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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRIM1-FEZ2 (FusionGDB2 ID:19437)

Fusion Gene Summary for CRIM1-FEZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: CRIM1-FEZ2
Fusion gene ID: 19437
HgeneTgene
Gene symbol

CRIM1

FEZ2

Gene ID

51232

9637

Gene namecysteine rich transmembrane BMP regulator 1fasciculation and elongation protein zeta 2
SynonymsCRIM-1|S52HUM3CL
Cytomap

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52fasciculation and elongation protein zeta-2pre-T/NK cell associated protein (3Cl)zygin 2zygin II
Modification date2020031320200313
UniProtAcc

Q9NZV1

Q9UHY8

Ensembl transtripts involved in fusion geneENST00000280527, ENST00000473403, 
ENST00000487919, ENST00000305852, 
ENST00000379245, ENST00000405912, 
Fusion gene scores* DoF score15 X 11 X 8=13203 X 4 X 3=36
# samples 164
** MAII scorelog2(16/1320*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CRIM1 [Title/Abstract] AND FEZ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRIM1(36669878)-FEZ2(36818154), # samples:1
CRIM1(36583766)-FEZ2(36785656), # samples:1
Anticipated loss of major functional domain due to fusion event.CRIM1-FEZ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CRIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FEZ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-50-6595-01ACRIM1chr2

36669878

+FEZ2chr2

36818154

-
ChimerDB4STADTCGA-BR-A4PE-01ACRIM1chr2

36583766

+FEZ2chr2

36785656

-


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Fusion Gene ORF analysis for CRIM1-FEZ2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000280527ENST00000487919CRIM1chr2

36583766

+FEZ2chr2

36785656

-
5CDS-intronENST00000280527ENST00000487919CRIM1chr2

36669878

+FEZ2chr2

36818154

-
Frame-shiftENST00000280527ENST00000305852CRIM1chr2

36669878

+FEZ2chr2

36818154

-
Frame-shiftENST00000280527ENST00000305852CRIM1chr2

36583766

+FEZ2chr2

36785656

-
Frame-shiftENST00000280527ENST00000379245CRIM1chr2

36583766

+FEZ2chr2

36785656

-
Frame-shiftENST00000280527ENST00000405912CRIM1chr2

36583766

+FEZ2chr2

36785656

-
In-frameENST00000280527ENST00000379245CRIM1chr2

36669878

+FEZ2chr2

36818154

-
In-frameENST00000280527ENST00000405912CRIM1chr2

36669878

+FEZ2chr2

36818154

-
intron-3CDSENST00000473403ENST00000305852CRIM1chr2

36669878

+FEZ2chr2

36818154

-
intron-3CDSENST00000473403ENST00000305852CRIM1chr2

36583766

+FEZ2chr2

36785656

-
intron-3CDSENST00000473403ENST00000379245CRIM1chr2

36669878

+FEZ2chr2

36818154

-
intron-3CDSENST00000473403ENST00000379245CRIM1chr2

36583766

+FEZ2chr2

36785656

-
intron-3CDSENST00000473403ENST00000405912CRIM1chr2

36669878

+FEZ2chr2

36818154

-
intron-3CDSENST00000473403ENST00000405912CRIM1chr2

36583766

+FEZ2chr2

36785656

-
intron-5UTRENST00000473403ENST00000487919CRIM1chr2

36583766

+FEZ2chr2

36785656

-
intron-intronENST00000473403ENST00000487919CRIM1chr2

36669878

+FEZ2chr2

36818154

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280527CRIM1chr236669878+ENST00000379245FEZ2chr236818154-301812363672112581
ENST00000280527CRIM1chr236669878+ENST00000405912FEZ2chr236818154-290112363672031554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280527ENST00000379245CRIM1chr236669878+FEZ2chr236818154-0.0013106540.99868935
ENST00000280527ENST00000405912CRIM1chr236669878+FEZ2chr236818154-0.0014224460.9985776

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Fusion Genomic Features for CRIM1-FEZ2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRIM1-FEZ2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:36669878/chr2:36818154)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRIM1

Q9NZV1

FEZ2

Q9UHY8

FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.FUNCTION: Involved in axonal outgrowth and fasciculation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+41735_1122891037.0DomainIGFBP N-terminal
TgeneFEZ2chr2:36669878chr2:36818154ENST0000037924509214_28688381.0Coiled coilOntology_term=ECO:0000255
TgeneFEZ2chr2:36669878chr2:36818154ENST0000040591208214_28688354.0Coiled coilOntology_term=ECO:0000255
TgeneFEZ2chr2:36669878chr2:36818154ENST0000037924509278_28488381.0Compositional biasNote=Poly-Lys
TgeneFEZ2chr2:36669878chr2:36818154ENST0000040591208278_28488354.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417334_3912891037.0DomainVWFC 1
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417401_4572891037.0DomainVWFC 2
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417469_4982891037.0DomainAntistasin-like 1
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417505_5322891037.0DomainAntistasin-like 2
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417539_5642891037.0DomainAntistasin-like 3
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417567_5922891037.0DomainAntistasin-like 4
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417606_6632891037.0DomainVWFC 3
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417677_7352891037.0DomainVWFC 4
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417751_8092891037.0DomainVWFC 5
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417817_8742891037.0DomainVWFC 6
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417314_3162891037.0MotifCell attachment site
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+41735_9392891037.0Topological domainExtracellular
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417961_10362891037.0Topological domainCytoplasmic
HgeneCRIM1chr2:36669878chr2:36818154ENST00000280527+417940_9602891037.0TransmembraneHelical


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Fusion Gene Sequence for CRIM1-FEZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19437_19437_1_CRIM1-FEZ2_CRIM1_chr2_36669878_ENST00000280527_FEZ2_chr2_36818154_ENST00000379245_length(transcript)=3018nt_BP=1236nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGGATTTGGAATGCCCTGACAGATAA
TTATGGGAATGTGATGCCTGTAGACTGGAAGTCATCGCATACTAGGACCTTGCACTTGCTTACTCTGAACCTCTCAGAAAAAGGGGTAAG
TGACAGTTTGCTCTTTGATACATCAGATGATGAAGAGCTGAGAGAACAGCTGGATATGCACTCAATCATCGTCTCCTGTGTTAATGATGA
ACCCCTCTTCACGGCAGACCAGGTTATTGAAGAAATTGAAGAAATGATGCAGGAATCACCGGACCCAGAAGATGATGAAACCCCTACACA
GTCAGATCGGCTTTCAATGCTTTCCCAGGAAATTCAAACTCTCAAGAGGTCTAGTACCGGCAGTTATGAAGAGAGAGTGAAAAGGCTCTC
AGTGTCTGAGTTAAATGAAATCCTGGAAGAAATTGAGACTGCCATTAAGGAGTACTCTGAGGAGCTGGTGCAGCAGTTGGCTTTACGAGA
TGAACTGGAGTTTGAAAAGGAAGTGAAAAACAGCTTTATTTCTGTTCTTATTGAAGTGCAAAACAAACAGAAAGAGCACAAAGAAACAGC
AAAAAAGAAAAAGAAACTAAAAAATGGCAGCTCTCAGAATGGGAAGAATGAGAGAAGTCATATGCCCGGCACACGCTTCAGCATGGAAGG
GATCTCAAATGTCATTCAGAATGGCCTCCGCCACACCTTTGGAAATTCAGGTGGAGAGAAACAGTATTTGACTACAGTCATTCCTTATGA
GAAAAAAAACGGACCACCGTCTGTTGAAGATCTTCAAATATTAACAAAAATTCTTCGTGCCATGAAGGAGGACAGTGAAAAAGTTCCGAG
CTTGTTAACTGATTATATTCTGAAAGTTCTGTGTCCTACATAGAGCAGCAACTTTATCTGCGGTGGGCTCCAAGCTAGATTTCCGACAGC
ATTATTCTGAGAGCTGGCTACCATTACCCTTCTTGCTATTGGAAACTCAGCACATTTGAACTTGGGTTTGATTCAGTATTAACAGATCTT
GACTACACTAATTCTTTATATTATAGAACCAACGGAAATATGGGCACTATTTTGAATTCTAGAGATGGTTTTTGTTAAATCTACTAATAA
ACTGTTCTCTTAGTAGATTAAGAGAGAGTAATATTAATTGTGCATGTGCAGTTGTATTTCTCATTAACTGACAGTATGCCCATTTGTTTT
TATGGCTTTCTTATCTAAACTGCACTGATGAACTAGATTAAAGCCTTGGGAGATTTATACTATAAATTCAGTGATGGCAAGAACCAACAC
TGTTTTTTTGTGAGAATTGTCAGTGTAACTATTACCTACCAGTATTGTTCAGAGAGATTGAAACAGAATAAACGGGCTGTTCTTGAAGAA
GCAAAACCAGAATATGCATTACTTTGGTTTAATACTTAGTGCTAACATTGAAACTGTTGGTGGTGATGGATTTTGTAGCTTGCTGCTTGT
TTCACCACTGGTCAAATTTTAACCATTAAATTGCCATTCACTTTTAGAATCTTGTATTTAAGTTTTGATTTTCAAATGTTCTGCTTCATG
TGTCTGTGAAGAATTGTACTTTAAGTGTGTGTCCTCTGAGGTGCTTGAGAAAGTGTACACTGCAGAACTGCCCATTCTCATTACTGTGTC
CTATTTTATTCATGCCTGTGTGTTTTTCTTAAGTATGAATTCTAGATACAGCTACTTATGGATTCATCAATATCATGAGCACTTTTGCTG

>19437_19437_1_CRIM1-FEZ2_CRIM1_chr2_36669878_ENST00000280527_FEZ2_chr2_36818154_ENST00000379245_length(amino acids)=581AA_BP=289
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP
DSYETQVRLTADGCCTLPTRIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPL
FTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDEL
EFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYLTTVIPYEKK

--------------------------------------------------------------
>19437_19437_2_CRIM1-FEZ2_CRIM1_chr2_36669878_ENST00000280527_FEZ2_chr2_36818154_ENST00000405912_length(transcript)=2901nt_BP=1236nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGGATTTGGAATGCCCTGACAGATAA
TTATGGGAATGTGATGCCTGTAGACTGGAAGTCATCGCATACTAGGACCTTGCACTTGCTTACTCTGAACCTCTCAGAAAAAGGGGTAAG
TGACAGTTTGCTCTTTGATACATCAGATGATGAAGAGCTGAGAGAACAGCTGGATATGCACTCAATCATCGTCTCCTGTGTTAATGATGA
ACCCCTCTTCACGGCAGACCAGGTTATTGAAGAAATTGAAGAAATGATGCAGGAATCACCGGACCCAGAAGATGATGAAACCCCTACACA
GTCAGATCGGCTTTCAATGCTTTCCCAGGAAATTCAAACTCTCAAGAGGTCTAGTACCGGCAGTTATGAAGAGAGAGTGAAAAGGCTCTC
AGTGTCTGAGTTAAATGAAATCCTGGAAGAAATTGAGACTGCCATTAAGGAGTACTCTGAGGAGCTGGTGCAGCAGTTGGCTTTACGAGA
TGAACTGGAGTTTGAAAAGGAAGTGAAAAACAGCTTTATTTCTGTTCTTATTGAAGTGCAAAACAAACAGAAAGAGCACAAAGAAACAGC
AAAAAAGAAAAAGAAACTAAAAAATGGCAGCTCTCAGAATGGGAAGAATGAGAGAAGTCATATGCCCGGCACATATTTGACTACAGTCAT
TCCTTATGAGAAAAAAAACGGACCACCGTCTGTTGAAGATCTTCAAATATTAACAAAAATTCTTCGTGCCATGAAGGAGGACAGTGAAAA
AGTTCCGAGCTTGTTAACTGATTATATTCTGAAAGTTCTGTGTCCTACATAGAGCAGCAACTTTATCTGCGGTGGGCTCCAAGCTAGATT
TCCGACAGCATTATTCTGAGAGCTGGCTACCATTACCCTTCTTGCTATTGGAAACTCAGCACATTTGAACTTGGGTTTGATTCAGTATTA
ACAGATCTTGACTACACTAATTCTTTATATTATAGAACCAACGGAAATATGGGCACTATTTTGAATTCTAGAGATGGTTTTTGTTAAATC
TACTAATAAACTGTTCTCTTAGTAGATTAAGAGAGAGTAATATTAATTGTGCATGTGCAGTTGTATTTCTCATTAACTGACAGTATGCCC
ATTTGTTTTTATGGCTTTCTTATCTAAACTGCACTGATGAACTAGATTAAAGCCTTGGGAGATTTATACTATAAATTCAGTGATGGCAAG
AACCAACACTGTTTTTTTGTGAGAATTGTCAGTGTAACTATTACCTACCAGTATTGTTCAGAGAGATTGAAACAGAATAAACGGGCTGTT
CTTGAAGAAGCAAAACCAGAATATGCATTACTTTGGTTTAATACTTAGTGCTAACATTGAAACTGTTGGTGGTGATGGATTTTGTAGCTT
GCTGCTTGTTTCACCACTGGTCAAATTTTAACCATTAAATTGCCATTCACTTTTAGAATCTTGTATTTAAGTTTTGATTTTCAAATGTTC
TGCTTCATGTGTCTGTGAAGAATTGTACTTTAAGTGTGTGTCCTCTGAGGTGCTTGAGAAAGTGTACACTGCAGAACTGCCCATTCTCAT
TACTGTGTCCTATTTTATTCATGCCTGTGTGTTTTTCTTAAGTATGAATTCTAGATACAGCTACTTATGGATTCATCAATATCATGAGCA

>19437_19437_2_CRIM1-FEZ2_CRIM1_chr2_36669878_ENST00000280527_FEZ2_chr2_36818154_ENST00000405912_length(amino acids)=554AA_BP=289
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP
DSYETQVRLTADGCCTLPTRIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPL
FTADQVIEEIEEMMQESPDPEDDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDEL
EFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPGTYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVP

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Fusion Gene PPI Analysis for CRIM1-FEZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRIM1-FEZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRIM1-FEZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource