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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CRK-ABR (FusionGDB2 ID:19479)

Fusion Gene Summary for CRK-ABR

Fusion gene summary

Fusion gene information	Fusion gene name: CRK-ABR
	Fusion gene ID: 19479
		Hgene	Tgene
	Gene symbol	CRK	ABR
	Gene ID	1398	29
	Gene name	CRK proto-oncogene, adaptor protein	ABR activator of RhoGEF and GTPase
	Synonyms	CRKII\|p38	MDB
	Cytomap	17p13.3	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein	active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related
	Modification date	20200327	20200313
	UniProtAcc	.	Q15018
	Ensembl transtripts involved in fusion gene	ENST00000398970, ENST00000572145, ENST00000300574, ENST00000574295,	ENST00000544583, ENST00000574437, ENST00000291107, ENST00000536794, ENST00000543210, ENST00000572441, ENST00000573895, ENST00000302538,
Fusion gene scores	* DoF score	15 X 11 X 7=1155	17 X 14 X 9=2142
	# samples	18	21
	** MAII score	log2(18/1155*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2142*10)=-3.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CRK [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABR(994905)-CRK(1340449), # samples:2 CRK(1340084)-ABR(1028702), # samples:2
Anticipated loss of major functional domain due to fusion event.	ABR-CRK seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CRK	GO:0009966	regulation of signal transduction	17515907
Hgene	CRK	GO:0032956	regulation of actin cytoskeleton organization	11870224
Hgene	CRK	GO:0043087	regulation of GTPase activity	11870224
Hgene	CRK	GO:0048013	ephrin receptor signaling pathway	11870224
Hgene	CRK	GO:0061045	negative regulation of wound healing	17515907
Hgene	CRK	GO:2000146	negative regulation of cell motility	17515907
Tgene	ABR	GO:0090630	activation of GTPase activity	7479768

Fusion gene breakpoints across CRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A1KY-01A	CRK	chr17	1340084	-	ABR	chr17	1028702	-

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Fusion Gene ORF analysis for CRK-ABR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000398970	ENST00000544583	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-5UTR	ENST00000398970	ENST00000574437	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-intron	ENST00000398970	ENST00000291107	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-intron	ENST00000398970	ENST00000536794	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-intron	ENST00000398970	ENST00000543210	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-intron	ENST00000398970	ENST00000572441	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5CDS-intron	ENST00000398970	ENST00000573895	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-3CDS	ENST00000572145	ENST00000302538	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-5UTR	ENST00000572145	ENST00000544583	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-5UTR	ENST00000572145	ENST00000574437	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-intron	ENST00000572145	ENST00000291107	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-intron	ENST00000572145	ENST00000536794	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-intron	ENST00000572145	ENST00000543210	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-intron	ENST00000572145	ENST00000572441	CRK	chr17	1340084	-	ABR	chr17	1028702	-
5UTR-intron	ENST00000572145	ENST00000573895	CRK	chr17	1340084	-	ABR	chr17	1028702	-
In-frame	ENST00000398970	ENST00000302538	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-3CDS	ENST00000300574	ENST00000302538	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-3CDS	ENST00000574295	ENST00000302538	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-5UTR	ENST00000300574	ENST00000544583	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-5UTR	ENST00000300574	ENST00000574437	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-5UTR	ENST00000574295	ENST00000544583	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-5UTR	ENST00000574295	ENST00000574437	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000300574	ENST00000291107	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000300574	ENST00000536794	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000300574	ENST00000543210	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000300574	ENST00000572441	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000300574	ENST00000573895	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000574295	ENST00000291107	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000574295	ENST00000536794	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000574295	ENST00000543210	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000574295	ENST00000572441	CRK	chr17	1340084	-	ABR	chr17	1028702	-
intron-intron	ENST00000574295	ENST00000573895	CRK	chr17	1340084	-	ABR	chr17	1028702	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000398970

CRK

chr17

1340084

ENST00000302538

ABR

chr17

1028702

5794

713

106

3231

1041

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398970	ENST00000302538	CRK	chr17	1340084	-	ABR	chr17	1028702	-	0.001456703	0.99854326

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Fusion Genomic Features for CRK-ABR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRK-ABR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:994905/chr17:1340449)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ABR Q15018
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250\|UniProtKB:Q3TCJ1, ECO:0000269\|PubMed:19214193, ECO:0000269\|PubMed:20032457, ECO:0000269\|PubMed:20656690, ECO:0000269\|PubMed:24075985, ECO:0000269\|PubMed:25283148}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000398970

132_192

202

205.0

Domain

SH3 1

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000398970

13_118

202

205.0

Domain

SH2

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000291107

417_420

823.0

Compositional bias

Note=Poly-Leu

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000302538

417_420

860.0

Compositional bias

Note=Poly-Leu

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000543210

417_420

311.0

Compositional bias

Note=Poly-Leu

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000544583

417_420

814.0

Compositional bias

Note=Poly-Leu

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000574437

417_420

814.0

Compositional bias

Note=Poly-Leu

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000291107

301_459

823.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000291107

484_613

823.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000291107

647_845

823.0

Domain

Rho-GAP

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000291107

91_284

823.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000302538

301_459

860.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000302538

484_613

860.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000302538

647_845

860.0

Domain

Rho-GAP

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000302538

91_284

860.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000543210

301_459

311.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000543210

484_613

311.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000543210

647_845

311.0

Domain

Rho-GAP

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000543210

91_284

311.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000544583

301_459

814.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000544583

484_613

814.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000544583

647_845

814.0

Domain

Rho-GAP

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000544583

91_284

814.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000574437

301_459

814.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000574437

484_613

814.0

Domain

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000574437

647_845

814.0

Domain

Rho-GAP

Tgene

ABR

chr17:1340084

chr17:1028702

ENST00000574437

91_284

814.0

Domain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000300574

132_192

305.0

Domain

SH3 1

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000300574

13_118

305.0

Domain

SH2

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000300574

235_296

305.0

Domain

SH3 2

Hgene

CRK

chr17:1340084

chr17:1028702

ENST00000398970

235_296

202

205.0

Domain

SH3 2

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Fusion Gene Sequence for CRK-ABR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19479_19479_1_CRK-ABR_CRK_chr17_1340084_ENST00000398970_ABR_chr17_1028702_ENST00000302538_length(transcript)=5794nt_BP=713nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTC
CAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGAT
AGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGG
GAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAG
CGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGACTTCAG
CTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTC
GCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGT
GGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCT
GTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGAT
CCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCT
CTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCA
GTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGA
AGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGA
CTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGAC
AACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCT
CTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGC
CGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAA
GATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGA
GAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTC
GGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCA
GGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTA
TGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTA
TTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCA
GTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAA
AGGACAGATCCAGCTGGACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGATCAAAGTGGAATTTTC
CATGAAATTCACCAGCCGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAAGATCAGCGTGGTGAC
GAAGCGGGAGCGCTCCAAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGAGGTTGGCATCTACAG
GATATCGGGCGTGGCCACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGATGCTGAGTGACATGGA
CATCAACGCCATCGCCGGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTACCCAGCCTTCATGGA
GGGCATCGCCCTGTCAGACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAACCTCATCACCTTCCT
CTTCCTGCTGGAACACTTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTACCGTGTTTGGACCCAC
GTTACTGAGACCCTCAGAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCATGGCGCAGGTCCAGGT
CCTCCTCTACTACCTGCAGCACCCCCCCATTTCCTTCGCAGAACTCAAGCGGAACACACTGTACTTCTCCACCGACGTGTAGCCCGAGGC
AGGGTGGCTGCGGGCGGGTGGTGGAACCAGCCCCTCCAGCCTGGGGTCCAACTCAGACTTGAAAGACTGCAATAGAAAACTCCCAAACCC
AGCACTCCAGACTCGAGGGAAGCCAGCTTCCAAGAACTGGAATGCGTACGTCTTTTGTGCCACCTTGTACAAAGCCGGCTGCCCAGCCCC
AGCCTCACCACCGCATCCCACCTCCTGCCCTCCATACCTCTAGTTGTGTCTGATGCTCCGTGCTGTTCGGGAATTGTTTTATGTACACTT
GTCAGGCAGAAAAGGTAGTGACCGGCCCGGCGTGGGCACACAGACAGCCCGCTTTGTTCTTTCATTTCCTCCAGCACTTTCTTTCCGCCT
GAGTCCAGCCCAAGGCCTTTTATTTTGCGCTGTGTAACTGCTGCCAGCTTCTCTCTTGGCCCTGCTCCCAGATGGCGGTCTCCTGGCAGC
CTCCCCTCAGTCTTCCTCCACCCGCTCTTCCTTCCCAGCCTGCCTGCATGCATGTGCACCCTTGGTCTTCGCTCCATCGCCTTGAAAGCT
CTGAAGAGGCCCTGGGTTGCCGCGGCAGCAGTGGTCTGTTTGATGCTGCCGTTTGCCGCTGCCGGCCCCTCCTCAGACTCCGCCTTTGGG
AGCACACCTGCTTTGCCTTGCTGCCTGTGCAAATGTTGGACAAGCAGACACACTCACACTCGTCCCCAGCTTAGCACAGAGCTGGAGCGC
CCATTTCTGGAATTTTCCGTTTGGGAATCTCCACTTCTGGGGTTTACCTGTTCGGCCTCCTGTCTATCAGTGAGGCATCTCTGACTGTTT
CTTCTACTGCTTTTCAGTTCCCTTCCCTGCTGTTCTATTTCCTTTGAGTGTAAAGACTCACAGGTGACCTGCTATCGAGATAGCCAGAGG
GTCAGGAGAGAATGGGGGAGGAGGCGGTCAGGCTGCTGAGGAAACACCACAGGCTGAACGGGGGAGGAATGCACATGCCACGCTGGGTGT
CCCGGGTCGCGGGGAGGCAGCTCAGCTCTTAGGAGCAAGTTGTGGGGGCTTTTCAAGAGGGGCCAGGCTTCCTGGAGGGTGACTGATGTG
GCCGAAGCAGGTGTCCAGGCAGGTAGGCTGCAGCCAGGAGCTCCCTGGCACCGCAGGACCTCGTGGTACTCTTGCCTTAGATTTTACACA
CACTCCACAGCCAAGCACTGCCACGGTCCTCCAGGACCTGGGAAGCAAAGGCACAGGCCCACGGTGGCCAGCCATTGTGGTGCCGCCCCA
GCTTCTGGATACAGCCTTTTGGGTAAACACTGGGAACTCCAGAAGTTGTGGGGAGAGTGGGGAATCAGACAGCCGCCTCTAGGGGCTGGG
TTCTGCTGGGGCCTCCTTGTTGGTGCTGTAGGCACCCGCCAGGGAGCAGGGACCCGACTTGCAGACGCATTGCCCGGTACTAGGAAGGAG
TGAGGTGTGTTCCCACCGTACACTTCCCACACGAGCTGCGGCTGCCAGCCTCGGGCCATCAGCCTAGGAGAGCAGATGCAGCTCCAGGGG
CTCGACTTATAGCCAGTTACAGCTCCCCGGCTCTTCTGTGTGGCAGAGCGTCGTTTCCGGGCCCTCAGGGCTGGGGAGCTCAGTTCCCAT
TGCTTGTGCTCAGGGCTGAGTCTTAAAGAAGGGTTTGCCGGCCCTAACGCTGCAGCGCGTGCGCGGTGAGAGGCCCTTTTTGAGCCTGTT
TACTCCTGTGGCCTTGGGCAGAACAGTAAATACTCTGTGCACGGAGGAAAGACATGCCCAAGAGGAAGGAAGTACTGACCATCGGCTGCC
TGTGAGCAGCTTAGCAAGGAGCCCTTGCTCCCTGGGAAAGGCGGTGAACTTGAGTCTAAAGATGCAGTGCCTGGCCCTTCCTAAGGTCCC
TGCCTGGCATCCGAGTGTCGGTGTGTGGCACAGAAGGCTCCTGCTTGCTTCCAAAGTGATGGACAGGAAGGGGCAGAGTGAGTCACGGCC
CAGACTGGGCACCTTCGCGTCTCAGCCTCAGGGAGCCCCACAGCCCCAAGCTCGCTGAGGCAACGTGAGAACAGGCTATGGGAAGGCTGC
AAAGGCTGAGAAATGCAAAGGCTCATATTTATAAATCCCACCCCCAGAGTGGGGAGGGTCAGGTGCCAGACCTGGACTAAACTGCACCAA
GGAAACACCCAGCAGGGTCTCCTGTGAGCCGGGGACCATGCAGCCCGAAACCTCCAGTCACTGCGCCCGGCAGGAGTCAGGAGCCAGGGA
CTGTGCAGCCTGGAACCTCCAGTCACTGTGCCCAGCAGGGTGGGCTGTGCCCAGCAGGAGTCAGGCTAAGAAACGCCAGGTCTGCCTGTT
CTTGCTGGGCAATGGCTGATGGCTGCCAGTTTCTGCTGATACACAGGTAGGATGGGACCCTTCATGAATATCTGACTTTAATAAGTTGGT
AAGGATATATTTTTTTGTCTATGTTCTGTTTCAACTTATGTAGATTATTATAAATTGATGTAAACCACGTGAGAGGAAAATGTTAATAAA

>19479_19479_1_CRK-ABR_CRK_chr17_1340084_ENST00000398970_ABR_chr17_1028702_ENST00000302538_length(amino acids)=1041AA_BP=0
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIG
DQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGDFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKG
LEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLA
SQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQ
DALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFP
SPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERS
EWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKA
KTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTS
RDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIA
GTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS

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Top

Fusion Gene PPI Analysis for CRK-ABR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CRK-ABR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CRK-ABR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source