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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREBBP-KAT6B (FusionGDB2 ID:19368)

Fusion Gene Summary for CREBBP-KAT6B

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP-KAT6B
Fusion gene ID: 19368
HgeneTgene
Gene symbol

CREBBP

KAT6B

Gene ID

1387

23522

Gene nameCREB binding proteinlysine acetyltransferase 6B
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf
Cytomap

16p13.3

10q22.2

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a
Modification date2020032920200313
UniProtAcc

Q92793

Q8WYB5

Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000490365, ENST00000287239, 
ENST00000372711, ENST00000372724, 
ENST00000372725, ENST00000372714, 
Fusion gene scores* DoF score43 X 38 X 17=277787 X 11 X 4=308
# samples 6110
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/308*10)=-1.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREBBP [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREBBP(3929833)-KAT6B(76788245), # samples:1
CREBBP(3902433)-KAT6B(76522543), # samples:1
KAT6B(76785007)-CREBBP(3900846), # samples:1
KAT6B(76785007)-CREBBP(3901010), # samples:1
KAT6B(76786164)-CREBBP(3902521), # samples:1
Anticipated loss of major functional domain due to fusion event.CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CREBBP-KAT6B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6B-CREBBP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930

TgeneKAT6B

GO:0016573

histone acetylation

11965546

TgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

TgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

TgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KAT6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB4..CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
ChimerKB4..CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
ChiTaRS5.0N/AAJ299262CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
ChiTaRS5.0N/AAJ299264CREBBPchr16

3902433

-KAT6Bchr10

76522543

+


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Fusion Gene ORF analysis for CREBBP-KAT6B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262367ENST00000490365CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
5CDS-intronENST00000382070ENST00000490365CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000262367ENST00000287239CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000262367ENST00000372711CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000262367ENST00000372724CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000262367ENST00000372725CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000382070ENST00000287239CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000382070ENST00000372711CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000382070ENST00000372724CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
Frame-shiftENST00000382070ENST00000372725CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
In-frameENST00000262367ENST00000372714CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
In-frameENST00000382070ENST00000372714CREBBPchr16

3929833

-KAT6Bchr10

76788245

+
intron-intronENST00000262367ENST00000287239CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000287239CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000287239CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000262367ENST00000372711CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000372711CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000372711CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000262367ENST00000372714CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000372714CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000372714CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000262367ENST00000372724CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000372724CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000372724CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000262367ENST00000372725CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000372725CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000372725CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000262367ENST00000490365CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000262367ENST00000490365CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000262367ENST00000490365CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000287239CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000287239CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000287239CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000372711CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000372711CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000372711CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000372714CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000372714CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000372714CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000372724CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000372724CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000372724CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000372725CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000372725CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000372725CREBBPchr16

3902433

-KAT6Bchr10

76522543

+
intron-intronENST00000382070ENST00000490365CREBBPchr16

3819354

-KAT6Bchr10

3819354

+
intron-intronENST00000382070ENST00000490365CREBBPchr16

3843627

-KAT6Bchr10

3843627

+
intron-intronENST00000382070ENST00000490365CREBBPchr16

3902433

-KAT6Bchr10

76522543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163929833-ENST00000372714KAT6Bchr1076788245+35978956063452948
ENST00000382070CREBBPchr163929833-ENST00000372714KAT6Bchr1076788245+299128902846948

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000372714CREBBPchr163929833-KAT6Bchr1076788245+0.0103955070.9896045
ENST00000382070ENST00000372714CREBBPchr163929833-KAT6Bchr1076788245+0.0121967590.9878033

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Fusion Genomic Features for CREBBP-KAT6B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CREBBPchr163929832-KAT6Bchr1076788246+1.69E-070.9999999
CREBBPchr163929832-KAT6Bchr1076788246+1.69E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CREBBP-KAT6B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3929833/chr10:76788245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

KAT6B

Q8WYB5

FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181351_137312212074.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181409_141712212074.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181594_176312212074.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181961_206112212074.0Compositional biasNote=Met-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171070_110410381891.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171204_120710381891.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171351_137310381891.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171409_141710381891.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171594_176310381891.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171961_206110381891.0Compositional biasNote=Met-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171070_11049291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171204_12079291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171351_13739291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171409_14179291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171594_17639291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171961_20619291782.0Compositional biasNote=Met-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181070_11049291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181204_12079291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181351_13739291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181409_14179291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181594_17639291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181961_20619291782.0Compositional biasNote=Met-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171070_11049291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171204_12079291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171351_13739291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171409_14179291782.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171594_17639291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171961_20619291782.0Compositional biasNote=Met-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311061_1064282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311199_1487282443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311555_1562282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311943_1948282443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311967_1970282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1312081_2085282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1312199_2216282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1312245_2248282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1312297_2300282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301061_1064282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301199_1487282405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301555_1562282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301943_1948282405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301967_1970282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1302081_2085282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1302199_2216282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1302245_2248282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1302297_2300282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311103_1175282443.0DomainBromo
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311323_1700282443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-131587_666282443.0DomainKIX
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301103_1175282405.0DomainBromo
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301323_1700282405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-130587_666282405.0DomainKIX
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311434_1436282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311446_1447282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301434_1436282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301446_1447282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311701_1744282443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311765_1846282443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-131347_433282443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301701_1744282405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301765_1846282405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-130347_433282405.0Zinc fingerTAZ-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181070_110412212074.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181204_120712212074.0Compositional biasNote=Poly-Glu
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618492_53312212074.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618521_52412212074.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618599_60512212074.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517492_53310381891.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517521_52410381891.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517599_60510381891.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517492_5339291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517521_5249291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517599_6059291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618492_5339291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618521_5249291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618599_6059291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517492_5339291782.0Compositional biasNote=Ser-rich
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517521_5249291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517599_6059291782.0Compositional biasNote=Poly-Ser
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618103_17612212074.0DomainH15
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618715_98912212074.0DomainMYST-type HAT
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517103_17610381891.0DomainH15
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517715_98910381891.0DomainMYST-type HAT
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517103_1769291782.0DomainH15
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517715_9899291782.0DomainMYST-type HAT
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618103_1769291782.0DomainH15
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618715_9899291782.0DomainMYST-type HAT
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517103_1769291782.0DomainH15
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517715_9899291782.0DomainMYST-type HAT
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618361_71712212074.0RegionNote=Negatively regulates HAT activity
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618718_100812212074.0RegionNote=Catalytic
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618856_86012212074.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618865_87112212074.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517361_71710381891.0RegionNote=Negatively regulates HAT activity
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517718_100810381891.0RegionNote=Catalytic
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517856_86010381891.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517865_87110381891.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517361_7179291782.0RegionNote=Negatively regulates HAT activity
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517718_10089291782.0RegionNote=Catalytic
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517856_8609291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517865_8719291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618361_7179291782.0RegionNote=Negatively regulates HAT activity
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618718_10089291782.0RegionNote=Catalytic
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618856_8609291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618865_8719291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517361_7179291782.0RegionNote=Negatively regulates HAT activity
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517718_10089291782.0RegionNote=Catalytic
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517856_8609291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517865_8719291782.0RegionAcetyl-CoA binding
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618213_27212212074.0Zinc fingerPHD-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618269_32012212074.0Zinc fingerPHD-type 2
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618748_77312212074.0Zinc fingerC2HC MYST-type
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517213_27210381891.0Zinc fingerPHD-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517269_32010381891.0Zinc fingerPHD-type 2
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517748_77310381891.0Zinc fingerC2HC MYST-type
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517213_2729291782.0Zinc fingerPHD-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517269_3209291782.0Zinc fingerPHD-type 2
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517748_7739291782.0Zinc fingerC2HC MYST-type
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618213_2729291782.0Zinc fingerPHD-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618269_3209291782.0Zinc fingerPHD-type 2
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618748_7739291782.0Zinc fingerC2HC MYST-type
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517213_2729291782.0Zinc fingerPHD-type 1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517269_3209291782.0Zinc fingerPHD-type 2
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517748_7739291782.0Zinc fingerC2HC MYST-type


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Fusion Gene Sequence for CREBBP-KAT6B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19368_19368_1_CREBBP-KAT6B_CREBBP_chr16_3929833_ENST00000262367_KAT6B_chr10_76788245_ENST00000372714_length(transcript)=3597nt_BP=895nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACAAT
ATGAATGATGATTCAAGTAACTTGAAAGAAGGCAGTAAAGACAATCCCGAACCTCTAAAGTGCAAACAAGTGTGGCCAAAAGGAACAAAG
CGCGGTCTATCTAAGTGGAGGCAAAACAAAGAGAGGAAGACCGGATTTAAACTGAATTTGTACACCCCGCCAGAAACACCCATGGAGCCT
GACGAGCAGGTAACAGTGGAAGAACAGAAGGAGACTTCAGAAGGAAAAACCAGCCCCAGTCCCATCAGGATTGAGGAGGAGGTCAAGGAA
ACTGGGGAAGCCCTGTTGCCTCAAGAGGAAAACAGAAGGGAAGAAACATGTGCCCCTGTAAGTCCAAACACATCACCAGGTGAAAAACCA
GAAGATGATCTCATCAAACCTGAGGAAGAGGAAGAGGAGGAGGAGGAGGAAGAGGAAGAAGAGGAAGAAGAGGAAGGGGAAGAAGAAGAA
GGAGGAGGAAATGTAGAAAAAGATCCAGATGGTGCTAAAAGCCAAGAAAAAGAGGAACCAGAAATCTCCACGGAAAAAGAAGACTCTGCA
CGTTTGGATGATCACGAAGAGGAGGAGGAAGAGGATGAAGAGCCATCCCACAACGAGGACCATGATGCCGATGACGAGGATGACAGCCAC
ATGGAGTCTGCCGAAGTGGAGAAGGAAGAGCTGCCCAGAGAAAGCTTCAAAGAAGTACTGGAAAACCAGGAGACTTTTTTAGACCTTAAT
GTGCAGCCTGGTCACTCGAACCCAGAGGTCTTAATGGACTGTGGCGTCGACCTGACAGCTTCTTGTAACAGTGAGCCCAAGGAGCTTGCT
GGGGACCCTGAAGCTGTACCCGAATCTGACGAGGAGCCACCCCCAGGAGAACAGGCACAGAAGCAGGACCAAAAGAACAGCAAGGAAGTC
GATACAGAGTTCAAAGAGGGAAACCCAGCAACCATGGAAATCGACTCTGAGACTGTCCAGGCCGTTCAGTCTTTGACCCAGGAGAGCAGC
GAACAGGACGACACCTTTCAGGATTGTGCCGAGACTCAAGAGGCCTGTAGAAGCCTACAGAACTACACCCGTGCAGACCAAAGTCCACAG
ATTGCCACCACGCTCGACGATTGCCAACAGTCGGACCACAGTAGCCCAGTTTCATCCGTCCACTCCCATCCTGGCCAGTCCGTACGTTCT
GTCAACAGCCCAAGTGTCCCTGCTCTGGAAAACAGCTACGCCCAAATCAGCCCAGATCAAAGTGCCATCTCAGTGCCATCTCTGCAGAAC
ATGGAAACCAGTCCCATGATGGATGTCCCATCAGTTTCAGATCATTCACAGCAAGTCGTAGACAGTGGATTTAGTGACCTGGGCAGTATC
GAGAGCACAACTGAGAACTACGAAAACCCAAGCAGCTACGATTCTACTATGGGAGGCAGCATCTGTGGAAACGGCTCTTCACAGAACAGC
TGCTCCTATAGCAACCTCACCTCCAGCAGTCTGACACAGAGCAGCTGTGCTGTCACCCAGCAGATGTCCAACATCAGCGGGAGCTGCAGC
ATGCTGCAGCAAACCAGCATCAGCTCCCCTCCGACCTGCAGCGTCAAGTCTCCTCAAGGCTGTGTGGTGGAGAGGCCTCCGAGCAGCAGC
CAGCAGCTGGCTCAGTGCAGCATGGCTGCTAACTTCACCCCACCCATGCAGCTGGCTGAAATCCCCGAGACGAGCAACGCCAACATTGGC
TTATACGAGCGAATGGGTCAGAGTGATTTTGGGGCTGGGCATTACCCGCAGCCGTCAGCCACCTTCAGCCTTGCCAAACTGCAGCAGTTA
ACTAATACACTTATTGATCATTCATTGCCTTACAGCCATTCCGCTGCTGTGACTTCCTATGCAAACAGTGCCTCTTTGTCCACACCATTA
AGTAACACAGGGCTTGTTCAACTTTCTCAGTCTCCACACTCCGTCCCTGGGGGACCCCAAGCACAAGCTACCATGACCCCACCCCCCAAC
CTGACTCCTCCTCCAATGAATCTGCCGCCGCCTCTTTTGCAACGGAACATGGCTGCATCAAATATTGGCATCTCTCACAGCCAAAGACTG
CAAACCCAGATTGCCAGCAAGGGCCACATCTCCATGAGAACCAAGTCAGCGTCTCTGTCACCAGCCGCTGCCACCCATCAGTCACAAATC
TATGGGCGCTCCCAGACTGTAGCCATGCAGGGTCCTGCACGGACTTTAACGATGCAAAGAGGCATGAACATGAGTGTGAACCTGATGCCA
GCGCCAGCCTACAATGTCAACTCTGTGAACATGAACATGAACACTCTCAACGCCATGAATGGGTACAGCATGTCCCAGCCAATGATGAAC
AGTGGCTACCACAGCAATCATGGCTATATGAATCAAACGCCCCAATACCCTATGCAGATGCAGATGGGCATGATGGGCACCCAGCCATAT
GCCCAGCAGCCAATGCAGACCCCACCCCACGGTAACATGATGTACACGGCCCCCGGACATCACGGCTACATGAACACAGGCATGTCCAAA
CAGTCTCTCAATGGCTCCTACATGAGAAGGTAGACAACGTGGGCAGTCCACAAAACCTACGGGGCATCACTATTGGATTGATCTGCACAA

>19368_19368_1_CREBBP-KAT6B_CREBBP_chr16_3929833_ENST00000262367_KAT6B_chr10_76788245_ENST00000372714_length(amino acids)=948AA_BP=96
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPI
RIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEI
STEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASC
NSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNY
TRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDS
GFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCV
VERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYAN
SASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPA
AATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQM

--------------------------------------------------------------
>19368_19368_2_CREBBP-KAT6B_CREBBP_chr16_3929833_ENST00000382070_KAT6B_chr10_76788245_ENST00000372714_length(transcript)=2991nt_BP=289nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGACAATATGAATGATGATTCAAGTAACTTGAAAGAAGGCAGTAAAGACAATCCCGAACCTCTAAAGTGCAAA
CAAGTGTGGCCAAAAGGAACAAAGCGCGGTCTATCTAAGTGGAGGCAAAACAAAGAGAGGAAGACCGGATTTAAACTGAATTTGTACACC
CCGCCAGAAACACCCATGGAGCCTGACGAGCAGGTAACAGTGGAAGAACAGAAGGAGACTTCAGAAGGAAAAACCAGCCCCAGTCCCATC
AGGATTGAGGAGGAGGTCAAGGAAACTGGGGAAGCCCTGTTGCCTCAAGAGGAAAACAGAAGGGAAGAAACATGTGCCCCTGTAAGTCCA
AACACATCACCAGGTGAAAAACCAGAAGATGATCTCATCAAACCTGAGGAAGAGGAAGAGGAGGAGGAGGAGGAAGAGGAAGAAGAGGAA
GAAGAGGAAGGGGAAGAAGAAGAAGGAGGAGGAAATGTAGAAAAAGATCCAGATGGTGCTAAAAGCCAAGAAAAAGAGGAACCAGAAATC
TCCACGGAAAAAGAAGACTCTGCACGTTTGGATGATCACGAAGAGGAGGAGGAAGAGGATGAAGAGCCATCCCACAACGAGGACCATGAT
GCCGATGACGAGGATGACAGCCACATGGAGTCTGCCGAAGTGGAGAAGGAAGAGCTGCCCAGAGAAAGCTTCAAAGAAGTACTGGAAAAC
CAGGAGACTTTTTTAGACCTTAATGTGCAGCCTGGTCACTCGAACCCAGAGGTCTTAATGGACTGTGGCGTCGACCTGACAGCTTCTTGT
AACAGTGAGCCCAAGGAGCTTGCTGGGGACCCTGAAGCTGTACCCGAATCTGACGAGGAGCCACCCCCAGGAGAACAGGCACAGAAGCAG
GACCAAAAGAACAGCAAGGAAGTCGATACAGAGTTCAAAGAGGGAAACCCAGCAACCATGGAAATCGACTCTGAGACTGTCCAGGCCGTT
CAGTCTTTGACCCAGGAGAGCAGCGAACAGGACGACACCTTTCAGGATTGTGCCGAGACTCAAGAGGCCTGTAGAAGCCTACAGAACTAC
ACCCGTGCAGACCAAAGTCCACAGATTGCCACCACGCTCGACGATTGCCAACAGTCGGACCACAGTAGCCCAGTTTCATCCGTCCACTCC
CATCCTGGCCAGTCCGTACGTTCTGTCAACAGCCCAAGTGTCCCTGCTCTGGAAAACAGCTACGCCCAAATCAGCCCAGATCAAAGTGCC
ATCTCAGTGCCATCTCTGCAGAACATGGAAACCAGTCCCATGATGGATGTCCCATCAGTTTCAGATCATTCACAGCAAGTCGTAGACAGT
GGATTTAGTGACCTGGGCAGTATCGAGAGCACAACTGAGAACTACGAAAACCCAAGCAGCTACGATTCTACTATGGGAGGCAGCATCTGT
GGAAACGGCTCTTCACAGAACAGCTGCTCCTATAGCAACCTCACCTCCAGCAGTCTGACACAGAGCAGCTGTGCTGTCACCCAGCAGATG
TCCAACATCAGCGGGAGCTGCAGCATGCTGCAGCAAACCAGCATCAGCTCCCCTCCGACCTGCAGCGTCAAGTCTCCTCAAGGCTGTGTG
GTGGAGAGGCCTCCGAGCAGCAGCCAGCAGCTGGCTCAGTGCAGCATGGCTGCTAACTTCACCCCACCCATGCAGCTGGCTGAAATCCCC
GAGACGAGCAACGCCAACATTGGCTTATACGAGCGAATGGGTCAGAGTGATTTTGGGGCTGGGCATTACCCGCAGCCGTCAGCCACCTTC
AGCCTTGCCAAACTGCAGCAGTTAACTAATACACTTATTGATCATTCATTGCCTTACAGCCATTCCGCTGCTGTGACTTCCTATGCAAAC
AGTGCCTCTTTGTCCACACCATTAAGTAACACAGGGCTTGTTCAACTTTCTCAGTCTCCACACTCCGTCCCTGGGGGACCCCAAGCACAA
GCTACCATGACCCCACCCCCCAACCTGACTCCTCCTCCAATGAATCTGCCGCCGCCTCTTTTGCAACGGAACATGGCTGCATCAAATATT
GGCATCTCTCACAGCCAAAGACTGCAAACCCAGATTGCCAGCAAGGGCCACATCTCCATGAGAACCAAGTCAGCGTCTCTGTCACCAGCC
GCTGCCACCCATCAGTCACAAATCTATGGGCGCTCCCAGACTGTAGCCATGCAGGGTCCTGCACGGACTTTAACGATGCAAAGAGGCATG
AACATGAGTGTGAACCTGATGCCAGCGCCAGCCTACAATGTCAACTCTGTGAACATGAACATGAACACTCTCAACGCCATGAATGGGTAC
AGCATGTCCCAGCCAATGATGAACAGTGGCTACCACAGCAATCATGGCTATATGAATCAAACGCCCCAATACCCTATGCAGATGCAGATG
GGCATGATGGGCACCCAGCCATATGCCCAGCAGCCAATGCAGACCCCACCCCACGGTAACATGATGTACACGGCCCCCGGACATCACGGC
TACATGAACACAGGCATGTCCAAACAGTCTCTCAATGGCTCCTACATGAGAAGGTAGACAACGTGGGCAGTCCACAAAACCTACGGGGCA
TCACTATTGGATTGATCTGCACAAATACCTTTGAAGAGTACGATTTCAAAACCAGCAATTGGTGTGAATGCAAAAACATTTGTTGGCACC

>19368_19368_2_CREBBP-KAT6B_CREBBP_chr16_3929833_ENST00000382070_KAT6B_chr10_76788245_ENST00000372714_length(amino acids)=948AA_BP=96
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSEGKTSPSPI
RIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEI
STEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASC
NSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNY
TRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDS
GFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCV
VERPPSSSQQLAQCSMAANFTPPMQLAEIPETSNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYAN
SASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHISMRTKSASLSPA
AATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQM

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Fusion Gene PPI Analysis for CREBBP-KAT6B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000028723916181560_20731221.33333333333332074.0RUNX1 and RUNX2
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271115171560_20731038.33333333333331891.0RUNX1 and RUNX2
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037271415171560_2073929.33333333333341782.0RUNX1 and RUNX2
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272416181560_2073929.33333333333341782.0RUNX1 and RUNX2
TgeneKAT6Bchr16:3929833chr10:76788245ENST0000037272515171560_2073929.33333333333341782.0RUNX1 and RUNX2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311162_118028.3333333333333322443.0ASF1A
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301162_118028.3333333333333322405.0ASF1A
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311433_143528.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301433_143528.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311124_117028.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301124_117028.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-131227_41028.3333333333333322443.0SRCAP
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-130227_41028.3333333333333322405.0SRCAP
HgeneCREBBPchr16:3929833chr10:76788245ENST00000262367-1311460_189128.3333333333333322443.0TRERF1
HgeneCREBBPchr16:3929833chr10:76788245ENST00000382070-1301460_189128.3333333333333322405.0TRERF1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000002872391618752_10081221.33333333333332074.0BRPF1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727111517752_10081038.33333333333331891.0BRPF1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727141517752_1008929.33333333333341782.0BRPF1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727241618752_1008929.33333333333341782.0BRPF1
TgeneKAT6Bchr16:3929833chr10:76788245ENST000003727251517752_1008929.33333333333341782.0BRPF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREBBP-KAT6B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREBBP-KAT6B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource