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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADAM10-MYO1E (FusionGDB2 ID:1949)

Fusion Gene Summary for ADAM10-MYO1E

Fusion gene summary

Fusion gene information	Fusion gene name: ADAM10-MYO1E
	Fusion gene ID: 1949
		Hgene	Tgene
	Gene symbol	ADAM10	MYO1E
	Gene ID	102	4643
	Gene name	ADAM metallopeptidase domain 10	myosin IE
	Synonyms	AD10\|AD18\|CD156c\|CDw156\|HsT18717\|MADM\|RAK\|kuz	FSGS6\|HuncM-IC\|MYO1C
	Cytomap	15q21.3	15q22.2
	Type of gene	protein-coding	protein-coding
	Description	disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease	unconventional myosin-IeMYO1E variant proteinmyosin-ICunconventional myosin 1E
	Modification date	20200329	20200313
	UniProtAcc	O14672	Q12965
	Ensembl transtripts involved in fusion gene	ENST00000260408, ENST00000558733, ENST00000396140, ENST00000402627, ENST00000561288,	ENST00000558814, ENST00000288235,
Fusion gene scores	* DoF score	14 X 12 X 7=1176	10 X 11 X 5=550
	# samples	17	12
	** MAII score	log2(17/1176*10)=-2.79028140869866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/550*10)=-2.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADAM10 [Title/Abstract] AND MYO1E [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADAM10(59009776)-MYO1E(59480415), # samples:2 MYO1E(59664697)-ADAM10(59009926), # samples:1
Anticipated loss of major functional domain due to fusion event.	MYO1E-ADAM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MYO1E-ADAM10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADAM10	GO:0006509	membrane protein ectodomain proteolysis	12714508\|17557115\|18355449\|18419754\|18676862\|19114711
Hgene	ADAM10	GO:0007162	negative regulation of cell adhesion	12714508
Hgene	ADAM10	GO:0034612	response to tumor necrosis factor	11831872
Hgene	ADAM10	GO:0051089	constitutive protein ectodomain proteolysis	12714508

Fusion gene breakpoints across ADAM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO1E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2262-01A	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
ChimerDB4	OV	TCGA-24-2262	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-

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Fusion Gene ORF analysis for ADAM10-MYO1E

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000260408	ENST00000558814	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
5CDS-intron	ENST00000260408	ENST00000558814	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
5UTR-3CDS	ENST00000558733	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
5UTR-3CDS	ENST00000558733	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
5UTR-intron	ENST00000558733	ENST00000558814	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
5UTR-intron	ENST00000558733	ENST00000558814	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
In-frame	ENST00000260408	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
In-frame	ENST00000260408	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000396140	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000396140	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000402627	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000402627	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000561288	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-3CDS	ENST00000561288	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000396140	ENST00000558814	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000396140	ENST00000558814	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000402627	ENST00000558814	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000402627	ENST00000558814	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000561288	ENST00000558814	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-
intron-intron	ENST00000561288	ENST00000558814	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000260408	ADAM10	chr15	59009776	-	ENST00000288235	MYO1E	chr15	59480415	-	4638	650	444	2171	575
ENST00000260408	ADAM10	chr15	59009775	-	ENST00000288235	MYO1E	chr15	59480415	-	4638	650	444	2171	575

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000260408	ENST00000288235	ADAM10	chr15	59009776	-	MYO1E	chr15	59480415	-	0.000432579	0.99956745
ENST00000260408	ENST00000288235	ADAM10	chr15	59009775	-	MYO1E	chr15	59480415	-	0.000432579	0.99956745

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Fusion Genomic Features for ADAM10-MYO1E

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM10-MYO1E

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:59009776/chr15:59480415)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADAM10 O14672	MYO1E Q12965
FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905, PubMed:29224781). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). {ECO:0000250\|UniProtKB:O35598, ECO:0000269\|PubMed:11477090, ECO:0000269\|PubMed:11786905, ECO:0000269\|PubMed:12475894, ECO:0000269\|PubMed:16239146, ECO:0000269\|PubMed:17557115, ECO:0000269\|PubMed:19114711, ECO:0000269\|PubMed:20592283, ECO:0000269\|PubMed:21288900, ECO:0000269\|PubMed:24990881, ECO:0000269\|PubMed:26686862, ECO:0000269\|PubMed:26876177, ECO:0000269\|PubMed:29224781}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269\|PubMed:20624979, ECO:0000269\|PubMed:30463011}.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269\|PubMed:11940582, ECO:0000269\|PubMed:17257598, ECO:0000269\|PubMed:20860408}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

1051_1108

601

1109.0

Domain

SH3

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

695_724

601

1109.0

Domain

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

730_922

601

1109.0

Domain

TH1

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

1051_1108

601

1109.0

Domain

SH3

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

695_724

601

1109.0

Domain

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

730_922

601

1109.0

Domain

TH1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

555_673

749.0

Compositional bias

Cys-rich

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

555_673

749.0

Compositional bias

Cys-rich

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

220_456

749.0

Domain

Peptidase M12B

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

457_551

749.0

Domain

Disintegrin

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

220_456

749.0

Domain

Peptidase M12B

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

457_551

749.0

Domain

Disintegrin

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

171_178

749.0

Motif

Cysteine switch

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

708_715

749.0

Motif

SH3-binding

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

722_728

749.0

Motif

SH3-binding

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

171_178

749.0

Motif

Cysteine switch

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

708_715

749.0

Motif

SH3-binding

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

722_728

749.0

Motif

SH3-binding

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

20_672

749.0

Topological domain

Extracellular

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

694_748

749.0

Topological domain

Cytoplasmic

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

20_672

749.0

Topological domain

Extracellular

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

694_748

749.0

Topological domain

Cytoplasmic

Hgene

ADAM10

chr15:59009775

chr15:59480415

ENST00000260408

673_693

749.0

Transmembrane

Helical

Hgene

ADAM10

chr15:59009776

chr15:59480415

ENST00000260408

673_693

749.0

Transmembrane

Helical

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

19_692

601

1109.0

Domain

Myosin motor

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

19_692

601

1109.0

Domain

Myosin motor

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

112_119

601

1109.0

Nucleotide binding

ATP

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

112_119

601

1109.0

Nucleotide binding

ATP

Tgene

MYO1E

chr15:59009775

chr15:59480415

ENST00000288235

581_591

601

1109.0

Region

Actin-binding

Tgene

MYO1E

chr15:59009776

chr15:59480415

ENST00000288235

581_591

601

1109.0

Region

Actin-binding

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Fusion Gene Sequence for ADAM10-MYO1E

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1949_1949_1_ADAM10-MYO1E_ADAM10_chr15_59009775_ENST00000260408_MYO1E_chr15_59480415_ENST00000288235_length(transcript)=4638nt_BP=650nt
GCGGCGGCAGGCCTAGCAGCACGGGAACCGTCCCCCGCGCGCATGCGCGCGCCCCTGAAGCGCCTGGGGGACGGGTAGGGGCGGGAGGTA
GGGGCGCGGCTCCGCGTGCCAGTTGGGTGCCCGCGCGTCACGTGGTGAGGAAGGAGGCGGAGGTCTGAGTTTCGAAGGAGGGGGGGAGAG
AAGAGGGAACGAGCAAGGGAAGGAAAGCGGGGAAAGGAGGAAGGAAACGAACGAGGGGGAGGGAGGTCCCTGTTTTGGAGGAGCTAGGAG
CGTTGCCGGCCCCTGAAGTGGAGCGAGAGGGAGGTGCTTCGCCGTTTCTCCTGCCAGGGGAGGTCCCGGCTTCCCGTGGAGGCTCCGGAC
CAAGCCCCTTCAGCTTCTCCCTCCGGATCGATGTGCTGCTGTTAACCCGTGAGGAGGCGGCGGCGGCGGCAGCGGCAGCGGAAGATGGTG
TTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGCGGCGGGGATGGGAGGTCAGTATGGGAATCCTTTAAATAAATATATCAGACATTAT
GAAGGATTATCTTACAATGTGGATTCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTCTCACATGAAGACCAATTTTTACGTCTA
GATTTCCATGCCCATGGAAGGGTAAAGCATCAAGTCGAATATTTGGGTCTGAAAGAGAACATTCGAGTGAGAAGAGCTGGCTATGCCTAT
CGGCGCATCTTCCAAAAATTCCTACAGAGGTATGCCATTCTGACCAAAGCCACCTGGCCTTCTTGGCAGGGAGAGGAGAAGCAAGGCGTC
CTGCACCTGCTGCAGTCGGTCAACATGGACAGCGACCAGTTCCAGCTGGGGAGGAGTAAAGTGTTCATCAAAGCCCCCGAGTCTCTATTT
CTTTTAGAAGAGATGAGAGAGAGAAAGTATGATGGGTATGCTCGAGTGATACAGAAATCATGGAGGAAATTCGTGGCCCGGAAGAAATAC
GTTCAAATGAGAGAAGAAGCCTCAGACCTCTTATTGAACAAGAAGGAGAGAAGGAGAAACAGTATTAACAGGAACTTTATAGGGGATTAT
ATTGGGATGGAAGAGCACCCAGAACTCCAGCAGTTCGTGGGCAAGAGGGAGAAGATTGATTTCGCAGACACAGTCACCAAGTATGACAGG
AGGTTCAAGGGTGTAAAGCGAGACCTGCTCCTTACCCCAAAGTGCTTGTACTTAATCGGACGAGAAAAAGTCAAACAGGGCCCAGACAAG
GGCCTGGTGAAAGAAGTCCTGAAGCGGAAAATCGAGATAGAACGGATCTTGTCTGTGTCCCTCAGTACTATGCAGGATGACATTTTTATT
CTCCATGAGCAAGAGTATGACAGTTTGCTTGAATCTGTCTTCAAAACTGAATTCCTAAGCCTCTTAGCAAAGCGTTACGAGGAGAAGACC
CAGAAGCAACTACCTCTGAAATTCAGCAATACGCTTGAACTGAAGTTGAAAAAGGAAAACTGGGGCCCCTGGAGTGCAGGGGGCTCCCGG
CAAGTGCAGTTCCACCAAGGGTTTGGGGACCTGGCTGTCCTCAAGCCCAGTAACAAAGTGCTGCAGGTCAGCATCGGACCTGGACTGCCC
AAGAACTCCCGTCCTACCAGAAGGAACACTACCCAAAATACAGGTTATTCCAGTGGGACTCAAAATGCCAACTACCCAGTGAGAGCTGCC
CCTCCTCCCCCAGGATACCATCAGAACGGAGTCATCAGAAACCAGTATGTGCCATATCCCCATGCTCCTGGAAGCCAGAGGTCCAATCAG
AAAAGCCTGTACACCTCCATGGCCCGCCCGCCCTTGCCTCGGCAGCAGTCTACCAGTTCAGACCGAGTGTCACAGACGCCAGAGAGCCTG
GATTTCCTCAAGGTCCCGGACCAGGGAGCTGCAGGGGTCAGGAGACAAACAACCAGTCGGCCTCCCCCAGCAGGGGGCAGACCCAAGCCC
CAGCCCAAGCCCAAGCCTCAGGTGCCACAGTGCAAGGCTTTGTATGCCTATGACGCTCAGGACACAGACGAACTCAGCTTTAATGCCAAT
GACATTATTGATATTATCAAAGAAGATCCTTCTGGCTGGTGGACGGGTCGACTACGAGGCAAGCAGGGCCTGTTCCCCAACAACTATGTG
ACCAAGATCTGAGGTGCCCGTGACTCTGACACATGGGGCAGAGGAGCTCCAGGCACAGACCAGGGGAGGGGATATTTAGGGGCTCCCCTT
ACAATCCACAATGAGCAATTGCTTCTCCAAGGCCTGGAGCTATTCTGGTACCTTCCCCATGGAGGACACTGAAAAGGCTGGGTTGGGGAC
AGGGAGTATCACTCCATAAGTGATCCTAAAAGGTAGCCTCTTCATAGGAACCCAGGAGGACAAAACCACCATGCATTAAGATTTATTTAT
TGTATTTAAACCTGGTGAGAGGACAAGTGAGGTCTGCTCAGACCTTGTAGGCTTCTATCAAAACAGCACCCTGCTTGCTCACCAGGCCTA
GAGAATGGCTGTAGGTGGCCGCTGACAAGTGCCTTTAGTTGAAGAGCACATTTCTTTCATCTCTCTTGTCCATACCTGATAGACACATTC
CTCTCTGCCACCTTCCTTCAGGGAGGACCCGCCCTCTGCAGACTGGGCTTAGCGTGAGCAGGCACTTCCCATGTACGTGCCAAGGGTAAG
CTGGCCTGCTGAGCCCAGGGCGACAGAGGGGCACTGGTTTACACTTTGCCGGGACCATCAGGGCCGCCAAGCAGGTCAGGGGCTGGGGGC
TGGGGGCTGGGCTGCTGGCTTTGCTTTCTCTGGGTCTTCAATTAGAATGTGGCTGGCCCATATTGGTTTGTGTTTAAATGCTGTACTTAC
TACAAGAAGGATCTTTTTTCAAGCTGTACATTTATAAAAACAGATCATATACTGTATATATAAAAATCTTGAGATGGTAGAAACATGTAT
GAATGTACTAAGTAGTATTCCACTGTACTCATTCATAAGGTAGGTTTTCTTACAAAACTCACACCAGGTACTTAAAGATGTGCTCTGCTT
TTTTCCAACTACGGAGTGTCACTGCTTTCTAGGTCAGTCCCTGCAGACTCTTCTCAACTCTTTCCCTATAGGAAACTTACTCCGCGTCCT
GCCCCCACCTCCTAAATAAATAAAGGAATCGGCGAACACCTTCTTCTTTTATGACATTTGTTATGGGTTGAATTGTGTGCCTCCAAAGAA
GATGTTGGAGTCCCAGCCACCAGTACCTCACAATATGACCTTATTTGGAAATAGAGTCTTTATGGAGCAAACAAACAAAACTAATTAAAA
TGAAGTCATTAGAGTGGGTCTTAATCCAATATAATGGTGTCCTGATGAAAAGGGGAAATTTGGACACAGAGACCAACATGCCAGAGGAAA
GACCATGTGAAAAGGCAGGGAGAAGACAGCCATTCACAAGCCCTGGACAGAGGCCTGGAACAGATTCTCCCTCACACCCTCACAAGGAAC
CAGCCCTGCCCACCTTGGTCTTGGACTTCCAACCTCCAGAACTGTGAGGCAATACATTTCGCTGTTTAAGCCACTCGGTTTGTGGTAGTT
TGTTACGGCAGCCCTAACAAACTAAAACAATGTTTTCTTGCCATAATAGTGAAAAGCTGGAATCAGTGTAATGCCCATCAATAATGGAAT
GGTTGTAAGTAGAGACTGCCATTTCTCTACCTTTCCTCCTCTGGGTGCCATAGCCATTCTTAAGCTACTGGTAACTTAGAGTTTGAGCAG
CATACACCTTTGAGGCTTTCAGGATCCTCAAGTCCATGGGAAAAAATTATCAGGGCTTACGTATAAGGGAAAAAAATTGATCTAGATTTG
AAACGAAGATACATTTAATTCTGCTGTGTTTTACTTCAAGAACAGGGAGCAAACTCCATTCTGTAACAGTAACGAATAATGTTAAAAGGC
TACTTCAGTTCCATGTTGCGACCAGAGAGGAAAGTAGAGCCATGATGCGGTGAGTTGAGGAAAGGTAATCCTGTTGACACTAGTGGTCTC
TAAAGTACTTTCACATTCATGGACTCCCCGCAGTGGGAGGAAGATACCACCAGAACTGGGACAGAGGAGCATGCTGGAGTCCCCACAGCC
ACCAGCACTCAGGCTGCGTTCTCAGGGCAGGAACACCAGGACCATCTTCCCTTGTTATCATAAGCCCCTGGCTGGCTGGGACAAGCCTTT
GTTTTTCCTCCTGATTGATTGATTGGCATTTTACACTTGTGTGTAACTGGGAACCATCGGGCTCTAGGTCACAAAACAGGGACTGAGTTA
AACCCCCACGAGTAACACCCTCATCCATGGAAATCACAGACCAAGCCCTTAGCACCTGCATCGTGTGCCCAGCCAGTGCCAGGCTCAAGG
AGATGCCCAACAAATGGTGCTGAAATAGGTAAGTGACCCACAGGGGAAGGAGACTTAGATCTGCGTAGAGATGCTGAAATGCTGACACTA
TTAAGAAAAGTTTGGAGAAATAGTGGTTTATCTTAAACTTATTTGTATATATTTAGAAATTCAACATGGGGACTACCAGAAAAATCTGGG

>1949_1949_1_ADAM10-MYO1E_ADAM10_chr15_59009775_ENST00000260408_MYO1E_chr15_59480415_ENST00000288235_length(amino acids)=575AA_BP=68
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRVKHQVEYLGLKENIRVRRAGY
AYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARK
KYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGP
DKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGG
SRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRS
NQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFN

--------------------------------------------------------------
>1949_1949_2_ADAM10-MYO1E_ADAM10_chr15_59009776_ENST00000260408_MYO1E_chr15_59480415_ENST00000288235_length(transcript)=4638nt_BP=650nt
GCGGCGGCAGGCCTAGCAGCACGGGAACCGTCCCCCGCGCGCATGCGCGCGCCCCTGAAGCGCCTGGGGGACGGGTAGGGGCGGGAGGTA
GGGGCGCGGCTCCGCGTGCCAGTTGGGTGCCCGCGCGTCACGTGGTGAGGAAGGAGGCGGAGGTCTGAGTTTCGAAGGAGGGGGGGAGAG
AAGAGGGAACGAGCAAGGGAAGGAAAGCGGGGAAAGGAGGAAGGAAACGAACGAGGGGGAGGGAGGTCCCTGTTTTGGAGGAGCTAGGAG
CGTTGCCGGCCCCTGAAGTGGAGCGAGAGGGAGGTGCTTCGCCGTTTCTCCTGCCAGGGGAGGTCCCGGCTTCCCGTGGAGGCTCCGGAC
CAAGCCCCTTCAGCTTCTCCCTCCGGATCGATGTGCTGCTGTTAACCCGTGAGGAGGCGGCGGCGGCGGCAGCGGCAGCGGAAGATGGTG
TTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGCGGCGGGGATGGGAGGTCAGTATGGGAATCCTTTAAATAAATATATCAGACATTAT
GAAGGATTATCTTACAATGTGGATTCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTCTCACATGAAGACCAATTTTTACGTCTA
GATTTCCATGCCCATGGAAGGGTAAAGCATCAAGTCGAATATTTGGGTCTGAAAGAGAACATTCGAGTGAGAAGAGCTGGCTATGCCTAT
CGGCGCATCTTCCAAAAATTCCTACAGAGGTATGCCATTCTGACCAAAGCCACCTGGCCTTCTTGGCAGGGAGAGGAGAAGCAAGGCGTC
CTGCACCTGCTGCAGTCGGTCAACATGGACAGCGACCAGTTCCAGCTGGGGAGGAGTAAAGTGTTCATCAAAGCCCCCGAGTCTCTATTT
CTTTTAGAAGAGATGAGAGAGAGAAAGTATGATGGGTATGCTCGAGTGATACAGAAATCATGGAGGAAATTCGTGGCCCGGAAGAAATAC
GTTCAAATGAGAGAAGAAGCCTCAGACCTCTTATTGAACAAGAAGGAGAGAAGGAGAAACAGTATTAACAGGAACTTTATAGGGGATTAT
ATTGGGATGGAAGAGCACCCAGAACTCCAGCAGTTCGTGGGCAAGAGGGAGAAGATTGATTTCGCAGACACAGTCACCAAGTATGACAGG
AGGTTCAAGGGTGTAAAGCGAGACCTGCTCCTTACCCCAAAGTGCTTGTACTTAATCGGACGAGAAAAAGTCAAACAGGGCCCAGACAAG
GGCCTGGTGAAAGAAGTCCTGAAGCGGAAAATCGAGATAGAACGGATCTTGTCTGTGTCCCTCAGTACTATGCAGGATGACATTTTTATT
CTCCATGAGCAAGAGTATGACAGTTTGCTTGAATCTGTCTTCAAAACTGAATTCCTAAGCCTCTTAGCAAAGCGTTACGAGGAGAAGACC
CAGAAGCAACTACCTCTGAAATTCAGCAATACGCTTGAACTGAAGTTGAAAAAGGAAAACTGGGGCCCCTGGAGTGCAGGGGGCTCCCGG
CAAGTGCAGTTCCACCAAGGGTTTGGGGACCTGGCTGTCCTCAAGCCCAGTAACAAAGTGCTGCAGGTCAGCATCGGACCTGGACTGCCC
AAGAACTCCCGTCCTACCAGAAGGAACACTACCCAAAATACAGGTTATTCCAGTGGGACTCAAAATGCCAACTACCCAGTGAGAGCTGCC
CCTCCTCCCCCAGGATACCATCAGAACGGAGTCATCAGAAACCAGTATGTGCCATATCCCCATGCTCCTGGAAGCCAGAGGTCCAATCAG
AAAAGCCTGTACACCTCCATGGCCCGCCCGCCCTTGCCTCGGCAGCAGTCTACCAGTTCAGACCGAGTGTCACAGACGCCAGAGAGCCTG
GATTTCCTCAAGGTCCCGGACCAGGGAGCTGCAGGGGTCAGGAGACAAACAACCAGTCGGCCTCCCCCAGCAGGGGGCAGACCCAAGCCC
CAGCCCAAGCCCAAGCCTCAGGTGCCACAGTGCAAGGCTTTGTATGCCTATGACGCTCAGGACACAGACGAACTCAGCTTTAATGCCAAT
GACATTATTGATATTATCAAAGAAGATCCTTCTGGCTGGTGGACGGGTCGACTACGAGGCAAGCAGGGCCTGTTCCCCAACAACTATGTG
ACCAAGATCTGAGGTGCCCGTGACTCTGACACATGGGGCAGAGGAGCTCCAGGCACAGACCAGGGGAGGGGATATTTAGGGGCTCCCCTT
ACAATCCACAATGAGCAATTGCTTCTCCAAGGCCTGGAGCTATTCTGGTACCTTCCCCATGGAGGACACTGAAAAGGCTGGGTTGGGGAC
AGGGAGTATCACTCCATAAGTGATCCTAAAAGGTAGCCTCTTCATAGGAACCCAGGAGGACAAAACCACCATGCATTAAGATTTATTTAT
TGTATTTAAACCTGGTGAGAGGACAAGTGAGGTCTGCTCAGACCTTGTAGGCTTCTATCAAAACAGCACCCTGCTTGCTCACCAGGCCTA
GAGAATGGCTGTAGGTGGCCGCTGACAAGTGCCTTTAGTTGAAGAGCACATTTCTTTCATCTCTCTTGTCCATACCTGATAGACACATTC
CTCTCTGCCACCTTCCTTCAGGGAGGACCCGCCCTCTGCAGACTGGGCTTAGCGTGAGCAGGCACTTCCCATGTACGTGCCAAGGGTAAG
CTGGCCTGCTGAGCCCAGGGCGACAGAGGGGCACTGGTTTACACTTTGCCGGGACCATCAGGGCCGCCAAGCAGGTCAGGGGCTGGGGGC
TGGGGGCTGGGCTGCTGGCTTTGCTTTCTCTGGGTCTTCAATTAGAATGTGGCTGGCCCATATTGGTTTGTGTTTAAATGCTGTACTTAC
TACAAGAAGGATCTTTTTTCAAGCTGTACATTTATAAAAACAGATCATATACTGTATATATAAAAATCTTGAGATGGTAGAAACATGTAT
GAATGTACTAAGTAGTATTCCACTGTACTCATTCATAAGGTAGGTTTTCTTACAAAACTCACACCAGGTACTTAAAGATGTGCTCTGCTT
TTTTCCAACTACGGAGTGTCACTGCTTTCTAGGTCAGTCCCTGCAGACTCTTCTCAACTCTTTCCCTATAGGAAACTTACTCCGCGTCCT
GCCCCCACCTCCTAAATAAATAAAGGAATCGGCGAACACCTTCTTCTTTTATGACATTTGTTATGGGTTGAATTGTGTGCCTCCAAAGAA
GATGTTGGAGTCCCAGCCACCAGTACCTCACAATATGACCTTATTTGGAAATAGAGTCTTTATGGAGCAAACAAACAAAACTAATTAAAA
TGAAGTCATTAGAGTGGGTCTTAATCCAATATAATGGTGTCCTGATGAAAAGGGGAAATTTGGACACAGAGACCAACATGCCAGAGGAAA
GACCATGTGAAAAGGCAGGGAGAAGACAGCCATTCACAAGCCCTGGACAGAGGCCTGGAACAGATTCTCCCTCACACCCTCACAAGGAAC
CAGCCCTGCCCACCTTGGTCTTGGACTTCCAACCTCCAGAACTGTGAGGCAATACATTTCGCTGTTTAAGCCACTCGGTTTGTGGTAGTT
TGTTACGGCAGCCCTAACAAACTAAAACAATGTTTTCTTGCCATAATAGTGAAAAGCTGGAATCAGTGTAATGCCCATCAATAATGGAAT
GGTTGTAAGTAGAGACTGCCATTTCTCTACCTTTCCTCCTCTGGGTGCCATAGCCATTCTTAAGCTACTGGTAACTTAGAGTTTGAGCAG
CATACACCTTTGAGGCTTTCAGGATCCTCAAGTCCATGGGAAAAAATTATCAGGGCTTACGTATAAGGGAAAAAAATTGATCTAGATTTG
AAACGAAGATACATTTAATTCTGCTGTGTTTTACTTCAAGAACAGGGAGCAAACTCCATTCTGTAACAGTAACGAATAATGTTAAAAGGC
TACTTCAGTTCCATGTTGCGACCAGAGAGGAAAGTAGAGCCATGATGCGGTGAGTTGAGGAAAGGTAATCCTGTTGACACTAGTGGTCTC
TAAAGTACTTTCACATTCATGGACTCCCCGCAGTGGGAGGAAGATACCACCAGAACTGGGACAGAGGAGCATGCTGGAGTCCCCACAGCC
ACCAGCACTCAGGCTGCGTTCTCAGGGCAGGAACACCAGGACCATCTTCCCTTGTTATCATAAGCCCCTGGCTGGCTGGGACAAGCCTTT
GTTTTTCCTCCTGATTGATTGATTGGCATTTTACACTTGTGTGTAACTGGGAACCATCGGGCTCTAGGTCACAAAACAGGGACTGAGTTA
AACCCCCACGAGTAACACCCTCATCCATGGAAATCACAGACCAAGCCCTTAGCACCTGCATCGTGTGCCCAGCCAGTGCCAGGCTCAAGG
AGATGCCCAACAAATGGTGCTGAAATAGGTAAGTGACCCACAGGGGAAGGAGACTTAGATCTGCGTAGAGATGCTGAAATGCTGACACTA
TTAAGAAAAGTTTGGAGAAATAGTGGTTTATCTTAAACTTATTTGTATATATTTAGAAATTCAACATGGGGACTACCAGAAAAATCTGGG

>1949_1949_2_ADAM10-MYO1E_ADAM10_chr15_59009776_ENST00000260408_MYO1E_chr15_59480415_ENST00000288235_length(amino acids)=575AA_BP=68
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRVKHQVEYLGLKENIRVRRAGY
AYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARK
KYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGP
DKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGG
SRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRS
NQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAM10-MYO1E

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ADAM10	chr15:59009775	chr15:59480415	ENST00000260408	-	2	16	734_748	68.66666666666667	749.0	AP2A1%2C AP2A2 and AP2M1
Hgene	ADAM10	chr15:59009776	chr15:59480415	ENST00000260408	-	2	16	734_748	68.66666666666667	749.0	AP2A1%2C AP2A2 and AP2M1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADAM10-MYO1E

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ADAM10-MYO1E

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source