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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CROT-KIAA1109 (FusionGDB2 ID:19539)

Fusion Gene Summary for CROT-KIAA1109

Fusion gene summary

Fusion gene information	Fusion gene name: CROT-KIAA1109
	Fusion gene ID: 19539
		Hgene	Tgene
	Gene symbol	CROT	KIAA1109
	Gene ID	54677	84162
	Gene name	carnitine O-octanoyltransferase	KIAA1109
	Synonyms	COT	ALKKUCS\|FSA\|Tweek
	Cytomap	7q21.12	4q27
	Type of gene	protein-coding	protein-coding
	Description	peroxisomal carnitine O-octanoyltransferaseperoxisomal carnitine acyltransferase	transmembrane protein KIAA1109fragile site-associated protein
	Modification date	20200313	20200327
	UniProtAcc	Q9UKG9	Q2LD37
	Ensembl transtripts involved in fusion gene	ENST00000331536, ENST00000419147, ENST00000442291, ENST00000412227,	ENST00000388738, ENST00000455637, ENST00000495260, ENST00000264501,
Fusion gene scores	* DoF score	3 X 3 X 3=27	4 X 5 X 3=60
	# samples	3	5
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CROT [Title/Abstract] AND KIAA1109 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CROT(87022383)-KIAA1109(123283186), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CROT	GO:0006091	generation of precursor metabolites and energy	10486279
Hgene	CROT	GO:0006635	fatty acid beta-oxidation	21619872
Hgene	CROT	GO:0051791	medium-chain fatty acid metabolic process	10486279

Fusion gene breakpoints across CROT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIAA1109 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IN-8462-11A	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+

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Fusion Gene ORF analysis for CROT-KIAA1109

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000331536	ENST00000388738	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000331536	ENST00000455637	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000331536	ENST00000495260	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000419147	ENST00000388738	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000419147	ENST00000455637	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000419147	ENST00000495260	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000442291	ENST00000388738	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000442291	ENST00000455637	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
5CDS-intron	ENST00000442291	ENST00000495260	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
In-frame	ENST00000331536	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
In-frame	ENST00000419147	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
In-frame	ENST00000442291	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
intron-3CDS	ENST00000412227	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
intron-intron	ENST00000412227	ENST00000388738	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
intron-intron	ENST00000412227	ENST00000455637	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+
intron-intron	ENST00000412227	ENST00000495260	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000419147

CROT

chr7

87022383

ENST00000264501

KIAA1109

chr4

123283186

2723

2001

175

2217

680

ENST00000331536

CROT

chr7

87022383

ENST00000264501

KIAA1109

chr4

123283186

2625

1903

161

2119

652

ENST00000442291

CROT

chr7

87022383

ENST00000264501

KIAA1109

chr4

123283186

2557

1835

2051

652

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000419147	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+	0.000253316	0.9997466
ENST00000331536	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+	0.000209208	0.99979085
ENST00000442291	ENST00000264501	CROT	chr7	87022383	+	KIAA1109	chr4	123283186	+	0.000176802	0.9998233

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Fusion Genomic Features for CROT-KIAA1109

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CROT	chr7	87022383	+	KIAA1109	chr4	123283185	+	0.05702558	0.9429744
CROT	chr7	87022383	+	KIAA1109	chr4	123283185	+	0.05702558	0.9429744

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CROT-KIAA1109

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:87022383/chr4:123283186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CROT Q9UKG9	KIAA1109 Q2LD37
FUNCTION: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. {ECO:0000269\|PubMed:10486279}.	FUNCTION: Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as regulator of phagocytosis (PubMed:31540829). {ECO:0000269\|PubMed:30906834, ECO:0000269\|PubMed:31540829}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000331536

534_537

572

613.0

Compositional bias

Note=Poly-Gly

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000419147

534_537

600

641.0

Compositional bias

Note=Poly-Gly

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000331536

410_417

572

613.0

Region

Coenzyme A binding

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000419147

410_417

600

641.0

Region

Coenzyme A binding

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1154_1157

3681.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1226_1233

3681.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1237_1240

3681.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1417_1421

3681.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1544_1547

3681.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

1991_1994

3681.0

Compositional bias

Note=Poly-Pro

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

3838_3841

3681.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

4110_4158

3681.0

Compositional bias

Note=Ser-rich

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

772_779

3681.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000455637

26_46

3681.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000412227

534_537

88.0

Compositional bias

Note=Poly-Gly

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000331536

610_612

572

613.0

Motif

Microbody targeting signal

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000412227

610_612

88.0

Motif

Microbody targeting signal

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000419147

610_612

600

641.0

Motif

Microbody targeting signal

Hgene

CROT

chr7:87022383

chr4:123283186

ENST00000412227

410_417

88.0

Region

Coenzyme A binding

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1154_1157

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1226_1233

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1237_1240

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1417_1421

4933

5006.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1544_1547

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

1991_1994

4933

5006.0

Compositional bias

Note=Poly-Pro

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

3838_3841

4933

5006.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

4110_4158

4933

5006.0

Compositional bias

Note=Ser-rich

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

772_779

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1154_1157

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1226_1233

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1237_1240

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1417_1421

4933

5006.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1544_1547

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

1991_1994

4933

5006.0

Compositional bias

Note=Poly-Pro

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

3838_3841

4933

5006.0

Compositional bias

Note=Poly-Lys

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

4110_4158

4933

5006.0

Compositional bias

Note=Ser-rich

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

772_779

4933

5006.0

Compositional bias

Note=Poly-Ser

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000264501

26_46

4933

5006.0

Transmembrane

Helical

Tgene

KIAA1109

chr7:87022383

chr4:123283186

ENST00000388738

26_46

4933

5006.0

Transmembrane

Helical

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Fusion Gene Sequence for CROT-KIAA1109

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19539_19539_1_CROT-KIAA1109_CROT_chr7_87022383_ENST00000331536_KIAA1109_chr4_123283186_ENST00000264501_length(transcript)=2625nt_BP=1903nt
GGGAGCGAGCCGGTGCTGCTGCAGGCTGAGGCTGCGGCAGAGGCGGCGAGGCGCGGGCGGTGAGGACGGACAGTCACCGACTTAGTCCAG
TTCCCTGTGATCTCAAAACAATTGTTGCAGCAGGCTCCTGGCAGTCTCAAGCAGTTCATCTTCTTGGTGTACTGGTTTCCTATTGTGATT
TTATCATGGAAAATCAATTGGCTAAATCAACTGAAGAACGAACATTTCAGTACCAGGATTCTCTTCCATCACTGCCTGTTCCTTCACTTG
AAGAATCATTAAAAAAATACCTTGAATCAGTGAAACCATTTGCAAATCAAGAAGAATATAAGAAAACTGAAGAAATAGTTCAAAAATTTC
AAAGTGGGATTGGAGAAAAATTGCACCAGAAATTGCTTGAAAGAGCAAAAGGAAAAAGAAATTGGCTGGAAGAGTGGTGGCTGAATGTTG
CCTATCTGGATGTTCGTATACCATCACAATTGAATGTCAACTTTGCGGGTCCTGCAGCTCATTTTGAACACTACTGGCCTCCAAAGGAAG
GGACTCAATTAGAAAGAGGAAGTATAACTCTTTGGCATAACTTGAACTACTGGCAGCTATTAAGAAAAGAAAAAGTGCCTGTTCATAAAG
TTGGAAATACTCCTCTAGATATGAATCAATTCCGAATGCTATTTTCTACCTGCAAGGTTCCAGGAATTACTAGAGACTCCATTATGAATT
ATTTTAGGACTGAGAGTGAAGGGCGTTCCCCAAACCACATTGTAGTGCTGTGTCGAGGCCGAGCTTTTGTCTTTGATGTAATACATGAAG
GATGTTTGGTCACCCCGCCAGAGCTTCTCAGACAACTGACATATATCCACAAGAAGTGCCATAGTGAACCTGATGGACCTGGGATTGCAG
CATTAACTAGTGAGGAGCGAACTCGATGGGCTAAGGCACGAGAATATCTGATTGGTCTTGATCCAGAGAACTTGGCTTTGTTAGAAAAAA
TTCAGAGTAGTTTACTGGTATATTCCATGGAGGATAGCAGTCCACATGTAACACCAGAGGATTATTCTGAGATTATTGCAGCCATCCTTA
TTGGAGATCCAACAGTACGCTGGGGTGACAAATCCTATAACTTGATTTCCTTTTCTAATGGAGTATTTGGCTGTAATTGTGATCATGCTC
CTTTTGATGCAATGATTATGGTGAACATCAGTTATTATGTGGATGAGAAAATTTTTCAGAATGAAGGAAGATGGAAGGGTTCAGAGAAGG
TACGAGATATACCACTTCCAGAAGAGCTCATTTTCATTGTGGATGAGAAAGTTTTAAATGACATCAACCAAGCTAAAGCCCAGTATCTCA
GGGAGGCATCTGATCTACAGATTGCGGCTTATGCCTTTACATCTTTTGGCAAAAAGCTAACCAAGAACAAGATGCTTCACCCGGATACGT
TTATTCAGCTTGCACTTCAGCTGGCCTATTACAGACTTCATGGACACCCTGGTTGTTGCTATGAAACAGCTATGACAAGACATTTTTATC
ATGGCCGTACAGAGACTATGCGATCATGCACAGTTGAAGCAGTGAGGTGGTGCCAGTCCATGCAGGATCCTTCTGTCAATCTTCGTGAGC
GGCAGCAAAAGATGTTACAAGCTTTTGCAAAGCATAATAAAATGATGAAAGATTGTTCAGCTGGAAAAGGATTTGATCGTCACCTTTTAG
GTCTCTTACTCATAGCAAAAGAGGAAGGTCTTCCTGTTCCAGAACTCTTTACGGACCCACTTTTTTCCAAAAGCGGAGGAGGTGGAAATT
TTGTTCTCTCAACAAGTCTGGTTGGCTATTTACGAGTCCAGGGAGTGGTAGTTCCCATGGTACACAATGGTTATGGATTTTTCTACCATA
TCAGAGATGACAGATTAATTTCTTGGACTGGAAGAAAGATTGATCCAGTAGGTGTTGATTATATTCTTCAAAAATTGGGCTTTCATCATG
CTAGGACTACTATTCCTAAATGGCTTCAAAGAGGAGTCATGGATCCACTGGACAAGGTTCTGTCAGTTCTTATCAAAAAGCTCGGTACTG
CACTACAGGATGAAAAGGAAAAGAAAGGCAAAGACAAAGAAGAACACTAAAAAAGTAATTTGATCTGTGAACAAATTATGATTGTGTCTG
TTTTATTACACTGGAGTGTTTTTTTAGTATAATAATTTGAAATATAACTTTAAAATAATTCTAAATTTGTGGCTATAATTAAAAGTTTGT
AAGTTAACCTGTTCTAGTTCCATCATTCTGTGTACAGTGAAGTATTGCATGATAATGTAAATTTTGTGAAAAACTAGATTAAAATATATA
ACTGCTTGTTATGGTTTATAATTATATAATGTGCAATACAATTCCTGCATCTTTAAAATGTCTGCAGAATAACTGTGAATTTTTTTGTTA
TTGGATTGGCCGTAACTTTTAGAAAAAAATCTTGTTGATGATAATGTGATTTTGGGGAGGTCATTAATTGCTTTTTCTTTTTTAAATGTA
GACTTATATAAATACCTGTTTGTATATAGCTTGAGTAATTGTGATATGATTGTATACCACTAAAATATTGTTAACTATTATAATAAAGTC

>19539_19539_1_CROT-KIAA1109_CROT_chr7_87022383_ENST00000331536_KIAA1109_chr4_123283186_ENST00000264501_length(amino acids)=652AA_BP=580
MVSYCDFIMENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLE
EWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGIT
RDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPEN
LALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGR
WKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETA
MTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSK
SGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVL

--------------------------------------------------------------
>19539_19539_2_CROT-KIAA1109_CROT_chr7_87022383_ENST00000419147_KIAA1109_chr4_123283186_ENST00000264501_length(transcript)=2723nt_BP=2001nt
TTTGAGGCCCAAGGGGGAGCGAGCCGGTGCTGCTGCAGGCTGAGGCTGCGGCAGAGGCGGCGAGGCGCGGGCGGTGAGGACGGACAGTCA
CCGACTTAGTCCAGTTCCCTGTGATCTCAAAACAATTGTTGCAGCAGGCTCCTGGCAGTCTCAAGCAGTTCATCTTCTTGGTGTACTGGT
TTCCTATTGTGATTTTATCATGGAAAATCAATTGGCTAAATCAACTGAAGAACGAACATTTCAGTACCAGGATTCTCTTCCATCACTGCC
TGTTCCTTCACTTGAAGAATCATTAAAAAAATACCTTGAATCAGTCACCAGAACATGCTACCAGATAAGGGGTCTTGATCCAGATGCTAA
GAGAGGGTTCTTGGATCTCACGCGGGAAGGAATTCAAGTGAAACCATTTGCAAATCAAGAAGAATATAAGAAAACTGAAGAAATAGTTCA
AAAATTTCAAAGTGGGATTGGAGAAAAATTGCACCAGAAATTGCTTGAAAGAGCAAAAGGAAAAAGAAATTGGCTGGAAGAGTGGTGGCT
GAATGTTGCCTATCTGGATGTTCGTATACCATCACAATTGAATGTCAACTTTGCGGGTCCTGCAGCTCATTTTGAACACTACTGGCCTCC
AAAGGAAGGGACTCAATTAGAAAGAGGAAGTATAACTCTTTGGCATAACTTGAACTACTGGCAGCTATTAAGAAAAGAAAAAGTGCCTGT
TCATAAAGTTGGAAATACTCCTCTAGATATGAATCAATTCCGAATGCTATTTTCTACCTGCAAGGTTCCAGGAATTACTAGAGACTCCAT
TATGAATTATTTTAGGACTGAGAGTGAAGGGCGTTCCCCAAACCACATTGTAGTGCTGTGTCGAGGCCGAGCTTTTGTCTTTGATGTAAT
ACATGAAGGATGTTTGGTCACCCCGCCAGAGCTTCTCAGACAACTGACATATATCCACAAGAAGTGCCATAGTGAACCTGATGGACCTGG
GATTGCAGCATTAACTAGTGAGGAGCGAACTCGATGGGCTAAGGCACGAGAATATCTGATTGGTCTTGATCCAGAGAACTTGGCTTTGTT
AGAAAAAATTCAGAGTAGTTTACTGGTATATTCCATGGAGGATAGCAGTCCACATGTAACACCAGAGGATTATTCTGAGATTATTGCAGC
CATCCTTATTGGAGATCCAACAGTACGCTGGGGTGACAAATCCTATAACTTGATTTCCTTTTCTAATGGAGTATTTGGCTGTAATTGTGA
TCATGCTCCTTTTGATGCAATGATTATGGTGAACATCAGTTATTATGTGGATGAGAAAATTTTTCAGAATGAAGGAAGATGGAAGGGTTC
AGAGAAGGTACGAGATATACCACTTCCAGAAGAGCTCATTTTCATTGTGGATGAGAAAGTTTTAAATGACATCAACCAAGCTAAAGCCCA
GTATCTCAGGGAGGCATCTGATCTACAGATTGCGGCTTATGCCTTTACATCTTTTGGCAAAAAGCTAACCAAGAACAAGATGCTTCACCC
GGATACGTTTATTCAGCTTGCACTTCAGCTGGCCTATTACAGACTTCATGGACACCCTGGTTGTTGCTATGAAACAGCTATGACAAGACA
TTTTTATCATGGCCGTACAGAGACTATGCGATCATGCACAGTTGAAGCAGTGAGGTGGTGCCAGTCCATGCAGGATCCTTCTGTCAATCT
TCGTGAGCGGCAGCAAAAGATGTTACAAGCTTTTGCAAAGCATAATAAAATGATGAAAGATTGTTCAGCTGGAAAAGGATTTGATCGTCA
CCTTTTAGGTCTCTTACTCATAGCAAAAGAGGAAGGTCTTCCTGTTCCAGAACTCTTTACGGACCCACTTTTTTCCAAAAGCGGAGGAGG
TGGAAATTTTGTTCTCTCAACAAGTCTGGTTGGCTATTTACGAGTCCAGGGAGTGGTAGTTCCCATGGTACACAATGGTTATGGATTTTT
CTACCATATCAGAGATGACAGATTAATTTCTTGGACTGGAAGAAAGATTGATCCAGTAGGTGTTGATTATATTCTTCAAAAATTGGGCTT
TCATCATGCTAGGACTACTATTCCTAAATGGCTTCAAAGAGGAGTCATGGATCCACTGGACAAGGTTCTGTCAGTTCTTATCAAAAAGCT
CGGTACTGCACTACAGGATGAAAAGGAAAAGAAAGGCAAAGACAAAGAAGAACACTAAAAAAGTAATTTGATCTGTGAACAAATTATGAT
TGTGTCTGTTTTATTACACTGGAGTGTTTTTTTAGTATAATAATTTGAAATATAACTTTAAAATAATTCTAAATTTGTGGCTATAATTAA
AAGTTTGTAAGTTAACCTGTTCTAGTTCCATCATTCTGTGTACAGTGAAGTATTGCATGATAATGTAAATTTTGTGAAAAACTAGATTAA
AATATATAACTGCTTGTTATGGTTTATAATTATATAATGTGCAATACAATTCCTGCATCTTTAAAATGTCTGCAGAATAACTGTGAATTT
TTTTGTTATTGGATTGGCCGTAACTTTTAGAAAAAAATCTTGTTGATGATAATGTGATTTTGGGGAGGTCATTAATTGCTTTTTCTTTTT
TAAATGTAGACTTATATAAATACCTGTTTGTATATAGCTTGAGTAATTGTGATATGATTGTATACCACTAAAATATTGTTAACTATTATA

>19539_19539_2_CROT-KIAA1109_CROT_chr7_87022383_ENST00000419147_KIAA1109_chr4_123283186_ENST00000264501_length(amino acids)=680AA_BP=608
MVSYCDFIMENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVTRTCYQIRGLDPDAKRGFLDLTREGIQVKPFANQEEYKKTEEI
VQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKV
PVHKVGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDG
PGIAALTSEERTRWAKAREYLIGLDPENLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCN
CDHAPFDAMIMVNISYYVDEKIFQNEGRWKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKML
HPDTFIQLALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFD
RHLLGLLLIAKEEGLPVPELFTDPLFSKSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRLISWTGRKIDPVGVDYILQKL

--------------------------------------------------------------
>19539_19539_3_CROT-KIAA1109_CROT_chr7_87022383_ENST00000442291_KIAA1109_chr4_123283186_ENST00000264501_length(transcript)=2557nt_BP=1835nt
CACAGTCACCGACTTAGTCCAGTTCCCTGTGATCTCAAAACAATTGTTGCAGCAGGCTCCTGGCAGTCTCAAGCAGTTCATCTTCTTGGT
GTACTGGTTTCCTATTGTGATTTTATCATGGAAAATCAATTGGCTAAATCAACTGAAGAACGAACATTTCAGTACCAGGATTCTCTTCCA
TCACTGCCTGTTCCTTCACTTGAAGAATCATTAAAAAAATACCTTGAATCAGTGAAACCATTTGCAAATCAAGAAGAATATAAGAAAACT
GAAGAAATAGTTCAAAAATTTCAAAGTGGGATTGGAGAAAAATTGCACCAGAAATTGCTTGAAAGAGCAAAAGGAAAAAGAAATTGGCTG
GAAGAGTGGTGGCTGAATGTTGCCTATCTGGATGTTCGTATACCATCACAATTGAATGTCAACTTTGCGGGTCCTGCAGCTCATTTTGAA
CACTACTGGCCTCCAAAGGAAGGGACTCAATTAGAAAGAGGAAGTATAACTCTTTGGCATAACTTGAACTACTGGCAGCTATTAAGAAAA
GAAAAAGTGCCTGTTCATAAAGTTGGAAATACTCCTCTAGATATGAATCAATTCCGAATGCTATTTTCTACCTGCAAGGTTCCAGGAATT
ACTAGAGACTCCATTATGAATTATTTTAGGACTGAGAGTGAAGGGCGTTCCCCAAACCACATTGTAGTGCTGTGTCGAGGCCGAGCTTTT
GTCTTTGATGTAATACATGAAGGATGTTTGGTCACCCCGCCAGAGCTTCTCAGACAACTGACATATATCCACAAGAAGTGCCATAGTGAA
CCTGATGGACCTGGGATTGCAGCATTAACTAGTGAGGAGCGAACTCGATGGGCTAAGGCACGAGAATATCTGATTGGTCTTGATCCAGAG
AACTTGGCTTTGTTAGAAAAAATTCAGAGTAGTTTACTGGTATATTCCATGGAGGATAGCAGTCCACATGTAACACCAGAGGATTATTCT
GAGATTATTGCAGCCATCCTTATTGGAGATCCAACAGTACGCTGGGGTGACAAATCCTATAACTTGATTTCCTTTTCTAATGGAGTATTT
GGCTGTAATTGTGATCATGCTCCTTTTGATGCAATGATTATGGTGAACATCAGTTATTATGTGGATGAGAAAATTTTTCAGAATGAAGGA
AGATGGAAGGGTTCAGAGAAGGTACGAGATATACCACTTCCAGAAGAGCTCATTTTCATTGTGGATGAGAAAGTTTTAAATGACATCAAC
CAAGCTAAAGCCCAGTATCTCAGGGAGGCATCTGATCTACAGATTGCGGCTTATGCCTTTACATCTTTTGGCAAAAAGCTAACCAAGAAC
AAGATGCTTCACCCGGATACGTTTATTCAGCTTGCACTTCAGCTGGCCTATTACAGACTTCATGGACACCCTGGTTGTTGCTATGAAACA
GCTATGACAAGACATTTTTATCATGGCCGTACAGAGACTATGCGATCATGCACAGTTGAAGCAGTGAGGTGGTGCCAGTCCATGCAGGAT
CCTTCTGTCAATCTTCGTGAGCGGCAGCAAAAGATGTTACAAGCTTTTGCAAAGCATAATAAAATGATGAAAGATTGTTCAGCTGGAAAA
GGATTTGATCGTCACCTTTTAGGTCTCTTACTCATAGCAAAAGAGGAAGGTCTTCCTGTTCCAGAACTCTTTACGGACCCACTTTTTTCC
AAAAGCGGAGGAGGTGGAAATTTTGTTCTCTCAACAAGTCTGGTTGGCTATTTACGAGTCCAGGGAGTGGTAGTTCCCATGGTACACAAT
GGTTATGGATTTTTCTACCATATCAGAGATGACAGATTAATTTCTTGGACTGGAAGAAAGATTGATCCAGTAGGTGTTGATTATATTCTT
CAAAAATTGGGCTTTCATCATGCTAGGACTACTATTCCTAAATGGCTTCAAAGAGGAGTCATGGATCCACTGGACAAGGTTCTGTCAGTT
CTTATCAAAAAGCTCGGTACTGCACTACAGGATGAAAAGGAAAAGAAAGGCAAAGACAAAGAAGAACACTAAAAAAGTAATTTGATCTGT
GAACAAATTATGATTGTGTCTGTTTTATTACACTGGAGTGTTTTTTTAGTATAATAATTTGAAATATAACTTTAAAATAATTCTAAATTT
GTGGCTATAATTAAAAGTTTGTAAGTTAACCTGTTCTAGTTCCATCATTCTGTGTACAGTGAAGTATTGCATGATAATGTAAATTTTGTG
AAAAACTAGATTAAAATATATAACTGCTTGTTATGGTTTATAATTATATAATGTGCAATACAATTCCTGCATCTTTAAAATGTCTGCAGA
ATAACTGTGAATTTTTTTGTTATTGGATTGGCCGTAACTTTTAGAAAAAAATCTTGTTGATGATAATGTGATTTTGGGGAGGTCATTAAT
TGCTTTTTCTTTTTTAAATGTAGACTTATATAAATACCTGTTTGTATATAGCTTGAGTAATTGTGATATGATTGTATACCACTAAAATAT

>19539_19539_3_CROT-KIAA1109_CROT_chr7_87022383_ENST00000442291_KIAA1109_chr4_123283186_ENST00000264501_length(amino acids)=652AA_BP=580
MVSYCDFIMENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLE
EWWLNVAYLDVRIPSQLNVNFAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGIT
RDSIMNYFRTESEGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCHSEPDGPGIAALTSEERTRWAKAREYLIGLDPEN
LALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYYVDEKIFQNEGR
WKGSEKVRDIPLPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQLALQLAYYRLHGHPGCCYETA
MTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGKGFDRHLLGLLLIAKEEGLPVPELFTDPLFSK
SGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CROT-KIAA1109

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CROT-KIAA1109

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CROT-KIAA1109

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source