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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRIM1-SYNRG (FusionGDB2 ID:19443)

Fusion Gene Summary for CRIM1-SYNRG

check button Fusion gene summary
Fusion gene informationFusion gene name: CRIM1-SYNRG
Fusion gene ID: 19443
HgeneTgene
Gene symbol

CRIM1

SYNRG

Gene ID

51232

11276

Gene namecysteine rich transmembrane BMP regulator 1synergin gamma
SynonymsCRIM-1|S52AP1GBP1|SYNG
Cytomap

2p22.2

17q12

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52synergin gammaAP1 gamma subunit binding protein 1AP1 subunit gamma-binding protein 1adaptor-related protein complex 1 gamma subunit-binding protein 1gamma-synergin
Modification date2020031320200313
UniProtAcc

Q9NZV1

.
Ensembl transtripts involved in fusion geneENST00000280527, ENST00000473403, 
ENST00000588194, ENST00000339208, 
ENST00000345615, ENST00000346661, 
ENST00000394378, ENST00000502449, 
ENST00000585472, ENST00000591288, 
Fusion gene scores* DoF score15 X 11 X 8=13206 X 8 X 3=144
# samples 169
** MAII scorelog2(16/1320*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRIM1 [Title/Abstract] AND SYNRG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRIM1(36691731)-SYNRG(35902508), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CRIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYNRG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG013273CRIM1chr2

36691731

+SYNRGchr17

35902508

+


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Fusion Gene ORF analysis for CRIM1-SYNRG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000280527ENST00000588194CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000339208CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000345615CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000346661CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000394378CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000502449CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000585472CRIM1chr2

36691731

+SYNRGchr17

35902508

+
In-frameENST00000280527ENST00000591288CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000339208CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000345615CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000346661CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000394378CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000502449CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000585472CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-3CDSENST00000473403ENST00000591288CRIM1chr2

36691731

+SYNRGchr17

35902508

+
intron-intronENST00000473403ENST00000588194CRIM1chr2

36691731

+SYNRGchr17

35902508

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280527CRIM1chr236691731+ENST00000339208SYNRGchr1735902508+662413033671245292
ENST00000280527CRIM1chr236691731+ENST00000346661SYNRGchr1735902508+658713033671245292
ENST00000280527CRIM1chr236691731+ENST00000345615SYNRGchr1735902508+355513033671245292
ENST00000280527CRIM1chr236691731+ENST00000502449SYNRGchr1735902508+292413033671245292
ENST00000280527CRIM1chr236691731+ENST00000591288SYNRGchr1735902508+253413033671245292
ENST00000280527CRIM1chr236691731+ENST00000394378SYNRGchr1735902508+260313033671245292
ENST00000280527CRIM1chr236691731+ENST00000585472SYNRGchr1735902508+253413033671245292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280527ENST00000339208CRIM1chr236691731+SYNRGchr1735902508+0.0017772610.99822277
ENST00000280527ENST00000346661CRIM1chr236691731+SYNRGchr1735902508+0.0018539950.99814606
ENST00000280527ENST00000345615CRIM1chr236691731+SYNRGchr1735902508+0.0052932860.9947067
ENST00000280527ENST00000502449CRIM1chr236691731+SYNRGchr1735902508+0.0073381640.99266183
ENST00000280527ENST00000591288CRIM1chr236691731+SYNRGchr1735902508+0.0096386130.99036145
ENST00000280527ENST00000394378CRIM1chr236691731+SYNRGchr1735902508+0.0087781920.9912218
ENST00000280527ENST00000585472CRIM1chr236691731+SYNRGchr1735902508+0.0096386130.99036145

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Fusion Genomic Features for CRIM1-SYNRG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRIM1-SYNRG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:36691731/chr17:35902508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRIM1

Q9NZV1

.
FUNCTION: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022115_15501315.0Coiled coilOntology_term=ECO:0000255
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020115_15501225.0Coiled coilOntology_term=ECO:0000255
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021115_15501303.0Coiled coilOntology_term=ECO:0000255
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021115_15501236.0Coiled coilOntology_term=ECO:0000255
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020115_15501109.0Coiled coilOntology_term=ECO:0000255
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022295_38801315.0DomainEH
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020295_38801225.0DomainEH
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021295_38801303.0DomainEH
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021295_38801236.0DomainEH
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020295_38801109.0DomainEH
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022457_46101315.0MotifNote=DFXDF motif 1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022690_69401315.0MotifNote=DFXDF motif 2
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022775_77901315.0MotifNote=DFXDF motif 3
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020457_46101225.0MotifNote=DFXDF motif 1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020690_69401225.0MotifNote=DFXDF motif 2
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020775_77901225.0MotifNote=DFXDF motif 3
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021457_46101303.0MotifNote=DFXDF motif 1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021690_69401303.0MotifNote=DFXDF motif 2
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021775_77901303.0MotifNote=DFXDF motif 3
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021457_46101236.0MotifNote=DFXDF motif 1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021690_69401236.0MotifNote=DFXDF motif 2
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021775_77901236.0MotifNote=DFXDF motif 3
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020457_46101109.0MotifNote=DFXDF motif 1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020690_69401109.0MotifNote=DFXDF motif 2
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020775_77901109.0MotifNote=DFXDF motif 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117334_39101037.0DomainVWFC 1
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+11735_11201037.0DomainIGFBP N-terminal
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117401_45701037.0DomainVWFC 2
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117469_49801037.0DomainAntistasin-like 1
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117505_53201037.0DomainAntistasin-like 2
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117539_56401037.0DomainAntistasin-like 3
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117567_59201037.0DomainAntistasin-like 4
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117606_66301037.0DomainVWFC 3
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117677_73501037.0DomainVWFC 4
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117751_80901037.0DomainVWFC 5
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117817_87401037.0DomainVWFC 6
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117314_31601037.0MotifCell attachment site
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+11735_93901037.0Topological domainExtracellular
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117961_103601037.0Topological domainCytoplasmic
HgeneCRIM1chr2:36691731chr17:35902508ENST00000280527+117940_96001037.0TransmembraneHelical


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Fusion Gene Sequence for CRIM1-SYNRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19443_19443_1_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000339208_length(transcript)=6624nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTGACAGGGACCAATAAATAGAATGCGAGCACTGCACAGTTCGC
TTCCCTGAATCGATATGAAGAACACCGCAAGGGACGGGGCCCCCGTCATCCCCACGGCCAGTCTGCAGGACTTCAGGTAAAATTGTCCCA
CCCAAACTGCACGTGGCACCAGAAGCTTGCTCACTTATCTCTACTTAAGATTTTCTGAAATACGGACCACGGCTTTCTTGATCTAAGGAA
GAACTTGCTGCTGCAGTATTGAAACTGTGAAGAACTGACATTTGAAGAAAAATAGATTACCGTTGCGGGACTAGAATGGGCGACTGCTTG
GAGCCAGTGCTTGTTTTTATCTAGGACACTTACTGTCCTGTGAAGTAGAATACATTTATCTGCATTTAGTTTGTTAATGTCTGAAATGAA
TAAAAAGAGGAAATTGCGATTAAACTGATGTTCTGCTTTTTATGGAGAAGATTCTGCCCATCTCCCCTGGACAGTAGCAGGCAGGTGAGG
GCAGATTTTACCCACTTGGTTGTCACAACTGAACCAGTTCTCTACTCCTTCCCTTCACTTCTGTCCACTCTCAAGACTTTTTCCCAAAAC
ATGCCTGGGCACTCTGCAGCCGTGAAGAATGCTCATTTTGACAGAGGCCCAAATCCTGTGTATTAGGATAATATCCTTCCCCCCGGGAGC
CTTCGCTGCAAACCTGTTCTGCCGCATGCAAAGACTGTGACCATGGAGTTTTCTCAGACAAGATTTGGAAAGGCAGTGGAATGAAATCTC
TTTGCAGTGGCCTCTCTCCAAATTTCCAAAGATGACTGCATAGGGACCAACACTGCCTGACTTTGCAGTATCTGTGAGAAAAACCTGAAA
ATTAATTCAGGGTGAAAATGTGGAGCTCTCGGCCTAGTGTAAAGTATCAAGATGTATATTTATGGGATAGATACATGACTTAGAAGAAGT
AGAAGAAAATTGTCCAGAAACAGTACTGAATTTTAGATAGAAAAGGCTCATGCTTCCTGGAGTAGGGAATTGTCTTTGCCATTTAATGTG
AATGCATAAAATTAGGGGAAAAACCCAAGTGGCTAAGAGCTGTGTTATTCCTGGGAAGAACTACCAATCTAGGGCACACGTCTCTCTGAA
TTGTTGATTATGCGCTTTATGAAGAGATTTTTCAATCTCGTGTGCTTTACTTTGTGTGGTTTAGACCCTCTGACCTAGACTTTTATTTTT
AAACTGAAAAAGTTGGTCTTGTCTATATAATTGCTGCTTTTACATAATTTATTTTCCCCTCTCAGGACAAATTCTGTCTTGCTCCATCTT
ACAGCTTTTCCATGTTCTCCAAGAAAGGTGTGGAACATTTTCATTAAACAGCTGTTGCTGAGGCTTCTGCTTGACCTTCTGCGTGCCCGA
ATGCACAGAGAGGCACCGAGGAGAGAAAGGCTTTTCTCACTCGCTCCCGATGATACCGTCTCTGGCCATTCCTGACTGAGGCAGCTCACT
CTGAATGGGCACCTTTGGAGCTTTTGCCCACCACAAGGCTAGTGGGGTGTTTCTAACAACACAAGTGGGACAGCTTTTGGCAGGCTTTTC
CTGAGGCCTCGGCGCTTCCATCCTGGACAGCACCACTTCCACATGGAGCTGGAATGCAAGCAGGCTGCTAATTGGCCTTAAAAATTCTTT
GTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGCACAATCTCAGCTCAGTGCAACCTCCGCCTCCCGGGT
TCAAGCGATTCTCCTGCCTCAGCCTCGTGAGTAGCTGGGATTACAGGCGTGCACCACCACGCCCAGCTAATTTTGTATTTTTAGTAGAGG
CAAGGTTTCTCCATGTTGGCCAGGCTTGAACTCCGGACCTCAGGCGATCCGCCCGCCTCAGCCTCCCAAAGTACCGGGATTACAGGCGTG
AGCCACTGCGCCTGGCCTAAATTTCATAACAGAACCATGACAGCAGAATCTACCTTTGCAATAAGAATGTTTCCCAGGAGTTAGAGACCA
GCCCTGGGCATGATGGTAAAGACCCCAGCTAATTATACAAAAAATAATTAGCCGGGTAGGTGGAGTGCATCTGTGGACATTCGTGGTCCC
AGCTACTAGGTAAGCTGAGGCGGGAGATCACAAGTCCAGGAGTTTGAGGCTGCACGTGACAGCGTAGGTGATGACAGAGCGAGACACTGT
CTCTTAAAAAAAAAAAAAAAAAAGTTTCCCAGTTTGAATTTGTATTGCTGAAGCATTTTTTTGAAATGCTATATAGATGCCTGTCATGTC
ACAGTGGCCCAGTATCAACATTTTAAAAAGCTCACTTGGTAGCTGGGCTGGTTTCTATTCCTGAGAAATTCCAGAATGCCTCAGATAAAA
TTCCTTAGTATAATCCCCATTTTCCTTACCAAGGATGGTAGGCTTAGTCACTCCTTGGGAGGTGCCACAGGAAAATTCAGCAGATGTCAA
CAGAAAAAAAGCCTTTGCTATGAAAAGTATTCACTACCTTTCATATCTCTTGAATACTTGAAATGTTTAATTAGATGCCACCAATAGGGA
TCCAAGGAGTGTGGGACACGGTTGCGCTGCTTTTCTTTATAAACGTTTATTAAAATGGCTCAACGCTGCATTCAGCTTCACCTCAGCTCT
TCTTGTCAGCCAGGAGCCCCGTGTCCTTGGAAACTGTAGCCAAGGTTACTTATTTCCATACTGTGCATTGTGTCAGCCCGCTTCACCCCA
CTGCTTGAATGGCCATTAATAAGCACTTTTCTTTTTTTGGTGGGATGTTTTGCCTTTAAAATTTTTATGGCTTAGTGTGTAATTTAATTT
TTGTCTGGACATGCTTGAGATAGAAGAGGTACTGGATATATGAGGATATTTTCCATGCTTTATTTTTCCTGTGGCTACTAGTTAGCATTC
CATAGGGGTTGTGAATTTTTAATTATTTGAATATTTTGTGTACATATACATATTTGAAGGGTTTTGGGGGGGTCTTATTTGTTTAAAGGT
GTCTTCTGTTTGCCTATTTCAAGTGTACTTCAGCTTTGCAAAGATTATAGGGCTGTATGTTACAGAAATAGGAAATGCTGGCCCTGTACT
GGGGACCACTACAAAAATTCCCTTTAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCCAGCACTTTGGGAGGCCGAGCCGGGTGGATCAC
CCGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCGAGACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCAGG
TGCCTGTAATCCGAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCAGAGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCAC
TGCACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAATAAAAAATTCCCTTTAACACCTTCAAGGTCAAATGCCTGCCTTTGT
GAACAGTTAATAAACTGACATTTTCAGACATTTGCCATTCAGAAGGGAGCATTGTAGCCTGCTGTAGACCATTCCAGCAAATGTCAGAAT
GCAGGGCAAGATGTGTGTCGACTATGTTTTTTATGTTTAAGTTACTTACTTATTTCTTCAGGTAAGTGTGTACCAAATAACAATACTGAA
AAGCCCTCCCCTTGCCAGGCCGAGGAAATAAAGCTTAAGTGAAACAGCTCTTGGGGGAAAAATGCCACTTTACAAATACTTTTCTAACAA
AATAGCATTATAATGAAGTTTTTACTTAATTCCATTATTTATATGTTGACGTGAATGTAAGTGGTTAAAAAGTATTCATGTGGGACATCT
CATTACTTTGTAGCTGTGGCTTTATTAACCAGTGAATGCTGTGGCCCTTAGCGAAATGCGTTGTCTTCTGCGTGATGTGGAATTCGCGCC
TGTATTTTAAAAGATGGTGTGGTTTCTCCCTTGTTTGTATTTTAATAAACAACTGCTCTAATTGATGTGTTTAGACATTATAAAGCTTCA
CCTTTAAAATATTTTCAGGGTCTGTTCTGAAATCACCCCTTGTTAAACTTCTCTAACCAAAATACAAGTGTAGAAGAATGTCAGGCTAAA
AGAAGAGAAGCCTGCAGAAGAACATCCTAAAAAACCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAA
TGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTG
GAGCTGGGGATAAAAGCCACTGCAGTGTGCAGTGAGAAACTCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGC
TTCATGTCACTCGCCACACTCACAGTCATTAAGAAGGCAAATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATT
CAGTCAGCTCAAGGCATGGAATATTTATTAGGAAAATGAGAGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCA
CACAAGAGGAGTTTGAGCCTTGGTGATAAAGAAATAAGCCGTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAAT
ACTCTGAATGAGAAGCCCGCCCTGCCCGTCATCCGAGACAAGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAG
AGACTTCATTTGGCAGTTCTGAAAACATCACCATGACATCTCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCA
CCTTCCCAGCTCTTGCCAGTTTTAAAGACACGATTCCTCAGACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAA
AACAGGACCTGCCTACGGCTGAACGGAGCCAGGAGGCCACGTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAAT
GTTCGGATGACTTTGGAGAGTTTCAAAGTGAAAAGCCCAAAATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAAT

>19443_19443_1_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000339208_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_2_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000345615_length(transcript)=3555nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTGACAGGGACCAATAAATAGAATGCGAGCACTGCACAGTTCGC
TTCCCTGAATCGATATGAAGAACACCGCAAGGGACGGGGCCCCCGTCATCCCCACGGCCAGTCTGCAGGACTTCAGGTAAAATTGTCCCA
CCCAAACTGCACGTGGCACCAGAAGCTTGCTCACTTATCTCTACTTAAGATTTTCTGAAATACGGACCACGGCTTTCTTGATCTAAGGAA
GAACTTGCTGCTGCAGTATTGAAACTGTGAAGAACTGACATTTGAAGAAAAATAGATTACCGTTGCGGGACTAGAATGGGCGACTGCTTG
GAGCCAGTGCTTGTTTTTATCTAGGACACTTACTGTCCTGTGAAGTAGAATACATTTATCTGCATTTAGTTTGTTAATGTCTGAAATGAA
TAAAAAGAGGAAATTGCGATTAAACTGATGTTCTGCTTTTTATGGAGAAGATTCTGCCCATCTCCCCTGGACAGTAGCAGGCAGGTGAGG
GCAGATTTTACCCACTTGGTTGTCACAACTGAACCAGTTCTCTACTCCTTCCCTTCACTTCTGTCCACTCTCAAGACTTTTTCCCAAAAC
ATGCCTGGGCACTCTGCAGCCGTGAAGAATGCTCATTTTGACAGAGGCCCAAATCCTGTGTATTAGGATAATATCCTTCCCCCCGGGAGC
CTTCGCTGCAAACCTGTTCTGCCGCATGCAAAGACTGTGACCATGGAGTTTTCTCAGACAAGATTTGGAAAGGCAGTGGAATGAAATCTC
TTTGCAGTGGCCTCTCTCCAAATTTCCAAAGATGACTGCATAGGGACCAACACTGCCTGACTTTGCAGTATCTGTGAGAAAAACCTGAAA
ATTAATTCAGGGTGAAAATGTGGAGCTCTCGGCCTAGTGTAAAGTATCAAGATGTATATTTATGGGATAGATACATGACTTAGAAGAAGT
AGAAGAAAATTGTCCAGAAACAGTACTGAATTTTAGATAGAAAAGGCTCATGCTTCCTGGAGTAGGGAATTGTCTTTGCCATTTAATGTG
AATGCATAAAATTAGGGGAAAAACCCCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGA
GCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGG
ATAAAAGCCACTGCAGTGTGCAGTGAGAAACTCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCA
CTCGCCACACTCACAGTCATTAAGAAGGCAAATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCT
CAAGGCATGGAATATTTATTAGGAAAATGAGAGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGG
AGTTTGAGCCTTGGTGATAAAGAAATAAGCCGTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAAT
GAGAAGCCCGCCCTGCCCGTCATCCGAGACAAGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCAT
TTGGCAGTTCTGAAAACATCACCATGACATCTCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAG
CTCTTGCCAGTTTTAAAGACACGATTCCTCAGACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAAAACAGGACC
TGCCTACGGCTGAACGGAGCCAGGAGGCCACGTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATG
ACTTTGGAGAGTTTCAAAGTGAAAAGCCCAAAATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAATCCAGTGAAG

>19443_19443_2_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000345615_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_3_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000346661_length(transcript)=6587nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTGACAGGGACCAATAAATAGAATGCGAGCACTGCACAGTTCGC
TTCCCTGAATCGATATGAAGAACACCGCAAGGGACGGGGCCCCCGTCATCCCCACGGCCAGTCTGCAGGACTTCAGGTAAAATTGTCCCA
CCCAAACTGCACGTGGCACCAGAAGCTTGCTCACTTATCTCTACTTAAGATTTTCTGAAATACGGACCACGGCTTTCTTGATCTAAGGAA
GAACTTGCTGCTGCAGTATTGAAACTGTGAAGAACTGACATTTGAAGAAAAATAGATTACCGTTGCGGGACTAGAATGGGCGACTGCTTG
GAGCCAGTGCTTGTTTTTATCTAGGACACTTACTGTCCTGTGAAGTAGAATACATTTATCTGCATTTAGTTTGTTAATGTCTGAAATGAA
TAAAAAGAGGAAATTGCGATTAAACTGATGTTCTGCTTTTTATGGAGAAGATTCTGCCCATCTCCCCTGGACAGTAGCAGGCAGGTGAGG
GCAGATTTTACCCACTTGGTTGTCACAACTGAACCAGTTCTCTACTCCTTCCCTTCACTTCTGTCCACTCTCAAGACTTTTTCCCAAAAC
ATGCCTGGGCACTCTGCAGCCGTGAAGAATGCTCATTTTGACAGAGGCCCAAATCCTGTGTATTAGGATAATATCCTTCCCCCCGGGAGC
CTTCGCTGCAAACCTGTTCTGCCGCATGCAAAGACTGTGACCATGGAGTTTTCTCAGACAAGATTTGGAAAGGCAGTGGAATGAAATCTC
TTTGCAGTGGCCTCTCTCCAAATTTCCAAAGATGACTGCATAGGGACCAACACTGCCTGACTTTGCAGTATCTGTGAGAAAAACCTGAAA
ATTAATTCAGGGTGAAAATGTGGAGCTCTCGGCCTAGTGTAAAGTATCAAGATGTATATTTATGGGATAGATACATGACTTAGAAGAAGT
AGAAGAAAATTGTCCAGAAACAGTACTGAATTTTAGATAGAAAAGGCTCATGCTTCCTGGAGTAGGGAATTGTCTTTGCCATTTAATGTG
AATGCATAAAATTAGGGGAAAAACCCAAGTGGCTAAGAGCTGTGTTATTCCTGGGAAGAACTACCAATCTAGGGCACACGTCTCTCTGAA
TTGTTGATTATGCGCTTTATGAAGAGATTTTTCAATCTCGTGTGCTTTACTTTGTGTGGTTTAGACCCTCTGACCTAGACTTTTATTTTT
AAACTGAAAAAGTTGGTCTTGTCTATATAATTGCTGCTTTTACATAATTTATTTTCCCCTCTCAGGACAAATTCTGTCTTGCTCCATCTT
ACAGCTTTTCCATGTTCTCCAAGAAAGGTGTGGAACATTTTCATTAAACAGCTGTTGCTGAGGCTTCTGCTTGACCTTCTGCGTGCCCGA
ATGCACAGAGAGGCACCGAGGAGAGAAAGGCTTTTCTCACTCGCTCCCGATGATACCGTCTCTGGCCATTCCTGACTGAGGCAGCTCACT
CTGAATGGGCACCTTTGGAGCTTTTGCCCACCACAAGGCTAGTGGGGTGTTTCTAACAACACAAGTGGGACAGCTTTTGGCAGGCTTTTC
CTGAGGCCTCGGCGCTTCCATCCTGGACAGCACCACTTCCACATGGAGCTGGAATGCAAGCAGGCTGCTAATTGGCCTTAAAAATTCTTT
GTTTTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGCACAATCTCAGCTCAGTGCAACCTCCGCCTCCCGGGT
TCAAGCGATTCTCCTGCCTCAGCCTCGTGAGTAGCTGGGATTACAGGCGTGCACCACCACGCCCAGCTAATTTTGTATTTTTAGTAGAGG
CAAGGTTTCTCCATGTTGGCCAGGCTTGAACTCCGGACCTCAGGCGATCCGCCCGCCTCAGCCTCCCAAAGTACCGGGATTACAGGCGTG
AGCCACTGCGCCTGGCCTAAATTTCATAACAGAACCATGACAGCAGAATCTACCTTTGCAATAAGAATGTTTCCCAGGAGTTAGAGACCA
GCCCTGGGCATGATGGTAAAGACCCCAGCTAATTATACAAAAAATAATTAGCCGGGTAGGTGGAGTGCATCTGTGGACATTCGTGGTCCC
AGCTACTAGGTAAGCTGAGGCGGGAGATCACAAGTCCAGGAGTTTGAGGCTGCACGTGACAGCGTAGGTGATGACAGAGCGAGACACTGT
CTCTTAAAAAAAAAAAAAAAAAAGTTTCCCAGTTTGAATTTGTATTGCTGAAGCATTTTTTTGAAATGCTATATAGATGCCTGTCATGTC
ACAGTGGCCCAGTATCAACATTTTAAAAAGCTCACTTGGTAGCTGGGCTGGTTTCTATTCCTGAGAAATTCCAGAATGCCTCAGATAAAA
TTCCTTAGTATAATCCCCATTTTCCTTACCAAGGATGGTAGGCTTAGTCACTCCTTGGGAGGTGCCACAGGAAAATTCAGCAGATGTCAA
CAGAAAAAAAGCCTTTGCTATGAAAAGTATTCACTACCTTTCATATCTCTTGAATACTTGAAATGTTTAATTAGATGCCACCAATAGGGA
TCCAAGGAGTGTGGGACACGGTTGCGCTGCTTTTCTTTATAAACGTTTATTAAAATGGCTCAACGCTGCATTCAGCTTCACCTCAGCTCT
TCTTGTCAGCCAGGAGCCCCGTGTCCTTGGAAACTGTAGCCAAGGTTACTTATTTCCATACTGTGCATTGTGTCAGCCCGCTTCACCCCA
CTGCTTGAATGGCCATTAATAAGCACTTTTCTTTTTTTGGTGGGATGTTTTGCCTTTAAAATTTTTATGGCTTAGTGTGTAATTTAATTT
TTGTCTGGACATGCTTGAGATAGAAGAGGTACTGGATATATGAGGATATTTTCCATGCTTTATTTTTCCTGTGGCTACTAGTTAGCATTC
CATAGGGGTTGTGAATTTTTAATTATTTGAATATTTTGTGTACATATACATATTTGAAGGGTTTTGGGGGGGTCTTATTTGTTTAAAGGT
GTCTTCTGTTTGCCTATTTCAAGTGTACTTCAGCTTTGCAAAGATTATAGGGCTGTATGTTACAGAAATAGGAAATGCTGGCCCTGTACT
GGGGACCACTACAAAAATTCCCTTTAGCCGGGCGTGGTGGCTCACGCCTGTAATCCCCAGCACTTTGGGAGGCCGAGCCGGGTGGATCAC
CCGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCGAGACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCAGG
TGCCTGTAATCCGAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCAGAGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGCCAC
TGCACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAATAAAAAATTCCCTTTAACACCTTCAAGGTCAAATGCCTGCCTTTGT
GAACAGTTAATAAACTGACATTTTCAGACATTTGCCATTCAGAAGGGAGCATTGTAGCCTGCTGTAGACCATTCCAGCAAATGTCAGAAT
GCAGGGCAAGATGTGTGTCGACTATGTTTTTTATGTTTAAGTTACTTACTTATTTCTTCAGGTAAGTGTGTACCAAATAACAATACTGAA
AAGCCCTCCCCTTGCCAGGCCGAGGAAATAAAGCTTAAGTGAAACAGCTCTTGGGGGAAAAATGCCACTTTACAAATACTTTTCTAACAA
AATAGCATTATAATGAAGTTTTTACTTAATTCCATTATTTATATGTTGACGTGAATGTAAGTGGTTAAAAAGTATTCATGTGGGACATCT
CATTACTTTGTAGCTGTGGCTTTATTAACCAGTGAATGCTGTGGCCCTTAGCGAAATGCGTTGTCTTCTGCGTGATGTGGAATTCGCGCC
TGTATTTTAAAAGATGGTGTGGTTTCTCCCTTGTTTGTATTTTAATAAACAACTGCTCTAATTGATGTGTTTAGACATTATAAAGCTTCA
CCTTTAAAATATTTTCAGGGTCTGTTCTGAAATCACCCCTTGTTAAACTTCTCTAACCAAAATACAAGTGTAGAAGAATGTCAGGCTCCA
GATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAAT
GTGGACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGGATAAAAGCCACTGCAGTGTGCAGTGAGA
AACTCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCACTCGCCACACTCACAGTCATTAAGAAGG
CAAATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCTCAAGGCATGGAATATTTATTAGGAAAAT
GAGAGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGGAGTTTGAGCCTTGGTGATAAAGAAATAA
GCCGTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAATGAGAAGCCCGCCCTGCCCGTCATCCGAG
ACAAGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCATTTGGCAGTTCTGAAAACATCACCATGAC
ATCTCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAGCTCTTGCCAGTTTTAAAGACACGATTCC
TCAGACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAAAACAGGACCTGCCTACGGCTGAACGGAGCCAGGAGGC
CACGTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATGACTTTGGAGAGTTTCAAAGTGAAAAGCC
CAAAATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAATCCAGTGAAGAAATGATCAAAAGTGAGCTGGCAACCTT

>19443_19443_3_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000346661_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_4_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000394378_length(transcript)=2603nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTAAAGAAGAGAAGCCTGCAGAAGAACATCCTAAAAAACCAGAT
GAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTG
GACTCGAGGAGCCGGTGCTGCTGGGAAAAGATGACTGTGATTACAAAGCATCTCTCTCCTTACCATGAGCTCTTAGAAGAAAAGGTGTTG
TTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGGATAAAAGCCACTGCAGTGTGCAGTGAGAAACTCCAGCAGTTGCTGAAGGACA
TCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCACTCGCCACACTCACAGTCATTAAGAAGGCAAATGATACCTTAAATGGAATCA
GTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCTCAAGGCATGGAATATTTATTAGGAAAATGAGAGATATGCATATGAATGGCAG
AGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGGAGTTTGAGCCTTGGTGATAAAGAAATAAGCCGTTCTTCTCCTTCTCCAGCTT
TGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAATGAGAAGCCCGCCCTGCCCGTCATCCGAGACAAGTACAAAGACCTGACGGGAG
AGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCATTTGGCAGTTCTGAAAACATCACCATGACATCTCTCTCCAAAGTAACGACCTT
TGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAGCTCTTGCCAGTTTTAAAGACACGATTCCTCAGACCAGTGAGCAAAAGGAATA
TGAAAACAGAGACTATAAAGATTTCACAAAACAGGACCTGCCTACGGCTGAACGGAGCCAGGAGGCCACGTGTCCCAGCCCAGCGTCCAG
TGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATGACTTTGGAGAGTTTCAAAGTGAAAAGCCCAAAATCAGCAAATTTGACTTCTT

>19443_19443_4_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000394378_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_5_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000502449_length(transcript)=2924nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTGACAGGGACCAATAAATAGAATGCGAGCACTGCACAGTTCGC
TTCCCTGAATCGATATGAAGAACACCGCAAGGGACGGGGCCCCCGTCATCCCCACGGCCAGTCTGCAGGACTTCAGGTAAAATTGTCCCA
CCCAAACTGCACGTGGCACCAGAAGCTTGCTCACTTATCTCTACTTAAGATTTTCTGAAATACGGACCACGGCTTTCTTGATCTAAGGAA
GAACTTGCTGCTGCAGTATTGAAACTGTGAAGAACTGACATTTGAAGAAAAATAGATTACCGTTGCGGGACTAGAATGGGCGACTGCTTG
GAGCCAGTGCTTGTTTTTATCTAGGACACTTACTGTCCTGTGAAGTAGAATACATTTATCTGCATTTAGTTTGTTAATGTCTGAAATGAA
TAAAAAGAGGAAATTGCGATTAAACCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAG
CTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGGA
TAAAAGCCACTGCAGTGTGCAGTGAGAAACTCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCAC
TCGCCACACTCACAGTCATTAAGAAGGCAAATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCTC
AAGGCATGGAATATTTATTAGGAAAATGAGAGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGGA
GTTTGAGCCTTGGTGATAAAGAAATAAGCCGTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAATG
AGAAGCCCGCCCTGCCCGTCATCCGAGACAAGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCATT
TGGCAGTTCTGAAAACATCACCATGACATCTCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAGC
TCTTGCCAGTTTTAAAGACACGATTCCTCAGACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAAAACAGGACCT
GCCTACGGCTGAACGGAGCCAGGAGGCCACGTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATGA
CTTTGGAGAGTTTCAAAGTGAAAAGCCCAAAATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAATCCAGTGAAGA

>19443_19443_5_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000502449_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_6_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000585472_length(transcript)=2534nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTAAAGAAGAGAAGCCTGCAGAAGAACATCCTAAAAAACCAGAT
GAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTG
GACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGGATAAAAGCCACTGCAGTGTGCAGTGAGAAAC
TCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCACTCGCCACACTCACAGTCATTAAGAAGGCAA
ATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCTCAAGGCATGGAATATTTATTAGGAAAATGAG
AGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGGAGTTTGAGCCTTGGTGATAAAGAAATAAGCC
GTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAATGAGAAGCCCGCCCTGCCCGTCATCCGAGACA
AGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCATTTGGCAGTTCTGAAAACATCACCATGACATC
TCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAGCTCTTGCCAGTTTTAAAGACACGATTCCTCA
GACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAAAACAGGACCTGCCTACGGCTGAACGGAGCCAGGAGGCCAC
GTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATGACTTTGGAGAGTTTCAAAGTGAAAAGCCCAA
AATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAATCCAGTGAAGAAATGATCAAAAGTGAGCTGGCAACCTTTGA

>19443_19443_6_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000585472_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------
>19443_19443_7_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000591288_length(transcript)=2534nt_BP=1303nt
GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT
TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG
GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC
TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG
CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC
GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG
CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT
GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGATGAGAACTGGACTGATGACCA
ACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTG
CAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCG
CTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAG
CCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCC
GGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTG
TCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGCCCCGCATAGTCTCTCGTGGCGAT
GGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGGCATTCAACTCAGAAACAGACAGTTTCAAGCTGGCCTATGGAGGGCA
CCAGTATCACGCCAGCTGTGCCAACTTCTGGATCAACTGTGTCGAACCAAAGCCTCCTGGCCTCGTCCTGCCTGACCTGCTCTGAACAAC
TCCTCTGTGAAGCATTGACTTTTTTTTTTCTGTGACACCCCACGGGGTAAAGAAGAGAAGCCTGCAGAAGAACATCCTAAAAAACCAGAT
GAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTG
GACTCGAGGAGCCGGGTGTTGTTGAAGTGTACAGGGTAACCAAGCGTGTGGAGCTGGGGATAAAAGCCACTGCAGTGTGCAGTGAGAAAC
TCCAGCAGTTGCTGAAGGACATCGATAAAGTATGGAATAACCTAATCGGCTTCATGTCACTCGCCACACTCACAGTCATTAAGAAGGCAA
ATGATACCTTAAATGGAATCAGTAGTAGTTCTGTTTGCACAGAAGTAATTCAGTCAGCTCAAGGCATGGAATATTTATTAGGAAAATGAG
AGATATGCATATGAATGGCAGAGATGCCTGGGGAGTGCCCTGAATGATCACACAAGAGGAGTTTGAGCCTTGGTGATAAAGAAATAAGCC
GTTCTTCTCCTTCTCCAGCTTTGGAGCAGCCTTTCAGAGACCGTTCCAATACTCTGAATGAGAAGCCCGCCCTGCCCGTCATCCGAGACA
AGTACAAAGACCTGACGGGAGAGGTGGAGCCTCAATTCTTCAAAAGAAAGAGACTTCATTTGGCAGTTCTGAAAACATCACCATGACATC
TCTCTCCAAAGTAACGACCTTTGTAAGTGAAGATGCTCTTCCAGAGACCACCTTCCCAGCTCTTGCCAGTTTTAAAGACACGATTCCTCA
GACCAGTGAGCAAAAGGAATATGAAAACAGAGACTATAAAGATTTCACAAAACAGGACCTGCCTACGGCTGAACGGAGCCAGGAGGCCAC
GTGTCCCAGCCCAGCGTCCAGTGGTGCCTCTCAAGAAACCCCGAACGAATGTTCGGATGACTTTGGAGAGTTTCAAAGTGAAAAGCCCAA
AATCAGCAAATTTGACTTCTTAGTAGCCACTTCACAAAGCAAAATGAAATCCAGTGAAGAAATGATCAAAAGTGAGCTGGCAACCTTTGA

>19443_19443_7_CRIM1-SYNRG_CRIM1_chr2_36691731_ENST00000280527_SYNRG_chr17_35902508_ENST00000591288_length(amino acids)=292AA_BP=
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CRIM1-SYNRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022666_67801315.0AP1G1%2C AP1G2 and GGA1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020666_67801225.0AP1G1%2C AP1G2 and GGA1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021666_67801303.0AP1G1%2C AP1G2 and GGA1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021666_67801236.0AP1G1%2C AP1G2 and GGA1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020666_67801109.0AP1G1%2C AP1G2 and GGA1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000339208022518_78601315.0AP1G1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000345615020518_78601225.0AP1G1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000346661021518_78601303.0AP1G1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000585472021518_78601236.0AP1G1
TgeneSYNRGchr2:36691731chr17:35902508ENST00000591288020518_78601109.0AP1G1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRIM1-SYNRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRIM1-SYNRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource