCCAGCGGCGCGTGGGCCGCAGCCACTCAGTGAGGGCGCCCGCA
GGTGCCGACAAGAACGTCAACCGCAGCCAGTCCTTTGCCGTGCGGCCCCGAAAGAAGGGGCCCCCGCCGCCCCCACCCAAGCGCTCCAGC
TCGGCCCTGGCTAGTGCCAACCTGGCGGATGAGCCGGTGCCTGACGCCGAGCCTGAGGATGGCCTGCTGGGGGTCCGGGCACAGTGCCGG
CGGGCCAGTGACCTGGCCGGCAGCGTGGACACGGGTAGTGCCGGCAGTGTGAAGAGCATCGCGGCCATGCTGGAGCTGTCCTCCATTGGG
GGTGGGGGCCGGGCTGCCCGCAGGCCTCCTGAGGGCCACCCCACTCCCCGCCCTGCCAGCCCAGAGCCGGGCCGGGTGGCCACCGTGCTG
GCCTCAGTGAAACACAAAGAGGCCATCGGGCCTGGCGGGGAGGTGGTGAACCGGCGCCGCACGCTCAGCGGGCCAGTCACCGGACTTCTG
GCCACTGCCCGCCGGGGGCCTGGGGAGTCGGCAGACCCAGGCCCCTTTGTGGAGGATGGCACTGGCCGGCAGCGGCCTCGGGGTCCCTCC
AAGGGCGAGGCGGGTGTCGAAGGCCCGCCCTTGGCCAAGGTGGAAGCCAGCGCCACACTCAAGAGGCGCATCCGGGCCAAGCAGAACCAG
CAGGAGAACGTCAAGTTCATCCTGACCGAGTCTGACACGGTCAAGCGCAGGCCCAAGGCCAAGGAGCGGGAGGCCGGGCCTGAGCCACCA
CCGCCACTGTCCGTGTACCATAATGGCACTGGCACCGTGCGCCGCCGACCGGCCTCGGAGCAGGCTGGGCCTCCGGAGCTGCCTCCACCG
CCCCCGCCTGCCGAACCCCCGCCCACCGACCTGGCGCACCTACCCCCATTGCCCCCGCCCGAGGGCGAAGCCCGGAAGCCGGCCAAGCCG
CCTGTCTCTCCCAAGCCCGTCCTGACGCAGCCTGTGCCCAAGCTCCAGGGCTCGCCCACACCCACCTCCAAGAAGGTGCCGCTGCCAGGC
CCTGGCAGCCCAGAGGTGAAGCGCGCCCACGGCACGCCACCGCCCGTGTCTCCCAAGCCGCCGCCGCCGCCCACAGCGCCCAAGCCCGTC
AAGGCGGTCGCGGGGCTGCCTTCGGGCAGCGCCGGCCCTTCACCCGCACCCTCGCCCGCGCGACAGCCGCCCGCCGCCCTCGCCAAGCCG
CCCGGTACGCCGCCCTCGCTGGGCGCCAGCCCCGCCAAGCCCCCGTCCCCCGGCGCGCCCGCGCTGCACGTGCCCGCCAAGCCCCCGCGA
GCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGCCCCCCGCCCCGCCCGAAGGCGCCTCGCCAGGGGACAGCGCCCGGCAGAAACTGGAG
GAGACAAGCGCGTGCCTGGCCGCGGCGCTGCAGGCGGTGGAGGAGAAGATCCGGCAGGAGGACGCGCAGGGCCCGCGCGACTCGGCGGCG
GAAAAGAGCACTGGCAGCATCCTGGACGACATCGGCAGCATGTTCGACGACCTGGCCGACCAGCTGGATGCCATGCTGGAGTGAACGCCG
CCTGGCCGGGCCCTCCCGCGCCGCCCGGGCCCTCCCCGCACACTGACCTATACCTCAGGATGGGCGCGTCTGGGCGCGGCGCGAGCGGCC
GGGCAGGGCCCTGCAGAAGCACAACTCCGGCCCCTGGACCCGGGCCGGGGCGCCCACCGGGGACCGCCTGGCCGGGGGCTCCAAGGGCTC
TAGGCAGACCCTGCGCCCGCGGGTCCTCCCCACCTGCTGCTCCCCGTGCAATACCTGCTGGGCCTCCTGCCCGCGCGGGAGGGGAGGGCG
CCCCGGGACCAGGGATGGGGCAGCGCACAGGCCCGGGCCCAGCACAGAACTGCCCATCGGGACGCCCGGCCAGCCGCTCGGGCGCAGCAC
AAGGGACAGGGGACCAAGGTCAGGGCCCCCCTGCCCCACCGCACCCCCAGAATATAAGCTATCAAGAGTATTAATTTATTGGGAATGAGC
TGAGGCGGATTTCCCCAGAGAAACAAAAAGGTATAACTTTAACAAATATATATTTAAAGAAAGAAATATTATTGATTCTATAGAAAACCA
TTTACCAACTGAAAGGACACGAAGTCTAGCTCCGGACAAAAGCTGTTAGAGGCCCAGGCTGTCTGCCTGCGGTCCTTCCTCCGGCCAGAG
TGGAGGCCCCAGGCTGCTAGCACAGGTGGAAGGCTGGGGCCCGGGGGCGGGTGCTCTGCCGGGGGCTCCTCCGTGCTTCTCTCCTAAGTT
CTCTGCGCCCCAAGAACTCGAGGTTGTGCCTTGCTCTCGGCGGCCGTGTCCTCCTCCTGGCGTGGCTGCGTCCCAGGGCGCGGGTGGGTT
TGGTGAATGTGGGTGTGTCAGCGTGGCAGCCACGTGGAAGCAGGGCATGTAGCAGGCCAGGCCACGGGCTTGCAGCTCCTCTGAGGGTGT
GCCTGGCCCCCTCTCCAGGGGCTGTGCAGGCAGCCCATCCACCCCAGTGGAGTTCCCACGGACGCTTCTGCTCATGGTCCAAGGCTGTGT
TGTGTGGTCATTCTCGCCCTCCCTTTTCCTCTCTCCTCCTGCCCCCTCCAAGAAGTACTGACTGGTCTCCTCTATCGTGTTTGCTGATCC
ACAGTGTTGGGCACAACTTTGACGTTTCTTAAAAAAAAAATTTAAAAAATGCCGAAAACCAGCGATTGTGGTGTGGGGCGGGTGGAGGCG
GCTGGCGGAGGTGGCGTCCCGGCGTGCAGGGCCCCTTCCTGCTGTCTCACCCCGTGTTTCCCTGCGAGTGGACGTGCCCAGCTGTCCCCC
CAGGCCTCTCCTCAGAGGGCGGCACAGGCTGGGCTCCAGCAGGTGGGCAGGGGAGGTCTGGGCAAGGCGCTGCCGTCGGCTGTCAATAAA

>19353_19353_3_CREBBP-CASKIN1_CREBBP_chr16_3794895_ENST00000262367_CASKIN1_chr16_2240359_ENST00000343516_length(amino acids)=2795AA_BP=1396
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSN
PNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLM
NDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYH
LLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPR
AASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNP
LNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAA
QAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGE
SKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALY
RQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPV
MQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVD
CKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVD
IKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQL
LLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQT
ALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIV
KRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKP
PEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIA
AEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGG
PLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSS
QELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHG
PAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRY
AASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGL
LGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTL
SGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKE
REAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPT
SKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPAL
HVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQL

--------------------------------------------------------------
>19353_19353_4_CREBBP-CASKIN1_CREBBP_chr16_3794895_ENST00000382070_CASKIN1_chr16_2240359_ENST00000343516_length(transcript)=9641nt_BP=4072nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGATTTTGGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGC
CTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATC
AACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATG
GCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGG
CCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGA
CCTGGTATCTGCATGAATGCTAACTTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCA
CAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAG
GGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGA
GGCATGGCCAAGATGGGAATAACTGGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGA
GTGAACCCCCAGTTAGCCAGCAAACAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTG
CCAAATATGTCTCAGATGCAAACATCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAA
CTGATACAGCAGCAGCTGGTTCTACTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTC
CCGCATTGTCGAACCATGAAAAACGTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGCCATCCTGGGGTCTCCAGCT
AGTGGAATTCAAAACACAATTGGTTCTGTTGGCACAGGGCAACAGAATGCCACTTCTTTAAGTAACCCAAATCCCATAGACCCCAGCTCC
ATGCAGCGAGCCTATGCTGCTCTCGGACTCCCCTACATGAACCAGCCCCAGACGCAGCTGCAGCCTCAGGTTCCTGGCCAGCAACCAGCA
CAGCCTCAAACCCACCAGCAGATGAGGACTCTCAACCCCCTGGGAAATAATCCAATGAACATTCCAGCAGGAGGAATAACAACAGATCAG
CAGCCCCCAAACTTGATTTCAGAATCAGCTCTTCCGACTTCCCTGGGGGCCACAAACCCACTGATGAACGATGGCTCCAACTCTGGTAAC
ATTGGAACCCTCAGCACTATACCAACAGCAGCTCCTCCTTCTAGCACCGGTGTAAGGAAAGGCTGGCACGAACATGTCACTCAGGACCTG
CGGAGCCATCTAGTGCATAAACTCGTCCAAGCCATCTTCCCAACACCTGATCCCGCAGCTCTAAAGGATCGCCGCATGGAAAACCTGGTA
GCCTATGCTAAGAAAGTGGAAGGGGACATGTACGAGTCTGCCAACAGCAGGGATGAATATTATCACTTATTAGCAGAGAAAATCTACAAG
ATACAAAAAGAACTAGAAGAAAAACGGAGGTCGCGTTTACATAAACAAGGCATCTTGGGGAACCAGCCAGCCTTACCAGCCCCGGGGGCT
CAGCCCCCTGTGATTCCACAGGCACAACCTGTGAGACCTCCAAATGGACCCCTGTCCCTGCCAGTGAATCGCATGCAAGTTTCTCAAGGG
ATGAATTCATTTAACCCCATGTCCTTGGGGAACGTCCAGTTGCCACAAGCACCCATGGGACCTCGTGCAGCCTCCCCAATGAACCACTCT
GTCCAGATGAACAGCATGGGCTCAGTGCCAGGGATGGCCATTTCTCCTTCCCGAATGCCTCAGCCTCCGAACATGATGGGTGCACACACC
AACAACATGATGGCCCAGGCGCCCGCTCAGAGCCAGTTTCTGCCACAGAACCAGTTCCCGTCATCCAGCGGGGCGATGAGTGTGGGCATG
GGGCAGCCGCCAGCCCAAACAGGCGTGTCACAGGGACAGGTGCCTGGTGCTGCTCTTCCTAACCCTCTCAACATGCTGGGGCCTCAGGCC
AGCCAGCTACCTTGCCCTCCAGTGACACAGTCACCACTGCACCCAACACCGCCTCCTGCTTCCACGGCTGCTGGCATGCCATCTCTCCAG
CACACGACACCACCTGGGATGACTCCTCCCCAGCCAGCAGCTCCCACTCAGCCATCAACTCCTGTGTCGTCTTCCGGGCAGACTCCCACC
CCGACTCCTGGCTCAGTGCCCAGTGCTACCCAAACCCAGAGCACCCCTACAGTCCAGGCAGCAGCCCAGGCCCAGGTGACCCCGCAGCCT
CAAACCCCAGTTCAGCCCCCGTCTGTGGCTACCCCTCAGTCATCGCAGCAACAGCCGACGCCTGTGCACGCCCAGCCTCCTGGCACACCG
CTTTCCCAGGCAGCAGCCAGCATTGATAACAGAGTCCCTACCCCCTCCTCGGTGGCCAGCGCAGAAACCAATTCCCAGCAGCCAGGACCT
GACGTACCTGTGCTGGAAATGAAGACGGAGACCCAAGCAGAGGACACTGAGCCCGATCCTGGTGAATCCAAAGGGGAGCCCAGGTCTGAG
ATGATGGAGGAGGATTTGCAAGGAGCTTCCCAAGTTAAAGAAGAAACAGACATAGCAGAGCAGAAATCAGAACCAATGGAAGTGGATGAA
AAGAAACCTGAAGTGAAAGTAGAAGTTAAAGAGGAAGAAGAGAGTAGCAGTAACGGCACAGCCTCTCAGTCAACATCTCCTTCGCAGCCG
CGCAAAAAAATCTTTAAACCAGAGGAGTTACGCCAGGCCCTCATGCCAACCCTAGAAGCACTGTATCGACAGGACCCAGAGTCATTACCT
TTCCGGCAGCCTGTAGATCCCCAGCTCCTCGGAATTCCAGACTATTTTGACATCGTAAAGAATCCCATGGACCTCTCCACCATCAAGCGG
AAGCTGGACACAGGGCAATACCAAGAGCCCTGGCAGTACGTGGACGACGTCTGGCTCATGTTCAACAATGCCTGGCTCTATAATCGCAAG
ACATCCCGAGTCTATAAGTTTTGCAGTAAGCTTGCAGAGGTCTTTGAGCAGGAAATTGACCCTGTCATGCAGTCCCTTGGATATTGCTGT
GGACGCAAGTATGAGTTTTCCCCACAGACTTTGTGCTGCTATGGGAAGCAGCTGTGTACCATTCCTCGCGATGCTGCCTACTACAGCTAT
CAGAATAGGTATCATTTCTGTGAGAAGTGTTTCACAGAGATCCAGGGCGAGAATGTGACCCTGGGTGACGACCCTTCACAGCCCCAGACG
ACAATTTCAAAGGATCAGTTTGAAAAGAAGAAAAATGATACCTTAGACCCCGAACCTTTCGTTGATTGCAAGGAGTGTGGCCGGAAGATG
CATCAGATTTGCGTTCTGCACTATGACATCATTTGGCCTTCAGGTTTTGTGTGCGACAACTGCTTGAAGAAAACTGGCAGACCTCGAAAA
GAAAACAAATTCAGTGCTAAGAAGCTCCTGGGTTCCACCAAGAAGATCAATGTCAACTTCCAGGACCCGGATGGCTTCTCGGCTCTGCAC
CATGCGGCCCTGAACGGCAACACGGAATTGATCAGCCTGCTGCTGGAGGCCCAGGCCGCTGTGGACATCAAGGACAACAAAGGCATGCGG
CCGCTGCACTATGCGGCCTGGCAGGGCCGGAAGGAGCCCATGAAGCTGGTGCTGAAGGCGGGCTCGGCCGTGAACATCCCGTCTGATGAG
GGCCACATCCCCCTGCACCTGGCGGCCCAGCATGGTCACTATGATGTGTCTGAGATGCTGCTACAGCACCAGTCTAACCCGTGCATGGTG
GACAACTCGGGGAAGACGCCCCTGGACCTGGCCTGCGAGTTCGGCCGCGTTGGGGTGGTCCAGCTGCTCCTCAGCAGCAATATGTGTGCG
GCGCTGCTGGAGCCCCGGCCGGGAGACGCCACCGACCCCAACGGCACCAGCCCTTTGCACCTCGCAGCTAAAAACGGCCACATCGACATC
ATCAGGCTCCTCCTCCAAGCCGGCATCGACATTAACCGCCAGACCAAGTCCGGCACGGCCCTGCACGAGGCTGCGCTCTGCGGAAAGACA
GAGGTGGTGCGGCTGCTGCTGGATAGCGGGATCAATGCCCACGTGAGGAACACCTACAGCCAGACAGCCCTGGACATCGTGCACCAGTTC
ACCACGTCCCAGGCCAGCAGGGAGATCAAGCAGCTGTTGCGAGAGGCCTCAGCGGCCCTGCAGGTCCGGGCGACCAAGGATTATTGCAAC
AATTACGACCTGACCAGCCTCAACGTGAAGGCAGGGGACATCATCACAGTCCTCGAGCAGCATCCGGATGGCCGGTGGAAGGGCTGCATC
CATGACAACCGGACGGGCAATGACCGGGTGGGCTACTTCCCGTCCTCCCTGGGCGAGGCCATTGTCAAGCGAGCAGGTTCCCGAGCAGGC
ACTGAACCAAGCCTGCCCCAGGGAAGCAGCTCATCGGGACCCTCTGCACCCCCAGAGGAGATCTGGGTGCTGAGGAAGCCTTTTGCAGGT
GGGGACCGAAGCGGCAGCATTAGCGGCATGGCTGGCGGCCGGGGCAGCGGGGGTCACGCCCTACACGCGGGCTCTGAAGGCGTCAAGCTC
CTGGCAACGGTGCTTTCCCAGAAGTCCGTCTCTGAGTCCGGCCCGGGGGACAGCCCCGCCAAGCCTCCGGAAGGCTCTGCAGGTGTGGCC
CGGTCCCAGCCTCCAGTGGCCCACGCCGGGCAGGTCTATGGGGAGCAGCCGCCCAAGAAGCTGGAGCCAGCATCGGAGGGCAAGAGCTCT
GAGGCCGTGAGCCAGTGGCTCACCGCGTTCCAGCTGCAGCTCTACGCCCCCAACTTCATCAGCGCCGGCTACGACCTGCCCACCATCAGC
CGCATGACTCCCGAGGACCTCACGGCCATTGGTGTCACCAAGCCGGGCCACCGGAAGAAGATCGCGGCAGAGATCAGCGGCCTAAGCATC
CCTGACTGGCTGCCTGAGCACAAACCCGCTAACCTGGCCGTGTGGCTGTCCATGATCGGCCTGGCCCAGTACTACAAGGTGTTGGTGGAC
AATGGCTACGAGAACATTGATTTCATCACCGACATCACCTGGGAGGACCTGCAGGAGATCGGCATCACCAAGCTGGGGCACCAGAAGAAG
CTGATGCTCGCTGTGAGGAAGCTGGCAGAGCTGCAGAAGGCTGAATACGCCAAGTATGAGGGGGGCCCCCTGCGCCGGAAGGCGCCCCAG
TCTCTTGAAGTGATGGCCATCGAGTCGCCGCCCCCGCCTGAGCCCACACCGGCCGACTGCCAGTCCCCTAAAATGACCACCTTCCAGGAC
AGCGAGCTCAGTGACGAGCTGCAGGCTGCCATGACTGGCCCGGCTGAGGTGGGGCCCACCACTGAGAAGCCCTCCAGCCACCTGCCACCC
ACCCCGAGGGCCACCACGCGGCAGGACTCCAGCCTGGGTGGTCGGGCACGGCACATGAGCAGCTCGCAGGAGCTGCTGGGAGATGGGCCC
CCTGGGCCCAGCAGCCCCATGTCTCGAAGCCAGGAGTACCTCCTGGATGAGGGCCCCGCCCCCGGCACCCCGCCCAGGGAGGCCCGGCCC
GGCCGCCACGGCCACAGCATCAAGAGGGCCAGCGTGCCCCCCGTGCCTGGCAAGCCACGGCAGGTCCTCCCACCAGGCACTAGCCACTTC
ACGCCCCCCCAGACGCCCACCAAAACCCGACCAGGCTCTCCCCAGGCCCTTGGGGGACCTCATGGTCCAGCCCCAGCTACGGCCAAGGTG
AAGCCCACCCCGCAGCTGCTGCCGCCGACAGAGCGCCCCATGTCACCCCGCTCCCTGCCTCAGTCACCGACGCACCGCGGCTTTGCCTAC
GTGCTGCCCCAGCCCGTGGAGGGCGAGGTGGGGCCGGCTGCCCCGGGGCCTGCGCCCCCACCCGTGCCGACGGCTGTGCCCACACTGTGC
CTGCCCCCTGAGGCCGACGCGGAGCCGGGGCGGCCCAAGAAGCGGGCCCACAGCCTGAATCGCTATGCGGCGTCCGACAGCGAGCCGGAG
CGGGACGAGCTGCTGGTGCCTGCGGCTGCCGGCCCCTATGCCACGGTCCAGCGGCGCGTGGGCCGCAGCCACTCAGTGAGGGCGCCCGCA
GGTGCCGACAAGAACGTCAACCGCAGCCAGTCCTTTGCCGTGCGGCCCCGAAAGAAGGGGCCCCCGCCGCCCCCACCCAAGCGCTCCAGC
TCGGCCCTGGCTAGTGCCAACCTGGCGGATGAGCCGGTGCCTGACGCCGAGCCTGAGGATGGCCTGCTGGGGGTCCGGGCACAGTGCCGG
CGGGCCAGTGACCTGGCCGGCAGCGTGGACACGGGTAGTGCCGGCAGTGTGAAGAGCATCGCGGCCATGCTGGAGCTGTCCTCCATTGGG
GGTGGGGGCCGGGCTGCCCGCAGGCCTCCTGAGGGCCACCCCACTCCCCGCCCTGCCAGCCCAGAGCCGGGCCGGGTGGCCACCGTGCTG
GCCTCAGTGAAACACAAAGAGGCCATCGGGCCTGGCGGGGAGGTGGTGAACCGGCGCCGCACGCTCAGCGGGCCAGTCACCGGACTTCTG
GCCACTGCCCGCCGGGGGCCTGGGGAGTCGGCAGACCCAGGCCCCTTTGTGGAGGATGGCACTGGCCGGCAGCGGCCTCGGGGTCCCTCC
AAGGGCGAGGCGGGTGTCGAAGGCCCGCCCTTGGCCAAGGTGGAAGCCAGCGCCACACTCAAGAGGCGCATCCGGGCCAAGCAGAACCAG
CAGGAGAACGTCAAGTTCATCCTGACCGAGTCTGACACGGTCAAGCGCAGGCCCAAGGCCAAGGAGCGGGAGGCCGGGCCTGAGCCACCA
CCGCCACTGTCCGTGTACCATAATGGCACTGGCACCGTGCGCCGCCGACCGGCCTCGGAGCAGGCTGGGCCTCCGGAGCTGCCTCCACCG
CCCCCGCCTGCCGAACCCCCGCCCACCGACCTGGCGCACCTACCCCCATTGCCCCCGCCCGAGGGCGAAGCCCGGAAGCCGGCCAAGCCG
CCTGTCTCTCCCAAGCCCGTCCTGACGCAGCCTGTGCCCAAGCTCCAGGGCTCGCCCACACCCACCTCCAAGAAGGTGCCGCTGCCAGGC
CCTGGCAGCCCAGAGGTGAAGCGCGCCCACGGCACGCCACCGCCCGTGTCTCCCAAGCCGCCGCCGCCGCCCACAGCGCCCAAGCCCGTC
AAGGCGGTCGCGGGGCTGCCTTCGGGCAGCGCCGGCCCTTCACCCGCACCCTCGCCCGCGCGACAGCCGCCCGCCGCCCTCGCCAAGCCG
CCCGGTACGCCGCCCTCGCTGGGCGCCAGCCCCGCCAAGCCCCCGTCCCCCGGCGCGCCCGCGCTGCACGTGCCCGCCAAGCCCCCGCGA
GCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCGCCCCCCGCCCCGCCCGAAGGCGCCTCGCCAGGGGACAGCGCCCGGCAGAAACTGGAG
GAGACAAGCGCGTGCCTGGCCGCGGCGCTGCAGGCGGTGGAGGAGAAGATCCGGCAGGAGGACGCGCAGGGCCCGCGCGACTCGGCGGCG
GAAAAGAGCACTGGCAGCATCCTGGACGACATCGGCAGCATGTTCGACGACCTGGCCGACCAGCTGGATGCCATGCTGGAGTGAACGCCG
CCTGGCCGGGCCCTCCCGCGCCGCCCGGGCCCTCCCCGCACACTGACCTATACCTCAGGATGGGCGCGTCTGGGCGCGGCGCGAGCGGCC
GGGCAGGGCCCTGCAGAAGCACAACTCCGGCCCCTGGACCCGGGCCGGGGCGCCCACCGGGGACCGCCTGGCCGGGGGCTCCAAGGGCTC
TAGGCAGACCCTGCGCCCGCGGGTCCTCCCCACCTGCTGCTCCCCGTGCAATACCTGCTGGGCCTCCTGCCCGCGCGGGAGGGGAGGGCG
CCCCGGGACCAGGGATGGGGCAGCGCACAGGCCCGGGCCCAGCACAGAACTGCCCATCGGGACGCCCGGCCAGCCGCTCGGGCGCAGCAC
AAGGGACAGGGGACCAAGGTCAGGGCCCCCCTGCCCCACCGCACCCCCAGAATATAAGCTATCAAGAGTATTAATTTATTGGGAATGAGC
TGAGGCGGATTTCCCCAGAGAAACAAAAAGGTATAACTTTAACAAATATATATTTAAAGAAAGAAATATTATTGATTCTATAGAAAACCA
TTTACCAACTGAAAGGACACGAAGTCTAGCTCCGGACAAAAGCTGTTAGAGGCCCAGGCTGTCTGCCTGCGGTCCTTCCTCCGGCCAGAG
TGGAGGCCCCAGGCTGCTAGCACAGGTGGAAGGCTGGGGCCCGGGGGCGGGTGCTCTGCCGGGGGCTCCTCCGTGCTTCTCTCCTAAGTT
CTCTGCGCCCCAAGAACTCGAGGTTGTGCCTTGCTCTCGGCGGCCGTGTCCTCCTCCTGGCGTGGCTGCGTCCCAGGGCGCGGGTGGGTT
TGGTGAATGTGGGTGTGTCAGCGTGGCAGCCACGTGGAAGCAGGGCATGTAGCAGGCCAGGCCACGGGCTTGCAGCTCCTCTGAGGGTGT
GCCTGGCCCCCTCTCCAGGGGCTGTGCAGGCAGCCCATCCACCCCAGTGGAGTTCCCACGGACGCTTCTGCTCATGGTCCAAGGCTGTGT
TGTGTGGTCATTCTCGCCCTCCCTTTTCCTCTCTCCTCCTGCCCCCTCCAAGAAGTACTGACTGGTCTCCTCTATCGTGTTTGCTGATCC
ACAGTGTTGGGCACAACTTTGACGTTTCTTAAAAAAAAAATTTAAAAAATGCCGAAAACCAGCGATTGTGGTGTGGGGCGGGTGGAGGCG
GCTGGCGGAGGTGGCGTCCCGGCGTGCAGGGCCCCTTCCTGCTGTCTCACCCCGTGTTTCCCTGCGAGTGGACGTGCCCAGCTGTCCCCC
CAGGCCTCTCCTCAGAGGGCGGCACAGGCTGGGCTCCAGCAGGTGGGCAGGGGAGGTCTGGGCAAGGCGCTGCCGTCGGCTGTCAATAAA

>19353_19353_4_CREBBP-CASKIN1_CREBBP_chr16_3794895_ENST00000382070_CASKIN1_chr16_2240359_ENST00000343516_length(amino acids)=2757AA_BP=1358
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA
QPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDL
RSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGA
QPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHT
NNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQ
HTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTP
LSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDE
KKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKR
KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSY
QNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK
ENKFSAKKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDE
GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI
IRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCN
NYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAG
GDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSS
EAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVD
NGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQD
SELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARP
GRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAY
VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPA
GADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIG
GGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPS
KGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPP
PPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPV
KAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLE

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Fusion Gene PPI Analysis for CREBBP-CASKIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311162_11801327.33333333333332443.0ASF1A
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301162_11801289.33333333333332405.0ASF1A
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311162_11801327.33333333333332443.0ASF1A
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301162_11801289.33333333333332405.0ASF1A
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311124_11701327.33333333333332443.0histone
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301124_11701289.33333333333332405.0histone
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311124_11701327.33333333333332443.0histone
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301124_11701289.33333333333332405.0histone
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-2331227_4101327.33333333333332443.0SRCAP
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-2230227_4101289.33333333333332405.0SRCAP
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-2331227_4101327.33333333333332443.0SRCAP
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-2230227_4101289.33333333333332405.0SRCAP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311433_14351327.33333333333332443.0histone
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301433_14351289.33333333333332405.0histone
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311433_14351327.33333333333332443.0histone
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301433_14351289.33333333333332405.0histone
HgeneCREBBPchr16:3794894chr16:2240359ENST00000262367-23311460_18911327.33333333333332443.0TRERF1
HgeneCREBBPchr16:3794894chr16:2240359ENST00000382070-22301460_18911289.33333333333332405.0TRERF1
HgeneCREBBPchr16:3794895chr16:2240359ENST00000262367-23311460_18911327.33333333333332443.0TRERF1
HgeneCREBBPchr16:3794895chr16:2240359ENST00000382070-22301460_18911289.33333333333332405.0TRERF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREBBP-CASKIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREBBP-CASKIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource