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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRTC1-HNRNPM (FusionGDB2 ID:19556)

Fusion Gene Summary for CRTC1-HNRNPM

check button Fusion gene summary
Fusion gene informationFusion gene name: CRTC1-HNRNPM
Fusion gene ID: 19556
HgeneTgene
Gene symbol

CRTC1

HNRNPM

Gene ID

23373

4670

Gene nameCREB regulated transcription coactivator 1heterogeneous nuclear ribonucleoprotein M
SynonymsMAML2|MECT1|Mam-2|TORC-1|TORC1|WAMTP1CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M
Cytomap

19p13.11

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionCREB-regulated transcription coactivator 1Mastermind-like protein 2mucoepidermoid carcinoma translocated protein 1transducer of regulated cAMP response element-binding protein (CREB) 1heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4
Modification date2020031320200322
UniProtAcc

Q6UUV9

P52272

Ensembl transtripts involved in fusion geneENST00000321949, ENST00000338797, 
ENST00000594658, ENST00000601916, 
ENST00000602219, ENST00000325495, 
ENST00000348943, 
Fusion gene scores* DoF score10 X 7 X 7=49016 X 16 X 5=1280
# samples 1018
** MAII scorelog2(10/490*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1280*10)=-2.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRTC1 [Title/Abstract] AND HNRNPM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRTC1(18860685)-HNRNPM(8548042), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRTC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14536081


check buttonFusion gene breakpoints across CRTC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HNRNPM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-A6J5-01ACRTC1chr19

18860685

+HNRNPMchr19

8548042

+


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Fusion Gene ORF analysis for CRTC1-HNRNPM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321949ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000338797ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000594658ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000601916ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000321949ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000321949ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000338797ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000338797ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000594658ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000594658ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000601916ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000601916ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321949CRTC1chr1918860685+ENST00000348943HNRNPMchr198548042+1897564261636536
ENST00000321949CRTC1chr1918860685+ENST00000325495HNRNPMchr198548042+1897564261636536
ENST00000338797CRTC1chr1918860685+ENST00000348943HNRNPMchr198548042+1944611251683552
ENST00000338797CRTC1chr1918860685+ENST00000325495HNRNPMchr198548042+1944611251683552
ENST00000594658CRTC1chr1918860685+ENST00000348943HNRNPMchr198548042+1780447171519500
ENST00000594658CRTC1chr1918860685+ENST00000325495HNRNPMchr198548042+1780447171519500
ENST00000601916CRTC1chr1918860685+ENST00000348943HNRNPMchr198548042+1745412241484486
ENST00000601916CRTC1chr1918860685+ENST00000325495HNRNPMchr198548042+1745412241484486

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321949ENST00000348943CRTC1chr1918860685+HNRNPMchr198548042+0.0205367930.9794632
ENST00000321949ENST00000325495CRTC1chr1918860685+HNRNPMchr198548042+0.0205367930.9794632
ENST00000338797ENST00000348943CRTC1chr1918860685+HNRNPMchr198548042+0.0195481030.9804519
ENST00000338797ENST00000325495CRTC1chr1918860685+HNRNPMchr198548042+0.0195481030.9804519
ENST00000594658ENST00000348943CRTC1chr1918860685+HNRNPMchr198548042+0.0186406370.98135936
ENST00000594658ENST00000325495CRTC1chr1918860685+HNRNPMchr198548042+0.0186406370.98135936
ENST00000601916ENST00000348943CRTC1chr1918860685+HNRNPMchr198548042+0.0205002820.9794997
ENST00000601916ENST00000325495CRTC1chr1918860685+HNRNPMchr198548042+0.0205002820.9794997

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Fusion Genomic Features for CRTC1-HNRNPM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CRTC1chr1918860685+HNRNPMchr198548041+1.39E-060.99999857
CRTC1chr1918860685+HNRNPMchr198548041+1.39E-060.99999857

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CRTC1-HNRNPM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:18860685/chr19:8548042)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRTC1

Q6UUV9

HNRNPM

P52272

FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}.FUNCTION: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116390_396373731.0Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116612_616373731.0Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217390_396334692.0Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217612_616334692.0Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116653_729373731.0DomainRRM 3
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217653_729334692.0DomainRRM 3
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116400_608373731.0RegionNote=27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217400_608334692.0RegionNote=27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116400_405373731.0RepeatNote=1
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116407_412373731.0RepeatNote=2
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116415_420373731.0RepeatNote=3
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116426_431373731.0RepeatNote=4
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116433_438373731.0RepeatNote=5
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116440_445373731.0RepeatNote=6
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116446_451373731.0RepeatNote=7
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116453_458373731.0RepeatNote=8
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116461_466373731.0RepeatNote=9
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116468_473373731.0RepeatNote=10
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116475_480373731.0RepeatNote=11
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116482_487373731.0RepeatNote=12
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116493_498373731.0RepeatNote=13
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116500_505373731.0RepeatNote=14
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116507_512373731.0RepeatNote=15
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116514_519373731.0RepeatNote=16
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116521_526373731.0RepeatNote=17
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116528_533373731.0RepeatNote=18
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116540_545373731.0RepeatNote=19
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116547_552373731.0RepeatNote=20
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116554_559373731.0RepeatNote=21
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116562_566373731.0RepeatNote=22
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116567_572373731.0RepeatNote=23
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116575_579373731.0RepeatNote=24
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116580_585373731.0RepeatNote=25
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116588_593373731.0RepeatNote=26
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116603_608373731.0RepeatNote=27
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217400_405334692.0RepeatNote=1
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217407_412334692.0RepeatNote=2
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217415_420334692.0RepeatNote=3
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217426_431334692.0RepeatNote=4
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217433_438334692.0RepeatNote=5
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217440_445334692.0RepeatNote=6
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217446_451334692.0RepeatNote=7
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217453_458334692.0RepeatNote=8
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217461_466334692.0RepeatNote=9
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217468_473334692.0RepeatNote=10
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217475_480334692.0RepeatNote=11
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217482_487334692.0RepeatNote=12
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217493_498334692.0RepeatNote=13
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217500_505334692.0RepeatNote=14
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217507_512334692.0RepeatNote=15
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217514_519334692.0RepeatNote=16
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217521_526334692.0RepeatNote=17
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217528_533334692.0RepeatNote=18
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217540_545334692.0RepeatNote=19
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217547_552334692.0RepeatNote=20
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217554_559334692.0RepeatNote=21
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217562_566334692.0RepeatNote=22
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217567_572334692.0RepeatNote=23
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217575_579334692.0RepeatNote=24
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217580_585334692.0RepeatNote=25
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217588_593334692.0RepeatNote=26
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217603_608334692.0RepeatNote=27

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRTC1chr19:18860685chr19:8548042ENST00000321949+514299_366179635.0Compositional biasNote=Ser-rich
HgeneCRTC1chr19:18860685chr19:8548042ENST00000338797+615299_366195651.0Compositional biasNote=Ser-rich
HgeneCRTC1chr19:18860685chr19:8548042ENST00000321949+514242_258179635.0MotifNuclear export signal
HgeneCRTC1chr19:18860685chr19:8548042ENST00000338797+615242_258195651.0MotifNuclear export signal
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003254951116204_281373731.0DomainRRM 2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495111671_149373731.0DomainRRM 1
TgeneHNRNPMchr19:18860685chr19:8548042ENST000003489431217204_281334692.0DomainRRM 2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943121771_149334692.0DomainRRM 1


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Fusion Gene Sequence for CRTC1-HNRNPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19556_19556_1_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000321949_HNRNPM_chr19_8548042_ENST00000325495_length(transcript)=1897nt_BP=564nt
GAGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGG
CGGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGC
AACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGA
CCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCG
GCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCG
CGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGT
CCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAG
GAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACG
GCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGC
GCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCA
TGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGG
AGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCC
CCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCC
TCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGC
GCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAG
GTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACAT
GGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCG
TGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAA
TTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGT
TGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTG
TTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGAATATGACTTTGATAATAAATACCGGTTC

>19556_19556_1_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000321949_HNRNPM_chr19_8548042_ENST00000325495_length(amino acids)=536AA_BP=179
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLD
TSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRE
ILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDH
MASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATG
LERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGH

--------------------------------------------------------------
>19556_19556_2_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000321949_HNRNPM_chr19_8548042_ENST00000348943_length(transcript)=1897nt_BP=564nt
GAGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGG
CGGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGC
AACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGA
CCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCG
GCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCG
CGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGT
CCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAG
GAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACG
GCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGC
GCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCA
TGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGG
AGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCC
CCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCC
TCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGC
GCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAG
GTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACAT
GGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCG
TGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAA
TTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGT
TGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTG
TTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGAATATGACTTTGATAATAAATACCGGTTC

>19556_19556_2_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000321949_HNRNPM_chr19_8548042_ENST00000348943_length(amino acids)=536AA_BP=179
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLD
TSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRE
ILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDH
MASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATG
LERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGH

--------------------------------------------------------------
>19556_19556_3_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000338797_HNRNPM_chr19_8548042_ENST00000325495_length(transcript)=1944nt_BP=611nt
AGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGC
GGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCA
ACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCC
CAGCGGATTTCTGGGGGAGGCCCTGGCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCG
GCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACG
GCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCA
CCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACT
GAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCG
CCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGT
CATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGA
GCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCC
CATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGA
GCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGC
CAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGA
GCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGA
CCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAG
GAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCT
GTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCG
GATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATA
CGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTT
GGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGT

>19556_19556_3_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000338797_HNRNPM_chr19_8548042_ENST00000325495_length(amino acids)=552AA_BP=195
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQPSGFLGEAL
AAAPVSLTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQ
PESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVE
RMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMG
AGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERG
NFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLS

--------------------------------------------------------------
>19556_19556_4_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000338797_HNRNPM_chr19_8548042_ENST00000348943_length(transcript)=1944nt_BP=611nt
AGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGC
GGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCA
ACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCC
CAGCGGATTTCTGGGGGAGGCCCTGGCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCG
GCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACG
GCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCA
CCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACT
GAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCG
CCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGT
CATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGA
GCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCC
CATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGA
GCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGC
CAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGA
GCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGA
CCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAG
GAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCT
GTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCG
GATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATA
CGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTT
GGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGT

>19556_19556_4_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000338797_HNRNPM_chr19_8548042_ENST00000348943_length(amino acids)=552AA_BP=195
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQPSGFLGEAL
AAAPVSLTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQ
PESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVE
RMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMG
AGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERG
NFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLS

--------------------------------------------------------------
>19556_19556_5_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000594658_HNRNPM_chr19_8548042_ENST00000325495_length(transcript)=1780nt_BP=447nt
CCCTTAGGGGAAGAGTCCTGCTCTGGCTGTTGATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACT
ATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACA
CCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAG
TGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATT
CTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAA
TCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGG
GTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCG
AGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACA
TGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTG
AGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCA
TGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCC
TGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGG
GTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTG
GCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATG
CTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACG
AGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGG
CCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCT
TTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAA
AATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAA

>19556_19556_5_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000594658_HNRNPM_chr19_8548042_ENST00000325495_length(amino acids)=500AA_BP=143
MLWLLMLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGR
QADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDR
LGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAP
IDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLE
RMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVL

--------------------------------------------------------------
>19556_19556_6_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000594658_HNRNPM_chr19_8548042_ENST00000348943_length(transcript)=1780nt_BP=447nt
CCCTTAGGGGAAGAGTCCTGCTCTGGCTGTTGATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACT
ATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACA
CCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAG
TGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATT
CTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAA
TCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGG
GTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCG
AGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACA
TGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTG
AGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCA
TGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCC
TGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGG
GTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTG
GCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATG
CTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACG
AGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGG
CCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCT
TTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAA
AATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAA

>19556_19556_6_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000594658_HNRNPM_chr19_8548042_ENST00000348943_length(amino acids)=500AA_BP=143
MLWLLMLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGR
QADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDR
LGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAP
IDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLE
RMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVL

--------------------------------------------------------------
>19556_19556_7_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000601916_HNRNPM_chr19_8548042_ENST00000325495_length(transcript)=1745nt_BP=412nt
CTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGG
AGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGAC
AGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCC
TATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCC
ACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATT
GCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATG
GAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCC
GTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATG
GAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAG
ACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGT
ATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATG
GGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATG
GGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAG
CGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTT
GTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATG
GAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAG
CTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTA
TTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTT
TTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGA

>19556_19556_7_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000601916_HNRNPM_chr19_8548042_ENST00000325495_length(amino acids)=486AA_BP=129
MQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSP
PADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLG
HGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSG
VERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGI
ERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGC

--------------------------------------------------------------
>19556_19556_8_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000601916_HNRNPM_chr19_8548042_ENST00000348943_length(transcript)=1745nt_BP=412nt
CTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGG
AGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGAC
AGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCC
TATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCC
ACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATT
GCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATG
GAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCC
GTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATG
GAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAG
ACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGT
ATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATG
GGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATG
GGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAG
CGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTT
GTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATG
GAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAG
CTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTA
TTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTT
TTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGA

>19556_19556_8_CRTC1-HNRNPM_CRTC1_chr19_18860685_ENST00000601916_HNRNPM_chr19_8548042_ENST00000348943_length(amino acids)=486AA_BP=129
MQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSP
PADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLG
HGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSG
VERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGI
ERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGC

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Fusion Gene PPI Analysis for CRTC1-HNRNPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRTC1-HNRNPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRTC1-HNRNPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource