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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:CRELD1-FANCD2 (FusionGDB2 ID:19413)

Fusion Gene Summary for CRELD1-FANCD2

Fusion gene summary

Fusion gene information	Fusion gene name: CRELD1-FANCD2
	Fusion gene ID: 19413
		Hgene	Tgene
	Gene symbol	CRELD1	FANCD2
	Gene ID	78987	2177
	Gene name	cysteine rich with EGF like domains 1	FA complementation group D2
	Synonyms	AVSD2\|CIRRIN	FA-D2\|FA4\|FACD\|FAD\|FAD2\|FANCD
	Cytomap	3p25.3	3p25.3
	Type of gene	protein-coding	protein-coding
	Description	protein disulfide isomerase CRELD1	Fanconi anemia group D2 proteinFanconi anemia complementation group D2
	Modification date	20200313	20200313
	UniProtAcc	Q96HD1	Q96PS1
	Ensembl transtripts involved in fusion gene	ENST00000489674, ENST00000326434, ENST00000383811, ENST00000397170, ENST00000452070,	ENST00000287647, ENST00000383806, ENST00000383807, ENST00000419585, ENST00000431693, ENST00000438741,
Fusion gene scores	* DoF score	3 X 4 X 3=36	9 X 13 X 7=819
	# samples	4	11
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(11/819*10)=-2.89635992811635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CRELD1 [Title/Abstract] AND FANCD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CRELD1(9985199)-FANCD2(10133865), # samples:1
Anticipated loss of major functional domain due to fusion event.	CRELD1-FANCD2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FANCD2	GO:0010332	response to gamma radiation	12874027

Fusion gene breakpoints across CRELD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FANCD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-S9-A6WM-01A	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+

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Fusion Gene ORF analysis for CRELD1-FANCD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000489674	ENST00000287647	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
3UTR-3CDS	ENST00000489674	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
3UTR-3CDS	ENST00000489674	ENST00000383807	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
3UTR-3CDS	ENST00000489674	ENST00000419585	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
3UTR-intron	ENST00000489674	ENST00000431693	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
3UTR-intron	ENST00000489674	ENST00000438741	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000326434	ENST00000431693	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000326434	ENST00000438741	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000383811	ENST00000431693	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000383811	ENST00000438741	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000397170	ENST00000431693	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000397170	ENST00000438741	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000452070	ENST00000431693	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
5CDS-intron	ENST00000452070	ENST00000438741	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000326434	ENST00000287647	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000326434	ENST00000383807	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000326434	ENST00000419585	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000383811	ENST00000287647	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000383811	ENST00000383807	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000383811	ENST00000419585	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000397170	ENST00000287647	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000397170	ENST00000383807	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000397170	ENST00000419585	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000452070	ENST00000287647	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000452070	ENST00000383807	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
Frame-shift	ENST00000452070	ENST00000419585	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
In-frame	ENST00000326434	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
In-frame	ENST00000383811	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
In-frame	ENST00000397170	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+
In-frame	ENST00000452070	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000397170

CRELD1

chr3

9985199

ENST00000383806

FANCD2

chr3

10133865

2345

1098

1105

351

ENST00000383811

CRELD1

chr3

9985199

ENST00000383806

FANCD2

chr3

10133865

2894

1647

599

1654

351

ENST00000452070

CRELD1

chr3

9985199

ENST00000383806

FANCD2

chr3

10133865

2390

1143

1150

351

ENST00000326434

CRELD1

chr3

9985199

ENST00000383806

FANCD2

chr3

10133865

2379

1132

1139

351

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397170	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+	0.004957873	0.9950421
ENST00000383811	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+	0.005008217	0.99499184
ENST00000452070	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+	0.004354091	0.99564594
ENST00000326434	ENST00000383806	CRELD1	chr3	9985199	+	FANCD2	chr3	10133865	+	0.004310237	0.9956898

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Fusion Genomic Features for CRELD1-FANCD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CRELD1	chr3	9985199	+	FANCD2	chr3	10133864	+	0.000106318	0.99989367
CRELD1	chr3	9985199	+	FANCD2	chr3	10133864	+	0.000106318	0.99989367

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRELD1-FANCD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:9985199/chr3:10133865)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CRELD1 Q96HD1	FANCD2 Q96PS1
FUNCTION: Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). {ECO:0000250\|UniProtKB:Q91XD7, ECO:0000250\|UniProtKB:Q9CYA0}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

3_45

349

423.0

Compositional bias

Note=Pro-rich

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

3_45

349

421.0

Compositional bias

Note=Pro-rich

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

3_45

349

421.0

Compositional bias

Note=Pro-rich

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

3_45

349

421.0

Compositional bias

Note=Pro-rich

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

153_193

349

423.0

Domain

EGF-like 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

305_344

349

423.0

Domain

EGF-like 2%3B calcium-binding

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

153_193

349

421.0

Domain

EGF-like 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

305_344

349

421.0

Domain

EGF-like 2%3B calcium-binding

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

153_193

349

421.0

Domain

EGF-like 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

305_344

349

421.0

Domain

EGF-like 2%3B calcium-binding

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

153_193

349

421.0

Domain

EGF-like 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

305_344

349

421.0

Domain

EGF-like 2%3B calcium-binding

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

208_256

349

423.0

Repeat

Note=FU 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

268_315

349

423.0

Repeat

Note=FU 2

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

208_256

349

421.0

Repeat

Note=FU 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

268_315

349

421.0

Repeat

Note=FU 2

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

208_256

349

421.0

Repeat

Note=FU 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

268_315

349

421.0

Repeat

Note=FU 2

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

208_256

349

421.0

Repeat

Note=FU 1

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

268_315

349

421.0

Repeat

Note=FU 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

30_362

349

423.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

384_384

349

423.0

Topological domain

Cytoplasmic

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

406_420

349

423.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

30_362

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

384_384

349

421.0

Topological domain

Cytoplasmic

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

406_420

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

30_362

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

384_384

349

421.0

Topological domain

Cytoplasmic

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

406_420

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

30_362

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

384_384

349

421.0

Topological domain

Cytoplasmic

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

406_420

349

421.0

Topological domain

Extracellular

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

363_383

349

423.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000326434

385_405

349

423.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

363_383

349

421.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000383811

385_405

349

421.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

363_383

349

421.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000397170

385_405

349

421.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

363_383

349

421.0

Transmembrane

Helical

Hgene

CRELD1

chr3:9985199

chr3:10133865

ENST00000452070

385_405

349

421.0

Transmembrane

Helical

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Fusion Gene Sequence for CRELD1-FANCD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19413_19413_1_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000326434_FANCD2_chr3_10133865_ENST00000383806_length(transcript)=2379nt_BP=1132nt
AGGAGACGGCCCACGGCGCCCGCGGGCTGGGGCGGTCGCTTCTTCCTTCTCCGTGGCCTACGAGGGTCCCCAGCCTGGGTAAAGATGGCC
CCATGGCCCCCGAAGGGCCTAGTCCCAGCTATGCTCTGGGGCCTCAGCCTCTTCCTCAACCTCCCAGGACCTATCTGGCTCCAGCCCTCT
CCACCTCCCCAGTCTTCTCCCCCGCCTCAGCCCCATCCGTGTCATACCTGCCGGGGACTGGTTGACAGCTTTAACAAGGGCCTGGAGAGA
ACCATCCGGGACAACTTTGGAGGTGGAAACACTGCCTGGGAGGAAGAGAATTTGTCCAAATACAAAGACAGTGAGACCCGCCTGGTAGAG
GTGCTGGAGGGTGTGTGCAGCAAGTCAGACTTCGAGTGCCACCGCCTGCTGGAGCTGAGTGAGGAGCTGGTGGAGAGCTGGTGGTTTCAC
AAGCAGCAGGAGGCCCCGGACCTCTTCCAGTGGCTGTGCTCAGATTCCCTGAAGCTCTGCTGCCCCGCAGGCACCTTCGGGCCCTCCTGC
CTTCCCTGTCCTGGGGGAACAGAGAGGCCCTGCGGTGGCTACGGGCAGTGTGAAGGAGAAGGGACACGAGGGGGCAGCGGGCACTGTGAC
TGCCAAGCCGGCTACGGGGGTGAGGCCTGTGGCCAGTGTGGCCTTGGCTACTTTGAGGCAGAACGCAACGCCAGCCATCTGGTATGTTCG
GCTTGTTTTGGCCCCTGTGCCCGATGCTCAGGACCTGAGGAATCAAACTGTTTGCAATGCAAGAAGGGCTGGGCCCTGCATCACCTCAAG
TGTGTAGACATTGATGAGTGTGGCACAGAGGGAGCCAACTGTGGAGCTGACCAATTCTGCGTGAACACTGAGGGCTCCTATGAGTGCCGA
GACTGTGCCAAGGCCTGCCTAGGCTGCATGGGGGCAGGGCCAGGTCGCTGTAAGAAGTGTAGCCCTGGCTATCAGCAGGTGGGCTCCAAG
TGTCTCGATGTGGATGAGTGTGAGACAGAGGTGTGTCCGGGAGAGAACAAGCAGTGTGAAAACACCGAGGGCGGTTATCGCTGCATCTGT
GCCGAGGGCTACAAGCAGATGGAAGGCATCTGTGTGAAGGAGCAGATCCCAGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGT
TCGAGACTTCAGTATCCTCATCAACTTGATAAAGGTATTTGATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGT
GGAAGCATTTCTGAAGCAATGTATGCCGCTCCTAGACTTCAGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCA
GTTGGACACAAGGCTGCTTCATCACCTGTGTGGGCATTCCAAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAA
GACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCTATGCTCACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCG
GGACTTGCAGGGTGAAGAGATTAAGTCCCAAAATTCCCAGGAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAA
GAGCAAAGCCACTGAGGATGGTGAAGAAGACGAAGTAAGTGCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGATGACTCTGATTA
GACCCCAGATAAATTGTTGCCTGCTTCTGTGTCTCTGCCAGCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGTTTGCCTTTCTT
ACTGGTAGGATCCTTTTTTGTTCCTCTTTTTTTTTTTTTTTTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAGGCTGGAGTGCA
GTGCTGCAATCTTGGCTCACTGCAACCTCCATCTCCTAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCA
CATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGATACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTCCTGAACTCATG
ATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGTGGGGTCTTTAT
TAACTTGTGGACATCATGGATTGTCTAACACCATCACAGTCCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTTTGGATAAACCC
AGCTGTGCTACACTGCAGAGTAAAATCTCTGAGTCATGATTCTGGACTTTGGGAGCTAGTTTTGAAACTCTGATTTATTGTAGAACTTAG

>19413_19413_1_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000326434_FANCD2_chr3_10133865_ENST00000383806_length(amino acids)=351AA_BP=
MAPWPPKGLVPAMLWGLSLFLNLPGPIWLQPSPPPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRL
VEVLEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGH
CDCQAGYGGEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYE

--------------------------------------------------------------
>19413_19413_2_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000383811_FANCD2_chr3_10133865_ENST00000383806_length(transcript)=2894nt_BP=1647nt
TGGCAGCGACGCGGTGAGGAGACGGCCCACGGCGCCCGCGGGCTGGGGCGGTCGCTTCTTCCTTCTCCGTGGCCTACGAGGGTCTGGATC
CTTCTCTGCCGGCTCGTGGGCCGTGCCTTTGCCCTTCTGCGAGGCCCTGAATCTGATCCCTTCCCTTCATATCCGGATCCGGGCTCCTCC
CTCCAAGCCCGGGGTTCCGGACACCTCCCCCAAGACAACCCCTCTGGCCTCCTCTCCTTCAGTACTTGGAATCTGATCTCTTCTCCCTAA
TTCTGCGGATCCGGCCCCTAATATTCTTTATCAGACCCTCAGACAAGAGGCTGACTTCTGCCCCCTTGTCAAGGAGCGAGGCCACTTTCC
TCTCCACCCCATGCTAGCGAGGATAACTTATTTCTCTTCTGGAATTGCATCTTATGCGCCTTTCCCCACCCATCCCCACAGCCCCTGCAA
TACCCAGTTTGGCCTCTTTTGCTTGTAATAACGCAGATCCCAGCGCCACGGCACCTTAGAACAGACCTTTTTCTTTCTCGCGTGGGGCCT
GACTCCTTCAGTGAAGCCTCTCCACGCCCTCTATCTGCAGGTCCCCAGCCTGGGTAAAGATGGCCCCATGGCCCCCGAAGGGCCTAGTCC
CAGCTATGCTCTGGGGCCTCAGCCTCTTCCTCAACCTCCCAGGACCTATCTGGCTCCAGCCCTCTCCACCTCCCCAGTCTTCTCCCCCGC
CTCAGCCCCATCCGTGTCATACCTGCCGGGGACTGGTTGACAGCTTTAACAAGGGCCTGGAGAGAACCATCCGGGACAACTTTGGAGGTG
GAAACACTGCCTGGGAGGAAGAGAATTTGTCCAAATACAAAGACAGTGAGACCCGCCTGGTAGAGGTGCTGGAGGGTGTGTGCAGCAAGT
CAGACTTCGAGTGCCACCGCCTGCTGGAGCTGAGTGAGGAGCTGGTGGAGAGCTGGTGGTTTCACAAGCAGCAGGAGGCCCCGGACCTCT
TCCAGTGGCTGTGCTCAGATTCCCTGAAGCTCTGCTGCCCCGCAGGCACCTTCGGGCCCTCCTGCCTTCCCTGTCCTGGGGGAACAGAGA
GGCCCTGCGGTGGCTACGGGCAGTGTGAAGGAGAAGGGACACGAGGGGGCAGCGGGCACTGTGACTGCCAAGCCGGCTACGGGGGTGAGG
CCTGTGGCCAGTGTGGCCTTGGCTACTTTGAGGCAGAACGCAACGCCAGCCATCTGGTATGTTCGGCTTGTTTTGGCCCCTGTGCCCGAT
GCTCAGGACCTGAGGAATCAAACTGTTTGCAATGCAAGAAGGGCTGGGCCCTGCATCACCTCAAGTGTGTAGACATTGATGAGTGTGGCA
CAGAGGGAGCCAACTGTGGAGCTGACCAATTCTGCGTGAACACTGAGGGCTCCTATGAGTGCCGAGACTGTGCCAAGGCCTGCCTAGGCT
GCATGGGGGCAGGGCCAGGTCGCTGTAAGAAGTGTAGCCCTGGCTATCAGCAGGTGGGCTCCAAGTGTCTCGATGTGGATGAGTGTGAGA
CAGAGGTGTGTCCGGGAGAGAACAAGCAGTGTGAAAACACCGAGGGCGGTTATCGCTGCATCTGTGCCGAGGGCTACAAGCAGATGGAAG
GCATCTGTGTGAAGGAGCAGATCCCAGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGTTCGAGACTTCAGTATCCTCATCAAC
TTGATAAAGGTATTTGATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATG
CCGCTCCTAGACTTCAGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCAGTTGGACACAAGGCTGCTTCATCAC
CTGTGTGGGCATTCCAAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGA
GTCAAAGCTATGCTCACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAG
TCCCAAAATTCCCAGGAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAAGAGCAAAGCCACTGAGGATGGTGAA
GAAGACGAAGTAAGTGCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGATGACTCTGATTAGACCCCAGATAAATTGTTGCCTGCT
TCTGTGTCTCTGCCAGCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGTTTGCCTTTCTTACTGGTAGGATCCTTTTTTGTTCCT
CTTTTTTTTTTTTTTTTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAGGCTGGAGTGCAGTGCTGCAATCTTGGCTCACTGCAA
CCTCCATCTCCTAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCACATGCCACCATGCCCAGCTAATTTT
TGTATTTTTAGTAGATACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTCCTGAACTCATGATCCACCTGCCTCAGCCTCCCAAAG
TGCTGGGATTACAGGCATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGTGGGGTCTTTATTAACTTGTGGACATCATGGATTGTC
TAACACCATCACAGTCCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTTTGGATAAACCCAGCTGTGCTACACTGCAGAGTAAAA
TCTCTGAGTCATGATTCTGGACTTTGGGAGCTAGTTTTGAAACTCTGATTTATTGTAGAACTTAGGCTTGTACCAATTTTACAAATAAAT

>19413_19413_2_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000383811_FANCD2_chr3_10133865_ENST00000383806_length(amino acids)=351AA_BP=
MAPWPPKGLVPAMLWGLSLFLNLPGPIWLQPSPPPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRL
VEVLEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGH
CDCQAGYGGEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYE

--------------------------------------------------------------
>19413_19413_3_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000397170_FANCD2_chr3_10133865_ENST00000383806_length(transcript)=2345nt_BP=1098nt
TGCGTTTTACGCAGGCTGTGGCAGCGACGCGGTCCCCAGCCTGGGTAAAGATGGCCCCATGGCCCCCGAAGGGCCTAGTCCCAGCTATGC
TCTGGGGCCTCAGCCTCTTCCTCAACCTCCCAGGACCTATCTGGCTCCAGCCCTCTCCACCTCCCCAGTCTTCTCCCCCGCCTCAGCCCC
ATCCGTGTCATACCTGCCGGGGACTGGTTGACAGCTTTAACAAGGGCCTGGAGAGAACCATCCGGGACAACTTTGGAGGTGGAAACACTG
CCTGGGAGGAAGAGAATTTGTCCAAATACAAAGACAGTGAGACCCGCCTGGTAGAGGTGCTGGAGGGTGTGTGCAGCAAGTCAGACTTCG
AGTGCCACCGCCTGCTGGAGCTGAGTGAGGAGCTGGTGGAGAGCTGGTGGTTTCACAAGCAGCAGGAGGCCCCGGACCTCTTCCAGTGGC
TGTGCTCAGATTCCCTGAAGCTCTGCTGCCCCGCAGGCACCTTCGGGCCCTCCTGCCTTCCCTGTCCTGGGGGAACAGAGAGGCCCTGCG
GTGGCTACGGGCAGTGTGAAGGAGAAGGGACACGAGGGGGCAGCGGGCACTGTGACTGCCAAGCCGGCTACGGGGGTGAGGCCTGTGGCC
AGTGTGGCCTTGGCTACTTTGAGGCAGAACGCAACGCCAGCCATCTGGTATGTTCGGCTTGTTTTGGCCCCTGTGCCCGATGCTCAGGAC
CTGAGGAATCAAACTGTTTGCAATGCAAGAAGGGCTGGGCCCTGCATCACCTCAAGTGTGTAGACATTGATGAGTGTGGCACAGAGGGAG
CCAACTGTGGAGCTGACCAATTCTGCGTGAACACTGAGGGCTCCTATGAGTGCCGAGACTGTGCCAAGGCCTGCCTAGGCTGCATGGGGG
CAGGGCCAGGTCGCTGTAAGAAGTGTAGCCCTGGCTATCAGCAGGTGGGCTCCAAGTGTCTCGATGTGGATGAGTGTGAGACAGAGGTGT
GTCCGGGAGAGAACAAGCAGTGTGAAAACACCGAGGGCGGTTATCGCTGCATCTGTGCCGAGGGCTACAAGCAGATGGAAGGCATCTGTG
TGAAGGAGCAGATCCCAGATTCATGAAGAGAAACTCCTCTACTGGAACATGGCTGTTCGAGACTTCAGTATCCTCATCAACTTGATAAAG
GTATTTGATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGGCGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATGCCGCTCCTA
GACTTCAGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTGGAAACCTTCCAGTTGGACACAAGGCTGCTTCATCACCTGTGTGGG
CATTCCAAGATTCACCAGGACACGAGACTCACCCAACATGTGCCTCTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCT
ATGCTCACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAATCTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAGTCCCAAAAT
TCCCAGGAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCCCAGGCCTCCAAGAGCAAAGCCACTGAGGATGGTGAAGAAGACGAA
GTAAGTGCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGATGACTCTGATTAGACCCCAGATAAATTGTTGCCTGCTTCTGTGTCT
CTGCCAGCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGTTTGCCTTTCTTACTGGTAGGATCCTTTTTTGTTCCTCTTTTTTTT
TTTTTTTTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAGGCTGGAGTGCAGTGCTGCAATCTTGGCTCACTGCAACCTCCATCT
CCTAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACGACAGGCACATGCCACCATGCCCAGCTAATTTTTGTATTTTT
AGTAGATACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTCCTGAACTCATGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGAT
TACAGGCATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGTGGGGTCTTTATTAACTTGTGGACATCATGGATTGTCTAACACCAT
CACAGTCCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTTTGGATAAACCCAGCTGTGCTACACTGCAGAGTAAAATCTCTGAGT
CATGATTCTGGACTTTGGGAGCTAGTTTTGAAACTCTGATTTATTGTAGAACTTAGGCTTGTACCAATTTTACAAATAAATTCTGTTCTA

>19413_19413_3_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000397170_FANCD2_chr3_10133865_ENST00000383806_length(amino acids)=351AA_BP=
MAPWPPKGLVPAMLWGLSLFLNLPGPIWLQPSPPPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRL
VEVLEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGH
CDCQAGYGGEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYE

--------------------------------------------------------------
>19413_19413_4_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000452070_FANCD2_chr3_10133865_ENST00000383806_length(transcript)=2390nt_BP=1143nt
GCGACGCGGTGAGGAGACGGCCCACGGCGCCCGCGGGCTGGGGCGGTCGCTTCTTCCTTCTCCGTGGCCTACGAGGGTCCCCAGCCTGGG
TAAAGATGGCCCCATGGCCCCCGAAGGGCCTAGTCCCAGCTATGCTCTGGGGCCTCAGCCTCTTCCTCAACCTCCCAGGACCTATCTGGC
TCCAGCCCTCTCCACCTCCCCAGTCTTCTCCCCCGCCTCAGCCCCATCCGTGTCATACCTGCCGGGGACTGGTTGACAGCTTTAACAAGG
GCCTGGAGAGAACCATCCGGGACAACTTTGGAGGTGGAAACACTGCCTGGGAGGAAGAGAATTTGTCCAAATACAAAGACAGTGAGACCC
GCCTGGTAGAGGTGCTGGAGGGTGTGTGCAGCAAGTCAGACTTCGAGTGCCACCGCCTGCTGGAGCTGAGTGAGGAGCTGGTGGAGAGCT
GGTGGTTTCACAAGCAGCAGGAGGCCCCGGACCTCTTCCAGTGGCTGTGCTCAGATTCCCTGAAGCTCTGCTGCCCCGCAGGCACCTTCG
GGCCCTCCTGCCTTCCCTGTCCTGGGGGAACAGAGAGGCCCTGCGGTGGCTACGGGCAGTGTGAAGGAGAAGGGACACGAGGGGGCAGCG
GGCACTGTGACTGCCAAGCCGGCTACGGGGGTGAGGCCTGTGGCCAGTGTGGCCTTGGCTACTTTGAGGCAGAACGCAACGCCAGCCATC
TGGTATGTTCGGCTTGTTTTGGCCCCTGTGCCCGATGCTCAGGACCTGAGGAATCAAACTGTTTGCAATGCAAGAAGGGCTGGGCCCTGC
ATCACCTCAAGTGTGTAGACATTGATGAGTGTGGCACAGAGGGAGCCAACTGTGGAGCTGACCAATTCTGCGTGAACACTGAGGGCTCCT
ATGAGTGCCGAGACTGTGCCAAGGCCTGCCTAGGCTGCATGGGGGCAGGGCCAGGTCGCTGTAAGAAGTGTAGCCCTGGCTATCAGCAGG
TGGGCTCCAAGTGTCTCGATGTGGATGAGTGTGAGACAGAGGTGTGTCCGGGAGAGAACAAGCAGTGTGAAAACACCGAGGGCGGTTATC
GCTGCATCTGTGCCGAGGGCTACAAGCAGATGGAAGGCATCTGTGTGAAGGAGCAGATCCCAGATTCATGAAGAGAAACTCCTCTACTGG
AACATGGCTGTTCGAGACTTCAGTATCCTCATCAACTTGATAAAGGTATTTGATAGTCATCCTGTTCTGCATGTATGTTTGAAGTATGGG
CGTCTCTTTGTGGAAGCATTTCTGAAGCAATGTATGCCGCTCCTAGACTTCAGTTTTAGAAAACACCGGGAAGATGTTCTGAGCTTACTG
GAAACCTTCCAGTTGGACACAAGGCTGCTTCATCACCTGTGTGGGCATTCCAAGATTCACCAGGACACGAGACTCACCCAACATGTGCCT
CTGCTCAAAAAGACCCTGGAACTTTTAGTTTGCAGAGTCAAAGCTATGCTCACTCTCAACAATTGTAGAGAGGCTTTCTGGCTGGGCAAT
CTAAAAAACCGGGACTTGCAGGGTGAAGAGATTAAGTCCCAAAATTCCCAGGAGAGCACAGCAGATGAGAGTGAGGATGACATGTCATCC
CAGGCCTCCAAGAGCAAAGCCACTGAGGATGGTGAAGAAGACGAAGTAAGTGCTGGAGAAAAGGAGCAAGATAGTGATGAGAGTTATGAT
GACTCTGATTAGACCCCAGATAAATTGTTGCCTGCTTCTGTGTCTCTGCCAGCCTGTGATCATTTTGTGTTAGAGTTTGAAATCCGCTGT
TTGCCTTTCTTACTGGTAGGATCCTTTTTTGTTCCTCTTTTTTTTTTTTTTTTTTTTTTTTTAAAGACGGGGACTCGCTGTGTTTCCCAG
GCTGGAGTGCAGTGCTGCAATCTTGGCTCACTGCAACCTCCATCTCCTAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG
GACGACAGGCACATGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGATACGGGGTTTTACCATGTCGGCCAGATGGTCTCAATCTC
CTGAACTCATGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCTCCCAGCCATATTTTGTTCTTAAAGT
GGGGTCTTTATTAACTTGTGGACATCATGGATTGTCTAACACCATCACAGTCCCTGGCTCAGGATTCTAATGTAGCATTATTTATTGGTT
TGGATAAACCCAGCTGTGCTACACTGCAGAGTAAAATCTCTGAGTCATGATTCTGGACTTTGGGAGCTAGTTTTGAAACTCTGATTTATT

>19413_19413_4_CRELD1-FANCD2_CRELD1_chr3_9985199_ENST00000452070_FANCD2_chr3_10133865_ENST00000383806_length(amino acids)=351AA_BP=
MAPWPPKGLVPAMLWGLSLFLNLPGPIWLQPSPPPQSSPPPQPHPCHTCRGLVDSFNKGLERTIRDNFGGGNTAWEEENLSKYKDSETRL
VEVLEGVCSKSDFECHRLLELSEELVESWWFHKQQEAPDLFQWLCSDSLKLCCPAGTFGPSCLPCPGGTERPCGGYGQCEGEGTRGGSGH
CDCQAGYGGEACGQCGLGYFEAERNASHLVCSACFGPCARCSGPEESNCLQCKKGWALHHLKCVDIDECGTEGANCGADQFCVNTEGSYE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CRELD1-FANCD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000431693		0	8	248_359	0	242.0	BRCA2
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000431693		0	8	1_291	0	242.0	FANCE

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000287647		36	43	248_359	1259.0	1472.0	BRCA2
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000383806		35	43	248_359	1227.6666666666667	1469.6666666666667	BRCA2
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000383807		36	44	248_359	1259.0	1452.0	BRCA2
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000419585		36	44	248_359	1259.0	1452.0	BRCA2
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000287647		36	43	1_291	1259.0	1472.0	FANCE
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000383806		35	43	1_291	1227.6666666666667	1469.6666666666667	FANCE
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000383807		36	44	1_291	1259.0	1452.0	FANCE
Tgene	FANCD2	chr3:9985199	chr3:10133865	ENST00000419585		36	44	1_291	1259.0	1452.0	FANCE

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CRELD1-FANCD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CRELD1-FANCD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source