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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CREG1-DCAF6 (FusionGDB2 ID:19409)

Fusion Gene Summary for CREG1-DCAF6

Fusion gene summary

Fusion gene information	Fusion gene name: CREG1-DCAF6
	Fusion gene ID: 19409
		Hgene	Tgene
	Gene symbol	CREG1	DCAF6
	Gene ID	8804	55827
	Gene name	cellular repressor of E1A stimulated genes 1	DDB1 and CUL4 associated factor 6
	Synonyms	CREG	1200006M05Rik\|ARCAP\|IQWD1\|MSTP055\|NRIP\|PC326
	Cytomap	1q24.2	1q24.2
	Type of gene	protein-coding	protein-coding
	Description	protein CREG1	DDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction protein
	Modification date	20200313	20200313
	UniProtAcc	O75629	Q58WW2
	Ensembl transtripts involved in fusion gene	ENST00000370509, ENST00000466652,	ENST00000470919, ENST00000312263, ENST00000367840, ENST00000367843, ENST00000432587,
Fusion gene scores	* DoF score	2 X 2 X 2=8	10 X 9 X 8=720
	# samples	2	10
	** MAII score	log2(2/8*10)=1.32192809488736	log2(10/720*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CREG1 [Title/Abstract] AND DCAF6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CREG1(167517238)-DCAF6(167971719), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CREG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	5263N	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+

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Fusion Gene ORF analysis for CREG1-DCAF6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000370509	ENST00000470919	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
In-frame	ENST00000370509	ENST00000312263	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
In-frame	ENST00000370509	ENST00000367840	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
In-frame	ENST00000370509	ENST00000367843	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
In-frame	ENST00000370509	ENST00000432587	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
intron-3CDS	ENST00000466652	ENST00000312263	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
intron-3CDS	ENST00000466652	ENST00000367840	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
intron-3CDS	ENST00000466652	ENST00000367843	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
intron-3CDS	ENST00000466652	ENST00000432587	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+
intron-intron	ENST00000466652	ENST00000470919	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000370509	CREG1	chr1	167517238	-	ENST00000367843	DCAF6	chr1	167971719	+	2648	500	26	2239	737
ENST00000370509	CREG1	chr1	167517238	-	ENST00000432587	DCAF6	chr1	167971719	+	2649	500	26	2452	808
ENST00000370509	CREG1	chr1	167517238	-	ENST00000312263	DCAF6	chr1	167971719	+	2579	500	26	2179	717
ENST00000370509	CREG1	chr1	167517238	-	ENST00000367840	DCAF6	chr1	167971719	+	2852	500	26	2452	808

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370509	ENST00000367843	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	0.001930249	0.9980698
ENST00000370509	ENST00000432587	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	0.003597672	0.9964024
ENST00000370509	ENST00000312263	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	0.002064388	0.99793565
ENST00000370509	ENST00000367840	CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	0.002331008	0.9976689

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Fusion Genomic Features for CREG1-DCAF6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	4.47E-06	0.9999956
CREG1	chr1	167517238	-	DCAF6	chr1	167971719	+	4.47E-06	0.9999956

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CREG1-DCAF6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:167517238/chr1:167971719)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CREG1 O75629	DCAF6 Q58WW2
FUNCTION: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. {ECO:0000269\|PubMed:12934103, ECO:0000269\|PubMed:9710587}.	FUNCTION: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:15784617, ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

676_705

301

861.0

Domain

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

676_705

301

952.0

Domain

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

676_705

301

881.0

Domain

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

676_705

270

921.0

Domain

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

718_756

301

861.0

Repeat

Note=WD 6

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

759_798

301

861.0

Repeat

Note=WD 7

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

718_756

301

952.0

Repeat

Note=WD 6

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

759_798

301

952.0

Repeat

Note=WD 7

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

718_756

301

881.0

Repeat

Note=WD 6

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

759_798

301

881.0

Repeat

Note=WD 7

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

718_756

270

921.0

Repeat

Note=WD 6

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

759_798

270

921.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

139_179

301

861.0

Repeat

Note=WD 3

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

189_229

301

861.0

Repeat

Note=WD 4

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

251_290

301

861.0

Repeat

Note=WD 5

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

49_88

301

861.0

Repeat

Note=WD 1

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000312263

92_133

301

861.0

Repeat

Note=WD 2

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

139_179

301

952.0

Repeat

Note=WD 3

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

189_229

301

952.0

Repeat

Note=WD 4

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

251_290

301

952.0

Repeat

Note=WD 5

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

49_88

301

952.0

Repeat

Note=WD 1

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367840

92_133

301

952.0

Repeat

Note=WD 2

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

139_179

301

881.0

Repeat

Note=WD 3

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

189_229

301

881.0

Repeat

Note=WD 4

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

251_290

301

881.0

Repeat

Note=WD 5

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

49_88

301

881.0

Repeat

Note=WD 1

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000367843

92_133

301

881.0

Repeat

Note=WD 2

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

139_179

270

921.0

Repeat

Note=WD 3

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

189_229

270

921.0

Repeat

Note=WD 4

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

251_290

270

921.0

Repeat

Note=WD 5

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

49_88

270

921.0

Repeat

Note=WD 1

Tgene

DCAF6

chr1:167517238

chr1:167971719

ENST00000432587

92_133

270

921.0

Repeat

Note=WD 2

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Fusion Gene Sequence for CREG1-DCAF6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19409_19409_1_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000312263_length(transcript)=2579nt_BP=500nt
CCGGGACTCTTCCTGGAGACACCGCCATGGCCGGGCTATCCCGCGGGTCCGCGCGCGCACTGCTCGCCGCCCTGCTGGCGTCGACGCTGT
TGGCGCTGCTCGTGTCGCCCGCGCGGGGTCGCGGCGGCCGGGACCACGGGGACTGGGACGAGGCCTCCCGGCTGCCGCCGCTACCACCCC
GCGAGGACGCGGCGCGCGTGGCCCGCTTCGTGACGCACGTCTCCGACTGGGGCGCTCTGGCCACCATCTCCACGCTGGAGGCGGTGCGCG
GCCGGCCCTTCGCCGACGTCCTCTCGCTCAGCGACGGGCCCCCGGGCGCGGGCAGCGGCGTGCCCTATTTCTACCTGAGCCCGCTGCAGC
TCTCCGTGAGCAACCTGCAGGAGAATCCATATGCTACACTGACCATGACTTTGGCACAGACCAACTTCTGCAAGAAACATGGATTTGATC
CACAAAGTCCCCTTTGTGTTCACATAATGCTGTCAGGAACTGTGACCAAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTG
ATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAA
TGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAA
CAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAG
CTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTC
CTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGATAACAATAATGAAA
AGCTGAGCCCCAAACCAGGGACAGGTGAACCAGTTTTAAGTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACT
TTACAGATGAATGGAGCAGTATAGCATCAAGTTCTAGAGGAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCAC
AGAGCTCAGTGCAACCACCAGAAGGAGACAGTGAAACAAAAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTAT
CTGCAGAAAACCCAGTTGAGAACCATATCAATATAACACAATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAA
ATGACCTCAATCTTGATCGCTCTTGTGGGGTTCCAGAAGAATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTA
GCACTGAGAGTGCTACCAATGAAAATAACACCAATCCTGAGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACAT
CCACCAGGGACTCTGCTCTTCAGGACACAGATGACAGTGATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTG
ATAGACGCTCTGCTGTTGCCCGTATTCAGGAGTTCTTCAGACGGAGAAAAGAAAGGAAAGAAATGGAAGAATTGGATACTTTGAACATTA
GAAGGCCGCTAGTAAAAATGGTTTATAAAGGCCATCGCAACTCCAGGACAATGATAAAAGAAGCCAATTTCTGGGGTGCTAACTTTGTAA
TGAGTGGTTCTGACTGTGGCCACATTTTCATCTGGGATCGGCACACTGCTGAGCATTTGATGCTTCTGGAAGCTGATAATCATGTGGTAA
ACTGCCTGCAGCCACATCCGTTTGACCCAATTTTAGCCTCATCTGGCATAGATTATGACATAAAGATCTGGTCACCATTAGAAGAGTCAA
GGATTTTTAACCGAAAACTTGCTGATGAAGTTATAACTCGAAACGAACTCATGCTGGAAGAAACTAGAAACACCATTACAGTTCCAGCCT
CTTTCATGTTGAGGATGTTGGCTTCACTTAATCATATCCGAGCTGACCGGTTGGAGGGTGACAGATCAGAAGGCTCTGGTCAAGAGAATG
AAAATGAGGATGAGGAATAATAAACTCTTTTTGGCAAGCACTTAAATGTTCTGAAATTTGTATAAGACATTTATTATATTTTTTTCTTTA
CAGAGCTTTAGTGCAATTTTAAGGTTATGGTTTTTGGAGTTTTTCCCTTTTTTTGGGATAACCTAACATTGGTTTGGAATGATTGTGTGC
ATGAATTTGGGAGATTGTATAAAACAAAACTAGCAGAATGTTTTTAAAACTTTTTGCCGTGTATGAGGAGTGCTAGAAAATGCAAAGTGC
AATATTTTCCCTAACCTTCAAATGTGGGAGCTTGGATCAATGTTGAAGAATAATTTTCATCATAGTGAAAATGTTGGTTCAAATAAATTT

>19409_19409_1_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000312263_length(amino acids)=717AA_BP=158
MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLS
LSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKLRQPPVKRLRLRGDWSDTGPRA
RPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPST
SSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIA
SSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSC
GVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARI
QEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFD

--------------------------------------------------------------
>19409_19409_2_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000367840_length(transcript)=2852nt_BP=500nt
CCGGGACTCTTCCTGGAGACACCGCCATGGCCGGGCTATCCCGCGGGTCCGCGCGCGCACTGCTCGCCGCCCTGCTGGCGTCGACGCTGT
TGGCGCTGCTCGTGTCGCCCGCGCGGGGTCGCGGCGGCCGGGACCACGGGGACTGGGACGAGGCCTCCCGGCTGCCGCCGCTACCACCCC
GCGAGGACGCGGCGCGCGTGGCCCGCTTCGTGACGCACGTCTCCGACTGGGGCGCTCTGGCCACCATCTCCACGCTGGAGGCGGTGCGCG
GCCGGCCCTTCGCCGACGTCCTCTCGCTCAGCGACGGGCCCCCGGGCGCGGGCAGCGGCGTGCCCTATTTCTACCTGAGCCCGCTGCAGC
TCTCCGTGAGCAACCTGCAGGAGAATCCATATGCTACACTGACCATGACTTTGGCACAGACCAACTTCTGCAAGAAACATGGATTTGATC
CACAAAGTCCCCTTTGTGTTCACATAATGCTGTCAGGAACTGTGACCAAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTG
ATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAA
TGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAA
CAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAG
CTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTC
CTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGAATTTTTAAGGGGCC
CTGAGATAGCTTTGCTTCGTAAGCGCCTGCAACAACTGAGGCTTAAGAAGGCTGAGCAGCAGAGGCAGCAAGAGCTAGCTGCACATACCC
AGCAACAGCCTTCCACTTCTGATCAGTCTTCTCATGAGGGCTCTTCACAGGACCCTCATGCTTCAGATTCTCCTTCTTCTGTGGTTAACA
AACAGCTCGGATCCATGTCACTTGACGAGCAACAGGATAACAATAATGAAAAGCTGAGCCCCAAACCAGGGACAGGTGAACCAGTTTTAA
GTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACTTTACAGATGAATGGAGCAGTATAGCATCAAGTTCTAGAG
GAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCACAGAGCTCAGTGCAACCACCAGAAGGAGACAGTGAAACAA
AAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTATCTGCAGAAAACCCAGTTGAGAACCATATCAATATAACAC
AATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAAATGACCTCAATCTTGATCGCTCTTGTGGGGTTCCAGAAG
AATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTAGCACTGAGAGTGCTACCAATGAAAATAACACCAATCCTG
AGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACATCCACCAGGGACTCTGCTCTTCAGGACACAGATGACAGTG
ATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTGATAGATTTAATATCAGAGGAACAACAATAGGTGATAGAA
TAATGAGACGCTCTGCTGTTGCCCGTATTCAGGAGTTCTTCAGACGGAGAAAAGAAAGGAAAGAAATGGAAGAATTGGATACTTTGAACA
TTAGAAGGCCGCTAGTAAAAATGGTTTATAAAGGCCATCGCAACTCCAGGACAATGATAAAAGAAGCCAATTTCTGGGGTGCTAACTTTG
TAATGAGTGGTTCTGACTGTGGCCACATTTTCATCTGGGATCGGCACACTGCTGAGCATTTGATGCTTCTGGAAGCTGATAATCATGTGG
TAAACTGCCTGCAGCCACATCCGTTTGACCCAATTTTAGCCTCATCTGGCATAGATTATGACATAAAGATCTGGTCACCATTAGAAGAGT
CAAGGATTTTTAACCGAAAACTTGCTGATGAAGTTATAACTCGAAACGAACTCATGCTGGAAGAAACTAGAAACACCATTACAGTTCCAG
CCTCTTTCATGTTGAGGATGTTGGCTTCACTTAATCATATCCGAGCTGACCGGTTGGAGGGTGACAGATCAGAAGGCTCTGGTCAAGAGA
ATGAAAATGAGGATGAGGAATAATAAACTCTTTTTGGCAAGCACTTAAATGTTCTGAAATTTGTATAAGACATTTATTATATTTTTTTCT
TTACAGAGCTTTAGTGCAATTTTAAGGTTATGGTTTTTGGAGTTTTTCCCTTTTTTTGGGATAACCTAACATTGGTTTGGAATGATTGTG
TGCATGAATTTGGGAGATTGTATAAAACAAAACTAGCAGAATGTTTTTAAAACTTTTTGCCGTGTATGAGGAGTGCTAGAAAATGCAAAG
TGCAATATTTTCCCTAACCTTCAAATGTGGGAGCTTGGATCAATGTTGAAGAATAATTTTCATCATAGTGAAAATGTTGGTTCAAATAAA

>19409_19409_2_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000367840_length(amino acids)=808AA_BP=158
MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLS
LSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKLRQPPVKRLRLRGDWSDTGPRA
RPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPST
SSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQ
SSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSE
GQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAK
EPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVAR
IQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPF

--------------------------------------------------------------
>19409_19409_3_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000367843_length(transcript)=2648nt_BP=500nt
CCGGGACTCTTCCTGGAGACACCGCCATGGCCGGGCTATCCCGCGGGTCCGCGCGCGCACTGCTCGCCGCCCTGCTGGCGTCGACGCTGT
TGGCGCTGCTCGTGTCGCCCGCGCGGGGTCGCGGCGGCCGGGACCACGGGGACTGGGACGAGGCCTCCCGGCTGCCGCCGCTACCACCCC
GCGAGGACGCGGCGCGCGTGGCCCGCTTCGTGACGCACGTCTCCGACTGGGGCGCTCTGGCCACCATCTCCACGCTGGAGGCGGTGCGCG
GCCGGCCCTTCGCCGACGTCCTCTCGCTCAGCGACGGGCCCCCGGGCGCGGGCAGCGGCGTGCCCTATTTCTACCTGAGCCCGCTGCAGC
TCTCCGTGAGCAACCTGCAGGAGAATCCATATGCTACACTGACCATGACTTTGGCACAGACCAACTTCTGCAAGAAACATGGATTTGATC
CACAAAGTCCCCTTTGTGTTCACATAATGCTGTCAGGAACTGTGACCAAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTG
ATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAA
TGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAA
CAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAG
CTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTC
CTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGATTCTCCTTCTTCTG
TGGTTAACAAACAGCTCGGATCCATGTCACTTGACGAGCAACAGGATAACAATAATGAAAAGCTGAGCCCCAAACCAGGGACAGGTGAAC
CAGTTTTAAGTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACTTTACAGATGAATGGAGCAGTATAGCATCAA
GTTCTAGAGGAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCACAGAGCTCAGTGCAACCACCAGAAGGAGACA
GTGAAACAAAAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTATCTGCAGAAAACCCAGTTGAGAACCATATCA
ATATAACACAATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAAATGACCTCAATCTTGATCGCTCTTGTGGGG
TTCCAGAAGAATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTAGCACTGAGAGTGCTACCAATGAAAATAACA
CCAATCCTGAGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACATCCACCAGGGACTCTGCTCTTCAGGACACAG
ATGACAGTGATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTGATAGACGCTCTGCTGTTGCCCGTATTCAGG
AGTTCTTCAGACGGAGAAAAGAAAGGAAAGAAATGGAAGAATTGGATACTTTGAACATTAGAAGGCCGCTAGTAAAAATGGTTTATAAAG
GCCATCGCAACTCCAGGACAATGATAAAAGAAGCCAATTTCTGGGGTGCTAACTTTGTAATGAGTGGTTCTGACTGTGGCCACATTTTCA
TCTGGGATCGGCACACTGCTGAGCATTTGATGCTTCTGGAAGCTGATAATCATGTGGTAAACTGCCTGCAGCCACATCCGTTTGACCCAA
TTTTAGCCTCATCTGGCATAGATTATGACATAAAGATCTGGTCACCATTAGAAGAGTCAAGGATTTTTAACCGAAAACTTGCTGATGAAG
TTATAACTCGAAACGAACTCATGCTGGAAGAAACTAGAAACACCATTACAGTTCCAGCCTCTTTCATGTTGAGGATGTTGGCTTCACTTA
ATCATATCCGAGCTGACCGGTTGGAGGGTGACAGATCAGAAGGCTCTGGTCAAGAGAATGAAAATGAGGATGAGGAATAATAAACTCTTT
TTGGCAAGCACTTAAATGTTCTGAAATTTGTATAAGACATTTATTATATTTTTTTCTTTACAGAGCTTTAGTGCAATTTTAAGGTTATGG
TTTTTGGAGTTTTTCCCTTTTTTTGGGATAACCTAACATTGGTTTGGAATGATTGTGTGCATGAATTTGGGAGATTGTATAAAACAAAAC
TAGCAGAATGTTTTTAAAACTTTTTGCCGTGTATGAGGAGTGCTAGAAAATGCAAAGTGCAATATTTTCCCTAACCTTCAAATGTGGGAG
CTTGGATCAATGTTGAAGAATAATTTTCATCATAGTGAAAATGTTGGTTCAAATAAATTTCTACACTTGCCATTTGCATGTTTGTTGCTT

>19409_19409_3_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000367843_length(amino acids)=737AA_BP=158
MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLS
LSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKLRQPPVKRLRLRGDWSDTGPRA
RPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPST
SSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYST
EGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFT
AKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVL
IPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEH
LMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLE

--------------------------------------------------------------
>19409_19409_4_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000432587_length(transcript)=2649nt_BP=500nt
CCGGGACTCTTCCTGGAGACACCGCCATGGCCGGGCTATCCCGCGGGTCCGCGCGCGCACTGCTCGCCGCCCTGCTGGCGTCGACGCTGT
TGGCGCTGCTCGTGTCGCCCGCGCGGGGTCGCGGCGGCCGGGACCACGGGGACTGGGACGAGGCCTCCCGGCTGCCGCCGCTACCACCCC
GCGAGGACGCGGCGCGCGTGGCCCGCTTCGTGACGCACGTCTCCGACTGGGGCGCTCTGGCCACCATCTCCACGCTGGAGGCGGTGCGCG
GCCGGCCCTTCGCCGACGTCCTCTCGCTCAGCGACGGGCCCCCGGGCGCGGGCAGCGGCGTGCCCTATTTCTACCTGAGCCCGCTGCAGC
TCTCCGTGAGCAACCTGCAGGAGAATCCATATGCTACACTGACCATGACTTTGGCACAGACCAACTTCTGCAAGAAACATGGATTTGATC
CACAAAGTCCCCTTTGTGTTCACATAATGCTGTCAGGAACTGTGACCAAGTTGCGACAACCACCAGTTAAGCGTTTGAGACTTCGTGGTG
ATTGGTCAGATACTGGACCCAGAGCAAGGCCGGAGAGTGAACGAGAACGAGATGGAGAGCAGAGTCCCAATGTGTCATTGATGCAGAGAA
TGTCTGATATGTTATCAAGATGGTTTGAAGAAGCAAGTGAGGTTGCACAAAGCAATAGAGGACGAGGAAGATCTCGACCCAGAGGTGGAA
CAAGTCAATCAGATATTTCAACTCTTCCTACGGTCCCATCAAGTCCTGATTTGGAAGTGAGTGAAACTGCAATGGAAGTAGATACTCCAG
CTGAACAATTTCTTCAGCCTTCTACATCCTCTACAATGTCAGCTCAGGCTCATTCGACATCATCTCCCACAGAAAGCCCTCATTCTACTC
CTTTGCTATCTTCTCCAGACAGTGAACAAAGGCAGTCTGTTGAGGCATCTGGACACCACACACATCATCAGTCTGAATTTTTAAGGGGCC
CTGAGATAGCTTTGCTTCGTAAGCGCCTGCAACAACTGAGGCTTAAGAAGGCTGAGCAGCAGAGGCAGCAAGAGCTAGCTGCACATACCC
AGCAACAGCCTTCCACTTCTGATCAGTCTTCTCATGAGGGCTCTTCACAGGACCCTCATGCTTCAGATTCTCCTTCTTCTGTGGTTAACA
AACAGCTCGGATCCATGTCACTTGACGAGCAACAGGATAACAATAATGAAAAGCTGAGCCCCAAACCAGGGACAGGTGAACCAGTTTTAA
GTTTGCACTACAGCACAGAAGGAACAACTACAAGCACAATAAAACTGAACTTTACAGATGAATGGAGCAGTATAGCATCAAGTTCTAGAG
GAATTGGGAGCCATTGCAAATCTGAGGGTCAGGAGGAATCTTTCGTCCCACAGAGCTCAGTGCAACCACCAGAAGGAGACAGTGAAACAA
AAGCTCCTGAAGAATCATCAGAGGATGTGACAAAATATCAGGAAGGAGTATCTGCAGAAAACCCAGTTGAGAACCATATCAATATAACAC
AATCAGATAAGTTCACAGCCAAGCCATTGGATTCCAACTCAGGAGAAAGAAATGACCTCAATCTTGATCGCTCTTGTGGGGTTCCAGAAG
AATCTGCTTCATCTGAAAAAGCCAAGGAACCAGAAACTTCAGATCAGACTAGCACTGAGAGTGCTACCAATGAAAATAACACCAATCCTG
AGCCTCAGTTCCAAACAGAAGCCACTGGGCCTTCAGCTCATGAAGAAACATCCACCAGGGACTCTGCTCTTCAGGACACAGATGACAGTG
ATGATGACCCAGTCCTGATCCCAGGTGCAAGGTATCGAGCAGGACCTGGTGATAGATTTAATATCAGAGGAACAACAATAGGTGATAGAA
TAATGAGACGCTCTGCTGTTGCCCGTATTCAGGAGTTCTTCAGACGGAGAAAAGAAAGGAAAGAAATGGAAGAATTGGATACTTTGAACA
TTAGAAGGCCGCTAGTAAAAATGGTTTATAAAGGCCATCGCAACTCCAGGACAATGATAAAAGAAGCCAATTTCTGGGGTGCTAACTTTG
TAATGAGTGGTTCTGACTGTGGCCACATTTTCATCTGGGATCGGCACACTGCTGAGCATTTGATGCTTCTGGAAGCTGATAATCATGTGG
TAAACTGCCTGCAGCCACATCCGTTTGACCCAATTTTAGCCTCATCTGGCATAGATTATGACATAAAGATCTGGTCACCATTAGAAGAGT
CAAGGATTTTTAACCGAAAACTTGCTGATGAAGTTATAACTCGAAACGAACTCATGCTGGAAGAAACTAGAAACACCATTACAGTTCCAG
CCTCTTTCATGTTGAGGATGTTGGCTTCACTTAATCATATCCGAGCTGACCGGTTGGAGGGTGACAGATCAGAAGGCTCTGGTCAAGAGA
ATGAAAATGAGGATGAGGAATAATAAACTCTTTTTGGCAAGCACTTAAATGTTCTGAAATTTGTATAAGACATTTATTATATTTTTTTCT
TTACAGAGCTTTAGTGCAATTTTAAGGTTATGGTTTTTGGAGTTTTTCCCTTTTTTTGGGATAACCTAACATTGGTTTGGAATGATTGTG

>19409_19409_4_CREG1-DCAF6_CREG1_chr1_167517238_ENST00000370509_DCAF6_chr1_167971719_ENST00000432587_length(amino acids)=808AA_BP=158
MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLS
LSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKLRQPPVKRLRLRGDWSDTGPRA
RPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPST
SSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQ
SSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSE
GQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAK
EPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVAR
IQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CREG1-DCAF6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CREG1-DCAF6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CREG1-DCAF6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source