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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CRTAC1-CCT5 (FusionGDB2 ID:19545)

Fusion Gene Summary for CRTAC1-CCT5

Fusion gene summary

Fusion gene information	Fusion gene name: CRTAC1-CCT5
	Fusion gene ID: 19545
		Hgene	Tgene
	Gene symbol	CRTAC1	CCT5
	Gene ID	55118	22948
	Gene name	cartilage acidic protein 1	chaperonin containing TCP1 subunit 5
	Synonyms	ASPIC\|ASPIC1\|CEP-68\|CEP68\|LOTUS	CCT-epsilon\|CCTE\|HEL-S-69\|PNAS-102\|TCP-1-epsilon
	Cytomap	10q24.2	5p15.2
	Type of gene	protein-coding	protein-coding
	Description	cartilage acidic protein 1acidic secreted protein in cartilagechondrocyte expressed protein 68 kDa CEP-68	T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
	Modification date	20200313	20200313
	UniProtAcc	Q9NQ79	P48643
	Ensembl transtripts involved in fusion gene	ENST00000298819, ENST00000370597, ENST00000370591, ENST00000468549,	ENST00000503026, ENST00000506600, ENST00000515390, ENST00000515676, ENST00000280326,
Fusion gene scores	* DoF score	2 X 2 X 2=8	58 X 14 X 17=13804
	# samples	2	61
	** MAII score	log2(2/8*10)=1.32192809488736	log2(61/13804*10)=-4.50013332598527 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CRTAC1 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CRTAC1(99624758)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.	CRTAC1-CCT5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CRTAC1-CCT5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CRTAC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UVM	TCGA-VD-A8KD-01A	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+

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Fusion Gene ORF analysis for CRTAC1-CCT5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000298819	ENST00000503026	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000298819	ENST00000506600	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000298819	ENST00000515390	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000298819	ENST00000515676	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000370597	ENST00000503026	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000370597	ENST00000506600	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000370597	ENST00000515390	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000370597	ENST00000515676	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
Frame-shift	ENST00000370597	ENST00000280326	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
In-frame	ENST00000298819	ENST00000280326	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000370591	ENST00000280326	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000468549	ENST00000280326	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000370591	ENST00000503026	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000370591	ENST00000506600	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000370591	ENST00000515390	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000370591	ENST00000515676	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000468549	ENST00000503026	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000468549	ENST00000506600	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000468549	ENST00000515390	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+
intron-intron	ENST00000468549	ENST00000515676	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000298819

CRTAC1

chr10

99624758

ENST00000280326

CCT5

chr5

10250033

6521

2846

2242

743

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000298819	ENST00000280326	CRTAC1	chr10	99624758	-	CCT5	chr5	10250033	+	0.000623226	0.99937683

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Fusion Genomic Features for CRTAC1-CCT5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CRTAC1	chr10	99624757	-	CCT5	chr5	10250032	+	0.15650329	0.84349674
CRTAC1	chr10	99624757	-	CCT5	chr5	10250032	+	0.15650329	0.84349674

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRTAC1-CCT5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:99624758/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CRTAC1 Q9NQ79	CCT5 P48643
	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

622_639

830

629.0

Compositional bias

Note=Ala-rich

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

622_639

844

662.0

Compositional bias

Note=Ala-rich

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

559_605

830

629.0

Domain

Note=EGF-like

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

559_605

844

662.0

Domain

Note=EGF-like

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

105_147

830

629.0

Repeat

Note=FG-GAP 2%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

283_333

830

629.0

Repeat

Note=FG-GAP 3%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

395_437

830

629.0

Repeat

Note=FG-GAP 4%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000298819

46_88

830

629.0

Repeat

Note=FG-GAP 1%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

105_147

844

662.0

Repeat

Note=FG-GAP 2%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

283_333

844

662.0

Repeat

Note=FG-GAP 3%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

395_437

844

662.0

Repeat

Note=FG-GAP 4%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370597

46_88

844

662.0

Repeat

Note=FG-GAP 1%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

622_639

646.0

Compositional bias

Note=Ala-rich

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

559_605

646.0

Domain

Note=EGF-like

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

105_147

646.0

Repeat

Note=FG-GAP 2%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

283_333

646.0

Repeat

Note=FG-GAP 3%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

395_437

646.0

Repeat

Note=FG-GAP 4%3B atypical

Hgene

CRTAC1

chr10:99624758

chr5:10250033

ENST00000370591

46_88

646.0

Repeat

Note=FG-GAP 1%3B atypical

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Fusion Gene Sequence for CRTAC1-CCT5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>19545_19545_1_CRTAC1-CCT5_CRTAC1_chr10_99624758_ENST00000298819_CCT5_chr5_10250033_ENST00000280326_length(transcript)=6521nt_BP=2846nt
CTGGCTGCCGGCTGCTGCCACCGCAATCCCGGCTCCTAAATCAGCGCGGGGAGGCGCTCCCTCCCCACGCCCGGCTCTCCGGGCTCTCGG
GGCCGCGATTGGCCGCGCCGGCGCCCCCCACCCCGGGCCCCCGGCTCCAGCTGCCGCGCCATTGGCTGCGGGCCTCCGCCAGCCTTTACA
TAAGACCGGGCGCGCTCGAGTGGAGTTGTATAAAGCGAGCGCGCGGCGTCGGGGCGGGAGGCTCGAGGCCAGCCCGGGACCGGGGCTGGG
AGCAAGCAGGCGGCGGCGCCGGCGGCAGAGGCGGCAGCGAGCGCCCGCTTCCCACGCCCCTAGGCGGCGGGGCCGAGAGCGGGAGGATGG
CTCCGAGCGCTGACCCCGGCATGTCCAGGATGTTACCGTTCCTGCTGCTGCTCTGGTTTCTGCCCATCACTGAGGGGTCCCAGCGGGCTG
AACCCATGTTCACTGCAGTCACCAACTCAGTTCTGCCTCCTGACTATGACAGTAATCCCACCCAGCTCAACTATGGTGTGGCAGTTACTG
ATGTGGACCATGATGGGGACTTTGAGATCGTCGTGGCGGGGTACAATGGACCCAACCTGGTTCTGAAGTATGACCGGGCCCAGAAGCGGC
TGGTGAACATCGCGGTCGATGAGCGCAGCTCACCCTACTACGCGCTGCGGGACCGGCAGGGGAACGCCATCGGGGTCACAGCCTGCGACA
TCGACGGGGACGGCCGGGAGGAGATCTACTTCCTCAACACCAATAATGCCTTCTCGGGGGTGGCCACGTACACCGACAAGTTGTTCAAGT
TCCGCAATAACCGGTGGGAAGACATCCTGAGCGATGAGGTCAACGTGGCCCGTGGTGTGGCCAGCCTCTTTGCCGGACGCTCTGTGGCCT
GTGTGGACAGAAAGGGCTCTGGACGCTACTCTATCTACATTGCCAATTACGCCTACGGTAATGTGGGCCCTGATGCCCTCATTGAAATGG
ACCCTGAGGCCAGTGACCTCTCCCGGGGCATTCTGGCGCTCAGAGATGTGGCTGCTGAGGCTGGGGTCAGCAAATATACAGGGGGCCGAG
GCGTCAGCGTGGGCCCCATCCTCAGCAGCAGTGCCTCGGATATCTTCTGCGACAATGAGAATGGGCCTAACTTCCTTTTCCACAACCGGG
GCGATGGCACCTTTGTGGACGCTGCGGCCAGTGCTGGTGTGGACGACCCCCACCAGCATGGGCGAGGTGTCGCCCTGGCTGACTTCAACC
GTGATGGCAAAGTGGACATCGTCTATGGCAACTGGAATGGCCCCCACCGCCTCTATCTGCAAATGAGCACCCATGGGAAGGTCCGCTTCC
GGGACATCGCCTCACCCAAGTTCTCCATGCCCTCCCCTGTCCGCACGGTCATCACCGCCGACTTTGACAATGACCAGGAGCTGGAGATCT
TCTTCAACAACATTGCCTACCGCAGCTCCTCAGCCAACCGCCTCTTCCGCGTCATCCGTAGAGAGCACGGAGACCCCCTCATCGAGGAGC
TCAATCCCGGCGACGCCTTGGAGCCTGAGGGCCGGGGCACAGGGGGTGTGGTGACCGACTTCGACGGAGACGGGATGCTGGACCTCATCT
TGTCCCATGGAGAGTCCATGGCTCAGCCGCTGTCCGTCTTCCGGGGCAATCAGGGCTTCAACAACAACTGGCTGCGAGTGGTGCCACGCA
CCCGGTTTGGGGCCTTTGCCAGGGGAGCTAAGGTCGTGCTCTACACCAAGAAGAGTGGGGCCCACCTGAGGATCATCGACGGGGGCTCAG
GCTACCTGTGTGAGATGGAGCCCGTGGCACACTTTGGCCTGGGGAAGGATGAAGCCAGCAGTGTGGAGGTGACGTGGCCAGATGGCAAGA
TGGTGAGCCGGAACGTGGCCAGCGGGGAGATGAACTCAGTGCTGGAGATCCTCTACCCCCGGGATGAGGACACACTTCAGGACCCAGCCC
CACTGGAGACACCAATGAATGCATCCAGTTCCCATTCGTGTGCCCTCGAGACAAGCCCGTATGTGTCAACACCTATGGAAGCTACAGGTG
CCGGACCAACAAGAAGTGCAGTCGGGGCTACGAGCCCAACGAGGATGGCACAGCCTGCGTGGGGACTCTCGGCCAGTCACCGGGCCCCCG
CCCCACCACCCCCACCGCTGCTGCTGCCACTGCCGCTGCTGCTGCCGCTGCTGGAGCTGCCACTGCTGCACCGGTCCTCGTAGATGGAGA
TCTCAATCTGGGGTCGGTGGTTAAGGAGAGCTGCGAGCCCAGCTGCTGAGCAGGGGTGGGACATGAACCAGCGGATGGAGTCCAGCAGGG
GAGTGGGAAAGTGGGCTTGTGCTGCTGCCTAGACAGTAGGGATGTAAAGGCCTGGGAGCTAGACCCTCCCCAAGCCCATCCATGCACATT
ACTTAGCTAACAATTAGGGAGACTCGTAAGGCCAGGCCCTGTGCTGGGCACATAGCTGTGATCACAGCAGACAGGGTCGCTGCCCTGATG
GCGCTTACATTCCAGTGGGTCTAATGACCATATCTTAGGACACAGATGTGCCCAGGGAGGTGGTGTCACTGCACAGGAAGTATGAGGACT
TTAGTGTCCTGAGTTCAAATCCTGATTCAGGAACTCACAAAGCTATGTGACCTTACACCAGTCACTTAACTTGTTAGCCATCCATTATCG
CATCTGCAAAATGGGGATTAAGAATAGAATCTTGGGGTTAGTGTGGAGATTAGATTAAATGTATGTAAGACACTTGGCACAAAACCTGGC
ACATAGTAAAGGCTCAATAAAAACAAGTGCCTCTCACTGGGCTTTGTCAACACGTGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCAT
CTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGT
GGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCC
GGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCC
GCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGG
GGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATC
AGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCAC
TTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGG
ATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCC
TGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTC
GTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCA
CGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGA
GAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACA
AGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAA
CAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAA
TTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGG
TTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGA
AGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAG
CTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACC
TCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCA
CCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCC
AGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGA
AGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATG
ACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCT
CGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTC
ACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATC
TTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAAT
AAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTAT
CTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACC
TGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAA
TCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAG
TGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAA
AGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACT
TTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAG
TCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCAT
TGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGT
CTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTC
TACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATAT
GGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTT
TGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTT
CCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAA

>19545_19545_1_CRTAC1-CCT5_CRTAC1_chr10_99624758_ENST00000298819_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=743AA_BP=
MLPPQSRLLNQRGEALPPHARLSGLSGPRLAAPAPPTPGPRLQLPRHWLRASASLYIRPGALEWSCIKRARGVGAGGSRPARDRGWEQAG
GGAGGRGGSERPLPTPLGGGAESGRMAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLNYGVAVTDVDH
DGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNN
RWEDILSDEVNVARGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVAAEAGVSKYTGGRGVSV
GPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIA
SPKFSMPSPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGRGTGGVVTDFDGDGMLDLILSHG
ESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSR
NVASGEMNSVLEILYPRDEDTLQDPAPLETPMNASSSHSCALETSPYVSTPMEATGAGPTRSAVGATSPTRMAQPAWGLSASHRAPAPPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CRTAC1-CCT5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CRTAC1-CCT5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CRTAC1-CCT5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source