FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CREBBP-GOLGA6L2 (FusionGDB2 ID:19363)

Fusion Gene Summary for CREBBP-GOLGA6L2

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP-GOLGA6L2
Fusion gene ID: 19363
HgeneTgene
Gene symbol

CREBBP

GOLGA6L2

Gene ID

1387

283685

Gene nameCREB binding proteingolgin A6 family like 2
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1CT105
Cytomap

16p13.3

15q11.2

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPgolgin subfamily A member 6-like protein 2cancer/testis antigen 105golgi autoantigen, golgin subfamily a, 6-like 2
Modification date2020032920200313
UniProtAcc

Q92793

Q8N9W4

Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000312015, ENST00000345070, 
ENST00000567107, 
Fusion gene scores* DoF score43 X 38 X 17=277782 X 2 X 2=8
# samples 612
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CREBBP [Title/Abstract] AND GOLGA6L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREBBP(3900298)-GOLGA6L2(23690585), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLGA6L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-KT-A7W1-01ACREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
ChimerDB4LGGTCGA-KT-A7W1CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-


Top

Fusion Gene ORF analysis for CREBBP-GOLGA6L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262367ENST00000312015CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
5CDS-5UTRENST00000262367ENST00000345070CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
5CDS-5UTRENST00000382070ENST00000312015CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
5CDS-5UTRENST00000382070ENST00000345070CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
In-frameENST00000262367ENST00000567107CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-
In-frameENST00000382070ENST00000567107CREBBPchr16

3900298

-GOLGA6L2chr15

23690585

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163900298-ENST00000567107GOLGA6L2chr1523690585-4501160860642531215
ENST00000382070CREBBPchr163900298-ENST00000567107GOLGA6L2chr1523690585-38951002036471215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000567107CREBBPchr163900298-GOLGA6L2chr1523690585-0.0140718750.9859282
ENST00000382070ENST00000567107CREBBPchr163900298-GOLGA6L2chr1523690585-0.0203143620.9796856

Top

Fusion Genomic Features for CREBBP-GOLGA6L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CREBBP-GOLGA6L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3900298/chr15:23690585)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

GOLGA6L2

Q8N9W4

FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGOLGA6L2chr16:3900298chr15:23690585ENST0000031201509192_52628651.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311061_10642662443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311199_14872662443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311555_15622662443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311943_19482662443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311967_19702662443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2312081_20852662443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2312199_22162662443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2312245_22482662443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2312297_23002662443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301061_10642662405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301199_14872662405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301555_15622662405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301943_19482662405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301967_19702662405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2302081_20852662405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2302199_22162662405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2302245_22482662405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2302297_23002662405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311103_11752662443.0DomainBromo
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311323_17002662443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-231587_6662662443.0DomainKIX
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301103_11752662405.0DomainBromo
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301323_17002662405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-230587_6662662405.0DomainKIX
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311434_14362662443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311446_14472662443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301434_14362662405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301446_14472662405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311701_17442662443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311765_18462662443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-231347_4332662443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301701_17442662405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301765_18462662405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-230347_4332662405.0Zinc fingerTAZ-type 1


Top

Fusion Gene Sequence for CREBBP-GOLGA6L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19363_19363_1_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000262367_GOLGA6L2_chr15_23690585_ENST00000567107_length(transcript)=4501nt_BP=1608nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGATTTT
GGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTT
CCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGC
GCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAG
AGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCA
CTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAAC
TTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAAT
GGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCT
GAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGTTTACAGACTAT
CGTCAGTGGAACATTGCTGGTGTTGGTACCAGAGCAACTGACACCAAAAAGAAGAAAATAAATAATGGCACTAACCCTGAGACAACCACT
TCGGAGGGTTGCCATTCACCTGAGGATACACAACAGAACCGAGCGCAGCTGAAAGAAGAAAAGAAGGCAAGCCACCAACATCAGGAAGCC
CTAAGGCGGGAGATAGAGGCCCAGGATCATACAATACGAATTCTCACGTGTCAGAAAACTGAACTGGAGACAGCGCTCTATTACAGCCAG
GATGCTGCCAGGAAATTTGAAGATGGGAACCTGGGCACCCCATCATCCTTCAACCTGGCACTTTCACAGGCCTTTAGGGGGAGTCCTTTG
GGCTGTGTCTCAACCTCTCTCATTCCAGGAGAGTCCAAGGATCTCGCCGGCCGCTTGCATCATTCCTGGCACTTTGCAGGAGAGTTACAG
CGGGCTCTCTCTGCTGTGTCCACATGGCACAAGAAGGCAGACAGGTACATCGAGGAGTTAACAAAGGAGAGGGACGCCCTGAGTCTGGAA
CTGTACAGGAACACCATAACCAATGAGGAGCTGAAGAAGAAAAATGCCGAACTACAAGAAAAACTTCGACTTGCAGAATCTGAAAAGTCT
GAGATCCAGCTCAACGTGAAGGAGCTAAAAAGGAAACTGGAGAGGGCCAAGTTCCTGCTGCCACAGGTTCAAACCAACACTTTGCAGGAG
GAGATGTGGAGGCAGGAGGAGGAGCTACGGGAGCAGGAAAAGAAGATACGGAAGCAGGAGGAGAAGATGTGGAGACAGGAGGAGAGACTG
CGGGAGCAGGAGGGGAAGATGCGGGAGCAGGAGGAGAAGATGCGGAGACAGGAGAAGAGGCTGCGAGAGCAGGAGAAGGAGCTGCGGGAG
CAGGAGAAGGAGCTGCGGGAGCAGAAGAAGCTGCGGGAGCAGGAGGAGCAGATGCAGGAGCAGGAGGAGAAGATGTGGGAGCAGGAGGAG
AAGATGCGGGAGCAGGAAGAGAAGATGTGGAGACAGGAGGAGAGGCTGTGGGAGCAGGAGAAGCAGATGCGGGAGCAGGAGCAGAAGATG
CGGGACCAAGAGGAGAGGATGTGGGAGCAGGACGAGAGGCTACGGGAGAAGGAGGAGAGGATGCGGGAGCAGGAGAAGATGTGGGAGCAG
GTGGAGAAGATGCGGGAGGAGAAGAAGATGCAGGAGCAGGAGAAGAAGACGCGGGACCAGGAGGAGAAGATGCAAGAGGAGGAGAGGATA
CGGGAGCGGGAGAAGAAGATGCGGGAAGAGGAGGAGACGATGCGGGAGCAGGAGGAGAAGATGCAGAAGCAGGAGGAGAATATGTGGGAG
CAGGAAGAGAAGGAGTGGCAGCAGCAGAGGCTGCCGGAACAGAAGGAGAAGCTGTGGGAACAGGAGAAGATGCAGGAGCAGGAGGAGAAG
ATATGGGAGCAGGAGGAGAAGATACGGGACCAGGAGGAGATGTGGGGGCAGGAGAAGAAGATGTGGCGGCAGGAGAAGATGCGGGAGCAG
GAAGATGTGGAGACAGGAGGAGAGGCTGCAGGAGCAGGAGAAGCAGATGTGGGAGCAGGAGGAGAAGATGCGGGATCAGGAGCAGAAGAT
GTGGGACCAGGAGGAGAGGATGTGGGAGCAGGACGAGAGGCTGCGGGAGAAGGAGGAGAGAATGCGGGAGCAGAAGAAGATGTGGCAGCA
GGAGGAGAAGATGCGGGAGGAGAAGAAGACGCAGGAGCAGGAGAAGAAGACATGGGACCAGGAGGAGAAGATGCGAGAGGAGGAGAGGAT
GCGGGAGCGGGAGAAGAAGATGCGGGAGGAGGAGGAGATGATGCGGGAGCAGGAGGAGAAGATGCAGGAGCAGGAAGAGAAGATGCGGGA
GCAGGAGGAGAAGATGTGGGAGCAGGAAGAGAAGATGCAGGAGCAGGAGGAGAAGATGTGGGAGCAGGAGGAGAAGATGTGGGAGCAGGA
AGAAGAAGATGTGGGAGCAGCAGAGGCTGCCGGAACAGAAGGAGAAGCTGTGGGAACACGAGAAGATGCAGGAGCAGGAGATCAGGAGCA
GAAGATGTGGGACCAGAAGGAGAGGATGTGGGAGCAGGACGAGAGGCTGCGGGAGAAGGAGGAGAGAATGCGGGAGCAGAAGATGTGGCA
GCAGGTGGAGAAGATGCGGGAGAAGAAGAAGACGCAGGAGGAGAAGATGCAGGAGCAGCAAGAGAAGATGCAGGAGCAGGAGGAGATGAT
GTGGGAGCAGGAAGAGAAGATGCAGGAGCAGGAGGAGAAGATGTGGGAGCAGGAGGAGAAGATGCGGGAGCAGGAGGAGAAGATGCGGGA
GCAGGAGGAGAAGATGCAGGGCCAGGAGGAGAAGATGCGGGAGCAGGAGGAGAAGATGCAGGGCCAGGAGGAGAAGATGCGGGAGCAGGA
GGAGAAGATGCGGGGCCAGGAGGAGAAGATGTGGGGCCAGGAGGAGAAGATGTGGGGGCAGGAGGAGAAGATGTGGGGGCAGGAGGAGAT
GCGAGAGAAGGAGGAGAGGATACGAGATCAGAAAGAGAAGATGCAGGAGAGGCTGCCAGAGCACGAGGAGCGGTGCTCAGAGCCCTGCCT
CCCTCCCTCCAAAGTTCTTTGTAATATGAGCCACACTGGCAGTGTGGAGCCTGCAGGAGGAGAGGCTGGGGAGGGTTCTCCGCAGGACAA
CCCCACTGCACAGGAGATCATGCAGCTGTTTTGTGGGATGAAGAACGCCCAGCAGTGCCCAGGATTAGGCAGTACCTCCTGCATCCCATT
CTTCTACCGAGGAGACAAGAGAAAGATGAAGATCATCAATATCTAAAAGTTGGCACTGTCAACAAGGCCTACAGAAGCATAAGCCGCCAT

>19363_19363_1_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000262367_GOLGA6L2_chr15_23690585_ENST00000567107_length(amino acids)=1215AA_BP=566
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFTDYRQWNIAGVGTRATDTKKKKINN
GTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS
QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL
RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR
EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR
EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE
KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENA
GAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGA
GGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAARE
DAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGG

--------------------------------------------------------------
>19363_19363_2_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000382070_GOLGA6L2_chr15_23690585_ENST00000567107_length(transcript)=3895nt_BP=1002nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGATTTTGGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGC
CTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATC
AACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATG
GCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGG
CCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGA
CCTGGTATCTGCATGAATGCTAACTTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCA
CAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAG
GGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGA
GGCATGGCCAAGTTTACAGACTATCGTCAGTGGAACATTGCTGGTGTTGGTACCAGAGCAACTGACACCAAAAAGAAGAAAATAAATAAT
GGCACTAACCCTGAGACAACCACTTCGGAGGGTTGCCATTCACCTGAGGATACACAACAGAACCGAGCGCAGCTGAAAGAAGAAAAGAAG
GCAAGCCACCAACATCAGGAAGCCCTAAGGCGGGAGATAGAGGCCCAGGATCATACAATACGAATTCTCACGTGTCAGAAAACTGAACTG
GAGACAGCGCTCTATTACAGCCAGGATGCTGCCAGGAAATTTGAAGATGGGAACCTGGGCACCCCATCATCCTTCAACCTGGCACTTTCA
CAGGCCTTTAGGGGGAGTCCTTTGGGCTGTGTCTCAACCTCTCTCATTCCAGGAGAGTCCAAGGATCTCGCCGGCCGCTTGCATCATTCC
TGGCACTTTGCAGGAGAGTTACAGCGGGCTCTCTCTGCTGTGTCCACATGGCACAAGAAGGCAGACAGGTACATCGAGGAGTTAACAAAG
GAGAGGGACGCCCTGAGTCTGGAACTGTACAGGAACACCATAACCAATGAGGAGCTGAAGAAGAAAAATGCCGAACTACAAGAAAAACTT
CGACTTGCAGAATCTGAAAAGTCTGAGATCCAGCTCAACGTGAAGGAGCTAAAAAGGAAACTGGAGAGGGCCAAGTTCCTGCTGCCACAG
GTTCAAACCAACACTTTGCAGGAGGAGATGTGGAGGCAGGAGGAGGAGCTACGGGAGCAGGAAAAGAAGATACGGAAGCAGGAGGAGAAG
ATGTGGAGACAGGAGGAGAGACTGCGGGAGCAGGAGGGGAAGATGCGGGAGCAGGAGGAGAAGATGCGGAGACAGGAGAAGAGGCTGCGA
GAGCAGGAGAAGGAGCTGCGGGAGCAGGAGAAGGAGCTGCGGGAGCAGAAGAAGCTGCGGGAGCAGGAGGAGCAGATGCAGGAGCAGGAG
GAGAAGATGTGGGAGCAGGAGGAGAAGATGCGGGAGCAGGAAGAGAAGATGTGGAGACAGGAGGAGAGGCTGTGGGAGCAGGAGAAGCAG
ATGCGGGAGCAGGAGCAGAAGATGCGGGACCAAGAGGAGAGGATGTGGGAGCAGGACGAGAGGCTACGGGAGAAGGAGGAGAGGATGCGG
GAGCAGGAGAAGATGTGGGAGCAGGTGGAGAAGATGCGGGAGGAGAAGAAGATGCAGGAGCAGGAGAAGAAGACGCGGGACCAGGAGGAG
AAGATGCAAGAGGAGGAGAGGATACGGGAGCGGGAGAAGAAGATGCGGGAAGAGGAGGAGACGATGCGGGAGCAGGAGGAGAAGATGCAG
AAGCAGGAGGAGAATATGTGGGAGCAGGAAGAGAAGGAGTGGCAGCAGCAGAGGCTGCCGGAACAGAAGGAGAAGCTGTGGGAACAGGAG
AAGATGCAGGAGCAGGAGGAGAAGATATGGGAGCAGGAGGAGAAGATACGGGACCAGGAGGAGATGTGGGGGCAGGAGAAGAAGATGTGG
CGGCAGGAGAAGATGCGGGAGCAGGAAGATGTGGAGACAGGAGGAGAGGCTGCAGGAGCAGGAGAAGCAGATGTGGGAGCAGGAGGAGAA
GATGCGGGATCAGGAGCAGAAGATGTGGGACCAGGAGGAGAGGATGTGGGAGCAGGACGAGAGGCTGCGGGAGAAGGAGGAGAGAATGCG
GGAGCAGAAGAAGATGTGGCAGCAGGAGGAGAAGATGCGGGAGGAGAAGAAGACGCAGGAGCAGGAGAAGAAGACATGGGACCAGGAGGA
GAAGATGCGAGAGGAGGAGAGGATGCGGGAGCGGGAGAAGAAGATGCGGGAGGAGGAGGAGATGATGCGGGAGCAGGAGGAGAAGATGCA
GGAGCAGGAAGAGAAGATGCGGGAGCAGGAGGAGAAGATGTGGGAGCAGGAAGAGAAGATGCAGGAGCAGGAGGAGAAGATGTGGGAGCA
GGAGGAGAAGATGTGGGAGCAGGAAGAAGAAGATGTGGGAGCAGCAGAGGCTGCCGGAACAGAAGGAGAAGCTGTGGGAACACGAGAAGA
TGCAGGAGCAGGAGATCAGGAGCAGAAGATGTGGGACCAGAAGGAGAGGATGTGGGAGCAGGACGAGAGGCTGCGGGAGAAGGAGGAGAG
AATGCGGGAGCAGAAGATGTGGCAGCAGGTGGAGAAGATGCGGGAGAAGAAGAAGACGCAGGAGGAGAAGATGCAGGAGCAGCAAGAGAA
GATGCAGGAGCAGGAGGAGATGATGTGGGAGCAGGAAGAGAAGATGCAGGAGCAGGAGGAGAAGATGTGGGAGCAGGAGGAGAAGATGCG
GGAGCAGGAGGAGAAGATGCGGGAGCAGGAGGAGAAGATGCAGGGCCAGGAGGAGAAGATGCGGGAGCAGGAGGAGAAGATGCAGGGCCA
GGAGGAGAAGATGCGGGAGCAGGAGGAGAAGATGCGGGGCCAGGAGGAGAAGATGTGGGGCCAGGAGGAGAAGATGTGGGGGCAGGAGGA
GAAGATGTGGGGGCAGGAGGAGATGCGAGAGAAGGAGGAGAGGATACGAGATCAGAAAGAGAAGATGCAGGAGAGGCTGCCAGAGCACGA
GGAGCGGTGCTCAGAGCCCTGCCTCCCTCCCTCCAAAGTTCTTTGTAATATGAGCCACACTGGCAGTGTGGAGCCTGCAGGAGGAGAGGC
TGGGGAGGGTTCTCCGCAGGACAACCCCACTGCACAGGAGATCATGCAGCTGTTTTGTGGGATGAAGAACGCCCAGCAGTGCCCAGGATT
AGGCAGTACCTCCTGCATCCCATTCTTCTACCGAGGAGACAAGAGAAAGATGAAGATCATCAATATCTAAAAGTTGGCACTGTCAACAAG

>19363_19363_2_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000382070_GOLGA6L2_chr15_23690585_ENST00000567107_length(amino acids)=1215AA_BP=566
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFTDYRQWNIAGVGTRATDTKKKKINN
GTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS
QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL
RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR
EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR
EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE
KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENA
GAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGA
GGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAARE
DAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CREBBP-GOLGA6L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311162_1180266.02443.0ASF1A
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301162_1180266.02405.0ASF1A
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311433_1435266.02443.0histone
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301433_1435266.02405.0histone
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311124_1170266.02443.0histone
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301124_1170266.02405.0histone
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-231227_410266.02443.0SRCAP
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-230227_410266.02405.0SRCAP
HgeneCREBBPchr16:3900298chr15:23690585ENST00000262367-2311460_1891266.02443.0TRERF1
HgeneCREBBPchr16:3900298chr15:23690585ENST00000382070-2301460_1891266.02405.0TRERF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CREBBP-GOLGA6L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CREBBP-GOLGA6L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource